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Arinda Lironika Suryana
"Kadar Zinc dan Cuprum pada Penderita Hipertensi Primer dan Normotensi. Salah satu pencetus hipertensi primer yaitu paparan radikal bebas. Pembentukan radikal bebas dalam tubuh dapat dicegah dengan antioksidan. Peran zinc dan cuprum adalah sebagai kofaktor dari enzim antioksidan endogen superoksida dismutase (SOD). Penelitian ini bertujuan untuk menganalisis perbedaan kadar serum zinc dan cuprum pada kelompok hipertensi primer dan normotensif. Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional dan metode simple random sampling. Subjek adalah orang yang berusia 40-70 tahun, mengunjungi Rumah Sakit Haji Surabaya, dan terdiri dari 15 responden hipertensi primer dan 15 responden normotensif (kelompok pembanding). Data dikumpulkan melalui wawancara dan uji laboratorium klinis sampel darah. Konsentrasi serum zinc dan cuprum diukur dengan metode AAS (Spektrofotometer Serapan Atom). Data dianalisis dengan chi-square dan independent T-test. Hasil penelitian menunjukkan bahwa tingkat rata-rata serum zinc dan cuprum responden pada kelompok hipertensi primer lebih rendah daripada kelompok normotensif. Namun, secara statistik tidak ada perbedaan yang signifikan (p=0,852) kadar serum zinc antara kelompok hipertensi primer dan kelompok normotensi, tapi ada perbedaan yang signifikan pada kadar serum cuprum (p=0,022). Kesimpulannya adalah ada yang berbeda dari kadar serum cuprum antara dua kelompok sedangkan untuk kadar serum zinc tidak berbeda.;One of the causes of primary hypertension is an exposure to free radicals. The formation of free radicals in the body can be prevented by taking antioxidants. Zinc and copper are cofactors of endogenous antioxidant enzyme superoxide dismutase. This study aimed to analyze the differences of zinc and copper levels in primary hypertensive and normotensive patients. This was an analytical observational study with cross sectional design and simple random sampling method. Subjects were patients aged 40-70 years at Haji General Hospital consisting of 15 primary hypertensive patients and 15 normotensive individuals (comparison group). Data was collected through interviews and laboratory test of blood samples. Zinc and Copper serum concentrations were measured by AAS. Data were analyzed by chi-square and independent samples t-test. The results showed that the mean levels of zinc and copper in primary hypertensive patients was lower than normotensive. However, statistically there was no difference in zinc serum levels (p=0.852) in the two groups, and there was a significant difference in copper serum levels (p=0.032). It can be concluded that there were differences in copper serum levels between the two groups but not with the levels of zinc.

One of the causes of primary hypertension is an exposure to free radicals. The formation of free radicals in the body can be prevented by taking antioxidants. Zinc and copper are cofactors of endogenous antioxidant enzyme superoxide dismutase. This study aimed to analyze the differences of zinc and copper levels in primary hypertensive and normotensive patients. This was an analytical observational study with cross sectional design and simple random sampling method. Subjects were patients aged 40-70 years at Haji General Hospital consisting of 15 primary hypertensive patients and 15 normotensive individuals (comparison group). Data was collected through interviews and laboratory test of blood samples. Zinc and Copper serum concentrations were measured by AAS. Data were analyzed by chi-square and independent samples t-test. The results showed that the mean levels of zinc and copper in primary hypertensive patients was lower than normotensive. However, statistically there was no difference in zinc serum levels (p=0.852) in the two groups, and there was a significant difference in copper serum levels (p=0.032). It can be concluded that there were differences in copper serum levels between the two groups but not with the levels of zinc."
