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"ABSTRAKLatar Belakang: Saat ini WHO memperkirakan 60 ndash;80 juta pasangan menderita infertilitas atau diperkirakan 8 ndash;12 persen dari pasangan di seluruh dunia. Salah satu penyebab infertilitas pada wanita adalah endometriois.1,2 Sekitar 20 ndash; 40 wanita infertilitas menderita endometriosis, dengan prevalensi endometriosis pada wanita usia reproduksi adalah 3 ndash;10 .5 Penelitian ini bertujuan untuk mengetahui persentase pasien endometriosis dengan infertilitas yang hamil dalam waktu satu tahun pasca prosedur laparoskopi dan factor-faktor yang mempengaruhinya.Metode: Penelitian ini merupakan studi kohort retrospektif, sumber data berasal dari rekam medis dengan pendekatan penelitian deskriptif-analitik kategorikal dengan menggunakan rekam medik pasien yang dilakukan laparoskopi di Rumah Sakit Fatmawati, kemudian di follow up untuk mengetahui kejadian kehamilannya. Data kemudian dianalisis untuk mengetahui hubungan antara usia, lama infertilitas, bilateralitas kista, patensi tuba, dan derajat r-AFS dengan kehamilan.Hasil: Terdapat 64 subjek yang dianalisis. Sebanyak 23 subjek 35,9 hamil dalam satu tahun pasca laparoskopi. Kelompok usia le; 35 tahun memiliki peluang untuk hamil lebih besar dengan OR 6,75 dan nilai p=0,01, lama infertilitas le; 3 tahun memiliki peluang untuk hamil lebih besar dengan OR 3,2 dan nilai p=0,032, derajat r-AFS II dan III juga memiliki peluang hamil yang besar dengan OR 3,25 dan 4,25 dengan nilai p=0,04.Kesimpulan: Pada penelitian ini didapatkan angka kehamilan dalam satu tahun pasca laparoskopi sebesar 35,9 . Terdapat hubungan antara usia, lama infertilitas dan derajat r-AFS dengan kehamilan.Kata Kunci: Endometriosis, infertilitas, laparoskopi, kehamilan

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ABSTRACTBackground WHO estimate about 60 ndash 80 million infertile couple in the world or about 8 12 from the whole couple. Endometriosis is one of the condition that cause infertility. About 20 40 infertile women are having endometriosis, and endometriosis prevalence in reproductive women is 3 10 . This study purpose is to know about percentage of pregnancy rate in women post laparoskopi.Methods This study is retrospektif cohort, data is taken from medical record of patient in RSUP Fatmawati with categorical descriptive analitic approachment. Data then analyze to know is there any association between age, infertility duration, bilaterality of the cyst, tubal patensy, r AFS stage with pregnancy rate.Results From 64 subject, there are 23 subject 35,9 that pregnant within one year after laparoscopic procedure. Age le 35 years old have a greater chance to get pregnant with OR 6,75 and p value 0,01, duration of infertility le 3 years have a greater chance to get pregnant with OR 3,2 and p value 0,032, r AFS stage II and III are have a greater chance to get pregnant to with OR 3,25 and 4,25 and p value 0,04. Conclusion The pregnancy rate after laparoscopic cystectomy is 35,9 in this study. There are correlation between age, duration of infertility, and r AFS staging with pregnancy rate.Key Words Endometriosis, infertility, laparoscopy, pregnancy "

"Latar Belakang: Kejadian infertilitas di Indonesia 10-15 dari 39,8 juta wanita usia subur. Infertilitas dapat memberi masalah fisik, mental, sosial hingga perceraian. Sekitar 25 -50 perempuan infertil disertai endometriosis dan laparoskopi telah menjadi salah satu pilihan tatalaksananya. Dalam menjalani suatu metode, ahli bedah dan pasangan selalu ingin mengetahui peluang keberhasilan mereka baik dari data praoperasi ataupun intraoperasi. Lee dkk menyatakan keberhasilan kehamilan alamiah pasca laparoskopi secara keseluruhan adalah 41,9 dan tidak berhubungan dengan derajat endometriosis atau temuan laparoskopi atau jenis operasi. Di Indonesia, belum ada studi yang membahas faktor yang paling mempengaruhi keberhasilan kehamilan alamiah pada perempuan yang menjalani metode laparoskopi operatif.Tujuan: Penelitian ini bertujuan untuk mengetahui faktor-faktor apa saja yang mempengaruhi keberhasilan kehamilan alamiah pasca laparoskopi operatif.Metode: Penelitian ini menggunakan desain kohort retrospektif. Dengan total sampling, data diambil dari catatan pasien yang menjalani operasi laparoskopi karena infertilitas dengan endometriosis di RS Cipto Mangunkusumo dan RS Yayasan Pemeliharaan Kesehatan YPK di Jakarta, Indonesia. Analisis data dilakukan dengan perangkat lunak SPSS 20 untuk mengetahui hubungan antara usia, durasi infertilitas, jenis infertilitas, kadar CA-125, ukuran dan bilateralitas endometrioma, perlekatan organ genitalia interna, nodul endometriosis dan patologi tuba dengan keberhasilan kehamilan alamiah dalam 1 tahun pasca laparoskopi operatif.Hasil: Terdapat 70 subjek yang dianalisis. Sebanyak 32 subjek 45,7 hamil dalam satu tahun pasca laparoskopi. Lama infertilitas menggunakan titik potong

