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Sitorus, Jans Juliana Raouli
Faktor yang berhubungan dengan terjadinya distres dan gambaran strategi koping pada pasien tumor otak sebelum mendapatkan terapi = Distress and coping strategies in pre treatment brain tumor patients / Jans Juliana Raouli Sitorus
"ABSTRAK
Latar Belakang. Pasien tumor otak sangat berpotensi mengalami distres karena tumor otak menimbulkan disabilitas, menurunkan kualitas hidup bahkan menyebabkan kematian. Kerentanan dalam mengalami distres dipengaruhi kemampuan koping pasien. Tujuan penelitian ini untuk mengetahui faktor-faktor yang berhubungan dengan terjadinya distres dan gambaran strategi koping pada pasien tumor otak sebelum mendapatkan terapi.Metode. Desain penelitian analitik observasional dengan rancangan studi potong lintang cross sectional , subyek penelitian pasien tumor otak yang belum mendapatkan terapi, berjumlah 140 orang. Pengambilan sampel menggunakan teknik non probability sampling berupa consecutive sampling. Instrumen penelitian menggunakan self report questionnaire: Distress Thermometer DT dan instrumen Coping Orientation to the Problem Experienced COPE yang telah diadaptasi di Indonesia. DT terdiri dari penilaian subyektif mengenai distres dan domain distres. Instrumen COPE termasuk Religious Coping Scale, terdiri dari 61 pernyataan dengan skala likert 1 sampai 4. Data dianalisis menggunakan SPSS versi 20. Tingkat kemaknaan yang digunakan untuk uji statistik adalah p< 0,05. Hasil. Proporsi distres pada pasien tumor otak sebelum mendapatkan terapi sebesar 68,6 . Domain distres banyak dilaporkan adalah masalah fisik 95,7 , masalah emosional 88,3 , dan masalah praktis 77,9 . Domain terkait gejala khas tumor otak yaitu nyeri kepala 78,6 , kelemahan di kaki atau lengan 54,3 dan pandangan/penglihatan ganda 50,7 . Subyek yang mengalami distres memiliki rerata active coping dan religious focused coping lebih rendah serta rerata emotion focused coping dan avoidance coping lebih tinggi dibandingkan yang tidak mengalami distres. Korelasi emotion focused coping dan avoidance coping dengan distres r=0,3 dan 0,2 ; p< 0,05 . Korelasi religious focused coping dengan distres r=-0,2 ; p< 0,05 Simpulan. Proporsi distres pasien tumor otak 68,6 . Domain distres antara lain masalah fisik 95,7 , masalah emosional 88,3 , dan masalah praktis 77,9 . Emotion focused coping memiliki korelasi positif sedang dan avoidance coping memiliki korelasi positif lemah dengan distres. Religious focused coping memiliki korelasi negatif lemah dengan distres. Kata Kunci: tumor otak, distres, strategi koping
ABSTRACT
Background. Brain tumor patients are potentially prone to distress because of the disability directly caused by the tumor. Vulnerability to distress affected by patients rsquo coping skills. The purpose of this study is to determine the factors associated with the occurrence of distress and coping strategies overview on brain tumor patients before therapy.Method. The study design was observational analytic with cross sectional design. The subjects were brain tumor patients who have not received treatment, amounted to 140 people. Sampling was done using non probability sampling in the form of consecutive sampling. The research instruments used were self report questionnaire Distress Thermometer DT and Coping Orientation to Problems Experienced COPE , which has been adapted to Indonesia. DT consisted of a subjective assessment of the distress and distress domains. COPE instrument, including the Religious Coping Scale, consisting of 61 statements with Likert scale of 1 to 4. Data were analyzed using SPSS version 20. The level of significance used for the statistical tests was p"
2016
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Tiara Nugraeni
Strategi Koping dan Faktor Terkait Distres pada Pasien Tumor Metastasis Spinal di RSUPN Cipto Mangunkusumo = Coping Strategies and Distress Related Factors in Patients with Metastatic Spinal Tumor at Cipto Mangunkusumo General Hospital
"Spinal merupakan tempat metastasis tumor terbanyak, menyebabkan defisit neurologis akibat kompresi saraf spinal, berpotensi distres sehingga mengakibatkan rendahnya kualitas hidup. Kerentanan terhadap distres dipengaruhi strategi koping. Penelitian potong lintang untuk mengetahui strategi koping dan faktor terkait distres pada pasien tumor metastasis spinal di RSCM. Sebanyak 104 subjek diambil dari rawat jalan maupun rawat inap. Analisis bivariat dan multivariat menilai hubungan antara gambaran masalah, strategi koping, faktor sosiodemografi, serta karakteristik tumor spinal dengan distres. Proporsi distres subjek penelitian ini adalah 57,7% masalah terbanyak spesifik tumor spinal (87,5%), namun hubungannya tidak bermakna terhadap distres. Hubungan bermakna ditemukan pada masalah keluarga dan masalah emosional. Strategi religious-focused coping paling sering digunakan. Subjek yang mengalami distres memiliki median total skor problem-focused coping (PFC) lebih rendah, emotional-focused coping (EFC) dan avoidance coping lebih tinggi dibandingkan dengan yang tidak mengalami distres. Hubungan bermakna juga ditemukan pada faktor usia dan karakteristik tumor spinal berupa gangguan motorik, sensorik, otonom, dan status pengobatan. Gangguan sensorik berisiko lebih tinggi terjadi distres dibandingkan defisit neurologis lain. Analisis multivariat menunjukkan strategi EFC dan avoidance coping sebagai faktor risiko. Perlunya dilakukan skrining dan pendampingan psikiatri pada pasien tumor metastasis spinal, serta peningkatan kerja sama psikiatri dengan layanan tumor terpadu.