Faculty of Public Health UNAIR;Airlangga University. Faculty of Public Health, 2015
J-Pdf
Artikel Jurnal  Universitas Indonesia Library
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Arinda Lironika Suryana
"One of the causes of primary hypertension is an exposure to free radicals. The formation of free radicals in the body can
be prevented by taking antioxidants. Zinc and copper are cofactors of endogenous antioxidant enzyme superoxide
dismutase. This study aimed to analyze the differences of zinc and copper levels in primary hypertensive and
normotensive patients. This was an analytical observational study with cross sectional design and simple random
sampling method. Subjects were patients aged 40-70 years at Haji General Hospital consisting of 15 primary
hypertensive patients and 15 normotensive individuals (comparison group). Data was collected through interviews and
laboratory test of blood samples. Zinc and Copper serum concentrations were measured by AAS. Data were analyzed
by chi-square and independent samples t-test. The results showed that the mean levels of zinc and copper in primary
hypertensive patients was lower than normotensive. However, statistically there was no difference in zinc serum levels
(p=0.852) in the two groups, and there was a significant difference in copper serum levels (p=0.032). It can be
concluded that there were differences in copper serum levels between the two groups but not with the levels of zinc.
Kadar Zinc dan Cuprum pada Penderita Hipertensi Primer dan Normotensi. Salah satu pencetus hipertensi primer
yaitu paparan radikal bebas. Pembentukan radikal bebas dalam tubuh dapat dicegah dengan antioksidan. Peran zinc dan
cuprum adalah sebagai kofaktor dari enzim antioksidan endogen superoksida dismutase (SOD). Penelitian ini bertujuan
untuk menganalisis perbedaan kadar serum zinc dan cuprum pada kelompok hipertensi primer dan normotensif.
Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional dan metode simple random
sampling. Subjek adalah orang yang berusia 40-70 tahun, mengunjungi Rumah Sakit Haji Surabaya, dan terdiri dari 15
responden hipertensi primer dan 15 responden normotensif (kelompok pembanding). Data dikumpulkan melalui
wawancara dan uji laboratorium klinis sampel darah. Konsentrasi serum zinc dan cuprum diukur dengan metode AAS
(Spektrofotometer Serapan Atom). Data dianalisis dengan chi-square dan independent T-test. Hasil penelitian
menunjukkan bahwa tingkat rata-rata serum zinc dan cuprum responden pada kelompok hipertensi primer lebih rendah
daripada kelompok normotensif. Namun, secara statistik tidak ada perbedaan yang signifikan (p=0,852) kadar serum
zinc antara kelompok hipertensi primer dan kelompok normotensi, tapi ada perbedaan yang signifikan pada kadar serum
cuprum (p=0,022). Kesimpulannya adalah ada yang berbeda dari kadar serum cuprum antara dua kelompok sedangkan
untuk kadar serum zinc tidak berbeda."
Airlangga University. Faculty of Public Health , 2015
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Artikel Jurnal  Universitas Indonesia Library
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Hanifah Ardiani
"Faktor Risiko Hipertensi pada Wanita Menopause di Rejomulyo, Madiun. Hipertensi merupakan keadaan dimana tekanan darah ≥140 mmHg (sistolik) atau ≥90 mmHg (diastolik). Kejadian hipertensi pada wanita di Rejomulyo pada bulan Januari-November 2013 mencapai 28,4%, dimana 87% dari jumlah tersebut merupakan wanita menopause. Faktor risiko meningkat sejak periode awal menopause. Tujuan dari penelitian ini adalah untuk menganalisis faktor- faktor risiko hipertensi pada wanita menopause di Rejomulyo, Madiun. Analisis pengamatan dilakukan dengan desain studi cross-sectional. Sampel studi adalah 