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Background and aims The incidence of infertility in Indonesia is 10 15 of the 39.8 million women of childbearing age. It can give physical, mental, social and divorce problems. Approximately 25 50 of infertile women cause by endometriosis. Laparoscopy operative LO has become one of its treatments. In choosing a method, surgeon and couples always want to know the chances of their success either from preoperative or intraoperative data. In Indonesia, there are no studies that address the factors influence the success of natural pregnancy in women undergoing LO methods. This study aims to determine what factors affect the success of natural pregnancy postoperative laparoscopy.Methods This study used a retrospective cohort design. With total sampling, the data were taken from the patient records who underwent laparoscopic operative due to infertility with endometriosis at RS Cipto Mangunkusumo and the Health Care Foundation Foundation YPK in Jakarta, Indonesia. Data analysis was performed with SPSS 20 software to determine the relationship between age, duration of infertility, type of infertility, ca 125 levels, size and bilaterality of endometrioma, internal genital adhesion, endometriosis nodules and tubal pathology with successful natural pregnancy in 1 year after laparoscopic operative.Result There were 70 subjects analyzed. A total of 32 subjects 45.7 were pregnant within one year after laparoscopy. The length of infertility using a "

"ABSTRAKLatar Belakang: Endometriosis merupakan isu utama yang sering ditemukan pada wanita usia reproduksi dengan keluhan infertilitas. Endometriosis Fertility Index EFI merupakan suatu sistem staging yang sederhana, bermakna, dan bermanfaat secara klinis untuk memprediksi prognosis fertilitas pada pasien endometriosis. Penelitian ini bertujuan untuk mengetahui angka kehamilan dan hubungannya dengan skor EFI pada pasien endometriosis yang menjalani terapi pembedahan laparoskopi di Rumah Sakit Cipto Mangunkusumo dan Rumah Sakit Carolus. Metode: Penelitian ini merupakan penelitian analitik dengan metode kohort prospektif yang dilakukan di RSCM dan RS Carolus pada subjek pasien endometriosis dengan keluhan infertilitas yang dilakukan terapi pembedahan laparoskopi pada tahun 2012-2014. Skor EFI ditentukan dengan mengambil data catatan rekam medis dan video operasi berdasarkan klasifikasi menurut Adamson. Data kehamilan diambil dalam periode 2 tahun follow up. Hubungan antara skor EFI dengan kehamilan dianalisis secara bivariat. Hasil: Terkumpul 51 pasien yang dianalisis. Sebanyak 18 pasien 35,3 diketahui hamil selama durasi pemantauan 2 tahun. Insidensi kehamilan sampai dengan tahun kedua pada kelompok skor EFI 0-3, 4, 5, 6, 7-8, 9-10 beturut turut adalah 0 , 0 , 50 , 25 , 92,9 , 100 . Median skor EFI pasien yang hamil vs tidak hamil yakni: 7 5-9 vs 4 1-8 dengan nilai p

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ABSTRACTBackground Endometriosis is among the main issue related to infertility among reproductive age women. Endometriosis Fertility Index EFI is a simple staging system, significant, and has clinical benefit to predict fertility prognosis among endometriosis patients. This study aimed to know incidence of pregnancy and the relationship between Endometriosis Fertility Index EFI score and pregnancy among endometriosis patients underwent laparoscopy in Cipto Mangunkusumo and Carolus Hospitals. Method This was a cohort prospective study conducted in Cipto Mangunkusumo and Carolus Hospitals. Subjects were endometriosis patinets with infertility who underwent laparoscopic surgery at 2012 2014. EFI score was noted by medical records and procedure video, using Adamson criteria. Pregnancy data was collected with two years of follow up duration. The relationship betweem EFI score and pregnancy was analyzed. Results Fifty one patients was recruited in this study with 18 of them 35,3 konw to be pregnant in follow up. Incidence of pregnancy in two years based on EFI score 0 3, 4, 5, 6, 7 8, 9 10 were respectively 0 , 0 , 50 , 25 , 92,9 , 100 . The median EFI score of pregnant patients vs non pregnant was 7 5 9 vs 4 1 8 , p"

