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"Aplikasi asam askorbat 10% meningkatkan shear bond strength resin pada dentin pasca pemutihan gigi. Gigi pasca pemutihan gigi interna merupakan kontra indikasi untuk segera dilakukan restorasi, karena adanya radikal bebas yang masih tertinggal di dalam dentin selama 2-3 minggu dan dapat menggangu adaptasi bahan restorasi resin komposit. Tujuan: Menganalisis pengaruh aplikasi asam askorbat 10% terhadap shear bond strength resin komposit pada dentin pasca pemutihan gigi interna dengan gel H2O2 35%. Metode: Dua puluh tujuh sampel gigi dibagi menjadi tiga kelompok. Grup 1: Dentin dietsa dengan asam fosfat 35%; Grup 2: Dentin dilakukan pemutihan gigi interna dengan gel H2O2 35%, dietsa dengan asam fosfat 35%; Grup 3: Dentin dilakukan pemutihan gigi interna dengan gel H2O2 35%, aplikasi asam askorbat 10% selama 10 menit, dan dietsa dengan asam fosfat35%. Semua gigi percobaan di inkubasi pada 37°C selama 24 jam. Uji shear bond strength dilakukan dengan alat Universal Testing Machine. Data yang diperoleh dianalisis secara statistik dengan tes Kruskal Wallis dan Mann Whitney. Hasil: Analisis sembilan sampel dari masing-masing grup menunjukkan bahwa peningkatan shear bond strength yang paling banyak terjadi pada Grup 3 (56,04±11,06MPa) dibanding dengan Grup 2 (29,09±7,63MPa) dan Grup 1 (25,55±2,22MPa) dan perbedaannya bermakna secara statistik (p<0,05). Simpulan: Aplikasi asam askorbat 10% pada dentin pasca pemutihan gigi interna dengan gel H2O2 35% dapat meningkatkan shear bond strength resin komposit.

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Restoration of the teeth immediately after bleaching with H2O2 35% is contraindicated due to the remnants of free radical that will stay inside dentin for 2-3 weeks which will compromise the adhesiveness of composite resin. Objective: The aim of this study was to evaluate the influence of 10% ascorbic acid on shear bond strength of composite placed on bleached dentin. Methods: Twenty seven samples were divided equally into three groups. Group 1: dentin was etched with 35% phosphoric acid; Group 2: dentin was bleached with 35% H2O2 followed by etching with 35% phosphoric acid; Group 3: dentin was bleached with 35% H2O2, followed by application of 10% ascorbic acid and etched with 35% phosphoric acid. All samples were then stored at 370C for 24 hours. The Universal Testing Machine was used to measure shear bond strength and the results were analyzed with Kruskal Wallis and Mann Whitney test. Results: After nine independent experiments, 10% ascorbic acid application on bleached dentin resulted in highest increased in bond stregth (56.04±11.06MPa) compared to Group 2 (29.09±7.63MPa) and Group 1 (25.55±2.22MPa) and the difference was statistically significant (p<0.05). Conclusion: Application of 10% ascorbic acid to the bleached dentin improved the shear bond strength of resin composite."

"The aim of this in vitro study was to evaluate the shear bond strength of resin composite materials to dentin by using different bonding agents. Forty human premolars were selected for the study, and cylindrical posts of either Spectrum TPH and Charisma were bonded vertically to a standard flat dentinal area, prepared on the buccal survace. A chisel-shaped shearing blade, attached to the crosshead of a universal mechanical testing machine. The shear bond strengths to dentin of 10 resin composite-dentin adhesive combinations were measured. The results showed that the bond strength values of dentin bonding agents were not significant (p>0.05). It seems important for clinicians to use the combination of resin composite and dentin bonding agent recommended by the manufacturer."

