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Segal Abdul Aziz
Kadar procalcitonin dan perannya sebagai biomarker sepsis pada pasien tumor padat dengan metastasis jauh = Level of procalcitonin and its role as a sepsis biomarker in patient with metastatic solid tumor
"ABSTRAK
Latar Belakang: Pengaruh metastasis sebagai penyebab peningkatan procalcitonin
(PCT) pada pasien tumor padat nonsepsis masih belum jelas. Studi-studi
sebelumnya memberikan hasil yang tidak konklusif. Nilai titik potong PCT untuk
diagnosis sepsis pada tumor padat metastasis juga belum diketahui.
Tujuan: Mengetahui peran PCT dalam diagnosis sepsis pada pasien tumor padat
dengan metastasis.
Metode: Studi potong lintang terhadap pasien tumor padat yang berobat di RSCM
September-Desember 2015. Pada pasien ditentukan ada tidaknya sepsis
menggunakan kriteria sepsis ACCP/SCCM 2001, dilakukan pemeriksaan darah
perifer, serta PCT. Dilakukan analisis untuk mengetahui perbedaan kadar PCT
pasien tumor padat metastasis dan tanpa metastasis yang tidak sepsis. Selain itu,
dilakukan pula pencarian nilai titik potong PCT untuk diagnosis sepsis pada pasien
tumor padat metastasis dengan menggunakan ROC.
Hasil dan Pembahasan: Didapatkan 112 pasien tumor padat, pria sebanyak 51%,
dengan rerata usia 47,9 ±12,47 tahun. Sebanyak 71 (63,4%) pasien sudah
didapatkan metastasis, 36 (32,1%) diantaranya sepsis, dan 6 (5,3%) mengalami
SIRS. Dari 41 (36,6%) pasien tanpa metastasis, 9 (8%) mengalami sepsis, dan 5
(4,4%) SIRS. Terdapat perbedaan bermakna kadar PCT pada pasien tumor padat
metastasis dibandingkan tanpa metastasis pada kondisi nonsepsis [0,25 ng/mL
(0,07-1,76) vs. 0,09 ng/mL (0,03-0,54); p<0,001]. Pasien tumor padat metastasis
yang mengalami sepsis memiliki kadar PCT lebih tinggi dibandingkan nonsepsis
[3,5 ng/mL (0,66-189,4) vs. 0,25 ng/mL (0,07-1,76); p<0,001]. Dari kurva ROC
kadar PCT pada tumor padat metastasis, didapatkan AUC [0,956, IK 0,916-0,996]
untuk mendiagnosis sepsis. Nilai titik potong PCT untuk diagnosis sepsis pada
pasien tumor padat metastasis adalah 1,14 ng/mL dengan sensitivitas 86% dan
spesifisitas 88%.
Kesimpulan: Pada kondisi nonsepsis, kadar PCT pasien tumor padat metastasis
lebih tinggi dibandingkan pasien tanpa metastasis. Nilai titik potong PCT untuk diagnosis sepsis pada tumor padat metastasis adalah 1,14 ng/mL. ABSTRACT
Background: The effect of metastasis as a cause of increased procalcitonin (PCT)
in patients with solid tumors without sepsis remains unclear. Previous studies did
not provide conclusive results. Cut off point of PCT for sepsis diagnosis in
metastatic solid tumors is also unknown.
Objective: To determine the role of PCT in the diagnosis of sepsis toward
metastatic solid tumors patients.
Methods: A cross sectional study was conducted in solid tumor patients who were
admitted to Cipto Mangunkusumo, Jakarta between September 2015 and December
2015. The ACCP/SCCM 2001 criteria was used to identify sepsis or SIRS in
patients. Procalcitonin level, as well as routine blood examination, was performed
to determine the differences of PCT level among solid tumor patients with and
without metastasis. Cut off point of PCT for diagnosing sepsis in patients with
metastatic solid tumors was determined using ROC curve.
Results and Discussion: There were 112 patients with solid tumors, 51% male,
with mean of age 47,9 ± 12,47 years. A total of 71 (63,4%) patients had metastasis,
while 36 (32,1%) of them had sepsis and 6 (5,3%) experienced SIRS. Among 41
(36,6%) patients without metastasis, 9 (8%) had sepsis and 5 (4,4%) had SIRS. In
the absence of sepsis, the PCT level was significantly higher in patients with
metastatic solid tumors compared those without metastasis [0,25 ng/mL (0,07-1,76)
vs. 0,09 ng/mL (0,03-0,54); p<0,001]. Metastatic solid tumor patients with sepsis
had PCT levels higher than those without sepsis [3,5 ng / mL (0,66 to 189,4) vs.
0,25 ng / mL (0,07-1,76); p <0,001]. ROC curve showed that level of PCT for sepsis
in metastatic solid tumors was AUC [0,956, IK 0,916-0,996]. Cut off point of PCT
for sepsis in patients with metastatic solid tumors was 1.14 ng / mL with a
sensitivity of 86% and specificity of 88%.
Conclusion: In the absence of sepsis, PCT levels of patients with metastatic solid
tumors is higher than patients without metastasis. Cut off point of PCT for sepsis
diagnosis in metastatic solid tumors was 1,14 ng / mL. ;Background: The effect of metastasis as a cause of increased procalcitonin (PCT)
in patients with solid tumors without sepsis remains unclear. Previous studies did
not provide conclusive results. Cut off point of PCT for sepsis diagnosis in
metastatic solid tumors is also unknown.
Objective: To determine the role of PCT in the diagnosis of sepsis toward
metastatic solid tumors patients.
Methods: A cross sectional study was conducted in solid tumor patients who were
admitted to Cipto Mangunkusumo, Jakarta between September 2015 and December
2015. The ACCP/SCCM 2001 criteria was used to identify sepsis or SIRS in
patients. Procalcitonin level, as well as routine blood examination, was performed
to determine the differences of PCT level among solid tumor patients with and
without metastasis. Cut off point of PCT for diagnosing sepsis in patients with
metastatic solid tumors was determined using ROC curve.