"ABSTRAKLatar Belakang: Endometriosis merupakan kondisi yang sering ditemukan pada wanita usia reproduksi. Keterlambatan dignosis masih menjadi kendala. Saat ini, metode diagnosis non invasif termasuk transvaginal sonography telah direkomendasikan. Penelitian ini bertujuan mengevaluasi akurasi transvaginal sonogrpahy untuk mendiagnosis kista endometriosis di RS Cipto MangunkusumoMetode: Penelitian ini merupakan penelitian uji diagnostik yang dilakukan di RS Cipto Mangunkusumo pada Januari 2014 ? Juni 2015. Subjek penelitian merupakan pasien rawat jalan dengan kecurigaan kista endometriosis berdasarkan anamnesis dan pemeriksaan fisik. Pasien kemudian diperiksa transvaginal sonography oleh pemeriksa berpengalaman sesuai dengan protokol penelitian. Selanjutnya, pemeriksaan histologi dengan sediaan masa yang diambil dari prosedur operasi dijadikan baku emasHasil: Terkumpul 98 pasien yang dianalisis. Kista endometriosis terkonfirmasi pada 85 pasien (86,7%) berdasarkan pemeriksaan histologi. Akurasi, sensitivitas, spesifisitas, nilai duga positif dan nilai duga negatif transvaginal sonography yakni 84,9 (71,0-98,8)%, 92,9%, 76,9%, 96,3%, and 62,5%. Transvaginal sonography memiliki area under the curve yang lebih tinggi secara signifikan dibandingkan dengan hanya pemeriksaan fisik (84,9% vs 78,8%).Kesimpulan: Transvaginal sonogprahy bermanfaat untuk mendiagnosis kista endometriosis dan dapat direkomendasikan dalam praktik sehari-hari

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ABSTRACTBackground: Endometriosis is common among reproductive age women. Late diagnosis is still the main concern. To date, non-invasive diagnostic test including transvaginal sonography is recommended. This study aimed to evaluate the accuracy of transvaginal sonography to diagnose endometriosis cyst among patients in Cipto Mangunkusumo Hospital.Method: This was a diagnostic study performed in Cipto Mangunkusumo Hospital from January 2014 to June 2015. Outpatients with suspicion to have endometrial cyst based on patients? history and clinical examination were recruited. Patients were then scanned by experienced sonologist using transvaginal sonography following our research protocol. The gold standard was histologic finding of removed surgical massResults: A total of 98 patients were analyzed. Endometrial cyst was confirmed by histology among85 patients (86.7%). The accuracy, sensitivity, specificity, positive predictive value and negative predictive value of transvaginal sonography were 84.9 (71.0-98.8)%, 92.9%, 76.9%, 96.3%, and 62.5%, respectively. Transvaginal sonogpraphy significantly had higher area under the curve compared to clinical examination alone (84.9% vs 78.8%).Conclusion: Transvaginal sonography appears to be usefull to diagnose endometriosis cyst among outpatients and recommended in daily clincial practice"

"Latar Belakang: Endometriosis dan infertilitas memiliki keterkaitan yang sangat erat. Namun etiopatogenesis terjadinya infertilitas pada kasus endometriosis sangat beragam. Teori yang berkembang akhir-akhir ini adalah buruknya reseptivitas endometrium. Gen HOXA 11 adalah salah satu gen yang berperan dalam reseptivitas endometrium karena berkorelasi dengan penanda lain seperti Leukemia Inhibitory Factor LIF, B3integrin, dan EMX2. Teori epigenetik yang berkembang adalah terjadi hipermetilasi pada gen HOXA 11 sehingga terjadi penurunan ekspresi gen tersebut.Metode: Penelitian potong lintang ini dilakukan di RS Cipto Mangunkusumo pada Juli 2015 - Juni 2016. Subjek penelitian adalah pasien endometriosis yang terbukti secara histopatologi dengan infertilitas dan kelompok kontrol merupakan pasien non-endometriosis yang fertil. Status metilasi gen HOXA 11 dari sampel endometrium eutopik pada kedua kelompok ini diperiksa dan dibandingkan.Hasil: Enam pasien endometriosis dan enam pasien kontrol diambil sebagai subjek. Perbedaan tingkat metilasi gen HOXA 11 pada kedua kelompok ini berbeda secara signifikan dengan nilai p 0.03 dengan perbedaan rerata peningkatan kadar metilasi pada kelompok pasien endometriosis sebesar 33.Kesimpulan: Gen HOXA 11 yang berperan dalam reseptivitas endometrium mengalami hipermetilasi pada pasien dengan endometriosis dan infertilitas.