"Latar Belakang. Mortalitas akibat sepsis di ICU masih cukup tinggi meskipun telah semakin cepatnya diagnosis dan perbaikan perawatan suportif dan angkanya semakin meningkat dengan insiden acute kidney injury yang merupakan bagian dari disfungsi organ akibat sepsis. Asam askorbat dikatakan dapat memperbaiki disfungsi organ disebabkan efeknya yang sinergis terhadap patofisiologi sepsis. Peranan asam askorbat dalam menurunkan disfungsi organ masih kontroversial. Penelitian ini ingin menganalisis efek pemberian asam askorbat intravena terhadap perbaikan fungsi ginjal pada pasien sepsis/ syok sepsis yaitu dengan melihat efek terhadap kadar urin neutrophil gelatinase associated lipocalin (uNGAL), produksi urin dan balans kumulatif. Metodologi. Penelitian ini merupakan penelitian uji klinis dengan desain penelitian uji acak terkontrol, dilakukan pada pasien usia > 18 tahun dengan sepsis berdasarkan kriteria sepsis-3 yang masuk ICU dalam 6 sampai 24 jam pascaresusitasi setelah diagnosis sepsis. Kriteria penolakan yaitu pasien dengan gangguan ginjal kronik dengan hemodialisis, kelainan batu ginjal, dengan masalah ginjal dalam 3 bulan terakhir. Pasien akan dikeluarkan apabila diberikan kortikosteroid dan mendapatkan terapi pengganti ginjal dalam < 72 jam observasi. Penelitian dilakukan di ICU Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo pada April 2019-Juli 2019. Sebanyak 33 sampel dirandomisasi secara randomisasi sederhana dan dikelompokan menjadi kelompok perlakuan (18 sampel) dan kontrol (15 sampel). Data demografik dasar dicatat saat masuk ICU. NGAL urin (ng/mL) diperiksa pada jam 0, 24, 48 dan 72 setelah terapi. Produksi urin (ml/kg/jam) dan balan kumulatif (L) dicatat pada jam 24, 48 dan 72 setelah terapi. Analisis statistik dengan uji Mann Whitney untuk data numerik dengan persebaran tidak normal, uji T independen untuk data dengan persebaran normal dan uji Fisher untuk data kategorik perbandingan antara kedua kelompok intervensi. Analisis multivariat untuk pengukuran serial menggunakan generalized estimating equations (GEE) untuk membandingkan antara kedua kelompok dalam waktu pengukuran yang berulang. Nilai signifikansi dengan nilai p < 0,05. Hasil. Tidak terdapat perbedaan pada kadar NGAL urin, produksi urin, balans kumulatif antara dua kelompok di setiap jamnya. Kesimpulan. Pada penelitian ini pemberian asam askorbat intravena tidak mempunyai efek terhadap kadar NGAL urin, produksi urin, balans kumulatif.

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Background. Sepsis-related mortality in intensive care unit (ICU) remains despite improved diagnostic technology and supportive treatment. Acute kidney injury, one of frequent organ dysfunctions in sepsis, increases risk of mortality. Ascorbic acid could improve organ dysfunction because its direct effect on sepsis pathophysiology. The role of ascorbic acid on improving organ dysfunction remains controversial. This study wished to analyze the effects of intravenous ascorbic acid on kidney function improvement among septic patients by evaluating urine neutrophil gelatinase associated lipocalin (uNGAL), urine output and cumulative fluid balance.

Method. This study was randomized controlled trial held in Cipto Mangunkusumo Hospital from April to July 2019. The inclusion criteria were adult patients aged > 18 years who met sepsis-3 criteria and were admitted to the ICU within 6-24 h after resuscitation and sepsis recognition. The exclusion criteria were patients with hemodialysis-dependent chronic kidney disease, kidney stones or other kidney problems within last 3 months. The drop out criteria were patients underwent renal replacement therapy in the ICU and given corticosteroid less than 72 h after recruitment. Subjects were randomized using simple randomization and divided into two groups with treatment (18 subjects) and control (15 subjects). Baseline demographic data was recorded on the first day. Daily measurements of urine NGAL (ng/ mL) was started as baseline level and continued at 24, 48 and 72 h after treatment. Urine output (ml/kg/h), cumulative fluid balance (L) was recorded at at 24, 48 and 72 h after treatment. Comparison between both groups was analysed by using Mann Whitney test (not normally distributed data), T independent test (normally distributed data) for numerical data and Fisher test for categorical data. Multivariate analysis using generalized estimating equations was used for serial measurement analysis. Level of significant was determined at p-value <0.05.

Result. There were no significant differences in uNGAL, urine output, cumulative fluid balance between the two groups at each hour respectively.

