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"Pemberian terapi yang sesuai, khususnya obat antiepilepsi (OAE) sebagai terapi utama dapat menyembuhkan pasien penyandang epilepsi.Seringkali faktor yang berkaitan erat dengan pemberian OAE kurang diperhatikan.Oleh karena itu, penelitian yang dilakukan penulis membahas bagaimana hubungan antara faktorfaktor yang memengaruhi respons terapi pada anak penyandang epilepsi.Penelitian dilakukan dengan metode cross-sectional, yaitu dengan menggunakan data sekunder dari rekam medis epilepsy registry pada pasien anak di Departemen Ilmu Kesehatan Anak RSUPN Cipto Mangunkusumo dengan tanggal kunjungan 1995-2010. Dari penelitian, ditemukan bahwa dari 174 subyek penelitian, 76,4% mengalami bangkitan umum dan 23,6% mengalami bangkitan fokal. Terdapat 62,1% subyek yang mengalami epilepsi simtomatik dan 37,9% epilepsi idiopatik. Sembilan puluh enam koma enam persen subyek mendapatkan regimen yang sesuai dengan lini pertama, 63,8% mendapatkan OAE dengan dosis sesuai, 77,0% subyek mendapatkan terapi tunggal (monoterapi), dan 70,3% tidak mengalami perubahan regimen selama terapi. Dari analisis bivariat menggunakan uji Chi-Square maupun Fisher's, tidak ditemukan hubungan yang signifikan baik untuk faktor kesesuaian regimen, dosis OAE, kombinasi OAE, maupun perubahan regimen selama terapi (seluruhnya memiliki nilai p > 0,05). Namun, nilai OR masing-masing faktor menunjukkan hasil yang sesuai dengan teori sehingga dapat disimpulkan bahwa secara klinis respons bebas kejang akan didapatkan pada pasien yang mendapatkan regimen sesuai, dosis sesuai, monoterapi, dan tidak ada pergantian regimen. Adapun bila dikaitkan dengan klasifikasi epilepsi yang dialami, pasien dengan epilepsi idiopatik memiliki kecenderungan mendapatkan respons bebas kejang (OR=1,407 95%CI 0,732-2,705). Analisis multivariat menggunakan uji regresi logistik menunjukkan monoterapi menjadi faktor yang terkuat dalam pencapaian respons terapi epilepsi walaupun hasil pada penelitian ini tidak signifikan.

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Appropiate therapy admission, especially antiepileptic drugs (AED) as the main therapy for epileptic patients, might help the patients to achieve its maximum recovery. Health care providers don?t pay much attention to factors related to AED admission. Therefore, this research was determined to analyze the association between several factors affecting treatment response in children with epilepsy. This research is a cross-sectional study, using secondary data from epilepsy registry medical record in pediatric patient at Pediatric Health Department of RSUPN Cipto Mangunkusumo during 1995-2010. This study showed that among 174 subjects, 76.4% subjects had general seizure and 23.6% subjects had focal seizure. It is also found that 62.1% subjects had symptomatic epilepsy and 37.9% subjects had idiophatic epilepsy. Ninety six point six percent subjects had appropriate regiment with first-line drugs, 63.8% subjects had appropriate AED dose, 77.0% subjects received monotherapy, and 70.3% did not receive any regiment modification during therapy. Through bivariate analysis using Chi-Square and Fisher?s test: there were no significant association between regiment compatibility, AED dose, AED combination, and regiment modification during therapy (p > 0.05). However, the odds ratio (OR) of each factors showed corresponding result with the theory. In conclusion, seizure-free response will be achieved by patients who had appropriate regiment, appropriate dose, monotherapy, and no regiment modification. Analysis about association between epilepsy classification and therapy response showed that patient with idiophatic epilepsy tended to be easier to be seizure-free. Multivariate analysis using logistic regression showed that monotherapy was the strongest factor affecting therapy response, even though in this study it was not statistically significant."