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Introduction: Endometriosis compromises infertility in some patients. They have close relationship and many etiologies have been proposed. HOXA11 has important role in window implantation because it is related to other endometrial receptivity markers such as Leukemia Inhibitory Factor LIF , B3integrin, and EMX2. Recently, many researchers found poor endometrial receptivity in endometriosis due to hyper methylation of HOXA11 gene. Therefore, this study aims to find out the HOXA11 gene profile on endometriosis patients with infertility in Indonesia.

Methods: This cross sectional study was conducted in Dr. Cipto Mangunkusumo Hospital from July 2015 June 2016. The subjects were endometriosis patients with infertility who have been confirmed histopathological. The control group was taken from non endometriosis and fertile patients. Eutopic endometrium samples were taken and examined for the methylation of HOXA11 gene.

Results: Both groups consist of six patients. The difference of methylation of HOXA 11 gene between those two groups is statistically significant p 0.03 . There was hyper methylation in endometriosis group.

Conclusion: There is a hyper methylation of HOXA 11 gene in eutopic endometrium of endometriosis patients with infertility. Thus, possibly can explain the poor endometrial receptivity in endometriosis patient and give a broad research area in epigenetic therapy of endometriosis."

"ABSTRACTProses pengembalian rekam medis pasien rawat jalan di RSUP Fatmawati masih belum optimal, ditunjukan dengan penyelenggaraan yang belum sesuai dengan peraturan, masih ada rekam medis yang terlambat, bahkan tidak kembali dari Instalasi Rawat Jalan IRJ ke Instalasi Rekam Medis dan Pusat Data Informasi IRMPDI pada hari dimana rekam medis digunakan. Penelitian ini dilakukan untuk mendapatkan hasil analisis proses pengembalian rekam medis pasien rawat jalan dari IRJ ke IRMPDI dengan pendekatan lean six sigma. Jenis penelitian ini adalah operational research, dengan desain penelitian kuantitatif dan kualitatif. Hasil penelitian digambarkan dengan value stream mapping yang memperlihatkan lead time proses pengembalian rekam medis pasien rawat jalan selama 183,09 menit dengan value added 41,55 menit 22,7 dan non value added 141,54 menit 77,3, proses paling lama terjadi pada langkah pengembalian rekam medis dari IRJ ke IRMPDI karena menunggu petugas IRMPDI mengambil rekam medis. Waste paling besar yaitu waste waiting sebesar 124,16 menit atau 87,72 dari total seluruh waste yang ditemukan. Berdasarkan analisis fishbone diagram diketahui bahwa akar penyebab masalah paling banyak berasal dari kategori man. Berdasarkan analisis tersebut diberikan usulan berupa pembuatan standarisasi kerja, penghitungan beban kerja, melakukan rapat koordinasi, membagi pekerjaan ke dalam periode waktu tertentu heijunka, dan meningkatkan pengawasan.

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ABSTRACTThe process of returning outpatient medical records at RSUP Fatmawati is not optimal enough, indicated by the process is not in accordance with existing regulations, medical records are late, and not returned from Outpatient Installation IRJ to Installation of Medical Record and Information Data Center IRMPDI at the same day when it used. The aim of this research is to get analysis result of outpatient medical records return process from IRJ to IRMPDI using lean six sigma approach. This research is operational research type that use quantity and quality design. The results of this research were described with the value stream mapping that showed lead time of outpatient medical records return process for 183,09 minutes, with value added 41,55 minutes 22,7 and non value added 141,54 minutes 77,3, the longest process occurs on returning of medical record form IRJ to IRMPDI due to the waiting of IRMPDI officers to take medical records. The biggest waste is waiting for amount of 124,16 minutes 87,72 of the total waste. Based on fishbone diagram analysis it is known that the root cause of medical record problem mostly comes from man category. Based on that analysis, an improvement proposal will be given as the following development of work standarization, workload calculation, coordination meeting, devide the work into a certain period of time implementation of heijunka, and improvement of supervision. "

