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"ABSTRAKLatar belakang : Airway remodelling pada asma juga melibatkan saluran napasperifer dan diduga dapat mempengaruhi alveoli hingga menyebabkan kelainan diparenkim paru Penelitian ini mencoba menemukan kelainan parenkim paru padapasien asma melalui pemeriksaan kapasitas difusi dengan DLCO metode napastunggal.Metode :.Penelitian potong lintang dengan membagi asma berdasarkan derajatkeparahannya dalam dua kelompok besar yaitu asma ringan (intermiten dan persistenringan) dan berat (persisten sedang dan berat). Terdapat 60 subjek yang diambilsecara konsekutif dari pasien asma stabil tanpa komorbid dan berobat di Poli Asma-PPOK RSUP Persahabatan dari Bulan Desember 2015-Mei 2016.Hasil : Nilai rerata DLCO/prediksi pada kelompok asma ringan yaitu 92,74±15,70%dan menurun pada kelompok asma berat yaitu 78,41±14,21%. Beberapa nilaispirometri menunjukkan hubungan positif bermakna dengan nilai DLCO/prediksiyaitu : KVP/prediksi, VEP1/prediksi dan FEF25-75%/prediksi dengan nilai p <0,05.Analisis korelasi menunjukkan KVP/prediksi secara nyata dapat mempengaruhikapasitas difusi pasien asma. Terdapat hubungan bermakna antara kelainan fungsiparu (p 0,004) dan derajat keparahan asma (p 0,000) dengan penurunan nilaiDLCO/prediksi (DLCO/prediksi ≤ 75%).Kesimpulan :.Derajat keparahan asma memiliki hubungan dengan kapasitas difusiparu, semakin berat derajat keparahannya maka semakin menurun kapasitas difusiparu. Penurunan kapasitas difusi menunjukkan bahwa kelainan pada asma tidakhanya terjadi di saluran napas tapi juga mungkin melibatkan parenkim paru.

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ABSTRACTBackground: Airway remodelling in asthma which is involved small airway isthought can affect until alveoli and cause abnormalities in the lung parenchyma Thisstudy tries to find lung parenchymal abnormalities in patients with asthma throughthe examination diffusion capacity with a single breath DLCO method .Methods : A cross-sectional study by dividing asthma based on the degree of severityinto two major groups, namely mild asthma ( intermittent and mild persistent ) andsevere ( persistent moderate and severe ). The amount of each group is 30 subjects ,which is taken consecutively from stable asthma patients without comorbid who isseeking treatment Persahabatan Hospital at December 2015 - May 2016Results : The average value of DLCO /predictions in mild asthma group is 92,74 ±15,70% and decreased in the severe asthma group is 77,45 ± 16,78%. Somespirometry values showed significant positive correlation with the value of DLCO/prediction , namely : KVP /prediction , VEP1 /prediction and FEF25-75 % / predictionwith p < 0.05 . Corellation analysis showed KVP / prediction could dramaticallyaffect the diffusion capacity of asthmatic patients . There is a significant relationshipbetween abnormalities in lung function ( p 0,004) and severity of asthma ( p 0.000 )with a corresponding decrease DLCO / prediction (DLCO / prediction ≤ 75 % )Conclusion : The severity of asthma has a relationship with the diffusion capacity ofthe lungs, increased severity will decrease the diffusion capacity in asthma patient.Decreasing diffusion capacity showed that abnormalities in asthma not only occur inthe respiratory tract but also in the lung parenchyma;"