Conclusion. This study showed that intravenous vitamin CMultin administration had no effect on urine NGAL, urine output, cumulative fluid balance."

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Saat ini penggunaan grafena dan senyawa turunannya berpotensi besar dalam berbagai aplikasi, termasuk sebagai pembersih tumpahan minyak. Dalam penelitian ini dilakukan sintesis grafena oksida tereduksi (rGO) dari limbah grafit batu baterai dengan pereduksi asam askorbat. Selanjutnya rGO digunakan pada pelapisan spons poliuretan (PU) yang menghasilkan spons rGO/PU sebagai adsorben pembersih tumpahan minyak. rGO disintesis dengan menggunakan metode Hummers termodifikasi untuk mendapatkan grafena oksida yang kemudian direduksi menggunakan reduktor asam askorbat. Pada penelitian ini dilakukan variasi konsentrasi asam askorbat (rGO 1:1,  rGO 2:3,rGO 1:2) dan konsentrasi rGO (3 mg/ml, 5 mg/ml, 10 mg/ml) pada proses penyerapan rGO oleh spons PU. Hasil XRD menunjukkan bahwa lapisan grafit telah terkelupas dari 81 lapisan menjadi 2-5 lapisan. Kandungan unsur C pada rGO yang dihasilkan berkisar antara 82,81-84,38%, dan kandungan unsur O yang dihasilkan 8,60-14,85%. Konsentrasi asam askorbat pada proses reduksi mempengaruhi jumlah lapisan yang terkelupas, kandungan unsur C dan kandungan unsur O yang dihasilkan. Dari ketiga variasi yang dilakukan yaitu rGO 1:1, rGO 2:3, dan rGO 1:2, hasil rGO yang paling baik berdasarkan jumlah lapisan yang terkelupas, kandungan unsur C dan O adalah rGO 1:2 dengan jumlah lapisan 2, kandungan unsur C 84,38% dan kandungan unsur O  8,60%. Spons rGO/PU yang telah disintesis berhasil membersihkan tumpahan minyak selama 10 detik dengan efisiensi sebesar 79,25%, 79,91%, dan 95,09%. Perbedaan nilai efisiensi tersebut karena adanya pengaruh konsentrasi rGO dalam penyerapan rGO ke spons PU. Efisiensi dalam membersihkan tumpahan minyak yang tertinggi dimiliki oleh spons rGO/PU 10 mg/ml dengan nilai sebesar 95,09%.

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Today the use of Graphene and its derivatives has great potential in many applications, including as an oil spills cleanup. In this study a synthesis of reduced graphene oxide (rGO) from graphite waste batteries was carried out by reducing graphene oxide with ascorbic acid. Furthermore, rGO is used for coating polyurethane sponges (PU) which produce rGO/PU sponges as oil spill cleanup adsorbents. rGO was synthesized by using the modified Hummers method to obtain graphene oxide, then reduced by ascorbic acid. In this study variations in ascorbic acid concentration (rGO 1:1, rGO 2:3, rGO 1:2) and the concentration of rGO (3 mg/ml, 5 mg/ml, 10 mg/ml) in the process of absorption of rGO by PU sponge. The XRD results show that the graphite layer has peeled from 81 layers into 2-5 layers. The content of C in the rGO ranged from 82.81 - 84.38%, and the content of O was 8,60 - 14,85%. Ascorbic acid concentration in the reduction process affects the number of layers that are peeled off, the C content and the O content produced. Of the three variations carried out, namely rGO 1:1, rGO 2:3, and rGO 1:2, the best rGO results are based on the number of peeled layers, the content of C and O is rGO 1:2 with the number of layers 2, the content C 84.38% and O 8.60%. The rGO/PU sponge synthesized successfully cleanup the oil spill for 10 seconds with an efficiency of 79.25%, 79.91% and 95.09%. The difference in the efficiency value is due to the influence of the concentration of rGO in the absorption of rGO into the PU sponge. The highest efficiency in cleanup the oil spill is owned by rGO/PU sponge 10 mg/ml with a value of 95.09%.