"ABSTRAK Latar belakang: Endometriosis merupakan kelainan ginekologik yang palingsering ditemukan. Seperti halnya endometrium di uterus juga dapat terjadiberbagai perubahan pada epitel yang melapisi kista endometriosis di ovarium,antara lain metaplasia, hiperplasia, atipia bahkan perubahan ke arah keganasan.Saat ini banyak penelitian yang menghubungkan antara endometriosis dan kankerovarium terutama jenis clear cell dan dikenal dengan istilah endometriosisassociatedovarian carcinoma (EAOC) dan dilaporkan adanya mutasi yangmenginaktifkan gen supresor tumor (ARID1A), sehingga protein BAF250a tidakdiekpresikan pada Clear cell carcinoma (CCC) ovarii.Bahan dan cara: Dilakukan pulasan imunohistokimia ARID1A pada sampel 20kasus endometriosis non atipik, 20 kasus atipik dan 20 kasus CCC ovarii tahun2012 hingga Maret 2015. Dari kelompok kasus CCC didapatkan 9 kasus EAOC.Selanjutnya dilihat adakah perbedaan persentase ekspresi ARID1A padaendometriosis non atipik, atipik, CCC ovarii serta endometriosis disertai CCC(EAOC).Hasil: Pada kelompok kasus endometriosis non atipik, atipik dan CCC adaperbedaan bermakna persentase ekspresi ARID1A (uji Kruskal-Wallis p=0,0035).Selanjutnya dilakukan analisis Post Hoc uji Mann-Whitney dan didapatkanperbedaan bermakna persentase ekspresi ARID1A antara endometriosis non atipikdan atipik dengan CCC ovarii (p=0,001 dan p=0,0015). Pada kelompok kasusendometriosis non atipik, atipik dan endometriosis pada EAOC, didapatkan adaperbedaan bermakna persentase ekspresi ARID1A (Uji Kruskal-Walis p=0,011).Selanjutnya dilakukan analisis Post Hoc uji Mann-Whitney dan ada perbedaanbermakna persentase ekspresi ARID1A antara endometriosis non atipik dan atipikdengan EAOC (p=0,005 dan p=0,008). Kesimpulan: Ekspresi ARID1A pada endometriosis non atipik dan atipik lebihtinggi bermakna dibanding CCC ovarii dan EAOC. Sehingga ekspresi ARID1Akemungkinan dapat digunakan sebagai petanda adanya transformasi ganas padaendometriosis.ABSTRACT Background: Endometriosis is one of the most common gynecologicalabnormalities found. Endometriosis cyst in the ovary also exhibited changes inepithelial cyst just like endometrium in the uterus. Changes in the epithelial cellsalso include metaplasia, hyperplasia, atyphia even changes toward malignancharacteristics. Nowadays, there are some research that linked endometriosis andclear cell ovarian cancer which is known with endometriosis-associated ovariancarcinoma (EAOC) it is reported that there?s a mutation that activated tumorsuppressor gene (ARID1A), so protein BAF250a is not expressed in Clear CellCarcinoma (CCC) in the ovarium.Materials and Methods: Immunohistochemistry staining of ARID1A were donein 20 samples of non-atypical endometriosis, 20 samples of atypicalendometriosis, 20 samples of CCC in the ovarium from the year 2012 until march2015. From the group that experienced CCC we get 9 cases of EAOC. After that,we see if there?s any difference in the percentage of ARID1A expression in nonatypicalendometrosis, atypical endometriosis, CCC in the ovarium andendometriosis with CCC( EAOC).Results: In non-atypical endometriosis, atypical and CCC cases groups there aresignificant differences on the percentage of ARID1A expression (Kruskal-Walistest p=0,0035). Post Hoc analysis were done using Mann-Whitney test and thereare significant differences on ARID1A expression between non-atypical andatypical endometriosis with CCC (p=0,001 and p=0,0015). In non-atypicalendometriosis, atypical and EAOC groups there are significant differences on thepercentage of ARID1A expression (Kruskal-Walis test p=0,011). Post Hocanalysis were done using Mann-Whitney test and there are significant differenceson ARID1A expression between non-atypical and atypical endometriosis withEAOC (p=0,005 and p=0,008).Conclusion: Expression of ARID1A in non atypical and atypical endometriosisare significantly higher compared to ovarian CCC and EAOC. So, we can say thatARID1A may be used as a marker for malignancy transformation inendometriosis.;Background: Endometriosis is one of the most common gynecologicalabnormalities found. Endometriosis cyst in the ovary also exhibited changes inepithelial cyst just like endometrium in the uterus. Changes in the epithelial cellsalso include metaplasia, hyperplasia, atyphia even changes toward malignancharacteristics. Nowadays, there are some research that linked endometriosis andclear cell ovarian cancer which is known with endometriosis-associated ovariancarcinoma (EAOC) it is reported that there?s a mutation that activated tumorsuppressor gene (ARID1A), so protein BAF250a is not expressed in Clear CellCarcinoma (CCC) in the ovarium.Materials and Methods: Immunohistochemistry staining of ARID1A were donein 20 samples of non-atypical endometriosis, 20 samples of atypicalendometriosis, 20 samples of CCC in the ovarium from the year 2012 until march2015. From the group that experienced CCC we get 9 cases of EAOC. After that,we see if there?s any difference in the percentage of ARID1A expression in nonatypicalendometrosis, atypical endometriosis, CCC in the ovarium andendometriosis with CCC( EAOC).Results: In non-atypical endometriosis, atypical and CCC cases groups there aresignificant differences on the percentage of ARID1A expression (Kruskal-Walistest p=0,0035). Post Hoc analysis were done using Mann-Whitney test and thereare significant differences on ARID1A expression between non-atypical andatypical endometriosis with CCC (p=0,001 and p=0,0015). In non-atypicalendometriosis, atypical and EAOC groups there are significant differences on thepercentage of ARID1A expression (Kruskal-Walis test p=0,011). Post Hocanalysis were done using Mann-Whitney test and there are significant differenceson ARID1A expression between non-atypical and atypical endometriosis withEAOC (p=0,005 and p=0,008).Conclusion: Expression of ARID1A in non atypical and atypical endometriosisare significantly higher compared to ovarian CCC and EAOC. So, we can say thatARID1A may be used as a marker for malignancy transformation inendometriosis.;Background: Endometriosis is one of the most common gynecologicalabnormalities found. Endometriosis cyst in the ovary also exhibited changes inepithelial cyst just like endometrium in the uterus. Changes in the epithelial cellsalso include metaplasia, hyperplasia, atyphia even changes toward malignancharacteristics. Nowadays, there are some research that linked endometriosis andclear cell ovarian cancer which is known with endometriosis-associated ovariancarcinoma (EAOC) it is reported that there?s a mutation that activated tumorsuppressor gene (ARID1A), so protein BAF250a is not expressed in Clear CellCarcinoma (CCC) in the ovarium.Materials and Methods: Immunohistochemistry staining of ARID1A were donein 20 samples of non-atypical endometriosis, 20 samples of atypicalendometriosis, 20 samples of CCC in the ovarium from the year 2012 until march2015. From the group that experienced CCC we get 9 cases of EAOC. After that,we see if there?s any difference in the percentage of ARID1A expression in nonatypicalendometrosis, atypical endometriosis, CCC in the ovarium andendometriosis with CCC( EAOC).Results: In non-atypical endometriosis, atypical and CCC cases groups there aresignificant differences on the percentage of ARID1A expression (Kruskal-Walistest p=0,0035). Post Hoc analysis were done using Mann-Whitney test and thereare significant differences on ARID1A expression between non-atypical andatypical endometriosis with CCC (p=0,001 and p=0,0015). In non-atypicalendometriosis, atypical and EAOC groups there are significant differences on thepercentage of ARID1A expression (Kruskal-Walis test p=0,011). Post Hocanalysis were done using Mann-Whitney test and there are significant differenceson ARID1A expression between non-atypical and atypical endometriosis withEAOC (p=0,005 and p=0,008).Conclusion: Expression of ARID1A in non atypical and atypical endometriosisare significantly higher compared to ovarian CCC and EAOC. So, we can say thatARID1A may be used as a marker for malignancy transformation inendometriosis.;Background: Endometriosis is one of the most common gynecologicalabnormalities found. Endometriosis cyst in the ovary also exhibited changes inepithelial cyst just like endometrium in the uterus. Changes in the epithelial cellsalso include metaplasia, hyperplasia, atyphia even changes toward malignancharacteristics. Nowadays, there are some research that linked endometriosis andclear cell ovarian cancer which is known with endometriosis-associated ovariancarcinoma (EAOC) it is reported that there?s a mutation that activated tumorsuppressor gene (ARID1A), so protein BAF250a is not expressed in Clear CellCarcinoma (CCC) in the ovarium.Materials and Methods: Immunohistochemistry staining of ARID1A were donein 20 samples of non-atypical endometriosis, 20 samples of atypicalendometriosis, 20 samples of CCC in the ovarium from the year 2012 until march2015. From the group that experienced CCC we get 9 cases of EAOC. After that,we see if there?s any difference in the percentage of ARID1A expression in nonatypicalendometrosis, atypical endometriosis, CCC in the ovarium andendometriosis with CCC( EAOC).Results: In non-atypical endometriosis, atypical and CCC cases groups there aresignificant differences on the percentage of ARID1A expression (Kruskal-Walistest p=0,0035). Post Hoc analysis were done using Mann-Whitney test and thereare significant differences on ARID1A expression between non-atypical andatypical endometriosis with CCC (p=0,001 and p=0,0015). In non-atypicalendometriosis, atypical and EAOC groups there are significant differences on thepercentage of ARID1A expression (Kruskal-Walis test p=0,011). Post Hocanalysis were done using Mann-Whitney test and there are significant differenceson ARID1A expression between non-atypical and atypical endometriosis withEAOC (p=0,005 and p=0,008).Conclusion: Expression of ARID1A in non atypical and atypical endometriosisare significantly higher compared to ovarian CCC and EAOC. So, we can say thatARID1A may be used as a marker for malignancy transformation inendometriosis."