Spinal is the most site of tumor metastases, causing neurological deficits due to spinal nerve compression, potentially causing distress resulting in low quality of life. Vulnerability to distress is influenced by coping strategies. A cross-sectional study to determine coping strategies and factors related to stress in patients with spinal metastatic tumors in RSCM. A total of 104 subjects were taken from outpatient and inpatient. Bivariate and multivariate analyzes assessed the relationship between problem description, coping strategies, sociodemographic factors, and characteristics of spinal tumors with distress. The proportion of the subject's distress in this study was 57.7%, the most problems were spinal tumor-specific (87.5%), but the relationship was not significant to distress. Significant relationships were found in family problems and emotional problems. Religious-focused coping strategies are most often used. Subjects who experienced distress had a lower median total score of problem-focused coping (PFC), emotional-focused coping (EFC) and higher avoidance coping than those who did not experience distress. A significant relationship was also found in the age factor and spinal tumor characteristics in the form of motor, sensory, autonomic disorders, and treatment status. Sensory disturbances are at a higher risk of developing distress than other neurologic deficits. Multivariate analysis showed EFC strategy and avoidance coping as risk factors. The need for screening and psychiatric assistance in spinal metastatic tumor patients, as well as increasing the cooperation of psychiatry with integrated tumor services"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
cover
Dian Oktaria Safitri
Efektivitas Psikoterapi Suportif pada Distres, Psikopatologi dan Kualitas Hidup Pasien Tumor Otak Metastasis = Effectiveness of Supportive Psychotherapy towards Distress, Psychopathology and Quality of Life of Patients with Metastatic Brain Tumors
"Latar belakang. Tumor otak metastasis berpotensi menyebabkan distres dan psikopatologi, serta menurunkan kualitas hidup pasien. Kerentanan ini terjadi karena beban gejala fisik dari tumor primer dan gejala dari metastasis otak yang dialami. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh psikoterapi suportif pada perbaikan distres, psikopatologi dan kualitas hidup pasien.
Metode. Desain penelitian yang digunakan dalam penelitian ini adalah uji klinis randomisasi, tersamar tunggal, desain paralel tanpa matching, pragmatis. 15 pasien kelompok perlakuan adalah pasien tumor otak metastasis yang mendapatkan intervensi psikoterapi suportif sebanyak 6 sesi selama 30-45 menit pada setiap sesi dan perawatan standar dari dokter saraf, sedangkan 15 pasien kelompok kontrol mendapatkan terapi standar dari dokter spesialis saraf saja. Penelitian ini menggunakan kuesioner distress thermometer (DT) untuk menilai distres, Self-rating Questionnaire 20 (SRQ 20) untuk menilai psikopatologi dan World Health Organization Quality of life-Bref (WHOQOL-Bref) untuk menilai kualitas hidup pasien sebelum dan setelah intervensi. Sebelum dilakukan intervensi, dilakukan validasi isi pada modul psikoterapi suportif yang akan digunakan. Tidak ada subjek yang dropped out (lepas pantau) dan loss to followup dalam penelitian ini.
Hasil. Hasil penelitian semua subjek kelompok perlakuan sebanyak 15 (100,0%) mengalami perbaikan skor distres, psikopatologi, dan kualitas hidup yang bermakna secara bermakna(P=0,00) sebelum dan sesudah psikoterapi suportif. Selain iut, didapatkan juga perbedaan yang bermakna secara bermaknadalam proporsi pasien yang mengalami masalah psikososial berupa masalah praktis sehari-hari, masalah emosional, dan masalah gejala tumor otak metastasis antara sebelum dan setelah intervensi (P<0,05). Ditemukan juga penurunan rata-rata skor variabel gejala tumor otak metastasis (p=0,00) berupa nyeri kepala (p=0,00), kelemahan (p=0,00), kejang dan penglihatan ganda antara sebelum dan sesudah intervensi psikoterapi suportif, pada kedua kelompok. Nilai keseluruhan validasi modul psikoterapi suportif 96,21% dan validasi isi setiap sesi lebih dari 90% sehingga menunjukkan hasil yang valid. Faktor demografi yang memengaruhi perbaikan skor psikopatologi adalah status ekonomi (p=0,03).
Kesimpulan. Psikoterapi suportif berpengaruh secara bermaknadalam menurunkan distres dan psikopatologi, serta meningkatkan kualitas hidup pasien tumor otak metastasis.
Background. Patients with metastatic brain tumors are in risk of distress, psychopathology, and reduced quality of life. This vulnerability occurs because of the burden of physical symptoms from the primary tumor and symptoms of metastatic brain tumors experienced by the patients. The purpose of this study was to determine the effectiveness of supportive psychotherapy in alleviating distress, psychopathology, and quality of life of patients with metastatic brain tumors.
Method. This study is a randomized, single-blind, parallel design without matching, pragmatic clinical trial study. 15 patients in the treatment group were metastatic brain tumor patients who received 6 sessions of supportive psychotherapy (30-45 minutes each) and standard care from neurologists, while 15 patients in the control group received standard therapy from neurologists only. This study used distress thermometer (DT) to measure distress, Self-rating Questionnaire 20 (SRQ 20) to measure psychopathology, and World Health Organization Quality of life-Bref (WHOQOL-Bref) to measure quality of life before and after intervention. Prior to intervention, content validation was carried out on the supportive psychotherapy module. There were no dropped out and lost to follow-up subjects in this study.