"ABSTRAK Latar belakang : Penelitian ini merupakan studi awal untuk mengukur kapasitasdifusi paru DLCO-SB ipada pasien PPOK di RSUP Persahabatan Jakarta untukmengetahui prevalens penurunan nilai DLCO pada pasien PPOK.Metode : Penelitian ini menggunakan desain studi potong lintang (cross sectional study) pada pasien PPOK yang berkunjung di Poliklinik Asma-PPOK RSUPPersahabatan Jakarta. Dilakukan uji spirometri dan DLCO pada pasien PPOKyang diambil secara konsekutif antara bulan Mei-Juli 2015. Komorbiditas jugadicatat.Hasil : Uji Spirometri and DLCO dilakukan pada 65 subjek didapatkan 7 subjek (10,8%) termasuk kedalam PPOK Grup A, 19 subjek (29,2%) PPOK Grup B, 21subjek (32,3%) PPOK grup C dan 18 subjek (27,7%) PPOK grup D. rerata usia64,15 (45-89) tahun;rerata VEP1% 46,05%, rerata nilai DLCO 19,42ml/menit/mmHg dan rerata DLCO % adalah 72.00%. prevalens penurunanDLCO pasien PPOK adalah 56,92% (37/65 subjek) sedangkan 28 subjek dengannilai DLCO normal. Ditemukan 15 subjek (23,07%) dengan penurunan ringan, 18subjek (27.69%) penurunan sedang dan 4 subjek (6,15%) dengan penurunan berat.Ditemukan 47 subjek (72,3%) memiliki komorbid. Terdapat hubungan bermaknaantara grup PPOK, derajat spirometri, VEP1, IMT dan komorbiditas dengan nilaihasil uji DLCO. Tidak terdapat hubungan bermakna antara nilai DLCO denganjenis kelamin, umur, riwayat merokok, Indeks Brinkmann, obstruksi-restriksi danlama terdiagnosis PPOK.Kesimpulan : Proporsi penurunan nilai DLCO pada pasien PPOK adalah 56,92%. Terdapat hubungan bermakna antara grup PPOK, derajat spirometri,VEP1, IMT dan riwayat TB dengan nilai hasil uji DLCO. Tidak terdapathubungan bermakna antara nilai DLCO dengan jenis kelamin, umur, riwayatmerokok, Indeks Brinkmann, obstruksi-restriksi, komorbid dan lama terdiagnosisPPOK.ABSTRACT Background and the aim of study : This is a preliminary study to measureDLCO-SB in COPD patients in Persahabatan Hospital. The aim of the study is toknow the magnitude of disturbance in diffusing capacity of the lung in COPDpatients.Methods : This was a cross sectional study in which COPD patients attending COPD-Asthma clinic in Persahabatan Hospital Jakarta were performed spirometryand DLCO-SB consecutively between May 2015?July 2015. Comorbiditiesconditions were also recorded.Results : Spirometry and DLCO-SB measurement were conducted on 65 COPDsubjects of which 7 subjects (10.8%) were COPD Group A, 19 subjects (29.2%)were Group B, 21 subjects (32.3%) were COPD group C and 18 subjects (27.7%)were COPD group D. The mean age was 64.15 (45-89); mean FEV1% was46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO%was 72.00%. The prevalence of decreasing in diffusing capacity of the lung inCOPD patients was 56.92% (37 subjects) While 28 subjects were normal. Therewere 15 subjects (23.07%) with mild decrease in DLCO, 18 subjects (27.69%)were moderate decrease and 4 subjects (6.15%) with severe decrease. 47 subjects(72.3%) had comorbid conditions. There was significant correlation between grupCOPD, GOLD COPD grade, VEP1, BMI and comorbidities with magnitude ofdecreasing DLCO value. There was no correlation between DLCO value with sex,smoking history, Brinkmann index, age, obstruction-mix criteria, length of COPDperiod. Conclusion : The proportion of decreasing in DLCO in COPD patients are56.92%. There is significant correlation among the group of COPD, GOLDCOPD grade, VEP1, BMI and previous TB history with magnitude of decreasingDLCO value. There is no correlation between DLCO value with sex, smokinghistory, brinkmann index, age, obstruction-mix criteria, comorbidities and lengthof COPD period. ;Background and the aim of study : This is a preliminary study to measureDLCO-SB in COPD patients in Persahabatan Hospital. The aim of the study is toknow the magnitude of disturbance in diffusing capacity of the lung in COPDpatients.Methods : This was a cross sectional study in which COPD patients attending COPD-Asthma clinic in Persahabatan Hospital Jakarta were performed spirometryand DLCO-SB consecutively between May 2015?July 2015. Comorbiditiesconditions were also recorded.Results : Spirometry and DLCO-SB measurement were conducted on 65 COPDsubjects of which 7 subjects (10.8%) were COPD Group A, 19 subjects (29.2%)were Group B, 21 subjects (32.3%) were COPD group C and 18 subjects (27.7%)were COPD group D. The mean age was 64.15 (45-89); mean FEV1% was46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO%was 72.00%. The prevalence of decreasing in diffusing capacity of the lung inCOPD patients was 56.92% (37 subjects) While 28 subjects were normal. Therewere 15 subjects (23.07%) with mild decrease in DLCO, 18 subjects (27.69%)were moderate decrease and 4 subjects (6.15%) with severe decrease. 47 subjects(72.3%) had comorbid conditions. There was significant correlation between grupCOPD, GOLD COPD grade, VEP1, BMI and comorbidities with magnitude ofdecreasing DLCO value. There was no correlation between DLCO value with sex,smoking history, Brinkmann index, age, obstruction-mix criteria, length of COPDperiod. Conclusion : The proportion of decreasing in DLCO in COPD patients are56.92%. There is significant correlation among the group of COPD, GOLDCOPD grade, VEP1, BMI and previous TB history with magnitude of decreasingDLCO value. There is no correlation between DLCO value with sex, smokinghistory, brinkmann index, age, obstruction-mix criteria, comorbidities and lengthof COPD period. ;Background and the aim of study : This is a preliminary study to measureDLCO-SB in COPD patients in Persahabatan Hospital. The aim of the study is toknow the magnitude of disturbance in diffusing capacity of the lung in COPDpatients.Methods : This was a cross sectional study in which COPD patients attending COPD-Asthma clinic in Persahabatan Hospital Jakarta were performed spirometryand DLCO-SB consecutively between May 2015?July 2015. Comorbiditiesconditions were also recorded.Results : Spirometry and DLCO-SB measurement were conducted on 65 COPDsubjects of which 7 subjects (10.8%) were COPD Group A, 19 subjects (29.2%)were Group B, 21 subjects (32.3%) were COPD group C and 18 subjects (27.7%)were COPD group D. The mean age was 64.15 (45-89); mean FEV1% was46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO%was 72.00%. The prevalence of decreasing in diffusing capacity of the lung inCOPD patients was 56.92% (37 subjects) While 28 subjects were normal. Therewere 15 subjects (23.07%) with mild decrease in DLCO, 18 subjects (27.69%)were moderate decrease and 4 subjects (6.15%) with severe decrease. 47 subjects(72.3%) had comorbid conditions. There was significant correlation between grupCOPD, GOLD COPD grade, VEP1, BMI and comorbidities with magnitude ofdecreasing DLCO value. There was no correlation between DLCO value with sex,smoking history, Brinkmann index, age, obstruction-mix criteria, length of COPDperiod. Conclusion : The proportion of decreasing in DLCO in COPD patients are56.92%. There is significant correlation among the group of COPD, GOLDCOPD grade, VEP1, BMI and previous TB history with magnitude of decreasingDLCO value. There is no correlation between DLCO value with sex, smokinghistory, brinkmann index, age, obstruction-mix criteria, comorbidities and lengthof COPD period. "