Results and Discussion: There were 112 patients with solid tumors, 51% male,
with mean of age 47,9 ± 12,47 years. A total of 71 (63,4%) patients had metastasis,
while 36 (32,1%) of them had sepsis and 6 (5,3%) experienced SIRS. Among 41
(36,6%) patients without metastasis, 9 (8%) had sepsis and 5 (4,4%) had SIRS. In
the absence of sepsis, the PCT level was significantly higher in patients with
metastatic solid tumors compared those without metastasis [0,25 ng/mL (0,07-1,76)
vs. 0,09 ng/mL (0,03-0,54); p<0,001]. Metastatic solid tumor patients with sepsis
had PCT levels higher than those without sepsis [3,5 ng / mL (0,66 to 189,4) vs.
0,25 ng / mL (0,07-1,76); p <0,001]. ROC curve showed that level of PCT for sepsis
in metastatic solid tumors was AUC [0,956, IK 0,916-0,996]. Cut off point of PCT
for sepsis in patients with metastatic solid tumors was 1.14 ng / mL with a
sensitivity of 86% and specificity of 88%.
Conclusion: In the absence of sepsis, PCT levels of patients with metastatic solid
tumors is higher than patients without metastasis. Cut off point of PCT for sepsis
diagnosis in metastatic solid tumors was 1,14 ng / mL. ;Background: The effect of metastasis as a cause of increased procalcitonin (PCT)
in patients with solid tumors without sepsis remains unclear. Previous studies did
not provide conclusive results. Cut off point of PCT for sepsis diagnosis in
metastatic solid tumors is also unknown.
Objective: To determine the role of PCT in the diagnosis of sepsis toward
metastatic solid tumors patients.
Methods: A cross sectional study was conducted in solid tumor patients who were
admitted to Cipto Mangunkusumo, Jakarta between September 2015 and December
2015. The ACCP/SCCM 2001 criteria was used to identify sepsis or SIRS in
patients. Procalcitonin level, as well as routine blood examination, was performed
to determine the differences of PCT level among solid tumor patients with and
without metastasis. Cut off point of PCT for diagnosing sepsis in patients with
metastatic solid tumors was determined using ROC curve.
Results and Discussion: There were 112 patients with solid tumors, 51% male,
with mean of age 47,9 ± 12,47 years. A total of 71 (63,4%) patients had metastasis,
while 36 (32,1%) of them had sepsis and 6 (5,3%) experienced SIRS. Among 41
(36,6%) patients without metastasis, 9 (8%) had sepsis and 5 (4,4%) had SIRS. In
the absence of sepsis, the PCT level was significantly higher in patients with
metastatic solid tumors compared those without metastasis [0,25 ng/mL (0,07-1,76)
vs. 0,09 ng/mL (0,03-0,54); p<0,001]. Metastatic solid tumor patients with sepsis
had PCT levels higher than those without sepsis [3,5 ng / mL (0,66 to 189,4) vs.
0,25 ng / mL (0,07-1,76); p <0,001]. ROC curve showed that level of PCT for sepsis
in metastatic solid tumors was AUC [0,956, IK 0,916-0,996]. Cut off point of PCT
for sepsis in patients with metastatic solid tumors was 1.14 ng / mL with a
sensitivity of 86% and specificity of 88%.
Conclusion: In the absence of sepsis, PCT levels of patients with metastatic solid
tumors is higher than patients without metastasis. Cut off point of PCT for sepsis
diagnosis in metastatic solid tumors was 1,14 ng / mL. ;Background: The effect of metastasis as a cause of increased procalcitonin (PCT)
in patients with solid tumors without sepsis remains unclear. Previous studies did
not provide conclusive results. Cut off point of PCT for sepsis diagnosis in
metastatic solid tumors is also unknown.
Objective: To determine the role of PCT in the diagnosis of sepsis toward
metastatic solid tumors patients.
Methods: A cross sectional study was conducted in solid tumor patients who were
admitted to Cipto Mangunkusumo, Jakarta between September 2015 and December
2015. The ACCP/SCCM 2001 criteria was used to identify sepsis or SIRS in
patients. Procalcitonin level, as well as routine blood examination, was performed
to determine the differences of PCT level among solid tumor patients with and
without metastasis. Cut off point of PCT for diagnosing sepsis in patients with
metastatic solid tumors was determined using ROC curve.
Results and Discussion: There were 112 patients with solid tumors, 51% male,
with mean of age 47,9 ± 12,47 years. A total of 71 (63,4%) patients had metastasis,
while 36 (32,1%) of them had sepsis and 6 (5,3%) experienced SIRS. Among 41
(36,6%) patients without metastasis, 9 (8%) had sepsis and 5 (4,4%) had SIRS. In
the absence of sepsis, the PCT level was significantly higher in patients with
metastatic solid tumors compared those without metastasis [0,25 ng/mL (0,07-1,76)
vs. 0,09 ng/mL (0,03-0,54); p<0,001]. Metastatic solid tumor patients with sepsis
had PCT levels higher than those without sepsis [3,5 ng / mL (0,66 to 189,4) vs.
0,25 ng / mL (0,07-1,76); p <0,001]. ROC curve showed that level of PCT for sepsis
in metastatic solid tumors was AUC [0,956, IK 0,916-0,996]. Cut off point of PCT
for sepsis in patients with metastatic solid tumors was 1.14 ng / mL with a
sensitivity of 86% and specificity of 88%.
Conclusion: In the absence of sepsis, PCT levels of patients with metastatic solid
tumors is higher than patients without metastasis. Cut off point of PCT for sepsis
diagnosis in metastatic solid tumors was 1,14 ng / mL. ;Background: The effect of metastasis as a cause of increased procalcitonin (PCT)
in patients with solid tumors without sepsis remains unclear. Previous studies did
not provide conclusive results. Cut off point of PCT for sepsis diagnosis in
metastatic solid tumors is also unknown.
Objective: To determine the role of PCT in the diagnosis of sepsis toward
metastatic solid tumors patients.
Methods: A cross sectional study was conducted in solid tumor patients who were
admitted to Cipto Mangunkusumo, Jakarta between September 2015 and December
2015. The ACCP/SCCM 2001 criteria was used to identify sepsis or SIRS in
patients. Procalcitonin level, as well as routine blood examination, was performed
to determine the differences of PCT level among solid tumor patients with and
without metastasis. Cut off point of PCT for diagnosing sepsis in patients with
metastatic solid tumors was determined using ROC curve.