90 wanita menopause berusia 50-80 tahun yang dipilih dengan stratified random sampling. Analisis bivariat menunjukkan adanya hubungan antara obesitas (p=0,023;CI: 1,4-116,8), obesitas abdominal (p=0,002;CI: 1,8-24,9), riwayat keluarga dengan hipertensi (p=0,018;CI: 1,2-7,1), usia lanjut (p=0,028;CI: 1,2-12,9), tingkat stres yang tinggi (p = 0,001;CI: 2,9-19,4), dan konsumsi natrium yang tinggi (p=0,001 CI: 2,4-15,2). Analisis multivariat menunjukkan bahwa faktor risiko hipertensi adalah obesitas abdominal (POR adj=9,2;CI: 1,7-50,9), usia tua atau >65 tahun (POR adj=8,6;CI: 1,6-45,1), tingkat stres tinggi (POR adj=8,6;CI: 2,6-28,3) dan konsumsi natrium yang tinggi (POR adj=6,4;CI: 1,9-20,5). Studi ini menemukan bahwa faktor risiko hipertensi adalah obesitas abdominal, usia tua (>65 tahun), tingkat stres yang tinggi, dan konsumsi natrium yang tinggi. Pusat Kesehatan Tawangrejo harus bekerja sama dengan berbagai sektor relevan seperti PKK dan kader kesehatan.;Hypertension is a state of blood pressure ≥140 mmHg (systolic) or ≥90 mmHg (diastolic). Incidence of women hypertension in Rejomulyo from January to November 2013 reached 28.4%, in which 87% were menopausal. Risk factors increased since early menopausal period. The aim of the study was to analyze risk factors of hypertension in menopausal women in Rejomulyo, Madiun. An observational analysis was conducted with cross-sectional study design. Samples were 90 menopausal women aged 50-80 years using stratified random sampling. Bivariate analysis showed association between obesity (p=0.023;CI: 1.4-116.8), abdominal obesity (p=0.002;CI: 1.8-24.9), family history suffering of hypertension (p=0.018;CI: 1.2-7.1), elderly age (p =0.028;CI: 1.2-12.9), high stress level (p=0.001;CI: 2.9- 19.4) and often natrium consumption (p=0.001;CI: 2.4-15.2). Multivariate analysis showed that risk factors of hypertension were abdominal obesity (POR adj=9.2 CI: 1.7-50.9), elderly age or >65 years old (POR adj=8.6;CI: 1.6- 45.1), high stress level (POR adj=8.6;CI: 2.6-28.3) and often natrium consumption (POR adj=6.4;CI: 1.9-20.5). This study found that risk factors of hypertension were abdominal obesity, elderly age (>65 years old), high stress level, and high natrium consumption. Tawangrejo Health Center should be in collaboration with relevant sectors such as the PKK and health cadres.

Hypertension is a state of blood pressure ≥140 mmHg (systolic) or ≥90 mmHg (diastolic). Incidence of women hypertension in Rejomulyo from January to November 2013 reached 28.4%, in which 87% were menopausal. Risk factors increased since early menopausal period. The aim of the study was to analyze risk factors of hypertension in menopausal women in Rejomulyo, Madiun. An observational analysis was conducted with cross-sectional study design. Samples were 90 menopausal women aged 50-80 years using stratified random sampling. Bivariate analysis showed association between obesity (p=0.023;CI: 1.4-116.8), abdominal obesity (p=0.002;CI: 1.8-24.9), family history suffering of hypertension (p=0.018;CI: 1.2-7.1), elderly age (p =0.028;CI: 1.2-12.9), high stress level (p=0.001;CI: 2.9- 19.4) and often natrium consumption (p=0.001;CI: 2.4-15.2). Multivariate analysis showed that risk factors of hypertension were abdominal obesity (POR adj=9.2 CI: 1.7-50.9), elderly age or >65 years old (POR adj=8.6;CI: 1.6- 45.1), high stress level (POR adj=8.6;CI: 2.6-28.3) and often natrium consumption (POR adj=6.4;CI: 1.9-20.5). This study found that risk factors of hypertension were abdominal obesity, elderly age (>65 years old), high stress level, and high natrium consumption. Tawangrejo Health Center should be in collaboration with relevant sectors such as the PKK and health cadres."