Results. This study showed that all subjects in the treatment group (n=15; 100%) experienced significant improvements on distress, psychopathology, and quality of life scores (P=0.00) before and after supportive psychotherapy. The proportion of patients experiencing psychosocial problems including daily activities, emotional problems, and symptoms of metastatic brain tumor between before and after the intervention showed a significant difference (P<0.05). There was also a decrease in the average score for metastatic brain tumor symptoms (p=0.00) including headache (p=0.00), weakness (p=0.00), seizures and double vision between before and after supportive psychotherapy intervention. In both groups, the overall validation value of the supportive psychotherapy module is 96.21% and the content validation value of each session is more than 90%, which means that it shows valid results. The demographic factor that affects the improvement of psychopathology scores was economic status (p=0.03).
Conclusion. Supportive psychotherapy shows significant effects in alleviating distress, psychopathology, and quality of life of patients with metastatic brain tumors."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
cover
Siregar, Marsintauli Hasudungan
Gambaran klinis radiologis histopatologis dan faktor prognostik tumor otak pada anak = Clinical radiology histopathology features and prognostic factor of child brain tumor
"[ABSTRAK
Tumor otak (TO) merupakan penyebab kematian kedua dari
semua kanker yang terjadi pada anak. TO memiliki gambaran klinis, radiologis
dan histopatologis yang sangat bervariasi karena proses pengembangan sel-sel
jaringan otak masih berlanjut sampai usia 3 tahun. Data penelitian mengenai TO
pada anak masih sedikit.
Tujuan: Untuk mengetahui gambaran klinis, radiologis, histopatologis dan faktor
prognostik TO di Departemen Ilmu Kesehatan Anak FKUI/ RS. Dr.
Ciptomangunkusumo Jakarta periode tahun 2010 - 2015.
Metode Penelitian: Kohort retrospektif dilakukan pada semua anak dengan TO
primer yang berobat/dirawat di Departemen Ilmu Kesehahatan Anak FKUI/RS
Dr. Ciptomangunkusumo Jakarta.
Hasil: Didapatkan 88 pasien TO primer, terdiri dari 16 pasien berusia kurang dari
3 tahun dan 72 pasien berusia lebih dari 3 tahun, laki-laki 53% dan perempuan
47%. Anak usia kurang dari 3 tahun mengalami gejala sakit kepala (63%) dan
kejang (56%), berdasarkan radiologis letak TO yang terbanyak adalah di cerebral
ventrikel (25%) dan cerebellum (24%), berdasarkan histopatologis jenis TO yang
terbanyak adalah Astrositoma (31%) dan Medulloblastoma (25%). Anak usia
lebih dari 3 tahun mengalami gejala sakit kepala (81%) dan gangguan penglihatan
(65%), berdasarkan radiologis letak TO yang terbanyak adalah di cerebellum
(24%) dan suprasellar (10 %), berdasarkan histopatologis jenis TO yang
terbanyak adalah Medulloblastoma (21%), Astrositoma (18%) dan Glioma (17%).
Angka kehidupan TO adalah 37 %. Tidak didapatkan faktor prognostik TO yang
bermakna.
Kesimpulan: Gejala TO tersering adalah sakit kepala, berdasarkan radiologis
letak tumor terbanyak adalah di cerebellum serta berdasarkan histopatologis jenis
tumor terbanyak adalah Medulloblastoma dan Astrositoma. Tidak didapatkan
faktor prognostik TO pada anak.
ABSTRACT
Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor., Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.]"
2016
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Anggreni Wiyono
Faktor-faktor yang berhubungan dengan lama rawat pra bedah pasien tumor yang dirawat di kelas III Irna A RSUPN dr. Cipto Mangunkusumo = Factors which are related to pre operative length of stay for hospitalized tumor patients in the third class of IRNA A wards dr. Cipto Mangunkusumo Hospital
"Memanjangnya lama rawat pra bedah pada pasien bedah secara umum dan pasien bedah tumor secara khusus merupakan masalah inefisiensi bagi rumah sakit. Di samping itu bagi pasien memanjangnya lama rawat ini menyebabkan bertambahnya biaya yang harus dikeluarkan sehingga kepuasan terhadap rumah sakit akan berkurang. Masalah ini melatarbelakangi penulis melakukan penelitian untuk mengetahui faktor-faktor yang yang berpengaruh terhadap lama rawat pra bedah pasien tumor tersebut.
Penelitian dilakukan pada sampel .yang terdiri dari 71 kasus pasien bedah tumor yang dirawat di IRNA A kelas 3 pads bulan Januari sampai pertengahan Februari dan bulan Juni 1996. Pada seluruh sampel dilakukan operasi di Instalasi Bedah Pusat RSUPN Dr. Cipto Mangunkusumo.
Penelitian ini merupakan penelitian deskriptif analitis dengan desain "cross sectional". Data sekunder diarnbil dari data rekam medis yang terdapat di IRNA A sebelum pasien dipulangkan. Selain itu juga dilakukan pengecekan di IBP pada saat pasien dioperasi.
Variabel bebas yang diteliti ialah kondisi medis pasien, jenis tindakan yang direncanakan, pemeriksaan penunjang yang dilaksanakan, keterlibatan dengan sub bagian lain, dan penundaan operasi. Variabel terikat ialah larva rawat pra bedah, yang terdiri dari 2 bagian, yaitu lama persiapan operasi dan lama menunggu jadwal operasi.
Hasil yang diperoleh pada penelitian ini adalah sebagai berikut :
Rata-rata lama rawat pra bedah pada keseluruhan sampel ialah 19,28 hari. Pada pasien dengan kondisi 1 tindakan medis berat ialah 24,92 hari, sedangkan pada pasien dengan kondisi 1 tindakan medis sedang ialah 11,47 hari.
Kesimpulan utama yang diperoleh adalah sebagai berikut :
1. Terdapat 4 faktor yang berhubungan dengan lama rawat pra bedah pada pasien secara keseluruhan , yaitu kondisi medis, jenis tindakan, keterlibatan sub bagian lain.
2. Faktor yang tidak berpengaruh terhadap lama rawat pra bedah pada keseluruhan sampel ialah pemeriksaan penunjang.
Saran yang diajukan oleh peneliti adalah sebagai berikut :
1. Membuat suatu alur pasien dari poliklinik bedah tumor sampai ke Instalasi Bedah Pusat, di mana pasien baru dapat dimasukkan ke IRNA A jika operasi sudah teijadwal. Pada keadaan ini tempat tidur di IRNA A sudah disiapkan. Alur ini diutamakan untuk pasien dengaan kondisi sedang, atau pasien yang tidak terlalu kompleks (dipakai pola dari SMF THT dan SMF Bedah Anak sebagai model).
2. Mengadakan upaya untuk menambah efisiensi dan utilisasi di Instalasi Bedah Pusat dengan mengacu pada hasil penelitian Duta Liana, 1966 dengan judul Analisis Faktor Faktor yang Berhubungan dengan Keterlambatan atau Pembatalan Operasi di Instalasi Bedah Pusat Rumah Sakit Dr. Cipto Mangunkusumo.