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"Efek sandblasting terhadap kekuatan rekat geser veneer indirek resin komposit. Perlekatan antara restorasi veneer indirek resin komposit (VIRK) dengan permukaan email diperoleh dari penggunaan resin semen multi-step (MS). Material self-adhesive dual-cured resin cement (SADRC) dengan satu tahap pemakaian mulai banyak diperkenalkan. Tujuan: Untuk mengetahui efek sandblasting (SB) terhadap kekuatan rekat geser VIRK pada email dengan menggunakan resin semen multi-step dan SADRC. Metode: Empat puluh spesimen yaitu bagian bukal email gigi premolar manusia, diratakan dan dipoles menggunakan silikon karbida. Spesimen VIRK dimasukkan dalam ruang Solidilite untuk penyinaran, kemudian dibagi menjadi 2 grup, tanpa sandblasting (n=20) dan dengan sandblasting selama 10 detik (n=20). Selanjutnya direkatkan pada email dengan menggunakan resin semen multi-step (n=10) dan SADRC (n=10). Setelah 2 jam disimpan dalam inkubator, kekuatan rekat geser spesimen diuji menggunakan Universal Mechanical Testing Machine. Data dianalisis statistik dengan uji one-way ANOVA. Hasil: Nilai rata-rata kekuatan rekat geser multi-step tanpa SB (18,95±7,80MPa) dan multi-step SB (19,30±8,21MPa) memiliki perbedaan bermakna dengan SADRC tanpa SB (4,85±2,12MPa) dan SADRC dengan SB (9,57±3,45MPa)(p<0,05). Simpulan: Sandblasting dapat meningkatkan kekuatan rekat geser VIRK pada email yang menggunakan resin semen multi-step dibandingkan dengan SADRC.

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Attachment between restoration and enamel surface in indirect resin composite veneer restoration (IRCV) is obtained using multi-step (MS) resin coment. Recently, a one step self-adhesive dual-cured resin coment (SADRC) was introduced. Objective: To determine the effect of sandblasting on shear bond strenght (SBS) of IRCV to enamel using MS resin coment and SADRC. Methods: Forty specimens of buccal surface of enamel human premolar were used. The specimens were flattened and polished using silicon carbide. IRCV cylindrical specimens were light-cured in Solidilite chamber and were divided into two groups: IRCV without sandblasting (n=20) and with sandblasting for 10 seconds (n=20) and then bonded to enamel using MS (n=10) and SADRC (n=10), respectively. After 24h SBS of specimens were tested using a Universal Testing machine. Data were analyzed statistically by one-way ANOVA. Results: The average SBS value of IRCV without SB and bonded with MS was 18.95±7.80MPa and MS with SB was 19.30±8.21MPa. They were differ significantly with SADRC without SB (4.85±2.12MPa) and SADRC with SB (9.57±3.45MPa)(p<0.05). Conclusion: Sandblasting significantly increased SBS VIRK to enamel using MS resin cement than SADRC."

"Objectives. The aim of this study was to compare the fracture toughness of a microhybrid and a flowable microhyrid resin composites. Methods. Test specimens (30x15x2)mm made of amicrohybrid and a flowable microhybrid were prepared in a double torsion mould and were then polymerized for 20 seconds using a light-curing device. Taken out from the mould, the specimens were than soaked in disfilled water (37°C) for 1 hour and then fractured in a double-torsion technique. t-Test was used to test significance difference between the microhybrid and flowable microhybrid resin composites. Result. The use of double-torsion technique resulted in crack initition and crack arrest which revealed Klc of 1.14 MN/m3/2 and 1.045 MN/m3/2 for the microhybrid and the flowable microhybrid resin composites, respectively. Both resin composites were insignificantly different in the fracture toughness values showed by t–Test. Conclusions. The present study suggested that there was no significant difference between the microhybrid and the flowable microhybrid resin composites tested. It appreared that filler fraction might not affect the fracture toughness of the resin composties tested."