Results and Discussion: There were 112 patients with solid tumors, 51% male,
with mean of age 47,9 ± 12,47 years. A total of 71 (63,4%) patients had metastasis,
while 36 (32,1%) of them had sepsis and 6 (5,3%) experienced SIRS. Among 41
(36,6%) patients without metastasis, 9 (8%) had sepsis and 5 (4,4%) had SIRS. In
the absence of sepsis, the PCT level was significantly higher in patients with
metastatic solid tumors compared those without metastasis [0,25 ng/mL (0,07-1,76)
vs. 0,09 ng/mL (0,03-0,54); p<0,001]. Metastatic solid tumor patients with sepsis
had PCT levels higher than those without sepsis [3,5 ng / mL (0,66 to 189,4) vs.
0,25 ng / mL (0,07-1,76); p <0,001]. ROC curve showed that level of PCT for sepsis
in metastatic solid tumors was AUC [0,956, IK 0,916-0,996]. Cut off point of PCT
for sepsis in patients with metastatic solid tumors was 1.14 ng / mL with a
sensitivity of 86% and specificity of 88%.
Conclusion: In the absence of sepsis, PCT levels of patients with metastatic solid
tumors is higher than patients without metastasis. Cut off point of PCT for sepsis
diagnosis in metastatic solid tumors was 1,14 ng / mL. "
Fakultas Kedokteran Universitas Indonesia, 2016
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UI - Tugas Akhir  Universitas Indonesia Library
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Reza Nugraha Yulisar
Kadar Procalcitonin sebagai Biomarker Sepsis pada Pasien Tumor Padat dengan Demam dan Leukositosis = Cut-off Level of Serum Procalcitonin for Sepsis Diagnosis in Advanced Solid Tumor Patients with Fever and Leucocytosis
"Latar Belakang: Diagnosis sepsis pada pasien tumor padat metastasis sulit karena adanya gejala, seperti demam dan leukositosis, dapat timbul tanpa adanya infeksi. Procalcitonin (PCT) merupakan salah satu parameter untuk mendiagnosis sepsis. Titik potong PCT untuk diagnosis sepsis pada pasien tumor padat metastasis dengan demam dan leukositosis masih belum diketahui. Studi sebelumnya belum ada yang menilai titik potong PCT pada pasien tumor padat metastasis dengan demam dan leukositosis.
Tujuan: Mengetahui titik potong PCT dalam diagnosis sepsis pada pasien tumor padat metastasis dengan demam dan leukositosis.
Metode: Studi potong lintang terhadap pasien tumor padat metastasis dengan demam dan leukositosis yang berobat di RSCM Juni 2016 - April 2018. Pada pasien ditentukan ada tidaknya sepsis menggunakan kriteria sepsis sesuai The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), yaitu menggunakan mSOFA. Dilakukan pemeriksaan darah perifer dan PCT. Dilakukan pencarian nilai titik potong PCT untuk diagnosis sepsis pada pasien tumor padat metastasis dengan demam dan leukositosios menggunakan ROC.
Hasil: Didapatkan 86 pasien tumor padat metastasis dengan demam dan lekositosis, dengan wanita sebanyak 61,6%, rerata usia 49,48 ±11,44 tahun. Sebanyak  43 pasien (50%) mengalami sepsis. Dari kurva ROC kadar PCT pada tumor padat metastasis dengan demam dan leukositosis yang mengalami sepsis, didapatkan AUC [0,873 ,IK 0,799 - 0,946, p <0,001]. Nilai titik potong PCT untuk diagnosis sepsis pada pasien tumor padat metastasis dengan demam dan leukositosis adalah 1,755 ng/mL dengan sensitivitas 76,7% dan spesifisitas 81,4%, NDP 80,5%, NDN 77,8%.
Kesimpulan: Nilai titik potong PCT untuk diagnosis sepsis pada tumor padat metastasis dengan demam dan leukositosis adalah 1,755 ng/mL.
Background: Diagnosis of infection in advanced solid tumor patients can be difficult since fever and leucocytosis is a non-specific clinical marker and can occur without infections. Untreated infections can lead to sepsis, increasing mortality in those patients. Procalcitonin has been used to support the diagnosis of sepsis. Procalcitonin cut off in advanced stage solid tumor patients with fever as a sepsis biomarker is still unclear. No study has seen procalcitonin cut-off in advanced solid tumor patients with fever.
Objective: To discover the cut-off point for sepsis in advanced solid tumor patients with fever.
Method: A cross-sectional study was conducted in the advanced solid tumor patients with fever patients who were admitted to Cipto Mangunkusumo Hospitals, Indonesia during June 2016 to April 2018. Demographic characteristics, physical examinations, laboratory examinations were recorded. Sepsis was defined using 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference criteria.
Results: A total of 86 subjects were enrolled in this study, 61,6% were female with mean age 49,5 years old. Among them, 43 patients (50%) were diagnosed with sepsis. The ROC curve showed that the levels of procalcitonin for sepsis in advanced solid tumor patients with fever was in the area under curve (AUC) 0,891 (CI 826 - 956). Cut-off procalcitonin for diagnosing sepsis in advanced solid tumor patients with fever was 1,755 ng/mL, sensitivity 76,7%, specificity 81,4%, PPV 80,5%, NPV 77,8%.