Efficiency is one of the most important parts in hospital management. Pre operative length of stay is a specific indicator for hospital efficiency. The increasing of length of stay causes the increasing cost which has to be born by patients and dissatisfaction among them.
This study was performed to 71 cases in hospitalized tumor patients to be operated in the third class of IRNA A in Cipto Mangunkusumo Hospital, from January until the middle of February and June 1996. This is a descriptive analytic study with the cross sectional design and based on the secondary data from the medical records in IRNA A wards after the surgeries.
The independent variables are : 1) The condition of the patients. 2) The type of the surgeries which are planned by the surgeons. 3) The waiting periods for the results of the laboratory tests or the waiting list for X ray tests in Radiology Department. 4) The consultations to other divisions. 5) Delayed or cancelled of the surgery. The dependent variables are the pre operative length of stay which is divided into 2 components, preparations time and waiting time for the surgeries.
The results of this study are: I) The average of pre operative length stay for all cases are 19.28 days. In the severe conditions are 24.92 days and in moderate cases 10.6 days.
The conclusions of the study are: There are relationships between condition of the patients, type of the surgeries, consultation to other divisions and delayed or cancelled of the surgeries. There is no relationship between waiting of the results of the laboratory tests or waiting lists for the radiology tests and pre operative length of stay.
The writer suggest that 1) The admission management has to be improved Surgeons should make the operation schedules in surgery room before patients are hospitalized. 2) Efficiency and utilization of the surgery department have to be increased, especially the delayed of the surgeries which caused by surgeries team not being on time (based on study of Liana, 1966)"
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 1996
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Rima Anindita Primandari
Gambaran gangguan fungsi kognitif pada tumor otak primer dan metastasis = Cognitive impairment profile in brain tumors
"Latar belakang: Gangguan fungsi kognitif merupakan salah satu defisit neurologis kedua tersering setelah sakit kepala pada tumor intrakranial. Gangguan fungsi kognitif yang paling sering terjadi pada tumor otak adalah gangguan fungsi eksekutif. Penilaian fungsi kognitif sebelum dilakukan operasi maupun radioterapi penting sebagai data dasar klinis pasien.
Tujuan: Mendapatkan informasi mengenai penilaian fungsi kognitif sebelum dilakukan operasi maupun radioterapi sebagai data dasar klinis pasien.
Metode: Disain penelitian ialah survei potong lintang dengan pengambilan sampel secara konsekutif. Data diperoleh dari Divisi Fungsi Luhur Poliklinik saraf dan Departemen Rekam Medis RSUPN Cipto Mangunkusumo periode Januari 2009-Maret 2016. Subjek penelitian berusia 18-65 tahun dan telah terdiagnosis tumor otak, memiliki hasil histopatologi, serta telah menjalani pemeriksaan fungsi luhur preoperatif.
Hasil: Terdapat 77 subjek penelitian dengan proporsi subjek laki-laki (50,6%) dan perempuan (49,4%) hampir sama, terbanyak berusia 40 tahun ke atas (67,5%), serta berpendidikan terutama 12 tahun ke atas (61%). Glioma (46,7%) dan meningioma (63,2%) merupakan dua tumor otak primer terbanyak, sedangkan paru (34,4%) dan payudara (18,8%) adalah asal metastasis otak terbanyak. Hampir semua subjek mengalami gangguan fungsi kognitif (96,1%), terutama ranah jamak (93,2%). Ranah memori dan fungsi eksekutif merupakan dua ranah yang paling sering terganggu. Proporsinya semua metastasis dan 80% tumor otak primer mengalami gangguan memori. Sebesar 77,5% tumor primer dan 89,7% metastasis otak mengalami gangguan fungsi eksekutif.
Kesimpulan: Hampir semua fungsi kognitif pada tumor otak primer dan metastasis terganggu, tetapi gangguan pada metastasis otak lebih berat. Ranah jamak merupakan ranah yang paling banyak terganggu, terutama memori dan fungsi eksekutif.
Aim: To obtain information about cognitive assessment before surgery and radiotherapy.
Methods: This study was a cross-sectional retrospective study using consecutive sampling. Data obtained from neurobehavior division of Neurology Clinic and Medical Record Department of Cipto Mangunkusumo Hospital started at January 2009 to April 2016. Subjects, aged 18 to 65 years old, diagnosed brain tumors, had histopatologic data, and done cognitive exam before surgery.
Results: There were 77 subjects, with no notable difference in gender proportion (50,6% male subjects and 49,4% female subjects). All were aged 40 years old above (67,5%) and had education level not lower than 12 years (61%). Glioma (46,7%) and meningioma (63,2%) are two most common primary brain tumors, whilst lungs (34,4%) and breast (18,8%) are two most major brain metastasis origin. Most subjects had cognitive impairments (96,1%), predominantly multidomain (93,2%). Of all domain, memory and executive function are mostly affected. All metastasis, and 80% primary brain tumor had memory impairment and 77,5% primary brain tumor and 89,7% brain metastasis had executive impairment.
Conclusion: Almost all cognitive domain impaired in brain tumors, particularly in brain metastasis. It suggested that multiple cognitive domain impairment were majorly impaired, with memory and executive function as the most common domain."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2016
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Yesi Astri
Gambaran arsitektur tidur pada pasien tumor otak primer yang mengalami gangguan tidur = Gambaran arsitektur tidur pada pasien tumor otak primer yang mengalami gangguan tidur
"