"Epilepsi merupakan penyakit kronik dengan gejala yang cukup khas yaitu adanya bangkitan kejang tanpa pemicu. Angka prevalensi epilepsi tergolong tinggi di Indonesia dan hal ini merupakan masalah yang harus segera diatasi. Selain itu, epilepsi pada anak dapat menyebabkan berbagai gangguan perkembangan. Salah satu pemeriksaan penunjang untuk mendiagnosis klasifikasi epilepsi yang tersedia saat ini adalah EEG yang memberikan gambaran pola gelombang spesifik tertentu. Oleh karena itu, dalam penelitian ini akan dianalisis hubungan antara epilepsi pada anak dengan gambaran EEG serta perkembangan anak. Desain penelitian ini adalah potong lintang dengan menggunakan data sekunder rekam medik dari Departemen Ilmu Kesehatan Anak RSUPN Cipto Mangunkusumo tahun 1995-2010. Hasil penelitian ini menunjukkan bahwa terdapat 115 anak (61,5%) dengan klasifikasi epilepsi simtomatik, 105 anak (56,1%) dengan gambaran EEG abnormal, dan 96 anak (51,3%) dengan perkembangan terlambat. Dari hasil analisis hubungan antar variabel menggunakan Chi-Square, terdapat hubungan bermakna antara perkembangan anak dengan klasifikasi epilepsi (p<0,001) disertai dengan hubungan bermakna antara aspek perkembangan yaitu motorik kasar (p<0,001), sosial personal (p=0,024), dan bahasa (p<0,001) tetapi tidak ada hubungan bermakna antara aspek motorik halus terhadap klasifikasi epilepsi.Tidak ada hubungan bermakna antara gambaran EEG secara umum dengan klasifikasi epilepsi tetapi terdapat hubungan bermakna antara adanya gambaran epileptiform multifokal (p=0,018) dan nonspesifik (p=0,015) terhadap klasifikasi epilepsi.

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Epilepsy is a chronic disease with typical symptom, seizure without provocation. The prevalence of epilepsy in Indonesia can be classified as high which creates another health problem to overcome. Furthermore, epilepsy in children may cause variety of development impairment. EEG is one of the current available examination to diagnose the classification of epilepsy through specific wave pattern findings. Therefore, this study is determined to analyze the association between epilepsy in children with EEG recording and child development. This study is a cross-sectional study using secondary data from Child Health Department of RSUPN Cipto Mangunkusumo medical records from 1995-2010.The result of the study shows that 115 subjects (61,5%) has symptomatic epilepsy, 105 subjects (56,1%) with abnormal EEG finding, and 96 subjects (51,3%) with delayed development. After performing Chi-Square test, there is a significant association between child development and epilepsy classification (p<0,001)followed by significant association between gross motoric (p<0,001), social personal (p=0,024), and language (p<0,001), however there were no association between gross motoric and epilepsy classification.There were no association between EEG recording with epilepsy classification,however there were a significant association between multifocal epileptiform finding (p=0,018) and nonspecific wave finding (p=0,015) to classify epilepsy"

"ABSTRAKLatar Belakang: Konstipasi pada anak merupakan masalah kesehatan dengan prevalensi yang cukup tinggi di dunia. Konstipasi pada anak memiliki dampak penurunan kualitas hidup pada orang tua dan anak, serta menimbulkan beban ekonomi untuk segi pelayanan kesehatan. Konstipasi fungsional pada anak bersifat multifaktorial. Faktor-faktor risiko konstipasi anak bervariasi pada setiap tempat. Penelitian ini bertujuan untuk mengetahui faktor-faktor risiko konstipasi fungsional pada anak di Rumah Sakit Cipto Mangunkusumo Jakarta tahun 2013-2016. Metode: Penelitian ini menggunakan data sekunder rekam medis yang terdapat di Departemen Ilmu Kesehatan Anak RSCM dengan desain penelitian potong lintang. Hasil: Hasil penelitian menunjukkan prevalensi konstipasi anak di RSCM adalah 6,85 dengan 84 diantaranya merupakan konstipasi fungsional. Melalui analisis bivariat, didapatkan hasil konsumsi ASI eksklusif p=0,088, status gizi p=1,000, riwayat keluarga p=0,332, urutan anak dalam keluarga p=0,076, dan riwayat toilet training p=1,000 tidak berhubungan bermakna dengan kejadian konstipasi fungsional anak. Pada analisis multivariat dengan menggunakan regresi logistik, didapatkan variabel yang paling berhubungan dan signifikan terhadap konstipasi fungsional anak adalah jenis kelamin OR 6,696; IK95 1,224-36,620; p=0,028. Kesimpulan: Jenis kelamin adalah faktor paling berhubungan terhadap konstipasi fungsional anak, hasil ini berbeda dengan penelitian sebelumnya.

