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"Diabetes mellitus is comma only hereditary metabolic disorder. The signs were hyperglycemic and glucosuric with or without acute or chronic clinically symptoms. It was cause effectively insulin deficiency. The primary was carbohydrate metabolism disorder which followed lipid and protein metabolism disorders. The increase of blood. Glucose concentration could increcesing salivary glucose concentration. Glucose was a good media for the growth of microorganism, for example: candida albicans. The most frequently infection on oral mucous diabetes mellitus patients was candidacies. The purpose of the study was to determine the relation of blood glucose concentration and C. albicans griwth on oral cavity diabetes mellitus patients. The subject consisted of 8 non regulated diabetes mellitus, 8 regulated diabetes mellitus, and 8 normal patients, respectively. The assessment of blood glucose concentration used Bio-Rad Diastat Halmoglobine AIC method. The growth of C. albicans was determined using swab on oral mucous. The result of swab was into culated on sabaurond agar, than gram sainning and glucose test was done. Data was analyzed using speaman test. The result indicated thet the growth of C. albicans was eughen on non regulated diabetes mellitus than regulated diabetes mellitus. It's also on regulated diabetes mellitus that normal patient."

"High carbohydrate intake is one of predisposing factors of oral candidiasis. Wheather glucose addition in medium will increase the growth of Candida albicans in vitro is subject to further investigation. Objective: Investigating the effect of 1%, 5%, 10% glucose addition on the growth of C. albicans in vitro. Method: C. albicans sample was taken from oral swab of a male oral candidiasis patient. Identification of C. albicans was conducted using CHROMagar and confirmed by germ tube formation in serum. C. albicans colonies were inoculated in SDB. As a comparison, C. albicans ATCC 10231 was used. After 2 days the cultures were serially diluted and inoculated in SDB without glucose (control), and with 1%, 5%, 10% addditional glucose, kept for 3 and 7 days in room temperature, then inoculated in SDA. The CFU/ml were counted after 2 days. ANOVA with α 0.05 was used. Result: After 3 days, additional 1%, 5%, and 10% glucose in media with clinical strain of C. albicans resulted in 181.5, 582, and 811 CFU/ml respectively while in media with C. albicans ATCC were 21.5, 177.5, 375.5 CFU/ml. The growth of C. albicans with no additional glucose were 970 (clinical strain) and 957 CFU/ml (ATCC). After 7 days, the growth of clinicalstrain of C. albicans with additional glucose 1%, 5%, 10% were 2350, 9650, 9560 CFU/ml respectively while the growth of C. albicans ATCC were 5000, 5450, 3550 CFU/ml. Statisticaly, additional 1% glucose for 3 days lead to significant decreased of growth of both clinical strain andATCC 10231 C. albicans (p < 0,05). However, only additional 5% and 10% glucose in clinical isolate for 7 days increased the growth of C. albicans significantly (p < 0,05). Conclusion: The effect of additional glucose on the increased growth of C. albicans in vitro is influenced by the concentration, exposure duration of glucose, and by the strain of C. albicans."

"Hiperglikemia merupakan gejala metabolik berupa peningkatan glukosa darah melebihi batas normal, yang dikaitkan dengan diabetes melitus (DM). Modifikasi gaya hidup yang lebih sehat, seperti dilakukannya restriksi kalori dengan metode fasting-mimicking diet (FMD) dapat dilakukan sebagai alternatif pendekatan untuk pengendalian DM tipe 2. Penelitian ini bertujuan untuk mengetahui pengaruh FMD berbahan nabati yang tersedia di Indonesia, terhadap kadar glukosa darah dan resistensi insulin. Penelitian dilakukan terhadap tikus jantan galur Sprague-Dawley model hiperglikemia yang dibagi menjadi 4 kelompok perlakuan (n=16), yakni kelompok hiperglikemia (high fat diet[HFD]-streptozotosin[STZ] 35 mg/kgBB dan CMC Na 0,5%), kelompok metformin (HFD-STZ 35 mg/kgBB dan metformin 250 mg/kgBB), kelompok FMD (HFD-STZ 35 mg/kgBB dan FMD), dan kelompok normal diet (ND) (CMC Na 0,5%). Pemberian perlakuan dilakukan selama 28 hari. Tikus dilakukan pengecekan glukosa darah puasa (GDP) dan berat badan setiap minggu perlakuan dan dikorbankan untuk diambil sampel darahnya setelah perlakuan berakhir. Homeostasis model assessment of insulin resistance (HOMA-IR) digunakan untuk mengukur resistensi insulin. Hasil penelitian menunjukkan penurunan kadar GDP dengan adanya pemberian FMD, walaupun tidak terdapat perbedaan signifikan antara GDP pra-perlakuan dengan GDP minggu ke-4 perlakuan (p>0,05). Hasil penelitian juga menunjukkan nilai HOMA-IR kelompok FMD mendekati nilai HOMA-IR kelompok ND dan lebih rendah secara signifikan dibandingkan nilai HOMA-IR kelompok hiperglikemia (p<0,05), yang berarti pemberian FMD pada tikus hiperglikemia menghasilkan tingkat resistensi insulin yang lebih rendah dibandingkan dengan tikus hiperglikemia yang tidak diberikan FMD. Sebagai kesimpulan, pemberian FMD dapat menurunkan GDP dan menghasilkan tingkat resistensi insulin yang lebih rendah pada tikus model hiperglikemia.