"Single-step self-etch adhesive systems are the system that combine self etching primer and bonding agent into one step application. This system was developed as the effort to simplified in application prosedures and give a good bond strength of resin composites to dentin surface. The purpose of this study was to examine the bond strength of resin composites with two singlestep self-etch adhesives system (Xeno III and Clearfil Tri-S Bond) to bovine dentin at temperature of adhesive 3ºC, 22ºC and 30ºC. Adhesive was applied to dentin surface (bovine insisivus mandibular dentin) follow by resin composites bonded according to the manufacturer’s instructions. Tensile bond strength of 60 specimens were tested UTM (universal testing machine) after 24 hours storage in aquadest at 37 ºC. The results were analyzed using ANOVA test followed by Tukey’s test (p< 0,05). The bond strength of Xeno III was significantly diffrent from that of Clearfil tri-S Bond, 0,66±0,271, 2,70±1,528, 0,23±0,104 versus 2,07±0,272, 4,77±0,689, 4,39±1,205 MPa at temperature of materials 3ºC, 22ºC and 30ºC respectively. The bond strength of two single- step adhesives system (Xeno III and Clearfil Tri-S Bond) were highest at temperature 22ºC than other temperatures of materials."

"[ABSTRAKPenelitian ini bertujuan untuk membandingkan kuat rekat geser dan AdhesiveRemnant Index (ARI) dua produk breket metal yang direkatkan dengan satu adesif.Dua puluh gigi premolar atas manusia ditanam pada silinder PVC dengan resinakrilik. Spesimen dibagi menjadi dua kelompok, kelompok A: breket metal 3B, Cina+ Transbond XT; kelompok B: breket metal Protect, Cina + Transbond XT (3M,Unitek, Amerika). Dihasilkan rerata kuat rekat geser 6,09 dan 7,91 MPa padakelompok A dan B (p<0,05) dan nilai ARI: 1 dan 2 pada kedua kelompok (p>0,05).Disimpulkan bahwa dua kelompok memiliki nilai kuat rekat geser yang berbedabermakna dengan kegagalan ikatan bersifat kohesifABSTRACTThe aims of this study were to compare in vitro shear bond strength (SBS)and Adhesive Remnant Index (ARI) of two metal bracket products bonded with anadhesive material. Twenty human upper first premolar embedded in acrylic resin.Specimens were divided into two groups, Group A: 3B, China metal bracket +Transbond XT; Group B: Protect, China metal bracket + Transbond XT (3M,Amerika). The mean SBS for Group A and B were 6,09 dan 7,91 MPa and ARI: 1and 2 (p>0,05). It was concluded that the SBS of two groups was significantlydifferent with cohesive bond failure.;The aims of this study were to compare in vitro shear bond strength (SBS)and Adhesive Remnant Index (ARI) of two metal bracket products bonded with anadhesive material. Twenty human upper first premolar embedded in acrylic resin.Specimens were divided into two groups, Group A: 3B, China metal bracket +Transbond XT; Group B: Protect, China metal bracket + Transbond XT (3M,Amerika). The mean SBS for Group A and B were 6,09 dan 7,91 MPa and ARI: 1and 2 (p>0,05). It was concluded that the SBS of two groups was significantlydifferent with cohesive bond failure., The aims of this study were to compare in vitro shear bond strength (SBS)and Adhesive Remnant Index (ARI) of two metal bracket products bonded with anadhesive material. Twenty human upper first premolar embedded in acrylic resin.Specimens were divided into two groups, Group A: 3B, China metal bracket +Transbond XT; Group B: Protect, China metal bracket + Transbond XT (3M,Amerika). The mean SBS for Group A and B were 6,09 dan 7,91 MPa and ARI: 1and 2 (p>0,05). It was concluded that the SBS of two groups was significantlydifferent with cohesive bond failure.]"