Pendahuluan:  Pasien dengan tumor otak pada umumnya mengalami nyeri kepala (90%) yang biasanya muncul pada malam hari sesuai dengan fisiologis tubuh. Hal ini menyebabkan pasien dapat berisiko mengalami gangguan tidur atau perubahan pola tidur. Sebaliknya, pasien tumor otak dapat mengalami penurunan kesadaran berupa cenderung tidur hingga sulit dibangunkan. Hal ini harus bisa dibedakan oleh dokter dan keluarga dengan gangguan tidur. Polisomnografi merupakan baku emas pemeriksaan klinis gangguan tidur yang akan menghasilkan luaran berupa arsitektur tidur. Penelitian ini bertujuan untuk mengetahui gambaran arsitektur tidur pada pasien tumor otak primer yang mengalami gangguan tidur dan faktor-faktor yang mempengaruhinya. 

Metode: Studi ini bersifat deskriptif dengan metode potong lintang pada pasien tumor otak primer dengan penapisan menggunakan Pittsburgh Sleep Quality Index (PSQI).  Pasien yang dinyatakan poor sleepers akan dilakukan pemeriksaan polisomnografi (PSG).

Hasil: Sebanyak 40 subjek penelitian, terdiri dari 14 laki-laki dan 26 perempuan. Rerata usia subjek penelitian adalah 45,5±11,7 tahun dengan median durasi sakit 12 (2-72) bulan. Arsitektur tidur didapatkan sleep latency 8,5 (1,0-212,5) menit, sleep efficiency 88,0 (22,0-99,0) menit, total sleep time342 (92,0-462,5) menit, N1 19,5 (4,0-99,0)%, N2 59,5 (1,0-92,0)%, 8,0 (0-29,0)%, REM 4,5 (0-24,0)%, dan arousal index 8,9 (0,4-36,9). Terdapat kemaknaan secara statistik antara jenis kelamin, nyeri kepala, efek desak ruang, riwayat penurunan kesadaran, dan lama tidur malam dengan total sleep time, N1, N3, dan REM.