"Latar Belakang: Informasi yang tidak efektif disebabkan oleh adanya keterlambatan pengembalian dan ketidaklengkapan pengisian data rekam medis. Kepmenkes Nomor 129 Tahun 2008 tentang Standar Pelayanan Minimal Rumah Sakit menetapkan waktu pengembalian dokumen rekam medis yaitu 1x24 jam dan kelengkapan dokumen rekam medis harus 100%. Di RSUP Fatmawati Jakarta terdapat peningkatan prosentase keterlambatan pengembalian dan ketidaklengkapan dokumen rekam medis rawat inap. Tujuan: Penelitian ini bertujuan untuk mengetahui dan mengidentifikasi alur, kebutuhan sistem informasi yang akan dikembangkan, serta merancang sistem informasi monitoring dokumen rekam medis rawat inap di RSUP Fatmawati. Metode: Penelitian ini menggunakan metode kualitatif dan dilakukan secara bertahap sesuai tahapan SDLC, serta menggunakan pendekatan metode prototype. Hasil: Adanya masalah-masalah pada sistem informasi rumah sakit saat ini yang membuat petugas masih harus melaksanakan pekerjaannya secara manual. Sistem informasi monitoring dokumen rekam medis rawat inap dirancang melalui penyusunan alur sistem, perancangan basis data, tampilan antarmuka (userinterface), SPO, dan manualbook. Kesimpulan dan Saran: Sistem informasi yang baru dapat mengatasi permasalahan yang terjadi, mempercepat dan mempermudah pekerjaan petugas, serta menghasilkan laporan yang bermutu. Sehingga capaian SPM rumah sakit dan indikator mutu IRMIK meningkat. Sebaiknya ada dukungan penyediaan sarana dan prasarana dari rumah sakit untuk pengembangan sistem informasi monitoring dokumen rekam medis rawat inap, perlu adanya sosialisasi SPO dan manualbook, proses uji coba sistem kepada user, serta sebaiknya dilakukan upaya perawatan basis data secara berkala.