"Rendahnya ketersediaan hayati zat besi merupakan tantangan bagi program fortifikasi pangan. Asam askorbat (AA) dan asam folat (AF) merupakan senyawa yang mampu meningkatkan penyerapan zat besi. Metode enkapsulasi akan digunakan untuk melindungi senyawa tersebut dari berbagai reaksi yang merugikan. Pada penelitian ini, besi (II) glukonat (FeG)–AA–AF, kitosan, dan tripolifosfat masing-masing digunakan sebagai bahan inti, material penyalut, dan senyawa tautan silang. Tujuan utama dari penelitian ini adalah (i) mengkaji pengaruh formulasi Fe, AA, dan AF terhadap karakteristik fisiko-kimia, profil rilis zat besi, dan ketersediaan hayati besi dari mikropartikel hasil spray dryer, dan (ii) mengkaji pengaruh jumlah mikropartikel hasil spray dryer dan konsentrasi gelatin yang ditambahkan terhadap karakteristik fisiko-kimia, profil rilis besi, dan ketersediaan hayati dari permen lunak terfortikasi. Produksi mikropartikel kitosan-tripolifosfat bermuatan FeG, AA, dan AF dilakukan menggunakan spray dryer (Mini Buchi B-290). Fortifikasi permen lunak dilakukan dengan cara menyebarkan mikropartikel ke dalam larutan permen yang sudah didinginkan. Campuran tersebut kemudian dikeringkan dan siap untuk dianalisis. Mikropartikel FeG–AA dan FeG–AA–AF memiliki ketersediaan hayati yang lebih tinggi dibandingkan dengan mikropartikel FeG. Lebih lanjut, ketersediaan hayati zat besi dari permen lunak terfortifikasi meningkat lebih dari 5 kali lipat dibandingkan dengan mikropartikel FeG–AA–AF. Penemuan ini akan membantu ahli teknologi pangan, dan pengembang produk memilih formulasi yang tepat sehingga produk pangan terfortifikasi memiliki ketersediaan hayati zat besi yang lebih tinggi.

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The low bioavailability of iron is a challenge for food fortification programs. Ascorbic acid (AA) and folic acid (FA) are compounds that can increase iron absorption. Encapsulation method will be used to protect the compound from various adverse reactions. In this study, iron (II) gluconate (FeG)–AA–FA, chitosan, and tripolyphosphate were used as core materials, coating materials, and crosslinked compounds, respectively. The main objectives of this study were (i) to examine the effect of the Fe, AA, and FA formulations on the physico-chemical characteristics, iron release profile, and iron bioavailability of microparticles produced by the spray dryer, and (ii) to examine the effect of the number of microparticles produced by the spray dryer and concentration of added gelatin on the physico-chemical characteristics, iron release profile, and bioavailability of the fortified soft candy. The production of chitosan-tripolyphosphate microparticles containing FeG, AA, and FA was carried out using a spray dryer (Mini Buchi B-290). Soft candy fortification is done by spreading microparticles into a cooled candy solution. The mixture is then dried and ready for analysis. FeG–AA and FeG–AA– FA microparticles have higher bioavailability than FeG microparticles. Furthermore, the bioavailability of iron from the fortified soft candy was increased more than 5-fold compared to the FeG–AA– FA microparticles. This discovery will help food technologists and product developers choose the right formulation so that fortified food products have a higher bioavailability of iron."

"Tujuan penelitian ini untuk mengetahui pengaruh penggunaan sumber sinar berbeda terhadap kekuatan tarik diametral resin komposit bulk-fill. Resin komposit bulk-fill Tetric N-Ceram Bulk Fill dibuat sebanyak 20 spesimen berbentuk lempeng dengan diameter 6 mm dan tebal 3 mm. Spesimen dibagi menjadi dua kelompok yaitu kelompok yang disinari dengan sumber sinar QTH dan sumber sinar LED. Uji kekuatan tarik diametral dilakukan dengan menggunakan Universal Testing Machine. Hasil penelitian menunjukkan nilai rerata kekuatan tarik diametral resin komposit bulk-fill yang disinari sumber sinar QTH dan LED sebesar 38.62 2.34 dan 42.02 3.21. Hasil uji independent sample T menunjukkan nilai rerata pada kedua kelompok berbeda bermakna.

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This study aimed to evaluate the effect of using different light sources on the diametral tensile strength of bulk fill resin composite. Bulk fill resin composite Tetric N Ceram Bulk Fill was used to make of 20 disc shape specimens with 6 mm in diameter and 3 mm in thickness. Specimens were divided into two groups, the two groups were polymerized with using QTH and LED light source curing unit. Diametral tensile strength test was conducted by using a Universal Testing Machine Shimadzu, Japan. The results showed that diametral tensile strength mean value of bulk fill resin composite that were cured with QTH and LED light source were 38.62 2.34 and 42.02 3.21 MPa respectively. Independent sample t test results showed that the mean value of the two groups was significantly different."