"Kasus kebakaran sebagai penghasil gas karbon monoksida (CO) yang tinggi masih menjadi salah satu permasalahan yang harus diselesaikan, mengingat seringnya terjadi peristiwa kebakaran. Jika terjadi kebakaran, potensi kematian akibat keracunan gas CO akan semakin meningkat. Oleh karena itu, diperlukan suatu usaha untuk mengurangi kadar CO, salah satunya adalah dengan metode adsorpsi gas CO menggunakan metode volumetrik dengan temperatur konstan (temperetur 25°C) pada tekanan 0 psia -315 psia dengan interval 50 psi. Sehingga dapat dilakukan perhitungan adsorpsi isotermal Gibbs menggunakan Zeolit Alam Lampung teraktivasi yang dimodifikasi oleh TiO2 melalui metode sol-gel. Variasi kandungan TiO2 yang dilakukan adalah 10, 15, 20, 25 dan 30 (wt%). Dari hasil penelitian diketahui bahwa pelapisan TiO2 terhadap Zeolit Alam Lampung dapat meningkatkan kapasitas adsorpsi. Dari variasi kandungan TiO2 yang telah dilakukan didapatkan komposisi optimum TiO2 sebesar 20 % dan didapatkan kapasitas adsorpsi paling besar yaitu nmax= 0,54361 mmol/gram dengan kandungan TiO2 3,58 (wt%) dan luas permukaan 96,25 m2/gram.

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Case of fire has a high content of gas carbon monoxide production which has to be solved because of the high frequency of this incident. If it happens, the potential death caused by CO poisoning will increase. Therefore, an effort is needed to reduce CO concentration. One of them is CO gas adsorption method using a volumetric method with a constant temperature (25°C) at pressure 0 psia -315 psia at intervals of 50 psi. It can be calculated by Gibbs adsorption isotherm using activated Lampung Natural Zeolites modified by TiO2 via sol-gel methods. Variations of TiO2 content is done with 10, 15, 20, 25 and 30 (wt%). From the result of this research shows that TiO2 coating on Natural Zeolites Lampung can increase adsorption capacity. TiO2 content of the variations that have been carried out the optimum composition of TiO2 obtained by 20% and the greatest adsorption capacity is nmax = 0.54361 mmol / g with a TiO2 content of 3.58 (wt%) and the surface area 96.25 m2/gram."