Universitas Diponegoro. Faculty of Public Health, 2015
AJ-Pdf
Artikel Jurnal  Universitas Indonesia Library
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Jesslyn Christabella
"Latar Belakang: Sebanyak 149,2 juta anak di dunia mengalami kejadian stunting. Stunting adalah kondisi gagal tumbuh kembang anak yang diakibatkan oleh kurangnya gizi di seribu hari pertama anak. Berbagai penyebab mampu mempengaruhi kejadian stunting dan salah satunya adalah status gizi yang kurang. Zink yang termasuk dalam mikronutrien diyakini memiliki kaitan dengan kejadian stunting. Kadar zink yang rendah kerap kali dihubungkan dengan gagalnya pertumbuhan linear anak. Tujuan: Mengevaluasi perbedaan kadar zink pada saliva anak usia 6 – 8 tahun pada kelompok anak stunting dan non stunting dan mengevaluasi hubungan antara kadar zink pada saliva anak usia 6 – 8 tahun dan status stunting dan non stunting. Metode: Penelitian ini merupakan penelitian laboratorik dengan menggunakan 86 sampel saliva anak usia 6 – 8 tahun yang mengalami stunting dan non stunting di NTT. Sampel saliva subjek diuji dengan QuantichromTM Zinc Assay Kit dan dibaca menggunakan microplate reader pada panjang gelombang 425 nm. Selanjutnya, data diolah menggunakan SPSS. Hasil: Kadar zink pada saliva anak stunting usia 6 – 8 tahun di NTT sebesar 0,096 ppm dan pada saliva anak non stunting sebesar 0,105 ppm. Selanjutnya, didapatkan nilai korelasi r sebesar 0,657 dan p< 0,05 antara kadar zink pada saliva anak usia 6 – 8 tahun di NTT dan status stunting. Kesimpulan: Terdapat perbedaan bermakna antara kadar zink pada saliva anak usia 6 – 8 tahun pada kelompok anak stunting dan non stunting. Selain itu, terdapat korelasi antara kadar zink dan status stunting dan non stunting pada saliva anak usia 6 – 8 tahun.

Background: As many as 149.2 million children worldwide experience stunting. Stunting is a condition of failure in child growth and development caused by a lack of nutrition in the child's first thousand days. Various causes can influence the incidence of stunting and one of them is poor nutritional status. Zinc, which is a micronutrient, is believed to have a connection with stunting. Low zinc levels are often associated with the failure of children's linear growth. Objectives: To evaluate differences in zinc levels in the saliva of children aged 6-8 years in the stunting and non-stunting groups and to evaluate the relationship between zinc levels in the saliva of children aged 6 – 8 years and stunting and non-stunting status. Methods: This study was a laboratory study using 86 saliva samples of children aged 6 – 8 years who were stunted and non-stunted in NTT. The subject's salivary samples were tested with the QuantichromTM Zinc Assay Kit and read using a microplate reader at a wavelength of 425 nm. Furthermore, the data is processed using SPSS. Results: The zinc level in the saliva of stunted children aged 6-8 years in NTT was 0.096 ppm and 0.105 ppm in the saliva of non-stunted children. Furthermore, a correlation value of 0.657 and p < 0.05 was obtained between zinc levels in the saliva of children aged 6-8 years in NTT and stunting status. Conclusion: There is a significant difference between zinc levels in the saliva of children aged 6-8 years in the stunting and non-stunting groups. In addition, there is a correlation between zinc levels and stunting and non-stunting status in the saliva of children aged 6-8 years"
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2022
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UI - Skripsi Membership  Universitas Indonesia Library
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Tanjung, Novi Dewi
"Penelitian ini bertujuan mengevaluasi efek dishomeostasis Zn terhadap jalur pensinyalan CREB/BDNF serta dampaknya terhadap fungsi kognitif pada tikus. Tingkat ekspresi CREB dan BDNF diukur pada hipokampus tikus yang dihasilkan dari induk yang memiliki diet Zn dengan variasi dosis. Kelompok perlakuan terdiri dari tikus yang mendapat diet Zn sangat rendah (a: 2.67 mg Zn/100 g), rendah (c: 3.75 mg Zn/100 g), normal (d: 4.84 mg Zn/100 g), tinggi (ds: 4.84 mg Zn/100 g + sonde 1.06 mg Zn/hari), dan sangat tinggi (es: 8.89 mg Zn/100 g + sonde 2.3 mg Zn/hari). Hasil penelitian menunjukkan terdapat kecendrungan peningkatan nilai rerata kadar Zn serum dari kelompok a sampai kelompok ds, kemudian menurun pada kelompok es. Kelompok a dan es menunjukkan ekspresi CREB dan BDNF yang rendah, sementara kelompok d menunjukkan hasil yang paling tinggi dalam semua parameter tersebut. Hasil pengukuran memori kerja spasial menunjukkan pola yang sejalan dengan ekspresi CREB/BDNF. Kelompok dengan diet Zn normal memiliki performa memori yang lebih baik, sedangkan kelompok dengan diet Zn sangat rendah atau sangat tinggi menunjukkan penurunan performa. Penelitian ini menunjukkan dishomeostasis Zn dapat mengganggu pensinyalan jalur CREB/BDNF dan fungsi kognitif pada tikus. Respons terhadap dishomeostasis tersebut bervariasi tergantung pada tingkat kekurangan atau kelebihan Zn dalam diet.