Conclusions: The cut-off point of procalcitonin level to support sepsis diagnosis in advanced solid tumor patients with fever was higher than normal populations."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
T58575
UI - Tesis Membership  Universitas Indonesia Library
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Harim Priyono
Kadar Rerata Interleukin (IL)-1a dan Tumor Necrosis Factor (TNF)-a Kolesteatoma, Kulit Retroaurikular, dan Serum Pasien OMSK Tipe Bahaya serta Hubungannya dengan Derajat Destruksi Tulang
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2008
T58789
UI - Tesis Membership  Universitas Indonesia Library
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Gema Nazri Yanni
Pengaruh intervensi nutrisi tinggi protein selama 3 hari dan peran polimorfisme gen tumor necrosis factor (TNF)-@ terhadap prognosis sepsis dengan pediatric logistic organ dysfunction pelod score = The effect of high protein nutrients intervention in 3 days and role of gene tumor necrosis factor (TNF) genes tumor genes against prognosis sepsis with pediatric logistic organ dysfunction pelod score
"Anak sakit kritis terutama sepsis mengalami degradasi protein yang tinggi, yang memperburuk luaran bila masukan nutrisi tidak adekuat. Kiraan jumlah kebutuhan protein yang ada saat ini ternyata dalam praktiknya kurang dari 90 memenuhi target kebutuhan. Di lain sisi, variasi genetik individu juga memengaruhi luaran. Polimorfisme gen TNF?-308 berhubungan dengan luaran yang buruk berbagai penyakit infeksi dan inflamasi, walaupun hasil yang diperoleh berbeda-beda.Penelitian ini bertujuan mengetahui hubungan nutrisi tinggi protein terhadap prognosis pasien sepsis skor PELOD , lama rawat dan lama pemakaian ventilator, serta menganalisis peran pelbagai faktor yang berperan terhadap skor PELOD, termasuk polimorfisme gen TNF?-308.Penelitian ini merupakan uji klinis randomisasi pada 80 anak sepsis di 4 rumah sakit. Intervensi diberikan asam amino parenteral, yaitu Aminosteril infant 6 untuk usia < 1 tahun dan Aminofusin pediatric 5 untuk usia ge; 1 tahun. Kelompok eksperimental diberikan asam amino 4 g/KgBB/hari, sedangkan kelompok kontrol menerima 2 g/KgBB/hari selama tiga hari, kemudian dilakukan pencatatan skor PELOD pada hari ke-1,2 dan 3, lama hari rawat dan lama pemakaian ventilator. Dilakukan pemeriksaan keseimbangan nitrogen selama tiga hari, pemeriksaan kadar prealbumin hari ke-1 dan ke-3, pemeriksaan kadar TNF-? dan IL-10. Pemeriksaan polimorfisme dengan metode PCR polymerase chain reaction ndash; RFLP restriction fragment length polymorphism . Pada kelompok kontrol, diperoleh rerata skor PELOD pada hari ke-1 20,5 10,6 , hari ke-2 19,8 13,8 dan hari ke-3 19,8 15,4 ; median lama rawat 7 hari 3 ndash;19 dan median lama pemakaian ventilator 5 hari 1 ndash;14 . Pada kelompok eksperimental, diperoleh rerata skor PELOD berturut-turut 22,4 10,8 ; 20,5 13,9 ; 18,8 14,5 ; median lama rawat 7 hari 4 ndash;27 dan median lama pemakaian ventilator 4 hari 1 ndash;27 . Tidak ditemukan perbedaan bermakna skor PELOD, lama rawat dan lama pemakaian ventilator antara 2 kelompok. Diperoleh perbedaan bermakna secara statistik pada keseimbangan nitrogen baik hari ke-1,2, dan 3 p = 0,003; p = 0,016; p = 0,046 . Dari 80 subjek, 6 subjek 7,5 dengan polimorfisme gen TNF?-308 G/A atau heterozigot dan tidak ditemukan homozigot.Tidak ditemukan peran usia, jenis kelamin, status gizi, pemberian nutrisi tinggi protein dan polimorfisme gen TNF?-308 terhadap skor PELOD. Kata kunci: polimorfisme gen TNF?-308, protein tinggi, sepsis
Critically ill children, particularly with sepsis, have high protein degradation which worsens outcome if nutritional intake are inadequate. Currently, the estimated protein requirement is less than 90 target requirement. In addition, individual genetic variation also affects the outcome of these population. Tumor necrosis factor TNF 308 gene polymorphism is associated with poorer outcome of several infectious disease and inflammation, although the results are conflicting.This study aimed to determine the association between high protein nutrition intervention with prognosis of sepsis which is measured by PELOD score, length of stay, and duration of mechanical ventilation use. We also analyze the role of TNF 308 gene polymorphism which contribute to PELOD score.This was a randomized clinical trial in 80 children with sepsis in four hospitals. The interventions were parenteral amino acid, which includes Aminosteril infant 6 for subjects aged below one year and Aminofusin pediatric 5 for subjects aged above one year. Subjects in the experimental group were provided with amino acid 4 g KgBW day while those in the control group were provided with amino acid 2 g KgBW day for three consecutive days. PELOD scores in day 1, 2, 3, length of stay, and duration of mechanical ventilation use, were recorded. Nitrogen balance was measured for three days and prealbumin levels were measured in day 1 and 3. TNF and IL 10 levels were also measured. Polymorphism was measured using polymerase chain reaction PCR ndash restriction fragment length polymorphism RFLP .In the control group, the mean PELOD score on day 1, 2, 3 were 20.5 10.6 , 19.8 13.8 , and 19.8 15.4 , respectively. Median length of stay was 7 3 ndash 19 days and median duration of mechanical ventilation was 5 1 ndash 14 days. In the experimental group, obtained mean PELOD score was 22.4 10.8 20.5 13.9 18.8 14.5 consecutively median length of stay was 7 days 4 ndash 27 and median duration of ventilator use was 4 days 1 ndash 27 . There was no significant difference in PELOD score, length of stay, and duration of mechanical ventilation use between both groups. There was a significant difference in nitrogen balance on day 1, 2, and 3 p 0.003, p 0.016, and p 0.046, respectively . Of the 80 subjects, 6 7.5 subjects with TNF 308 G A gene polymorphism or heterozygotes, and no homozygote was found.Age, gender, nutritional status, provision of high protein nutrients, and TNF 308 gene polymorphism have no significant role in PELOD score. Keywords high protein, sepsis, TNF 308 gene polymorphism."