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Hyperglycemia is a metabolic symptom in the form of an increase in blood glucose exceeding normal limits, which is associated with diabetes mellitus (DM). Healthy lifestyle modifications, such as calorie restriction with the fasting-mimicking diet (FMD) method, can be used as an alternative approach to controlling type 2 diabetes. This study aims to determine the effect of FMD using plant-based ingredients available in Indonesia on blood glucose levels and insulin resistance. The study was conducted on male rats of the Sprague-Dawley strain model of hyperglycemia, which were divided into 4 treatment groups (n = 16), namely the hyperglycemic group (high fat diet [HFD]-streptozotocin [STZ] 35 mg/kgBW and CMC Na 0.5%), the metformin group (HFD-STZ 35 mg/kgBW and metformin 250 mg/kgBW), the FMD group (HFD-STZ 35 mg/kgBW and FMD), and the normal diet (ND) group (CMC Na 0.5%). The treatment was carried out for 28 days. Rats were checked for fasting blood glucose (FBG) and body weight every week of treatment and sacrificed for blood samples after the treatment ended. Homeostasis model assessment of insulin resistance (HOMA-IR) was used to measure insulin resistance. The results showed a decrease in FBG levels with the administration of FMD, although there was no significant difference between pre-treatment FBG and FBG at the 4th week of treatment (p>0,05). The results also showed that the HOMA-IR value of the FMD group was close to the HOMA-IR value of the ND group and was significantly lower than the HOMA-IR value of the hyperglycemic group (p<0,05), which means that administering FMD to hyperglycemic rats resulted in lower levels of insulin resistance than the hyperglycemic rats that were not given FMD. In conclusion, administration of FMD can reduce FBG and result in lower levels of insulin resistance in hyperglycemic rats."

"Pendahuluan. Stress pembedahan merupakan faktor yang dapat mempengaruhi keluaran pasca pembedahan ortopedi, khususnya pada populasi diabetes mellitus tipe dua dimana regulasi glukosa sangat penting baik sebelum maupun pasca bedah. Kadar glukosa dan C-reactive protein merupakan biomarker yang akan meningkat bila terjadi stress pembedahan. Penelitian ini bertujuan untuk membandingkan kadar rerata glukosa dan C-reactive protein pada subjek penelitian dengan diberikan lidokain intravena dan kontrol pada operasi ortopedi.Metode. Penelitian ini merupakan uji klinis acak tersamar yang mengikutsertakan 42 pasien yang menjalani pembedahan ortopedi. Sampel dilakukan pengelompokan dengan metode randomisasi menjadi dua kelompok. Kelompok pertama adalah pasien yang diberikan lidokain intravena selama pembedahan dalam anestesia umum. Kelompok kedua adalah pasien dalam anestesia umum tanpa lidokain. Pada kedua kelompok dilakukan dua kali pemeriksaan sampel glukosa dan C-reactive protein pada sebelum operasi dan sesudah operasi. Kedua kelompok dilakukan uji hipotesis untuk melihat perbedaan rerata glukosa dan C-reactive protein dengan analisa statistik menggunakan software SPSS.Hasil. Tidak terdapat perbedaan bermakna antara rerata kadar glukosa dan C-reactive protein antara kelompok pasien dengan lidokain intravena dan kontrol. Rerata kadar glukosa pasca pembedahan lebih rendah pada kelompok lidokain dibandingkan kelompok kontrol, namun tidak berbeda bermakna (p>0.05). Tidak terdapat perbedaan rerata C-reactive protein pada kelompok lidokain dan kelompok kontrol (p>0.05).Kesimpulan. Tidak terdapat perbedaan kadar glukosa dan C-reactive protein yang bermakna antara kelompok lidokain dan kelompok kontrol pada operasi ortopedi dalam anestesia umum pada populasi dengan diabetes mellitus tipe dua.