"ABSTRAKLatar belakang: Kapasitas difusi paru berdasarkan karbon ke sirkulasi pulmoner. Nilai DLCO prediksi pada asma cenderung normal atau sedikit monoksida (DLCO) didesain untuk mengukur laju perpindahan gas CO dari alveolus meningkat sedangkan pada PPOK kapasitas difusi cenderung menurun akibat emfisema. Sindrom tumpang-tindih asma-PPOK dinyatakan sebagai entitas yang unik dengan kombinasi karakteristik asma dan PPOK. Tujuan utama penelitian ini adalah mengetahui nilai DLCO pada pasien tumpang tindih asma- PPOK (TAP) di RSUP Persahabatan Jakarta.Metode: Uji DLCO dengan metode napas tunggal dan beberapa pemeriksaan penunjang lainnya telah dilakukan pada 40 pasien yang terdiagnosis sebagai TAP. Diagnosis TAP pada subjek penelitian ditegakkan menggunakan kriteria pedoman GINA/GOLD 2017. Kriteria akseptabilitas dan reprodusibilitas DLCO napas tunggal dinilai menggunakan kriteria dari ATS/ERS 2017. Hasil uji DLCO disajikan dalam nilai mutlak dan nilai persen prediksi.Hasil: Rerata nilai DLCO mutlak dan %DLCO prediksi yang didapatkan dalam penelitian ini adalah 17.98 ± 5.37 mL/menit/mmHg dan 84.16 ± 18.29%. Jika menggunakan persamaan penyesuaian DLCO berdasarkan kadar hemoglobin didapatkan nilai %DLCO prediksi sedikit meningkat dibanding sebelumnya, 85.17 ± 18.04%. Terdapat 10 subjek (25.0%) yang mengalami penurunan nilai DLCO. Enam diantaranya mengalami penurunan ringan dan empat lainnya mengalami penurunan sedang.Kesimpulan : Rerata nilai DLCO pada subjek TAP di RSUP Persahabatan Jakarta dapat diinterpretasikan normal, lebih menyerupai asma dibandingkan PPOK. Hasil ini juga mengindikasikan kebanyakan pasien TAP dalam penelitian ini tidak mengalami penurunan luas permukaan alveolar yang mengganggu proses difusi.

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ABSTRACTBackground: Diffusing capacity of the lung for carbon monoxide (DLCO) was designed to measure transfer rate of carbon monoxide from alveoli to pulmonary circulation. As we know, DLCO predicted value in asthma proved to be normal or slightly elevated. On contrary it decreased in COPD with emphysematous pattern. Asthma-chronic obstructive pulmonary disease overlap (ACO) declared as a unique entity with combined characteristics between asthma and COPD. The aim of the research is to find out DLCO value of ACO patient in Persahabatan Hospital, Jakarta.Method: We have conducted single-breath DLCO and other required test to 40 patients diagnosed with ACO using GINA/GOLD 2017 guidelines. The acceptability and reproducibility of single-breath DLCO was done according to ATS/ERS 2017 criteria. The result then presented as absolute value and percent predicted value.Results: The mean DLCO of our patient is 17.98 ± 5.37 mL/minute/mmHg with percent predicted value is 84.16 ± 18.29%. Using adjusted DLCO equation for hemoglobin, we found that the value is slightly increased, 85.17 ± 18.04%. However, we found 10 patient (25.0%) with DLCO decrease. Six of them have DLCO predicted value <75% (mild-decrease) and four of them have DLCO predicted value <60% (moderate-decrease).Conclusion: The mean DLCO value of patient with ACO in our hospital can be interpreted as normal, similar with asthma, rather than COPD. It also indicate most of our patient did not have alveolar loss that altering diffusion process."

"ABSTRACTGas CO merupakan salah satu gas yang berbahaya. Gas ini bisa menyebabkan kematian apabila dihirup dengan kadar yang sangat tinggi. Sudah banyak kejadian atau kecelakaan fatal yang disebabkan oleh gas ini. Gas CO tidak berwarna, tidak berbau namun sangat beracun. Jika tidak berhati-hati, bisa berbahaya bagi kelangsungan hidup makhluk hidup, utamanya manusia. Sintesis nanopartikel NdFeO3 atau senyawa-senyawa dari logam tanah jarang (rare-earth orthoferrites) merupakan salah satu upaya untuk meningkatkan sensitivitas pada sensor gas. Dalam penelitian ini disintesis empat macam sampel NdFeO3 yang disintesis melalui sintesis presipitasi dansol-gel citrate serta digunakan dua bahan baku, yakni bahan baku impor dan lokal. Karakterisasi sintesis menggunakan XRD, TEM, FT-IR dan TGA. Hasil XRD menunjukkan jika sampel NdFeO3 memiliki struktur orthorombic dan partikel berukuran 21,3 ; 15,56; 37,55 dan 46,53 nanometer, FT-IR menunjukkan adanya fase pembentukan NdFeO3 pada peak 400 cm-1-750 cm-1, TEM menunjukkan morfologi partikel serta ukuran partikel berukuran nanometer. dan TGA menunjukkan karakterisasi thermal serta perubahan massa partikel NdFeO3 dan hasil pengujian sensor menunjukkan jika respon sensor terhadap gas CO memiliki hasil yang variatif.