Depok: Universitas Indonesia, 2017
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UI - Disertasi Membership  Universitas Indonesia Library
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Minyak atsiri kunyit sebagai anti radang pada penderita gout artritis dengan diet tinggi purin / Lailatul Muniroh, Santi Martini, Triska Susila Nindya, Rondius Solfaine
"Peningkatan konsentrasi kristal monosodium urea pada sendi dan jaringan menunjukkan adanya keradangan Gout artritis (GA). Angka insiden dan prevalensi GA tersebar di negara berkembang sebesar 2?15%. Di Indonesia, prevalensi GA sekitar 29% dan sering terjadi pada suku Minahasa, Toraja dan Batak. Penelitian ini bertujuan untuk menganalisis aplikasi minyak atsiri kunyit sebagai anti-radang pada penderita GA dengan diet tinggi purin serta mengukur mediator
seluler tumor necrosis factor-α (TNF-α). Desain penelitian adalah randomized pretest-posttest control group design dengan pemberian secara single blind. Tes GCMS dilakukan untuk mengetahui komponen aktif minyak atsiri. Sampel penelitian ini adalah pasien baru GA di RS Haji Surabaya. Selama tujuh hari, kelompok perlakuan diberi minyak atsiri kunyit dengan dosis 25 mg/kg BB, sedangkan kelompok kontrol diberi indometasin dengan dosis 150 mg/kg BB. Sampel darah diambil sebelum dan sesudah perlakuan. Minyak atsiri kunyit mempunyai empat fraksi komponen aktif. Terdapat penurunan kadar urea darah pada kelompok perlakuan (p = 0,001) dan kelompok kontrol (p = 0,007). Terdapat penurunan konsentrasi pelepasan TNF-α, tetapi penurunan ini tidak berbeda secara signifikan pada kelompok kontrol dan perlakuan.
Increased concentrations of crystal monosodium urea at joint and soft tissue represent induced of inflammation at gout arthritis (GA). Incidence and prevalence GA disseminate wide in developed countries in Asian range from 2-15% and In Indonesia, GA prevalence was 29% and mostly found in Minahasa, Toraja, and Batak ethnics. This research was aimed to analyse application of curcuma domestica volatile oil as anti inflammation agent on gout arthritis patient who has high purin diet and to assess specific cellular mediator Tumor Necrosis Factor-α (TNF-α). The design of the study was randomized pretest-posttest control group design with single blind treatment. The GCMS test was performed to identify active component in volatile oil. The sample was the new gout arthritis patient in Haji Public Hospital Surabaya. For a week, treatment group was assigned with volatile oil with dose 25 mg/kg body weight and the control group was given indometasin 150 mg/kg body weight. Blood samples were taken before and after treatment. Volatile oil of curcuma domestica (Curcuma domestica, val) has four fraction of active component. There was
decreasing in blood urea level in treatment group (p = 0.001) and control group (p = 0.007). Both in control and treatment group, there was also decreasing in TNF-α, however it was not statistically significant. "
[Direktorat Riset dan Pengabdian Masyarakat UI;Universitas Airlangga. Fakultas Kesehatan Masyarakat, Universitas Airlangga. Fakultas Kesehatan Masyarakat], 2010
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Artikel Jurnal  Universitas Indonesia Library
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Ahmad Tahta Kurniawan
Hubungan pajanan particulate matter 2.5 terhadap nilai kadar tumor necrosis factor dalam darah pada petugas uji mekanis pusat pengujian kendaraan bermotor (PKB) Ujung Menteng dan Pulogadung Jakarta Timur = Association between particulate matter 2 5 with value level tumor necrosis factor in blood in test mechanics motor pusat pengujian kendaraan bermotor (PKB) Ujung Menteng and Pulogadung East Jakarta
"ABSTRAK
Pajanan particulate matter 2.5 kepada manusia dapat menyebabkan terjadinya inflamasi akut dan kronik hingga menimbulkan terjadinya perubahan sel yang abnormal. Inflamasi terjadi akibat adanya respon tubuh terhadap dengan melepaskan Tumor Necrosis Factor ? Alpha sebagai protein stimulus inflamasi di dalam tubuh. Penelitian ini bertujuan untuk menganalisis hubungan dengan kadar di Pusat Pengujian Kendaraan Bermotor (PKB) Ujung Menteng dan Pulogadung, penelitian ini juga menganalisis status merokok, kategori obesitas, dan umur pada pekerja, dengan menggunakan Uji ? T independen (T ? test). Sampel penelitian sejumlah 42 pekerja di PKB Ujung Menteng dan Pulogadung sebagai kelompok terpajan dan 27 pekerja Fakultas Kesehatan Masyarakat Universitas Indonesia (FKM UI) sebagai kelompok kontrol. Analisis nilai kadar dalam darah dilakukan di laboratorium dengan teknik quantitative sandwich enzyme immune assay / ELISA dengan Human / TNFSF1A HS (R&D Systems). Jenis penelitian ini menggunakan metode analitik kuantitatif dengan membandingkan nilai kadar pada variabel kelompok terpajan dengan kelompok kontrol. Hasil penelitian menunjukkan bahwa pajanan berhubungan dengan nilai kadar dalam darah karakteristik pekerja yang merokok dan obesitas tidak berhubungan nilai kadar dalam darah Selain itu, hubungan umur dengan nilai kadar berhubungan sangat lemah Pajanan pada pekerja secara kronis menimbulkan inflamasi kronik dengan menghasilkan dalam darah melalui proses oxidative stress di dalam tubuh hingga menimbulkan gangguan pada sistem pernapasan dan sistem kardiovaskuler di dalam tubuh.
ABSTRAK
The exposure of particulate matter 2.5 (PM25) to human can provoke the occurrence of acute and chronic inflammatory that can potentially lead to abnormal cell change. Inflammation occurs due to body response to PM25 by discharging Tumor Necrosis Factor ? Alpha ) as protein inflammatory stimulus inside the body. This research aims to analyze the correlation between PM2.5 exposure concentration with level at Pengujian Kendaraan Bermotor (PKB) center Ujung Menteng and Pulogadung, also to analyze smoking status, obese category, and age of workers, by using independent T ? Test. Research samples of 42 workers at PKB Ujung Menteng and Pulogadung as exposed group and 27 workers of Faculty of Public Health Universitas Indonesia (FKM UI) as control group. Analysis of level in the blood is conducted at laboratory with quantitative sandwich enzyme immune assay / ELISA technique with Human / TNFSF1A HS (R&D Systems). This research is performed with quantitative analytical method by comparing level score on exposed group variable and control group variable. The research result showed that exposure correlated with level score in the blood characteristics on workers who smoke and obese are not correlated with level score in the blood. Other than that, the correlation between workers? age and level score is proven weak exposure on workers chronically inflicts chronic inflammatory by producing in the blood through oxidative stress process in the body causing disruption of respiratory and cardiovascular system in the body."