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Introduction. Surgical stress is a factor that can influence orthopaedic postoperative outcomes, particularly in the type two diabetes mellitus population where blood sugar regulation is critical both before and after surgery. Blood sugar levels and C-reactive protein are biomarkers that will increase in the event of surgical stress. This study aimed to compare the average levels of blood sugar and C-reactive protein in study subjects with intravenous lidocaine and control in orthopaedic surgery.

Methods. The study was a randomized clinical trial that included 42 patients undergoing orthopaedic surgery. Samples were grouped by randomization method into two groups. The first group were patients who were given lidocaine intravenously during surgery under general anaesthesia. The second group is patients under general anaesthesia without lidocaine. In both groups, two blood sugar and c-reactive protein samples were examined before surgery and after surgery. Both groups tested the hypothesis to see the difference in average blood sugar and C-reactive protein with statistical analysis using SPSS software.

Results. There were no significant differences between mean blood sugar levels and C-reactive protein between the intravenous and control lidocaine groups. Average postoperative blood sugar levels were lower in the lidocaine group than in the control group, but not significantly different (p>0.05). There was no difference in mean C-reactive protein in the lidocaine group and the control group (p>0.05).

Conclusions. There were no significant differences in blood sugar and C-reactive protein levels between the lidocaine group and the control group in orthopaedic surgery under general anaesthesia in the population with type two diabetes mellitus."

"Prevalensi DM di Kota Bogor yakni sebesar 2,1% hal ini masih lebih tinggi dibandingkan dengan prevalensi DM di Indonesia menurut data Riskesdas 2013 yakni sebesar 2,0%. Tujuan penelitian ini adalah untuk mengetahui pengaruh aktivitas fisik terhadap kontrol kadar Glukosa darah penderita diabetes mellitus tipe 2 pada studi kohort PTM di Kota Bogor tahun 2011-2016. Menurut uji Log-rank survival berdasarkan aktivitas fisik tidak berbeda bermakna dengan nilai signifikansi 0,941. Bahwa survival antara kelompok aktivitas fisik cukup dan kurang tidak berbeda survival-nya terhadap event kontrol glukosa darah buruk. Penderita DM tipe 2 yang cukup beraktivitas fisik memiliki HR sebesar 0,788 kali (95%CI: 0,456-1,360) dengan p value 0,392. Artinya, penderita DM tipe 2 yang cukup beraktifitas fisik maupun yang kurang tidak menunjukkan perbedaan yang bermakna terhadap kontrol glukosa darah. Tidak ditemukan pengaruh aktivitas fisik terhadap kontrol Glukosa darah penderita diabetes mellitus tipe 2 pada studi kohort PTM di Kota Bogor tahun 2011-2016. Hal ini dikarenakan banyak terjadi sensor dan lost to follow up juga titik pengamatan yang cukup jauh rentangnya yakni 2 tahun. Diperlukan upaya promosi kesehatan yang berkelanjutan dan bagi peneliti lain dapat melakukan studi dengan titik pengamatan dengan rentang waktu yang lebih singkat agar efek dari aktivitas fisik terhadap kontrol glukosa darah penderita DM tipe 2 dapat diukur lebih tepat.

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The prevalence of DM in Bogor City which is equal to 2.1%, this is still higher than the prevalence of DM in Indonesia according to Riskesdas 2013 data which is equal to 2.0%. The purpose of this study was to determine the effect of physical activity on blood glucose level control in patients with type 2 diabetes mellitus in the PTM cohort study in Bogor City in 2011-2016. According to the Log-rank survival test based on physical activity there was no significant difference with a significance value of 0.941. That survival between groups of physical activity is sufficient and the survival of the blood glucose control event is not different. Patients with type 2 DM who have enough physical activity have HR of 0.788 times (95% CI: 0.456-1.360) with p value 0.392. That is, patients with type 2 diabetes who have sufficient physical activity or those who do not show significant differences in blood glucose control. There was no effect of physical activity on blood glucose control in patients with type 2 diabetes mellitus in the PTM cohort study in Bogor City in 2011-2016. This is because there are a lot of sensors and lost to follow-up as well as a far enough observation point, which is 2 years. Continuous health promotion efforts are needed and other researchers can conduct studies with observation points with a shorter time span so that the effects of physical activity on blood glucose control in patients with type 2 diabetes can be measured more precisely."

