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"Caveolins are important structural proteins of caveolae, small invaginations of the membrane. They have been shown to play an important role in the pathogenesis of multiple cancers. In this volume, we will mainly focus on the importance of caveolin-1 in breast, prostate, lung, skin, colon, pancreatic and brain cancers with also a mention of the novel role of caveolin-3 in breast cancer."

"This text describes research suggesting that abnormal activation of signaling pathways is a critical event in cancer pathogenesis, and describes the emerging ability to design small molecules, protein therapeutics, and other forms of targeted cancer therapies."

"The purposes of this study are to study the pathogenesis of oral cancer and to see the role play of oncogenes, onco-suppressor genes in cancer growth and their mutation type. There are many predisposing factors which may influence the development of cancer. The factors are divided intrinsic (hereditary) and extrinsic factors (bacteria, viruses, fungi, chemical, drugs, radiation, trauma, heat, cold and nutrition). These agents may act individually, in combination with other carcinogen (co-carcinogen) or in combination with other agents that do not in themselves causes cancer (promoters), but that help the carcinogens to mutate or depress cells, but in the mechanism still enigma. Oncogenes oncosuppressor genes are normal genes in human. Oncogenes functions are as growth factor (e.g. sis), growth factor receptor (e.g. erbB1), signal transducer (e.g. ras) or nuclear factor (e.g.myc, jun). Tumor (oral cancer) will be arises if oncogenes andonco-suppressor genes function are disturbed by some carcinogenand these genes have mutation, deletion, amplification or translocation. That was also related to the loss or inactivation of onco-suppressor genes such as p53, so that causes the loss of the normal growth regulation/strait control that associated with tumorigenesis."

"This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as both a pathologic factor and therapeutic agent."

"Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials."

"Explains when and how you can use them to most effectively combat cancer. This concise, practical oncology reference examines more than 120 targeted therapy agents for which clinical trial data are available."

"This book in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. "

"This third volume of the Springer series discussing pediatric cancer focuses on diagnosing, treating, and assessing the future course of malignant brain neoplasms in children. In addition to a general introduction to the principals involved, the material includes vital research in molecular genetics, a major contribution to the molecular characterization of solid tumors, which will define new biomarkers of the disease and identify molecular pathways. The volume includes presentations of present and future therapies. The volume also explains AT/RT’s dissemination to the cerebral fluid, the molecular mechanisms underlying the progression of medulloblastoma, and the importance of gamma knife radiosurgery during multimodality management of medulloblastoma/PNET tumors. Other topics discussed include using magnetic resonance imaging for diagnosing retinoblastoma, and mapping the effects of radiotherapy in low-grade glioma in children. Information on alterations in cell-cycle regulators that are influenced by tumor suppressor genes and oncogenes is detailed. Contributors provide recommendations concerning non-narcotic analgesic routines for children recovering from cranial and spinal surgery. "