2016
S36318
UI - Skripsi Membership  Universitas Indonesia Library
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Jonathan Hartanto
Efek Pemberian Ekstrak Etanol Centella Asiatica L. terhadap Kadar Tumor Necrosis Factor-Alpha pada Jantung dan Ginjal Tikus Sprague-Dawley Tua = Effects of Centella Asiatica L. ethanolic extract administration on Tumor Necrosis Factor-Alpha Concentration in Hearts and Kidneys of Aged Sprague-Dawley Rats
"Pendahuluan: Saat ini, dunia secara global termasuk Indonesia tengah mengalami tren pesat peningkatan populasi lansia. Hal ini dapat menjadi tantangan kesehatan besar karena penuaan meningkatkan kerentanan terjadinya penyakit degeneratif. Sayangnya, agen antipenuaan seperti suplemen vitamin masih sulit terjangkau secara biaya atau diperoleh secara luas. Centella asiatica L. (CA) adalah tanaman herbal tradisional yang dilaporkan memiliki efek antiinflamasi dan antioksidan poten dalam banyak studi. Namun, studi yang meneliti efek CA dalam konteks penuaan masih sangat terbatas. Tujuan: Studi ini meneliti efek pemberian ekstrak etanol CA terhadap kadar TNF-α pada jantung dan ginjal tikus Sprague-Dawley tua Metode: Tikus Sprague Dawley jantan usia 8-12 minggu dan 20-24 bulan dibagi menjadi empat kelompok uji: kontrol positif (vitamin E 6 IU), kontrol negatif (air ad libitum), CA 300 (CA 300 mg/kgBB), dan kontrol muda (tikus usia 8-12 minggu dengan air ad libitum). Setelah 28 hari perlakuan, tikus diterminasi. Organ jantung dan ginjal setiap tikus diambil dan melewati pengukuran kadar TNF-α dengan metode enzyme-linked immunosorbent assay (ELISA). Hasil: Pada kelompok CA 300, terdapat penurunan kadar TNF-α jantung secara signifikan (p = 0,023) disertai penurunan kadar TNF-α ginjal secara tidak signifikan (p = 0,574). Namun, kadar TNF-α ginjal pada kelompok yang diberikan CA tetap paling rendah dibandingkan kelompok lainnya. Kesimpulan: Pemberian ekstrak etanol CA menurunkan kadar TNF- α jantung secara signifikan pada tikus Sprague-Dawley tua namun tidak berpengaruh terhadap kadar TNF-α ginjal. Diperlukan penelitian lebih lanjut untuk menyelidiki efek CA sebagai agen antipenuaan.
Introduction: Currently, the world including Indonesia are experiencing a trend of rapid growth in aging population. This poses a major challenge to healthcare due to increasing incidence of degenerative diseases. In spite of this, preventive antiaging agents such as vitamin supplements are not widely available nor affordable. Centella asiatica L. (CA), a traditional herbal plant native to Southeast Asia, has been widely studied and demonstrated potent anti-inflammatory and antioxidant effects in clinical studies. However, studies examining effects of CA in aging population are very limited. Objective: This study investigates effects of CA treatment on aged Sprague-Dawley rats. Methods: Male Sprague-Dawley rats aged 8-12 weeks and 20-24 months were split into four experimental groups: positive control (vitamin E 6 IU), negative control (water ad libitum), CA 300 (CA 300 mg/kgBW), and young control (young rats given water ad libitum). After 28 days of treatment, the rats underwent termination with kidneys and hearts harvested. TNF-α concentration were determined using enzyme-linked immunosorbent assay (ELISA) method. Results: In the CA 300 group, there was a significant decrease in heart TNF-α levels (p = 0,023) accompanied by an insignificant decrease in kidney TNF-α levels (p = 0,574). However, renal TNF-α levels in the group given with CA is still the lowest among all groups. Conclusion: The administration of CA ethanolic extract on aged Sprague-Dawley rats significantly reduced heart TNF-α level and had no effect on the kidney TNF-α level. Further research and exploration needs to be made to investigate the effects of CA as an antiaging agent"
Depok: Fakultas Kedokteran Universitas Indonesia, 2020
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Adang Sabarudin
Perubahan kadar tumor nekrosis faktor alfa dan interleukin 6 pada penderita ikterus obstruktif akibat kanker pankreatobilier yang menjalani drainase bilier = Change of tumor necrosis factor alpha and interleukin 6 in obstructive jaundice caused by pancreaticbiliary cancer with undergoing biliary drainage
"Latar Belakang: Ikterus obstruktif merupakan salah satu komplikasi tersering keganasan sistem bilier. Keadaan ini akan memicu pelepasan sitokin proinflamasi. Terdapat kontroversi mengenai pengaruh drainase bilier terhadap perubahan kadar sitokin proinflamasi pada penderita kanker pankreatobilier.
Tujuan: Untuk mengetahui kadar Tumor Necrosis Faktor alfa (TNF-alfa) dan Interleukin 6 (IL6) sebelum dan sesudah Endoscopic Retrograde Cholangio Pancreatography (ERCP) atau Percutaneus Transhepatic Biliary Drainage (PTBD) pada penderita ikterus obstruksi etiologi kanker pankreatobilier.
Metode: Desain penelitian adalah one group before after study. Pemilihan sampel secara consecutive sampling. Sampel darah diambil sebelum dan lima hari sesudah ERCP atau PTBD. Pengukuran kadar TNF-alfa dan IL-6 dengan cara Enzyme Linked Immunosorbed Assay (ELISA).