"Diabetes Melitus Tipe 1 merupakan penyakit kronis yang melibatkan perubahan perilaku baik pola hidup maupun aktivitas dalam  sehari-hari. Tidaklah mudah untuk mencapai perubahan perilaku yang dapat secara langsung mempengaruhi pengendalian glukosa darah dan komplikasi. Serangkaian tindakan pengobatan yang rutin dipatuhi pada dasarnya bukanlah hal yang mudah untuk dijalankan. Ketidakpatuhan pada umumnya dapat meningkatkan masalah kesehatan bahkan dapat memperburuk penyakit yang dideritanya. Penelitian ini bertujuan untuk mendapatkan hubungan tingkat kepatuhan perawatan diri anak dengan DMT1 tentang pemeriksaan glukosa darah harian dan pemberian terapi insulin. Penelitian ini dilakukan secara cross sectional dengan teknik consecutive sampling terhadap 49 anak diabetes melitus tipe 1 usia 1 – 18 tahun di wilayah Jabodetabek. Data diperoleh dari pengisian logbook selama 14 hari. Analisis menggunakan spearman sesuai jenis data. Hasil penelitian menunjukkan tidak ada hubungan kepatuhan pemeriksaan glukosa terhadap kadar glukosa prepandrial dan postpandrial (p>0.05). Demikian pula didapatkan tidak ada hubungan tingkat kepatuhan  terapi insulin dengan kadar glukosa prepandrial dan postpandrial (p>0,05). Namun secara univariat  didapatkan dara bahwa tingkat kepatuhan insulin sudah sesuai, tetapi tidak demikian dengan tingkat kepatuhan glukosa darah yaitu kurang baik. Hasil penelitian ini memberikan dasar ilmiah dalam memberikan asuhan keperawatan pada anak diabetes melitus tipe 1, bahwa perawatan diri pada anak diabetes melitus tipe 1 harus dipantau dan ditingkatkan agar mendapatkan kualitas hidup yang baik.Kata kunci : Diabetes melitus tipe 1, kepatuhan pemeriksaan glukosa, kepatuhan insulin

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Type 1 Diabetes is a chronic disease involving changing behaviour in both lifestyle and daily activities. Series of treatment that routinely obeyed in fact not easy to follow. Nonadherence in general can increase health problem even worsen his ilness. The Research aimed to find out correlation between level of adherence self-treatment with type 1 diabetes mellitus about checking daily blood glucose and giving therapy of insulin. The research used cross sectional design with consecutive technique sampling to 49 children suffering type 1 diabetes mellitus aged 1 – 18 years old in Jabotabek areas. Data was collected from filling out logbook for 14 days. Analysis used Spearman method according to the type of databased on type of data. The result of the study showed that there was no compliance relationship of blood glucose examination with prepandrial blood glucose level (p>0,05). It was found that there was no association with the level of insulin compliance with prepandrial blood glucose levels (p>0,05). Nevertheless, univariate data showed that the level of insulin compliance was appropriate, but not so with the level of blood glucose adherence that is not good. This research gives scientific basis in giving nursing care to children with type 1 diabetes that self care in children with type 1 diabetes mellitus must be monitored and increased to get good quality of life.

Key words : Type 1 diabetes mellitus, adherence of glucose checkup, insulin adherence"