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ABSTRACTCarbon monoxide is a one of dangerous gases. It can cause a death if it is inhaled in a high concentration. There are so many moments or fatality accident caused by this gas. Carbon monoxide is colorless, has no smell but it is very-very toxic. If we are not aware, life of organism, especially human being is under danger. Therefore,  detector devices of carbon monoxide is urgently needed, in order to prevent the toxic influences of carbon monoxide gas around us.nanoparticle synthesis from rare-earth orthoferrite is a one of attempts to improve the sensivity of a gas sensor. In this research where nanoparticle NdFeO3 is synthesized with precipitation and sol-gel citrate method and use two kind of raw materials, Sigma Aldrich and PSTA-BATAN. XRD result showed that NdFeO3 nanoparticles is an orthorombic structure and showed that the size of the particle is in 21,3; 15,56; 37,55 and 46,55 nanometer, FT-IR showed theres a forming phase of NdFeO3 at 400 cm-1-750 cm-1, TEM showed the particless morphology and TGA showed the thermal characteristics. The result of CO gas sensor test, showed that response to the analit gas is variative."

"Dengan masih kurangnya pemakaian gerbang tol otomatis diharapkan dapat meningkatkan pemakaian gerbang tol otomatis untuk mengurangi emisi karbon monoksida. Penelitian ini adalah penelitian kulitatif dengan menghubungkan hasil dengan faktor yang mempengaruhinya menggunakan perhitungan dan analisa terkait. Penelitian ini menggunakan metode NDIR untuk mengambil emisi karbon monoksida dan menggunakan teori antrian untuk mengambil rata ndash; rata waktu antrian setiap gerbang tol. Hasil penelitian ini adalah pada gerbang tol otomatis didapatkan rata ndash; rata emisi karbon monoksida selama 5 hari sampling sebesar 8150.13 ?g/Nm3 dan gerbang tol manual didapatkan didapatkan rata ndash; rata emisi karbon monoksida selama 5 hari sampling sebesar 11198.26 ?g/Nm3, dengan uji signifikansi yang menunjukkan rata ndash; rata konsentrasi karbon monoksida gerbang tol manual dan otomatis berbeda. Faktor ndash; faktor yang mempengaruhi emisi karbon monoksida di gerbang tol adalah waktu antrian yaitu semakin tinggi waktu antrian maka semakin tinggi emisi karbon monsoksida disebebkan peningkatan laju percepatan dan perlambatan kendaraan dan faktor kedua adalah suhu yaitu semakin tinggi suhu maka semakin tinggi emisi karbon monoksida disebabkan bahan pencemar yaitu karbon monoksida dalam udara menjadi kering sehingga polutan akan cenderung tinggi . Walaupun demikian, konsentrasi karbon monoksida di tiap gerbang tol masih berada di bawah baku mutu dan emisi di gerbang tol otomatis di bawah gerbang tol manual. Dengan penelitian ini, disimpulkan bahwa gerbang tol otomatis dapat mengurangi emisi karbon monoksida sebesar 24.54 .

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With the lack of utilization of automatic toll gates is expected to increase the use of automatic toll gates to reduce carbon monoxide emissions. This research is a skin related research by linking the results with the factors that influence it using the calculation and related analysis. This study uses the NDIR method to extract carbon monoxide emissions and use queuing theory to take the average queue time for each toll gate. The result of this research is at automatic toll gate obtained average carbon monoxide emission during 5 days sampling equal to 8150.13 g Nm3 and manual toll gate obtained got average carbon monoxide emission during 5 day sampling equal to 11198.26 g Nm3, with significance test which Shows the average carbon monoxide concentration of manual and automatic toll gates differently. Factors affecting carbon monoxide emission at toll gate is queue time that is higher queue time hence higher carbon emission of monsoksida disebebkan increase of acceleration rate and slowing of vehicle and second factor is temperature that is higher temperature then higher carbon monoxide emission caused by pollutant Ie carbon monoxide in the air becomes dry so that pollutants will tend to be high. However, carbon monoxide concentrations in each toll gate are still below the standard and emissions at auto toll gates beneath manual toll gates. With this study, it was concluded that automatic toll gates could reduce carbon monoxide emissions by 24.54."