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Background: In the hospital, ineffective information is caused by late referral and incomplete medical records. Decree of the Minister of Health No. 129/2008 of Hospital Minimum Service Standards explained this case. The standard said that medical record documents must be returned in 1x24hours and its completeness must be 100%. Nevertheless, Fatmawati Jakarta Hospital underwent an increase of late returns and incomplete inpatient medical record documents percentages. Objectives: Aims of this study are determining and identifying flow and needs of the development of an information system. Also, this study aims to design an information system for monitoring inpatient medical record documents. Methods: This study used a qualitative method, SDLC stages, and a prototype method approach. Results: There are problems in the current hospital information system. Also, it makes employees still need to do their works manually. Therefore, an inpatient medical record document monitoring information system was designed through some stages. Those are the system flow, database, user interface, OPS, and manualbook formings. Conclusions and Recommendations: The new information system provides some improvements in the hospital. Those are particularly in achievement and enhancement of quality indicators and standards. This is because it can overcome problems and produce quality reports. Also, it makes employees do their works efficiently. For recommendations, the hospital should support this development by facilities and infrastructure provision. They also need to socialize the operational procedure standard and manualbook. Then, they should do the process of testing the system to users and database maintenance efforts regularly."

"Pelayanan rekam medis di Instalasi Rekam Medis dan Pusat Data Informasi RSUP Fatmawati yang berkaitan dengan Respon Time Distribusi rekam medis terdiri dari Proses di Bagian Registrasi dan bagian penyimpan dan mendapat pengaruh dari proses di bagian pengolahan. Tujuan penelitian ini adalah untuk mengetahui gambararan Respon Time distribusi rekam medis di Instalasi Rekam Medis dan Pusat Data Informasi yang dilihat dari input, proses dan output. Metode penelitian yang digunakan adalah studi kualitatif. Seluruh data dalam penelitian ini diperoleh dari hasil wawancara mendalam dan telaah dokumen. Hasil penelitian menunjukkan bahwa Respon Time Distribusi rekam medis di Instalasi Rekam Medis dan Pusat Data Informasi RSUP Fatmawati belum mencapai target pelayanan, baik target rumah sakit maupun target Standar Pelayanan Minimal penyiapan berkas rawat jalan. Kesimpulan dari penelitian ini, penyebab belum tercapainya target Respon Time Distribusi rekam medis ini dipengaruhi oleh belum cukupnya SDM dibagian penyimpanan, minimnya pelatihan tentang penyimpanan belum optimalnya lemari penyimpanan rekam medis yang ada dibagian penyimpanan, serta jarak ruang penyimpanan dengan Instalasi Rawat Jalan.