Hasil: Terdapat 40 orang responden yang diikutsertakan dalam penelitian ini, 22 laki laki dan 18 perempuan dengan usia rata rata 55,3 tahun. Berdasarkan imaging dan endoskopi, ditegakkan diagnosis kolangiokarsinoma sebanyak 22 orang, tumor ampula Vateri 10 orang, dan tumor pankreas 8 orang. Kadar rata-rata TNF- alfa sebelum tindakan 4,81 (2,91) pg/ml dan sesudah tindakan 8,05 (6,7) pg/ml, terdapat peningkatan yang bermakna setelah tindakan drainase bilier (p:0,02). Kadar rata-rata IL-6 sebelum tindakan 7,79 (1,57) pg/ml dan sesudah tindakan 7,75 (1,76) pg/ml, tidak terdapat perbedaan yang bermakna setelah tindakan drainase bilier (p:0.52). Kadar rata-rata bilirubin sebelum tindakan 15,5 mg% dan sesudah tindakan 11,3 mg%.
Simpulan: Terjadi peningkatan kadar rata-rata TNF-alfa secara bermakna setelah drainase. Tidak ada penurunan yang bermakna kadar rata-rata IL-6.
Background: Obstructive jaundice represents the most common complication of biliary tract malignancy. Obstructive jaundice causes releases of proinflammatory cytokine. There has been controversy about effect of biliary drainage on the change in proinflammatory cytokine level in pancreatobiliary cancer patients.
Objective: The present study was designed to determine levels of Tumor Necrosis Factor Alpha (TNF-Alpha) and Interleukin 6 (IL-6) in preprocedure of either Endoscopic Retrograde Cholangio Pancreatography (ERCP) or Percutaneus Transhepatic Biliary Drainage (PTBD) and postprocedure of them in obstructive jaundice patient caused by pancreatobiliary cancer.
Methods : The study method is before- and- after case study design with consecutive sampling. Blood was collected five days prior to either Endoscopic Retrograde Cholangio Pancreatography (ERCP) procedure or Percutaneus Transhepatic Biliary Drainage (PTBD) procedure and five days after either of them. Enzyme Linked Immunosorbed Assay (ELISA) was used to determine TNF-Alpha and IL-6.
Results: Forty subjects were included in this study which consisted of 22 men and 18 women. The mean age was 55.3 years old. According to the results of imaging and endoscopy procedure, twenty two (22) people were diagnosed cholangi carcinoma, ten (10) people were diagnosed ampulla varteri and eigth (8) people were diagnosed pancreatic tumor. In preprocedure, the mean of TNF-Alpha concentration was 4.81 (2.91) pg/mL, the mean of IL-6 concentration was 7.79 (1.57) pg/mL and the mean of bilirubin concentration was 15.5 mg%. In postprocedure, the mean of TNF-Alpha concentration was 8.05 (6.7) pg/mL, there was significant increase in TNF-Alpha concentration (p:0.02). However, the mean of IL-6 concentration was 7.75 (1.76) pg/mL, there was not any significant chance in IL-6 concentration (p:0.52). The mean of bilirubin concentration was 11.3 mg%.
Conclusions: On one hand, there was significant increase in mean concentration value of TNF-Alpha after biliary drainage procedure. On the other hand there was not any significant decrease in mean concentration value of IL-6 after biliary drainage procedure."
Depok: Fakultas Kedokteran Universitas Indonesia, 2016
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Agita Pramustika
Analisis ekspresi tumor necrosis factor-a pada pasien ortodontik yang menggunakan sistem self-ligating dan preadjusted edgewise appliance pada tahap awal perawatan = Tumor necrosis factor expression analysis in orthodontic patients with passive self ligating and conventional preadjusted brackets in initial stage of orthodontic treatment
"Fase awal pergerakan gigi ortodontik diawali dengan respon inflamasi akut. Proses ini menimbulkan respon dari sel paradental dan sel pertahanan tubuh dengan mensintesis dan melepaskan berbagai biomolekul seperti sitokin. Tumor necrosis factor-a TNF-? merupakan sitokin pro-inflamasi penting yang meregulasi respon awal inflamasi pada pergerakan gigi ortodontik. Tujuan dari penelitian ini adalah untuk menganalisis ekspresi TNF-? dengan membandingkan konsentrasinya pada gingival crevicular fluid GCF antara sistem self-ligating SL dan preadjusted edgewise appliance PEA pada tahap awal perawatan.
Metode: Delapan belas pasien usia 15-35 tahun yang berpartisipasi dalam penelitian ini dibagi menjadi dua kelompok eksperimental PEA dan SL dan satu kelompok kontrol tanpa perawatan ortodontik. Pasien dipilih berdasarkan kriteria inklusi: indeks iregularitas Little sebesar 4-9 mm pada anterior maksila dengan indikasi perawatan non-ekstrakasi serta tanpa karies aktif, penyakit periodontal, dan penyakit sistemik terkait kerusakan tulang. Cairan krevikular gingiva subjek diambil pada lima titik di anterior maksila sebelum perawatan dan pada: 1, 24, dan 168 jam setelah aplikasi gaya ortodontik. Konsentrasi TNF-? pada sampel GCF diperiksa menggunakan metode enzyme-linked immunoabsorbent assay ELISA.
Hasil: Konsentrasi TNF-? meningkat pada 1 jam dan 24 jam setelah aplikasi gaya ortodontik pada kedua sistem baik pada kelompok SL dan PEA. Konsentrasi TNF-? menurun signifikan pada 168 jam setelah aplikasi gaya ortodontik pada kelompok PEA. Sementara itu, pada kelompok SL konsentrasi TNF-? pada 168 jam tetap meningkat walaupun secara statistik tidak signifikan.
Kesimpulan: Konsentrasi TNF-? meningkat pada 1 jam dan 24 jam setelah aplikasi gaya ortodontik pada kelompok PEA dan SL. Pada kelopok PEA, konsentrasi TNF-? menurun signifikaan pada 168 jam, sedangkan pada kelompok SL konsentrasi TNF-? tetap meningkat. Perbedaan konsentrasi TNF-? antara kelompok PEA dan SL mungkin disebabkan oleh perbedaan braket, kawat, dan sistem ligasi yang digunakan antara kedua sistem tersebut.