"Karbon monoksida merupakan senyawa gas yang tidak berbau, tidak berwarna dan tidak berasa tetapi sangat beracun. Karbon monoksida terutama berasal dari asap hasil pembakaran mesin dan kendaraan bermotor. Keracunan terutama terjadi karena proses inhalasi dan melalui mekanisme hipoksia, selanjutnya dapat menimbulkan gangguan sistem saraf pusat dengan gejala gangguan neurobehavioral dan fungsi kognitif.Penelitian ini mengkaji hubungan antara pajanan kronis karbon monoksida dengan gangguan fungsi kognitif pada pekerja di lokasi parkir dalam gedung. Penelitian ini menggunakan desain cross sectional, melibatkan 93 pekerja di lokasi parkir dalam gedung rumah sakit dan hotel di Jakarta pada tahun 2015. Pengukuran kadar karbon monoksida di udara lingkungan kerja dilakukan 1 kali menggunakan metode spektrofotometri dengan iodida pentoksida. Pengukuran kadar COHb dilakukan dengan metode kromatografi gas melalui udara CO ekshalasi, sedangkan fungsi kognitif dinilai menggunakan kuesioner Montreal Cognitive Assessment. Prevalensi gangguan fungsi kognitif pada populasi pekerja di lokasi parkir dalam gedung 22,58%. Gangguan fungsi kognitif memiliki hubungan bermakna (p<0,05) berturut-turut dengan kadar CO ruang (ORcr=4,28; 95% CI = 1,15-15,86), kadar COHb (ORcr=6,5; 95% CI = 2,21-19,10) dan kebiasaan merokok (ORcr=6,81; 95% CI = 1,98-23,42).Hasil analisis multivariat menunjukkan faktor risiko utama yang berhubungan dengan gangguan fungsi kognitif adalah kadar COHb ≥5% (ORadj=4,47; 95% CI = 1,23-16,25). Disimpulkan pajanan kronis CO di udara lingkungan kerja dapat menimbulkan gangguan fungsi kognitif yang ditandai dengan peningkatan kadar COHb dalam darah. Kebiasaan merokok merupakan faktor perancu utama, karena dapat secara langsung meningkatkan kadar COHb dalam darah dan menimbulkan gangguan fungsi kognitif melalui mekanisme kerusakan sel syaraf. Pemerintah perlu menyusun regulasi terkait pembangunan fasilitas parkir dalam gedung untuk menjamin kesehatan dan keselamatan pekerja.

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Carbon monoxide (CO) is a colorless, nonirritating, odorless and tasteless gas. The most important human-made source of CO arises from the exhaust of automobiles. Carbon monoxide chronic intoxication mostly occurs from an inhalation process and can cause brain damage due to its sensitivity over hypoxia, and leads to various neural defects including neurobehavioral and cognitive function disturbance.This study aimed to determine the relationship between chronic CO exposure and cognitive function among basement parking lot workers. This study used a cross-sectional design, involving 93 people age 20-40 years who work in a hospital or hotel basement parking lot in Jakarta on 2015. Carbon monoxide air levels in workplace were measured using iodine pentoxidespectrophotometric method, while COHb levels were measured once using Gas Chromatography through a CO exhalation procedure. Cognitive function was determined using the Montreal Cognitive Assessment (MoCA) questionnaire.Study result showed the CO air levels were all below threshold limit value (TLV) of 29 mg/m3. The prevalence of impaired cognitive function among basement parking lot workers was 22,58%. Carbon monoxide air levels, COHb levels and smoking habit factors were statistically significant related to impaired cognitive function, with ORcr 4.28 (95% CI = 1,15-15,86); ORcr 6.5 (95% CI = 2,21-19,10); and ORcr 6.81(95% CI = 1,98-23,42). Logistic regression method shows COHb levels is the only predictive factor of cognitive function with ORadj 4.47 (95% CI = 1,23-16,25). Therefore, it is concluded that chronic exposure of CO in the air workplace can cause cognitive function impairment, marked by a significant increase of COHb levels. Smoking habit is the main confounding factor, for it can directly increase COHb levels and impair cognitive function. Government should establish a punctual and effective regulation on how to build a basement parking lot facility regarding the safety of the workers."