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Medical Record services in Medical Record and Center Data Information Installation RSUP Fatmawati relating to the Response Time Distribution of medical record consists of a process in the Registration section and storage section and under the influence of the process on the medical record processing.

The aims of this study is to get the description of distribution Response Time medical records in Medical Record and Center Data Information Installation from input, process and output. The research method has been used is a qualitative study. All of the data in this study were obtained from in-depth interviews and document review.

The results showed that the medical record Response Time Distribution in Medical Record and Center Data Information Installation RSUP Fatmawati has not reached the target, either the hospital’s target or the target Standards Minimum Serviceses of outpatient setup file.

The conclusion of this study, the cause of not achieving the target of Response Time Distribution of medical records is not influenced by the storage section of inadequate human resources, lack of training on storage cabinets storage, storage cabinets not optimal existing medical record storage section, and the distance between the storage space Outpatient Installation."

"Pendahuluan: Endometriosis merupakan penyakit yang secara klinis berhubungan dengan fertilitas dan memiliki beban ekonomi yang signifikan. Patogenesis endometriosis dan hubungannya dengan subfertilitas masih belum dipahami dengan jelas. Fertilisasi in Vitro (FIV) adalah terapi yang efektif untuk pasien dengan subfertilitas terkait endometriosis. Tingkat keberhasilan FIV di RSCM tidak dapat diperkirakan karena belum ada studi epidemiologi. Tujuan: Mengetahui angka kehamilan FIV pada pasien endometriosis di RSUPN dr. Cipto Mangunkusumo dan faktor-faktor yang mempengaruhinya.Metode: Penelitian ini menggunakan metode desain cross sectional. Sebanyak 225 pasien endometriosis dan blok tuba sebagai kontrol yang menjalani FIV di Klinik Yasmin Rumah Sakit Umum Nasional Dr. Cipto Mangunkusumo, Jakarta, pada periode Januari 2013 – Agustus 2021 disertakan dalam penelitian ini. Infertilitas karena faktor laki-laki diekslusi. Data demografi, dosis hormon rekombinan, durasi stimulasi, tingkat pembuahan, dan tingkat kehamilan yang diperoleh dari penelitian ini. Hasil: Angka kehamilan dibagi menjadi 3 jenis: biokimia, klinis, dan kehamilan berkelanjutan. Angka kehamilan pada pasien endometriosis lebih rendah dari faktor tuba, kehamilan biokimia (47,3% vs 52,7%, nilai p 0,375), kehamilan klinis (43,1% vs 56,9%, nilai p 0,215), dan kehamilan berkelanjutan (45,5% vs 54,5%) , nilai p 0,511). Kesimpulan: Penelitian kami menunjukkan bahwa angka kehamilan IVF pada pasien endometriosis lebih rendah daripada pasien dengan blok tuba, tetapi secara statistik tidak signifikan.

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Introduction: Endometriosis is a disease that is clinically related to fertility and has a significant economic burden. The pathogenesis of endometriosis and its relationship to subfertility is still not clearly understood. IVF is an effective therapy for patients with endometriosis-associated subfertility. The success rate of IVF in RSCM can’t be estimated because there is no epidemiological study. Objective: Knowing the pregnancy rate of IVF in endometriosis patients at the Yasmin Clinic, RSCM and the factors that influence it. Methods: This study was using cross sectional design. A total of 225 patients with endometriosis and tubal block as control who undergoing IVF at the Yasmin Clinic Dr. Cipto Mangunkusumo National General Hospital, Jakarta, in the period January 2013 – August 2021 were enrolled in this study.Infertility due to male factor were excluded. Demographic data, doses of recombinant hormone, duration of stimulation, fertilization rate, and pregnancy rate were obtained. Results: Pregnancy rate was divided into 3 types: biochemical, clinical, and ongoing pregnancy. Pregnancy rate in endometriosis patients were lower than tubal factor, biochemical pregnancy (47.3% vs 52.7%, p value 0.375), clinical pregnancy (43,1% vs 56.9%, p value 0.215), and ongoing pregnancy (45.5% vs 54.5%, p value 0.511). Conclusions: Our study demonstrated that pregnancy rate of IVF in endometriosis patient was lower than patient with tubal block, but statistically not significant. "