Kesimpulan: Pasien tumor otak primer yang mengalami gangguan tidur memiliki abnormalitas arsitektur tidur dan memiliki kecenderungan tidur hanya sampai fase light sleep.

Kata Kunci: arsitektur tidur, gangguan tidur, polisomnografi, tumor otak primer

Background: Brain tumor patients run into cephalgia (90%) and commonly experienced at night that conform to physiology of the body. It generate the patients have higher risk to underwent sleep disorders or change the sleep cycle. Whereas brain tumor patients also experience altered consciousness in the form of tend to sleep and difficult to wake up.This condition must be able to be distinguished with sleep disoders by doctor and family. Polysomnography known as gold standard method to examine sleep disorder and obtain sleep architecture. This research aimed to get sleep architecture profile in primary brain tumor that experience sleep disorder and the influenced factors.

Method: This is a cross sectional research in primary brain tumor patients that passed the screening of Pittsburgh Sleep Quality Index (PSQI). Poor sleepers then undergoing polysomnography.

Results: There are 40 subjects consist of 14 male and 26 female. Age median 45,5±11,7 years and duration of illness 12 (2-72) months. Sleep architecture’s profiles are sleep latency 8,5 (1,0-212,5) minute, sleep efficiency 88,0 (22,0-99,0) minute, total sleep time 342 (92,0-462,5) minute, N1 19,5 (4,0-99,0)%, N2 59,5 (1,0-92,0)%, 8,0 (0-29,0)%, REM 4,5 (0-24,0)%, and arousal index 8,9 (0,4-36,9). There are statistical significancy of gender, cephalgia, space occupying effect, altered conccioussness, and duration of sleep with total sleep time, N1, N3, and REM.

Conclusion: Primary brain tumor patients experience abnormal of sleep architectures and tend to have light sleep.

Keywords: polysomnography, primary brain tumor, sleep architecture, sleep disorder

 

 

 