"Gas karbon monoksida (CO) adalah hasil produksi dari pembakaran tidak sempurna senyawa-senyawa organik dan berbagai bentuk karbon yang paling banyak dihasilkan dibanding komponen lainya dalam asap. Simulasi proses adsorpsi digunakan untuk untuk mengetahui laju adsorpsi yang efektif, kemampuan adsorpsi dari tiap ukuran partikel, dan konsentrasi sisa pada ruang uji. Ruang uji yang digunakan berukuran 0,4 m x 0,4 m x 1,2 m. Pada penelitian ini digunakan adsorben karbon aktif komesial yang memiliki nilai bilangan Iodin 1000 mg/g, luas permukaan (BET) 1050 m2/g, adsorpsi maksimum gas karbon monoksida (CO) (nmaks) 1,58827 mol/g, dan konstanta adsorpsi Langmuir untuk gas karbon monoksida (b) 0,00305. Massa adsorben yang digunakan adalah 3 gram. Ukuran partikel adsorben yang digunakan adalah 1,59.10-4 m, 7,95.10-5 m, 8.10-7 m, dan 4.10-7 m. Simulasi menggunakan aplikasi Comsol Multiphysics versi 4.3b. Berdasarkan hasil simulasi, diperoleh unggun dengan ukuran partikel 8.10-7 m memiliki waktu jenuh yang paling lama dan konsentrasi sisa 35,4 mol. Konsentrasi sisa yang terbentuk setelah proses adsorpsi unggun dengan partikel berukuran 7,95.10-5 m, 8.10-7 m, dan 4.10-7 m nilainya berkisar antara 0,03545 mol - 0,0355 mol.

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Carbon monoxide (CO) is the highest composition in combustion smoke. Carbon monoxide (CO) is produced by incomplete combustion of organic compounds and various forms of carbon. Simulation of adsorption process used to determine the effective adsorption rate, adsorption capacity of each particle size, and the residual concentration in the test chamber. Test chamber size is 0,4 m x 0,4 m x 1,2 m.

In this research, properties of activated carbon which is used for adsorbent 1000 mg/g Iodine number, surface area (BET) 1050 m2/g, maximum adsorption capacity of carbon monoxide (CO) (nmaks) 1.58827 mol/g, and Langmuir adsorption constants for carbon monoxide (b) 0.00305. Mass of activated carbon adsorbent is 3 grams. Variations of particle size used for this research are 1,59.10-4 m, 7,95.10-5 m, 8.10-7 m, and 4.10-7 m. Comsol Multiphysics simulation program version 4.3b used for process simulation.

Based on the simulation results, bed with particle size 8.10-7 m has the longest saturated time and residual gas carbon monoxide (CO) is 35,4 mol. Residue of gas carbon monoxide (CO) composition in the chamber for particle size 7,95.10-5 m, 8.10-7 m, and 4.10-7 m approximately 0,03545 mol - 0,0355 mol."

"Tingkat kematian karena keracunan asap kebakaran jauh lebih besar dibandingkan dengan kematian karena luka bakar. Penelitian ini bertujuan untuk penjernihan asap dan penyerapan CO mengunakan material berukuran nano. Penelitian ini dibagi tiga tahapan, tahap pertama dilakukan seleksi adsorben dalam menyerap CO dengan metode adsorpsi isotemis. Tahap kedua dilakukan uji pembuatan asap dari tisu. Tahap ketiga dilakukan uji penjernihan asap menggunakan adsorben terpilih di tahap pertama dalam kompartemen tunggal yang dilengkapi alat pendeteksi asap fotoeletrik berbasis micro controller. Variabel penelitian adalah ukuran partikel, massa adsorben dan ketinggian sensor di dalam ruang uji dengan parameter tingkat penjernihan 10% (t10).Hasil penelitian menunjukkan bahwa karbon aktif dan zeolit alam teraktifasi memiliki kemampuan yang baik dalam penyerapan CO. Nilai ngibbs berturut-turut karbon aktif dan zeolit alam teraktifasi, adalah 0,0682 dan 0,0352 mmol/g. Massa tisu 6 gram dapat menghasilkan asap yang pekat. Proses penjernihan asap lebih efektif menggunakan adsoben dibandingkan tanpa adsorben, waktu t10 adsorben dibawah 50% dari t10 tanpa adsorben. Adsorben dengan ukuran partikel 53 μm mempunyai kemampuan paling baik. Kolom bagian atas lebih cepat jernih dibandingkan tengah dan bawah. Urutan kemampuan adsorben dalam menjernihkan asap berturut-turut: Accom> ACZnCl2> zeolit alam. Nilai t10 terbaik dari ACcom untuk bagian atas, tengah dan bawah kolom adalah 4, 4,6 dan 7,7 menit.