"Kontrol gula darah dipengaruhi oleh banyak hal, salah satunya adalah tingkat stres. Dalam penatalaksanaan diabetes melitus komponen intervensi untuk menurunkan stres terabaikan. Terapi progressive muscle relaxation (PMR) diketahui mampu mengontrol kadar gula darahyang merupakan salah satu bagian dari intervensi keperawatan. Tujuan penelitian adalah untuk mengetahui pengaruh latihan PMR terhadap tingkat stres dan kadar gula darah sewaktu pada pasien diabetes melitus tipe 2. Metode penelitian ini adalah kuasi eksperimen dengandesain pre and post test with control group. Masing-masing kelompok terdiri dari 18 responden. Pengambilan sampel dilakukan dengan consecutive sampling. Kelompok intervensi diberikan latihan PMR 2 kali sehari selama 3 hari. Kadar gula darah sewaktu diambil melalui pembuluh darah kapiler. Tingkat stres diukur menggunakan kuesioner depression anxiety stress scale (DASS) yang telah dimodifikasi menjadi 7 item. Hasil penelitian menunjukan bahwa terdapat pengaruh latihan PMR terhadap tingkat stres pada kelompok intervensi dengan nilai p didapat 0,0001. Pada penelitian ini pula didapatkanadanya perubahan yang bermakna kadar gula darah sewaktu pada kelompok intervensi dan kelompok kontrol. Namun pada kedua kelompok tidak berbeda bermakna dengan pvalue 0,448 (p>0,05). Kesimpulan dari peneliian ini adalah latihan PMR berpengaruh secara signifikan terhadap tingkat stres pada pasien diabetes melitus tipe 2 pada kelompok intervensi akan tetapi tidak terdapat perbedaan yang bermakna pada kadar gula darah sewaktu antar kedua kelompok.

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Blood glucose control is influenced by many factors, one of which is the level of stress. In the

management of diabetes mellitus component interventions to reduce stress neglected. Treatment of progressive muscle relaxation (PMR) is known to control blood sugar levels which is one part of nursing interventions. The research objective was to determine the effect of PMR on the level of stress and blood glucose levels in patients with type 2 diabetes mellitus. Methods This study applied a quasi experimental design with a pre and post test control group. Each group consisted of 18 respondents. Purposive sampling technique was used in this study. PMR exercise intervention group was given twice a day for 3 days. Blood sugar levels when taken through the capillaries. Stress levels were measured using a questionnaire depression anxiety stress scales

(DASS) which has been modified to 7 items, to measure stress levels. The results shows that there is a significant effect of PMR exercise on the level of stress in the intervention group with a p value of 0.0001, found also the presence of significant changes in blood glucose levels in the intervention group and the control group. But, the two groups did not differ significantly with p value 0.448 (p> 0.05). This study concludes that PMR exercises significant has a significant effect on stress levels in patients with type 2 diabetes mellitus intervention group and there is no significant difference on blood glucose levels between the two groups."

"Diabetes Mellitus (DM) merupakan salah satu penyakit yang paling banyak diderita oleh manusia. Salah satu tipe DM adalah diabetes tipe 1 yang disebabkan oleh rusaknya sel beta pada pankreas sehingga tubuh tidak dapat menghasilkan insulin untuk meregulasi konsentrasi glukosa dalam darah. Penderita DM tipe 1 harus melakukan terapi insulin dengan memberikan suntik insulin eksternal untuk meregulasi konsentrasi glukosa di dalam darah. Selain itu, penderita DM tipe 1 harus melakukan kontrol secara kontinu terhadap konsentrasi glukosa di dalam darahnya. Pada sebuah penelitian, terdapat sebuah alat yang dapat memantau glukosa secara berkelanjutan yang disebut dengan Continuous Glucose Monitoring (CGM). Pada penelitian ini, dilakukan simulasi dengan sebuah model matematika yang menggambarkan regulasi glukosa-insulin dalam tubuh saat makanan dicerna di dalam tubuh, yaitu model hovorka, untuk diimplementasikan ke dalam CGM. Hasil dari penelitian ini menunjukkan bahwa model dari hovorka dapat menunjukkan regulasi glukosa insulin di dalam tubuh. Namun untuk evaluasi terhadap model ini dilakukan sebuah fitting terhadap parameter model hovorka dan didapatkan hasil yang kurang baik sehingga perlu dilakukan fitting ulang dengan data yang lebih baik.

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Diabetes Mellitus (DM) is one of the most common diseases suffered by humans. One type of DM is Type 1 diabetes caused by the destruction of beta cells in the pancreas so that the body can not produce insulin to regulate the concentration of glucose in the blood. Patients with Type 1 diabetes have to do insulin therapy by giving external insulin injections to regulate the concentration of glucose in the blood. In addition, patients with Type 1 diabetes must continuously control the concentration of glucose in their blood. In one study, there was a tool that can monitor glucose continuously called Continuous Glucose Monitoring (CGM). In this study, a simulation with a mathematical model that describes the regulation of glucose-insulin in the body when food is digested in the body, the Hovorka model, to be implemented into CGM. The results of this study show that the model from hovorka can demonstrate the regulation of insulin glucose in the body. However, for the evaluation of this model, a fitting was made to the parameters of the hovorka model and poor results were obtained so that re-fitting with better data was necessary."