This study evaluated the effect of zinc dyshomeostasis on the CREB/BDNF signaling pathway and its impact on cognitive function. Levels of CREB and BDNF expression were measured in the hippocampus of offsprings produced from rats with varying doses of zinc diets. Groups included rat on diets with very low Zn (a: 2.67 mg Zn/100 g), low Zn (c: 3.75 mg Zn/100 g), normal Zn (d: 4.84 mg Zn/100 g), high Zn (ds: 4.84 mg Zn/100 g + orally 1.06 mg Zn/day), and very high Zn (es: 8.89 mg Zn/100 g + orally 2.3 mg Zn/day). Research results showed a trend of increasing mean serum zinc levels from group a to group ds, then decreasing in group es. Groups a and es exhibited low CREB and BDNF expression, while group d showed the highest levels in all parameters. Spatial working memory measurements indicated a pattern consistent with CREB/BDNF expression. Group with normal zinc diets showed better memory performance, whereas groups with very low or very high zinc diets showed decreased performance. This study suggests that zinc dyshomeostasis may disrupt CREB/BDNF signaling pathway and cognitive function. Response to dyshomeostasis varies depending on the level of zinc deficiency or excess in the diet."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
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UI - Tesis Membership  Universitas Indonesia Library
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Ghini Alfikra
"Hipertensi adalah salah satu penyakit tidak menular yang berkontribusi pada sebagian besar kematian di dunia. Sebagai fasilitas pelayanan kesehatan tingkat pertama, puskesmas berperan dalam tindakan preventif, promotif, dan kuratif terhadap hipertensi. Praktik kolaborasi interprofesi menjadi salah satu faktor yang berkontribusi pada penatalaksanaan klien hipertensi. Penelitian ini bertujuan untuk mengidentifikasi bagaimana persepsi tenaga kesehatan terhadap praktik kolaborasi interprofesi dalam penanganan klien hipertensi di Kota Bekasi. Penelitian dilakukan di 9 Puskesmas di Kota Bekasi, yaitu dokter, perawat, bidan, apoteker/ asisten apoteker, kesehatan masyarakat, dan ahli gizi. Desain penelitian ini menggunakan desain penelitian deskriptif cross-sectional, sampel 112 responden dengan teknik quota sampling. Instrumen yang digunakan adalah Perception of Collaboration Model Questionnaire (PINCOM-Q) versi Bahasa Indonesia. Hasil penelitian menunjukkan persepsi kolaborasi interprofesi pada kategori baik (50,9%) dan kurang baik (49,1%). Hasil penelitian dapat menjadi landasan bagi tenaga kesehatan untuk mengevaluasi praktik kolaborasi interprofesi pada pelayanan hipertensi.