The early phase of orthodontic tooth movement begins with acute inflammation response. This processes engender a response on the part of paradental cells and migrating inflammatory cells from periodontal ligament capillaries via the synthesis and release of various biomolecules such as cytokines. Tumor necrosis factor a TNF is an important pro inflammatory cytokine that regulates the early phase of inflammation reaction during orthodontic tooth movement. The aim of the present study was to analyze TNF expression by comparing its concentrations in the gingival crevicular fluid GCF between self ligating SL and preadjusted edgewise appliance PEA systems during the early levelling stage of orthodontic treatment.
Methods: Eighteen patients aged 15 35 years who participated in this study were divided into two experimental groups PEA and SL and control group without orthodontic treatment. Patients were selected according to the inclusion criteria Little irregularity index on maxillary anterior teeth ranging from 4 9 mm non extraction orthodontic treatment for the experimental group no active dental caries, periodontitis, and medical history of bone disorder. The GCF was taken at five sites in the maxilla anterior teeth from each subject just before bracket bonding and at 1, 24, and 168 hours after orthodontic force application. TNF levels in GCF were determined by enzyme linked immunoabsorbent assay ELISA.
Results: The concentration of TNF was significantly higher in the experimental groups than in the control group at 24 hours after force application. TNF levels were significantly decreased at 168 hours after force application in the PEA group. Meanwhile, in the SL group, the level of TNF at 168 hours was still increased, although there was no statistically significant difference.
Conclusion: TNF concentration was increased at 1 hour and 24 hours after orthodontic force application in both the PEA and SL groups. In the PEA group, TNF concentration was significantly decreased at 168 hours, meanwhile in the SL group, this value remained increased at this time point. The differences in TNF concentration between the PEA and SL groups may be caused by their different types of brackets, wires, and ligation methods."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2018
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Chikih
Pengaruh latihan fisik submaksimal akut pra-penyelaman dekompresi tunggal terhadap perubahan kadar tumor nekrosis faktor alpha pada penyelam laki-laki terlatih = Effect of acute submaximal physical exercise before decompression dive on tumor necrosis factor alpha concentration among trained male divers
"Latar Belakang : Terjadinya peningkatan biomarker inflamasi akibat penyelaman dekompresi merupakan salah satu faktor yang dapat menyebabkan terjadinya penyakit dekompresi, hal ini telah dibuktikan dengan terjadinya peningkatan ekspresi TNF? akibat penyelaman dekompresi tunggal. Pencegahan peningkatan biomarker inflamasi dapat dilakukan dengan memberikan perlakuan sebelum penyelaman dekompresi, sesuai dengan preconditioning theory, yang salah satunya adalah pemberian latihan fisik sebelum penyelaman yang dapat mengurangi ukuran dan jumlah gas bubble akibat penyelaman. Pengaruh latihan fisik sebelum penyelaman terhadap kadar biomarker inflamasi TNF? sesudah penyelaman belum pernah diteliti. Penelitian ini bertujuan untuk membuktikan bahwa latihan fisik sebelum penyelaman dekompresi dapat mencegah terjadinya peningkatan kadar biomarker inflamasi TNF?.
Metode : Penelitian ini menggunakan desain studi eksperimental murni dengan seluruh subjek penelitian adalah penyelam laki-laki terlatih, terbagi secara random kedalam dua kelompok, yaitu perlakuan dan kontrol, di mana kelompok perlakuan mendapatkan latihan fisik submaksimal dengan intensitas 70 frekuensi jantung maksimal menggunakan cycle ergometer dengan 60 kayuhan permenit, 24 jam sebelum penyelaman dekompresi 280 kPa bottom time 80 menit, pada kelompok kontrol tidak diberikan latihan fisik submaksimal. Ekspresi biomarker diperiksa sebanyak tiga kali, awal penelitian, sebelum penyelaman dan sesudah penyelaman.
Hasil : Pada kelompok perlakuan tidak terjadi peningkatan, bahkan terjadi penurunan eskpresi TNF? yang tidak bermakna, dari 7.06 1.85 pg/ml menjadi 6,75 1,81 pg/ml, sedangkan kelompok kontrol mengalami peningkatan ekspresi TNF? yang bermakna, dari 8,22 1,45-13,11 pg/ml menjadi 8,39 1,73-12,18 pg/ml, dan terdapat perbedaan selisih rerata yang signifikan antara kelompok yang mendapatkan latihan fisik sebelum penyelaman dan kelompok yang tidak mendapatkan latihan fisik sebelum penyelaman dengan perbedaan rerata -024 -2.74 - 1.67 pg/ml dan 0.45 -0.94 ndash; 0.95 pg/ml.
Kesimpulan dan Saran : Latihan fisik submaksimal akut dapat mencegah terjadinya peningkatan kadar TNF? akibat penyelaman dekompresi tunggal.
Background : The increase of Inflammatory biomarkers due to decompression dive is one of the factors that could cause decompression sickness, which has been proven by the increased expression of TNF due to a single decompression dive. According to the preconditioning theory, physical exercise before the dive, can reduce the size and the amount of gas bubble caused by the dive, but no research has been done on the influence of physical exercise before diving to the expression of inflammatory biomarkers like TNF. This study aims to prove that physical exercise before diving can prevent increase of the inflammatory biomarker TNF.
Methods : This study used an experimental study design with trained male divers as a subjects, who are divided randomly into two groups, treatment and control. The treatment group got submaximal physical exercise with 70 maximal cardia rate intensity, using cycle ergometer 24 hours before decompression diving 280 kPa bottom time 80 minute, whereas the control group did not get physical exercise. Biomarker expression was checked three times, at beginning of the study, before the dive and after the dive.
Results : In the treatment group there was no increase in TNF expression, and even showed an insignificant decrease, from 7.06 1.85 pg ml to 6.75 1.81 pg ml, whereas the control group showed a significant increased TNF concentration, from 8.22 1.45 to 13.11 pg ml to 8.39 1.73 to 12.18 pg ml, and significant difference was found between the mean difference of treatment and control groups from 0.24 2.74 ndash 1.67 pg ml and 0.45 0.94 ndash 0.95 pg ml.
Conclusions and Recommendations : It can be concluded that acute submaximal physical exercise prevent an increase in the expression of TNF after single dive decompression. "
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2017
T55644
UI - Tesis Membership  Universitas Indonesia Library
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