"Penyakit Diabetes Mellitus masih menjadi salah satu penyakit tidak menular dengan angka kejadian yang terus meningkat dan menyebabkan komplikasi berbagai organ bagi penderitanya. Lansia menjadi populasi paling berisiko terkena Diabetes Mellitus karena telah mengalami penurunan fungsi organ pankreas sehingga terjadi kegagalan sekresi hormon insulin.  Lansia dengan diabetes mellitus membutuhkan dukungan baik dari keluarga maupun komunitas disekitarnya untuk dapat menjalankan perawatan diri. Intervensi keperawatan melalui pendekatan pada keluarga dan kelompok dinilai dapat meningkatkan perilaku perawatan diri lansia DM. Karya ilmiah akhir spesialis ini bertujuan untuk memberikan gambaran pengaruh penerapan Cegah dan Rawat Diabetes melalui Serat, Aktivitas dan Relaksasi (CERDAS SERASI) sebagai bentuk praktik keperawatan berbasis fakta pada lansia DM di keluarga dan komunitas. Metode penelitian dalam karya ilmiah ini adalah studi kasus terhadao keluarga dan kelompok binaan. Hasil evaluasi terhadap 10 keluarga binaan menunjukkan terjadinya peningakatan kemandirian keluarga setelah diintervensi selama 6 bulan. Selain itu baik keluarga maupun kelompok yang dilakukan intervensi CERDAS SERASI menunjukkan terjadi peningkatan perilaku perawatan diri lansia DM meliputi peningkatan pengetahuan, sikap dan keterampilan dalam melakukan perawatan diri DM. Hasil menunjukkan bahwa terdapat perbedaan signifikan pada perilaku perawatan diri dan penurunan kadar glukosa darah lansia DM sebelum dan sesudah intervensi (p=0.000) dan perubahan pada status kemandirian fungsional lansia setelah dilakukan intervensi kelompok (p=0.000). Intervensi CERDAS SERASI efektif dalam meningkatkan perilaku perawatan diri, penurunan kadar glukosa darah, dan peningkatan status kemandirian fungsional lansia. Intervensi ini sebaiknya dilakukan berkelanjutan untuk mempertahankan status kesehatan dan meningkatkan kualitas hidup lansia dengan maslah penyakit diabetes mellitus.

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Diabetes Mellitus is still a non-communicable disease with an increasing incidence and causing complications in various organs for sufferers. The elderly are the population most at risk of developing Diabetes Mellitus because they have experienced a decrease in the function of the pancreas organ resulting in failure of insulin secretion. The elderly with diabetes mellitus need support from both their family and the surrounding community to be able to carry out self-care. Nursing interventions through approaches to families and groups are considered to be able to improve self-care behavior of DM elderly. This specialist's final scientific work aims to provide an overview of the effect of implementing Prevent and Treat Diabetes through Fiber, Activity and Relaxation (CERDAS SERASI) as a form of fact-based nursing practice for DM elderly in the family and community. The research method in this paper is a case study of families and target groups. The results of the evaluation of 10 assisted families showed an increase in family independence after 6 months of intervention. In addition, both families and groups with the CERDAS SERASI intervention showed an increase in self-care behavior for the elderly with DM including increased knowledge, attitudes and skills in self-care for DM. Further analysis showed that there were significant differences in self-care behavior and a decrease in blood glucose levels in DM elderly before and after the intervention (p=0.000) and changes in the functional independence status of the elderly after group intervention (p=0.000). The SMART SERASI intervention was effective in improving self-care behavior, decreasing blood glucose levels, and increasing the functional independence status of the elderly. This intervention should be carried out continuously to maintain health status and improve the quality of life of the elderly with diabetes mellitus."