Hypertension is a non-communicable disease that contributes to the majority of deaths in the world. As a first-level health service facility, community health centers play a role in preventive, promotive, and curative measures against hypertension. The practice of interprofessional collaboration is one of the factors that contribute to the management of hypertensive clients. This study aims to identify the perceptions of health workers regarding the practice of interprofessional collaboration in treating hypertensive clients in Bekasi City. The research was conducted at 9 Community Health Centers in Bekasi City, namely doctors, nurses, midwives, pharmacists/pharmacist assistants, public health, and nutritionists. This research design uses a cross-sectional descriptive research design, a sample of 112 respondents using a quota sampling technique. The instrument used was the Indonesian version of the Perception of Collaboration Model Questionnaire (PINCOM-Q). The research results show that perceptions of interprofessional collaboration are in the good (50.9%) and poor (49.1%) categories. The results of the research can be a basis for health workers to practice interprofessional collaboration in hypertension services."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2024
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UI - Skripsi Membership  Universitas Indonesia Library
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Sahroni
"Studi terdahulu telah menunjukkan hubungan yang positif antara literasi kesehatan dengan status kesehatan serta pemanfaatan layanan kesehatan, namun belum banyak penelitian mengenai literasi kesehatan pada penderita hipertensi di Indonesia. Penelitian ini bertujuan untuk mengetahui determinan sosial yang mempengaruhi tingkat literasi kesehatan pada pasien hipertensi di Puskesmas Kota Cilegon, Banten. Dengan menggunakan disain potong lintang, penelitian ini mengambil data dari pasien hipertensi di delapan puskesmas di Kota Cilegon (n=138). Pengukuran literasi kesehatan dilakukan menggunakan instrumen Health Literacy Scale European Union dengan 16 pertanyaan yang telah diadaptasi.  Analisis dilakukan menggunakan model regresi linier ganda dengan literasi kesehatan sebagai variabel dependen dan determinan sosial seperti jenis kelamin, kelompok usia, pendidikan, penghasilan, dan pekerjaan sebagai variabel independen. Hasil penelitian menunjukkan rerata skor literasi kesehatan pada penderita hipertensi adalah 58.4 (SD=14.2) dari skala 100. Hasil analisis regresi linier ganda menunjukkan hubungan yang bermakna antara skor literasi kesehatan dengan usia (b=-6.1, SE=1.8, p=0.01), pendidikan (b=12.5, SE=2.7, p<0.001), penghasilan (b=9.1, SE=2.2, p<0.001) dan pengetahuan hipertensi(b=14,4 SE=1,5, p<0.001)  Hasil ini mengindikasikan perlunya penanganan ekstra pada penderita hipertensi yang berusia lanjut, berpendidikan kurang dari SMA, berpenghasilan di bawah upah minimum regional dan pengetahuan hipertensi yang kurang.

Previous studies have shown positive association between health literacy and access to health care systems as well as health outcomes. However, research assessing such association among hypertension patients in Indonesia is limited.This study aimed to assess social determinants for health literacy among hypertension patients in Cilegon, the capital city of Banten Province, Indonesia. Data for this cross sectional study were collected using face to face interviews with quota based samples from registered patients of eight community health centers (n=138). Multiple regression was conducted to assess the association of health literacy and social determinants (i.e., sex, age, education, income, and employment status). Univariate analysis showed that the average score of health literacy was 58.4 (SD=14.2) on a scale of 100. Bivariate analysis showed positive associations between health literacy with all independent variables, except for sex and employment status. Multiple linear regression showed that patients health literacy was significantly associated with age (=-6.1, SE=1.8, p=0.01), education (=12.5, SE=2.7, p<0.001), and income (=9.1, SE=2.2, p<0.001). Results showed that doctors and health care workers need to provide extra treatment for hypertension patients who are older, have education below high school, and have limited income."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2019
T53927
UI - Tesis Membership  Universitas Indonesia Library
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Pius A.L. Berek
"Slow deep breathing (SDB) adalah tindakan nonfarmakologis untuk menurunkan tekanan darah pasien hipertensi primer. Penelitian ini bertujuan untuk mengetahui efektifitas SDB terhadap penurunan tekanan darah pasien hipertensi primer. Metode penelitian ini menggunakan desain Randomized Clinical Trial dengan pretest dan post test control group. Sampelnya 142 responden, meliputi 33 responden kelompok rendah garam (RG), 37 responden kelompok SDB, 39 responden kombinasi kelompok SDB dan RG; dan 33 responden kelompok kontrol. Sampel diambil dengan cara randomisasi.