"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
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Nurul Asyrifah
Studi Teknik Penyinaran Radioterapi Adaptif: Evaluasi Dosimetri pada Pasien Tumor Otak = Study on Adaptive Radiotherapy Beam Delivery Technique: Dosimetry Evaluation in Brain Tumor Patients
"Penelitian ini bertujuan untuk mengevaluasi perhitungan dosis berdasarkan citra Cone Beam Computed Tomography (CBCT) pada pasien dengan diagnosa tumor otak. Perencanaan dan perhitungan dosis berdasarkan citra CBCT fraksinasi ke-16 yang dilakukan terhadap 13 pasien yang disinari menggunakan pesawat linac Elekta Versa HD dan 7 pasien yang disinari menggunakan pesawat linac Halcyon 2.0. Perencanaan dan perhitungan dosis dilakukan pada Treatment Planning System (TPS) Eclipse dan TPS Monaco. Hasil perhitungan dosis berdasarkan citra CBCT dibandingkan dengan citra Computed Tomography (CT) simulator. Penelitian ini memiliki beberapa tahapan, (1) kalibrasi Hounsfield Unit (HU) citra CBCT menggunakan fantom CIRS CT electron density 062M untuk melakukan perhitungan dosis di TPS dengan nilai HU yang sesuai, (2) proses pengumpulan data citra pasien yang memenuhi kriteria penelitian dan dilanjutkan dengan proses registrasi dan perencanaan citra CBCT, (3) analisis Dose Volume Histogram (DVH) untuk mengevaluasi kualitas perencanaan dengan parameter dosis yaitu Conformity Index (CI) dan Homogeneity Index (HI), (4) analisis dosis Organ at Risk (OAR) terhadap dose-constraint (batas dosis) untuk OAR batang otak, kiasma, sumsum tulang belakang, saraf optik, mata dan lensa. Nilai CI pada perencanaan berdasarkan CT tidak berbeda secara signifikan, Berdasarkan CBCT dari pesawat linac Elekta Versa HD diperoleh CI sebesar 0,05±0,21 (p=0,08) dan -0,01 ± 0,06 (p=0,02) berdasarkan CBCT dari pesawat linac Halcyon 2.0. Sementara itu, nilai HI pada perencanaan berdasarkan CBCT diamati berbeda secara signifikan terhadap CT, Berdasarkan CBCT dari pesawat linac Elekta Versa HD diperoleh HI sebesar 0,25 ± 0,43 (p=0,01) dan 0,08 ± 0,04 (p=0,01) berdasarkan CBCT dari pesawat linac Halcyon 2.0.
This research aims to evaluate dose calculations based on Cone Beam Computed Tomography (CBCT) images in patients diagnosed with brain tumors. Planning and dose calculations based on the 16th fraction of CBCT images were performed on 13 patients irradiated using Elekta Versa HD linear accelerator and 7 patients irradiated using Halcyon 2.0 linear accelerator. The planning and dose calculations were conducted using the Treatment Planning System (TPS) Eclipse and TPS Monaco. The results of the dose calculations based on CBCT images were compared with the Computed Tomography (CT) simulator images. The research comprised several stages: (1) calibration of Hounsfield Unit (HU) of CBCT images using CIRS CT electron density 062M phantom to perform dose calculations in TPS with appropriate HU values, (2) data collection of patient images meeting the research criteria followed by image registration and CBCT planning, (3) analysis of Dose Volume Histogram (DVH) to evaluate planning quality using dose parameters such as Conformity Index (CI) and Homogeneity Index (HI), (4) analysis of dose to Organs at Risk (OAR) against dose constraints for OARs such as brainstem, chiasm, spinal cord, optic nerves, eyes, and lenses. The CI values for the planning based on CT were not significantly different. Based on CBCT from Elekta Versa HD linear accelerator, the CI obtained was 0.05 ± 0.21 (p=0.08), and based on CBCT from Halcyon 2.0 linear accelerator, the CI obtained was -0.01 ± 0.06 (p=0.02). However, the HI values for planning based on CBCT significantly differed from CT. Based on CBCT from Elekta Versa HD linear accelerator, the HI obtained was 0.25 ± 0.43 (p=0.01), and based on CBCT from Halcyon 2.0 linear accelerator, the HI obtained was 0.08 ± 0.04 (p=0.01)."
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2023
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Eva Lathifah Tyas Utami
Strategi koping dan distres psikologis pada mahasiswa Fakultas Kedokteran Universitas Indonesia = Coping strategy and psychological distress among medical students of Universitas Indonesia
"Penelitian ini bertujuan untuk mengetahui hubungan antara strategi koping dan distres psikologis pada mahasiswa FKUI. Penelitian terkait dengan strategi koping serta distres psikologis masih sedikit dibahas pada mahasiswa kedokteran di Indonesia. Hal ini penting untuk diteliti mengingingat banyaknya kompetensi yang harus dipenuhi oleh mahasiswa kedokteran dan dapat menimbulkan stres pada diri mereka. Jika tidak ditangani dengan baik, maka hal tersebut mampu memunculkan distres pada diri individu yang kemudian dapat menghambat pendidikannya. Sebanyak 187 partisipan yang merupakan mahasiswa FKUI mengisi alat ukur Kuesioner Kesehatan Umum untuk mengukur tingkat distres psikologis, dan The Brief COPE untuk mengukur strategi koping. Pengolahan data dilakukan menggunakan teknik statistik pearson correlation menunjukkan tidak terdapat korelasi positif yang signifikan antara strategi coping dengan distres psikologis dengan nilai korelasi yaitu r = 0,035 dan p = 0,637 two tailed. Tidak terdapat korelasi negatif yang signifikan antara jenis koping problem-focused coping dengan distres psikologis, kemudian distres psikologis dan emotion-focused coping juga ditemukan tidak berkorelasi positif secara signifikan. Artinya, semakin tinggi tingkat penggunaan problem-focused coping individu maka semakin tinggi pula tingkat distres psikologis individu tersebut. Terdapat korelasi negatif yang signifikan antara distres psikologis dengan adaptive coping, dan begitu pula pada distres psikologis dan maladaptive coping. Semakin tinggi tingkat penggunaan maladaptive coping maupun adaptive coping maka akan semakin rendah tingkat distres psikologis yang dialami. Namun jika dilihat dari korelasinya maka individu yang menggunakan strategi maladaptive coping memiliki distres psikologis yang lebih tinggi dibandingkan dengan individu yang menggunakan strategi adaptive coping.
Indonesian medical students are very prone to stress because of the high standards of competencies that they must fulfill in order to become future doctors. This puts the individuals at risk of further distress that might eventually become a barrier for their education. A lot of research under the topic of psychological distress have not yet focused on Indonesian medical students particular condition. Therefore, it is urgent to dig deeper upon the problem in this current research.This research aims to unravel the relationship between coping strategy and psychological distress in medical students in University of Indonesia. As much as 187 medical students from University of Indonesia participated in the study. They completed a questionnaire on general health Kuesioner Kesehatan Umum in order to measure their level of psychological distress and the Brief COPE to measure their coping strategy.The final data were produced by using Pearson correlation statistics, which showed that there was no significant positive correlation between coping strategy and psychological distress, with r 0,035 and p 0,637 two tailed. There was no signicificant negative correlation between problem focused coping and psychological distress. Furthermore, the positive correlation between psychological distress and emotion focused coping was also found to be insignificant. This means that the more a person uses problem focused coping strategy, the higher the psychological distress level that the person has. There were, however, a significant negative correlation between psychological distress and adaptive coping, and also between psychological distress and maladaptive coping. Both the users of adaptive coping and maladaptive coping seem to have lower levels of psychological distress. However, judging from the correlation, individuals who use maladaptive coping strategy actually have higher levels of psychological distress compared to their counterparts who use adaptive coping."
Depok: Fakultas Psikologi Unversitas Indonesia, 2018
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Irma Savitri
Preservasi Memori pada Pasien Tumor Otak Metastasis yang Menjalani Whole Brain Radiotherapy dengan dan tanpa Hippocampal Sparing: Telaah Sistematis = Memory Preservation in Whole Brain Radiotherapy with and without Hippocampal Sparing: A Systematic Review
"