"Pola makan modern kaya karbohidrat merupakan salah satu faktor predisposisi terjadinya kandidiasis oral. Namun belum jelas diketahui apakah pertumbuhan C. albicans akan meningkat bila terjadi glukosa dalam medium pertumbuhan. Tujuan: Menganalisis efek penambahan glukosa 1%, 5%, 10% terhadap pertumbuhan C. albicans in vitro. Metode: Isolat C. albicans klinik dari usapan mukosa mulut pasien kandidiasis oral dideteksi pada CHROMagar dan serum. Sebagai pembanding, C. albicans strain ATCC 10231 juga dideteksi dengan cara yang sama. C. albicans yang tumbuh dibiak dalam SDA selama 2 hari, kemudian dikumpulkan dan dibiakkan kembali dalam SDB yang telah ditambah glukosa 1%, 5%, dan 10% selama 3 atau 7 hari pada suhu ruang. Sebagai kontrol adalah C. albicans yang ditumbuhkan dalam SDB tanpa penambahan glukosa. Pertumbuhan C. albicans diukur dengan menghitung CFU/ml C. albicans dalam cawan petri. Uji statistik menggunaka ANOVA dengan a 0.05. Hasil: Setelah 3 hari, pertumbuhan C. albicans isolat klinik 1%, 5%, dan 10% berturut-turut adalah 181.5, 582, dan 811 CFU/ml; sedangkan C. albicans ATCC 10231 adalah 21.5, 177.5, 375.5 CFU/ml. Pertumbuhan tersebut lebih rendah dibandingkan kelompok kontrol yaitu 970 (isolat klinik) dan 957 (ATCC) CFU/ml. Setelah 7 hari diperoleh pertumbuhan C. albicans isolat klinik adalah 2350, 9650, dan 9650 CFU/ml; sedangkan C. albicans ATCC 10231 adalah 5000, 5450, 3550 CFU/ml. Pertumbuhan kelompok kontrol 7 hari adalah 5000 (klinik) dan 5150 (ATCC) CFU/ml. Analisis ANOVA menunjukkan bahwa setelah 3 hari penambahan glukosa 1% menurunkan pertumbuhan C. albicans secara bermakna baik pada isolat klinik maupun strain ATCC 10231 (p < 0,05). Pada kelompok 7 hari penambahan glukosa 5% dan 10% meningkatkan pertumbuhan C. albicans isolat klinik secara bermakna (p < 0,05). Simpulan: Glukosa 5% dan 10% dapat meningkatkan pertumbuhan C. albicans in vitro. Penambahan glukosa 1% dapat menghambat pertumbuhan C. albicans pada durasi 3 hari.

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High carbohydrate intake is one predisposing factor of oral andidiasis. Whether glucose addition in medium will increase the growth of Candida albicans is still unclear. Objective: Investigating the effect of 1%, 5%, 10% glucose addition on the growth of C.albicans in vitro. Methods: C. albicans sample was from oral swab of a male oral candidiasis patient. Detection of C. albicans used CHROMagar and confirmed by germ tube test. C. albicans colonies were inoculated in Sabouraud Dextrose Agar (SDA). As a comparison, C. albicans ATCC 10231 was also detected inthe same way. After 2 days the cultures were serially diluted and inoculated in Sabouraud Dextrose Broth (SDB) without glucose (control), 1%, 5%, or 10% additional glucose, kept for 3 or 7 days in room temperature, then inoculated in SDA. The Colony Forming Unit (CFU) were counted after 2 days. ANOVA with a 0.05 was used. Results: After 3 days, additional 1%, 5%, 10% glucose in media with clinical strain of C. albicans resulted in 181.5, 582, 811 CFU/ml respectively while in media with C. albicans ATCC were 21.5, 177.5, 375.5 CFU/ml. The growth of controls C. albicans were 970 (clinical strain) and 957 CFU/ml (ATCC). After 7 days, the growth of clinical strain of C. albicans with additional glucose 1%, 5%, 10% were 2350, 9650, 9650 CFU/ml respectively while the growth of C. albicans ATCC were 5000, 5450, 3550 CFU/ml. The growth of 7 days controls were 5000 (clinical strain) and 5150 (ATCC) CFU/ml. Statisticaly, additional 1% glucose for 3 days lead to significant decreased of growth of both clinical strain and ATCC 10231 C. albicans (p < 0,05). Additional 5% and 10% glucose for 7 days increased the growth of C.albicans significantly (p < 0,05). Conclusion: Additional 5% and 10% glucose for 7 days increase the growth of C. albicans in vitro. While additional 1% glucose for 3 days decrease the growth of C. albicans."