Hasil penelitian menunjukan penurunan tekanan darah secara bermakna terutama pada kelompok SDB. Tekanan darah sistolik menurun 28,59 mmHg (P value=0,002) dan tekanan darah diastolik 16,92 mmHg (P value=0,007). Analisis dengan uji Tukey diketahui tekanan darah sistolik yang berbeda secara bermakna yaitu antara SDB dan kelompok kontrol (P value=0,001). Tekanan darah diastolik yang berbeda secara bermakna, yaitu: RG dan SDB-RG (P value=0,046); RG dan kelompok kontrol (P value=0,003); SDB dan SDB-RG (P value=0,038) serta SDB dan kelompok kontrol (P value=0,005). Penelitian ini merekomendasikan penerapan SDB untuk membantu menurunkan prevalensi hipertensi sehingga meminimalkan komplikasi yang mungkin timbul.

Slow deep breathing is a nonpharmacology therapy to reduce blood pressure in patients with primary hypertension. The purpose of this study was to determine the effectiveness of slow deep breathing exercise to reduce blood pressure in patients with primary hypertension in Atambua East Nusa Tenggara. The method of this research was a quantitative research: a randomized clinical trial design with pretest and post test control group. The sample was 142 respondents, which consisted of 33 respondents in the lower salt (RG) group, 37 respondents in the slow deep breathing (SDB) group, 39 respondents in the combination of SDB-RG group; and 33 respondents in the control group. The method of sampling used a randomization.
The results showed that there were differences in the reduction of systolic blood pressure in SDB group for 28.59 mm Hg and diastolic blood pressure for 16.92 mmHg. The result of Anova analysis showed that there was a significant decrease on average of systolic blood pressure (p = 0.002) and diastolic blood pressure (p = 0.007). Further analysis by Tuckey test of systolic blood pressure found that between SDB group and control group were significantly different, however the other groups was not significant. (P = 0.001). After undergoing further Tukey analysis we found that the systolic blood pressure of four groups has significant differences. The SDB and controlling groups have P value=0,001 differences. RG and the controlling groups have P value=0,003 differences. SDB and SDB-RG groups have P value=0,038 differences. And SDB and controlling groups have P value=0,005 differences. This research would like to suggest applied non-pharmacological actions particularly toward SDB groups in order to decrease the prevalence of hypertension. This will minimize consequences caused by this problem."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2010
T29384
UI - Tesis Open  Universitas Indonesia Library
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Muningtya Philiyanisa Alam
"Proses inflamasi pada kanker kepala dan leher menyebabkan peningkatan sitokin proinflamasi dan sintesis protein fase akut c-reactive protein, CRP yang kemudian menyebabkan perubahan metabolisme dan anoreksia pada penderitanya. Seng merupakan zat gizi yang memiliki peran penting dalam menekan inflamasi, namun dilaporkan sekitar 65 pasien kanker kepala dan leher mengalami kekurangan seng. Penelitian potong lintang ini bertujuan mengetahui korelasi antara asupan seng dan kadar seng serum dengan kadar c-reactive protein CRP sebagai upaya menekan inflamasi sehingga dapat mengurangi morbiditas dan mortalitas pasien kanker kepala leher. Dari 49 subyek yang dikumpulkan secara konsekutif di Poliklinik Onkologi RS Kanker Dharmais, 67,3 adalah laki-laki, rentang usia subyek 46 ndash;65 tahun. Frekuensi terbanyak 65,3 adalah kanker nasofaring dan 69,4 berada pada stadium IV. Seratus persen subyek memiliki asupan seng dibawah nilai angka kecukupan gizi. Rerata kadar seng serum subyek adalah 9,83 2,62 mol/L. Sebanyak 51 subyek memiliki kadar CRP yang meningkat. Terdapat korelasi negatif yang lemah antara kadar seng dengan kadar CRP subyek r =-0,292, p =0,042, namun tidak terdapat korelasi antara asupan seng dengan kadar CRP subyek p =0,86.