Latar Belakang: WBRT adalah salah satu terapi utama pada tumor otak metastasis. Gangguan kognitif, terutama memori, adalah komplikasi yang umum terjadi pada WBRT. Preservasi memori merupakan hal yang penting diteliti karena memori memiliki banyak keterkaitan dengan domain kognitif lain, serta dengan kualitas hidup. WBRT dengan hippocampal sparing, dimana hipokampus dilindungi dari radiasi, telah menunjukkan efek protektif pada preservasi memori pada bukti-bukti ilmiah sebelumnya.

Metode: Dilakukan sebuah tinjauan sistematis untuk mengkaji apakah WBRT dengan hippocampal sparing bermanfaat dalam preservasi memori, dibandingkan dengan WBRT konvensional. Pencarian sistematis dilakukan untuk uji klinis dan studi observasional, dengan WBRT hippocampal sparing sebagai intervensi dan memori sebagai salah satu luaran pada basis data mayor, register uji klinis, dan basis data lokal serta gray literature. Penilaian risiko bias dilakukan menggunakan Risk of Bias-2 (RoB-2), Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I), dan Newcastle-Ottawa Scale (NOS), sesuai jenis studi. Data dipresentasikan menggunakan Harvest plot dan focused narrative synthesis.

Hasil: Kami menemukan 8 studi. Studi yang dirandomisasi memiliki risiko bias rendah dan studi yang tidak dirandomisasi memiliki risiko bias sedang. Distribusi Harvest plot menunjukkan gradien positif, yaitu efek protektif WBRT dengan hippocampal sparing.

Kesimpulan: WBRT dengan hippocampal sparing menujukkan efek protektif terhadap fungsi memori pasien tumor otak metastasis dan aplikabel untuk dilakukan di setting RSCM. Diperlukan penelitian lebih lanjut mengenai peran WBRT hippocampal sparing pada pasien di RSCM.

Background: Whole brain radiotherapy (WBRT) is the mainstay therapy for metastatic brain tumor. Cognitive dysfunction, particularly memory, is a common side effect of WBRT. Memory preservation has become increasingly popular, as memory is inter-related with other cognitive domains as well as with quality of life. WBRT with hippocampal sparing, where the hippocampus is avoided from radiation, has shown some protective effects in memory preservation in previous studies.

Methods: We conducted systematic review to determine whether WBRT with hippocampal sparing is beneficial in preserving memory compared to conventional WBRT. We systematically searched for clinical trials and observational studies with hippocampal sparing WBRT as the intervention and memory as one of the outcomes. Major databases, clinical trial registries, as well as local databases and gray literature were searched. Risk of bias assessment was performed using Risk of Bias-2 (RoB-2), Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I), and Newcastle-Ottawa Scale (NOS) tools, according to study type. Data were presented using Harvest plot and focused narrative synthesis.

Results: We identified 8 studies, which consisted of randomized and non-randomized studies. All randomized clinical trials showed overall low risk of bias, whereas nonrandomized trials and cohort studies showed moderate risk of bias. Harvest plot distribution showed a positive gradient. i.e. protective effect of hippocampal sparing WBRT.

Conclusions: WBRT with hippocampal sparing is effective in preserving memory in metastatic brain tumor patients. It is applicable to be performed in Cipto Mangukusumo Hospital. Further research is needed to assess its effectiveness in patients of Cipto Mangunkusumo Hospital.

"
Depok: Fakultas Kedokteran Universitas Indonesia, 2021
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