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Mortality level due to fire smoke poisoning larger than caused by burn. The aim of this study is smoke clearing and CO adsorption using nano sized material. This study is conducted in three stages, the first stage is the selection of adsorbent to adsorb CO using isotherm adsorption method. The second stage is smoke production testing from tissue as raw material. The final stage is smoke clearing testing using adsorbent chosen in the first stage, conducted in a single compartment equipped with a photoelectric smoke detector based on micro controller. The variables in this study are particle size, adsorbent mass, and detector height in the compartment test, with degree of clearing called t10 as observed parameter.The results showed that activated carbon and activated natural zeolite has the best ability to adsorb CO. ngibbs value for activated carbon and activated natural zeolite is 0.0682 and 0.0352 mmole/g respectively. 6 grams of tissue can produce high density of smoke. Smoke clearing process using adsorbent more effective than without adsorbent, with t10 using adsorbent less that 50% compared to without adsorbent. Adsorbent with particle size 53μm has the most excellent abilities. Top section of compartment cleared faster than middle and bottom section. The order of adsorbent ability in smoke clearing is as follows: ACcom > ACZnCl2 > natural zeolite. The best parameter of t10 for ACcom at the top, middle, and bottom of compartment is 4, 4.6 and 7.7 minutes respectively."

"Merokok dianggap sebagai sumber utama pajanan terhadap karbon monoksida (CO). Pemeriksaan kadar CO udara ekspirasi dapat digunakan sebagai biomarker status merokok. Metode ini mudah dilakukan, non invasif dan menimbulkan kepatuhan yang lebih baik bagi pasien. Penelitian ini bertujuan untuk mengetahui kadar CO udara ekspirasi pada perokok dan bukan perokok sekaligus mengetahui kadar CO pada masing-masing jenis perokok terutama perokok kretek sebagai perokok mayoritas di Indonesia.METODEPenelitian potong lintang yang dilaksanakan pada Januari 2013 sampai Oktober 2013. Jumlah sampel sebanyak 125 orang yang terdiri dari 85 orang kelompok perokok dan 40 orang kelompok bukan perokok dipilih secara consecutive sampling. Dilakukan wawancara untuk mengisi kuesioner data dasar, kuesioner Fagerstorm dan skor Horn yang dilanjutkan dengan anamnesis, pemeriksaan fisis dan pengukuran kadar CO udara ekspirasi dengan menggunakan alat pengukur CO portabel (piCO+cSmokerlyzer Bedfont).HASILPenelitian ini mendapatkan kadar CO udara ekspirasi pada kelompok perokok lebih tinggi dibandingkan kelompok bukan perokok dengan rerata kadar CO pada kelompok perokok sebesar 22 (4;48) ppm dan kelompok bukan perokok sebesar 5,83 + 1,82 ppm (p=0,000). Tidak didapatkan perbedaan kadar CO antara kelompok perokok kretek, perokok putih dan perokok campuran (22 + 10,96 ; 22,60 + 10,44 ; 21,43 + 11,72 ; p=0,943). Faktor yang paling berkorelasi terhadap kadar CO udara ekspirasi pada perokok adalah jenis kelamin, laki-laki cenderung memiliki kadar CO yang lebih tinggi dibandingkan dengan perempuan.KESIMPULANKadar CO udara ekspirasi pada perokok lebih tinggi dibandingkan bukan perokok serta tidak ditemukan perbedaan kadar CO diantara perokok kretek, perokok putih dan perokok campuran. Faktor yang paling berkorelasi terhadap kadar CO udara expirasi pada kelompok perokok adalah jenis kelamin.Kata kunci : Kadar CO udara ekspirasi, perokok, perokok kretek

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Smoking has been considered as a prime cause of carbon monoxide (CO) exposures.Exhaled air CO measurement is a reliable indicator for smoking status. It is noninvasive, easy procedure and better compliance. The present study was undertaken to measure exhaled air CO levels in smokers and non smokers and also to measure exhaled air CO levels in clove cigarette (kretek) smokers as a majority smokers in Indonesia.

METHOD

This study used cross sectional method conducted from Januari 2013 until October 2013. A Total of 125 subject consist of 85 smokers and 40 non smokers selected based on consecutive sampling. Interview was done to fill out question about sociodemografic and smoking habit, Fagerstorm test for nicotine dependence and Horn score for smokers profile if the respondent is smoker follow by anamnesis, physical examination and breath CO measurement using portable CO analyzer ((piCO+cSmokerlyzer Bedfont).

RESULT

Average exhaled air CO levels were 22 (4;48) ppm in smokers, significantly higher compared to non smokers with the level of exhaled air CO were 5,83 + 1,82 ppm (p=0,000). No significant difference was found (p = 0,943) in the distribution of CO readings of the clove cigarette smokers compared to white cigarette and mix cigarette smokers (22 + 10,96 vs 22,60 + 10,44 vs 21,43 + 11,72) ppm. Gender was the most correlated factor to exhaled air CO levels, men tend to have higher exhaled air CO levels compared to women.

CONCLUSION

Exhaled air CO levels in smokers is higher than non smokers whereas no significant difference in the distribution of breath CO readings between clove cigarette, white cigarette en mix cigarette smokers. The most correlated factor that influence CO levels is gender."