The inflammatory process of head and neck cancer leads to increase the proinflammatory cytokines and the synthesis of c reactive protein CRP , which then causes metabolic alteration and anorexia in the patients. Zinc is one of nutrient that has an important role in suppressing inflammation. It is reported that about 65 of head and neck cancer patients have zinc deficiency. The aim of this cross sectional study is to determine the correlation between zinc intake and serum zinc levels with CRP level as an effort to reduce inflammation to reduce the morbidity and mortality of head and neck cancer patients. Subjects were collected by consecutive sampling in the Oncology Polyclinic Dharmais Cancer Hospital, from 49 subjects 67,3 were men, most subjects were in the age range between 46 ndash 65 years. The highest frequency 65,3 is nasopharyngeal cancer and 69,4 are already in stage IV. All subjects in this study have a zinc intake below the recommended dietary allowance RDA in Indonesia. The mean serum zinc level of the subjects was 9.83 2.62 mol L. Most subjects have elevated CRP levels. There was a weak significant negative correlation between zinc concentration and CRP levels of subjects r 0.292, p 0.042, but there was no correlation between zinc intake and CRP levels of subjects p 0.86. "
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2017
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
cover
Wahyu Nurhayati
"ABSTRAK
Hipertensi atau tekanan darah tinggi merupakan faktor risiko penyakit jantung, stroke dan menjadi salah satu penyebab utama kematian di seluruh dunia. Keberadaan penyakit ini seringkali tidak disadari oleh penderita sehingga dikenal sebagai pembunuh diam-diam (silent killer). Jumlah penderita hipertensi setiap tahun semakin meningkat, sehingga dibutuhkan suatu program untuk meningkatkan kesadaran dan pengetahuan masyarakat tentang penyakit hipertensi.
Penelitian ini bertujuan untuk memperoleh mengukur tingkat pengetahuan pasien penderita hipertensi tentang definisi, gejala, penyebab, akibat yang ditimbulkan, dan cara pengobatan hipertensi sebagai upaya untuk mengembangkan media promosi kesehatan bagi pasien penderita hipertensi. Penelitian ini bersifat deskriptif.
Untuk mengetahui tingkat pengetahuan pasien tentang hipertensi digunakan
kuesioner Pengetahuan Hipertensi. Penelitian dilakukan di Poliklinik Rawat Jalan Bagian Penyakit Dalam, RSPAD Gatot Soebroto Jakarta. Jumlah sampel penelitian adalah 77 orang terdiri dari 37 orang wanita dan 40 orang pria. Berumur antara 43-63 tahun, berasal dari jenjang pendidikan SD, SMP, SMA, 03 dan S I.
Hasil penelitian menunjukkan bahwa tingkat pengetahuan pasien tentang hipertensi berada pada kategori Sedang. Sehingga kesimpulan yang bisa diambil adalah masih dibutuhkan promosi kesehatan tentang hipertensi untuk meningkatkan pengetahuan pasien hipertensi. Media promosi kesehatan yang akan dikembangkan, memuat informasi mengenai definisi hipertensi, gejala, pencegahan, pengobatan dan penyakit lain yang diakibatkan oleh hipertensi. Media promosi kesehatan yang akan dikembangkan adalah berbentuk leaflet.

ABSTRACT
Hypertension or high blood pressure is a risk factor for heart disease, stroke, and the leading cause of death in the world. Most people are not aware that they have hypertension because of a general lack of symptoms until major complications arise. Hypertension is a silent killer because it is deadly and has no early significant symptoms. Each year the number of patients with hypertension increase significantly. So, it needs a program to increase people awareness and knowledge about hypertension.
The aim of this study is to asses patients knowledge in definitions, symptoms, causes, effect ilness, and treatment for hypertension disease. Those information can be use for developing health promotion for hypertenssive patients. This study using descriptive study.
The Hypertension Knowledge questionaire used to measure the level of patients knowledge about hypertension. This study was conducted in RSPAD Gatot Soebroto Jakarta. The sample of this study were 77 hypertensive patients (37 female and 40 male), with age between 43-63 years old, and education from SD, SMP, SMA, D3, and S1.
The level of patients knowledge about hypertension is in average level. The patients need health promotion's media that can be practical, easy to read, and include some information about definitions, symptom, causes, effect ilness, and treatment about hypertension. The result from this study is a hypertension leaflet for health promotion's media to hypertensive patients.
"
Depok: Fakultas Psikologi Universitas Indonesia, 2009
T38445
UI - Tesis Membership  Universitas Indonesia Library
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