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ABSTRACTBackground Childhood constipation is one of the health problem with high prevalence worldwide. It affects both patients and parents quality of life. It also causes economic burdens especially for health services. Childhood constipation is multifactorial. Risk factors of childhood functional constipation differs from one place to another. This study aimed to determine factors associated with childhood functional constipation in Cipto Mangunkusumo hospital Jakarta year of 2013 2016. Methods This cross sectional study used secondary data from medical records in the Pediatrics Department RSCM. Results The results showed that the prevalence of childhood constipation is 6.85 with 84 among those are functional constipation. Through the bivariate analysis, it was found that exclusive breast milk consumption p 0.088, nutritional status p 1.000, family history p 0.332, the order of children in the family p 0.076, and history of toilet training p 1.000 were not significantly related with childhood functional constipation. On multivariate analysis with logistic regression, it was found that gender was associated with childhood functional constipation OR 6.696 IK95 1.224 36.620 p 0.028 . Conclusion It was found that gender was associated with childhood functional constipation. This result differs from other previous studies. "

"Latar Belakang Asma persisten banyak terjadi pada anak di bawah usia tiga hingga enam tahun. Karakteristik pada anak dengan asma persisten cukup bervariasi sehingga menyebabkan anak rentan mengalami kondisi yang tidak terkendali jika tidak segera ditangani. Di Indonesia, belum ada data yang menggambarkan karakteristik anak dengan asma persisten dan faktor-faktor yang memengaruhi derajat kendalinya. Metode Desain penelitian potong lintang dilakukan terhadap 81 anak berusia 6-18 tahun dengan asma persisten yang melakukan kontrol ke RSCM dalam rentang tahun 2019-2023. Pemilihan sampel dan pengambilan data dilakukan menggunakan rekam medis milik RSCM Kiara dengan metode total sampling. Hasil Asma persisten yang tidak terkendali terjadi pada 53 subjek (65.4%). Sebagian besar subjek berada dalam rentang usia 6-11 tahun (61.7%), berjenis kelamin laki-laki (55.6%), terpapar oleh alergen (72.8%), faktor lingkungan (34.6%), memiliki komorbiditas (88.9%), berada dalam kelompok gizi baik (43.2%), patuh terhadap pengobatan (74.1%), dan menggunakan terapi pengendali jenis metered dose inhaler (84.0%). Dari hasil analisis bivariat dan regresi logistik, tidak ada karakteristik yang menunjukkan hubungan signifikan terhadap derajat kendali asma. Kesimpulan Terdapat 65.4% anak dengan asma persisten yang tidak terkendali. Tidak ada karakteristik yang berhubungan signifikan dan berperan sebagai prediktor independen dengan derajat kendali asma.

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Introduction Persistent asthma often occurs in children under the age of three to six years. The characteristics of children with persistent asthma are quite varied, making children vulnerable to experiencing uncontrollable conditions if not treated immediately. In Indonesia, there is no data that describes the characteristics of children with persistent asthma and the factors that influence the level of control. Method A cross-sectional research design was carried out on 81 children aged 6-18 years with persistent asthma who underwent control at RSCM in the period 2019-2023. Sample selection and data collection were carried out using medical records belonging to RSCM Kiara using the total sampling method. Results Persistent uncontrolled asthma occurred in 53 subjects (65.4%). Most of the subjects were in the age range of 6-11 years (61.7%), male (55.6%), exposed to allergens (72.8%), environmental factors (34.6%), had comorbidities (88.9%), were in the healthy weight group (43.2%), adherent to treatment (74.1%), and used metered dose inhaler control therapy (84.0%). From the results of bivariate analysis and logistic regression, there were no characteristics that showed a significant relationship to the level of asthma control. Conclusion There are 65.4% of children with persistent uncontrolled asthma. There were no characteristics that were significantly related and acted as independent predictors with the level of asthma control."

"[ABSTRAK Latar belakang Pemeriksaan EEG merupakan modalitas terpenting dalam diagnosis multi aksial pada epilepsi dan pemberian obat anti epilepsi yang tepat Sensitivitas EEG untuk memperoleh gelombang epileptiform cukup rendah sehingga berbagai upaya dilakukan untuk meningkatkan sensitivitas EEG Faktor faktor yang memengaruhi kejadian gelombang epileptiform telah banyak diteliti pada pasien dewasa namun belum ada penelitian yang spesifik pada anak Tujuan Mengetahui proporsi kejadian gelombang epileptiform pada EEG anak dengan epilepsi dan faktor faktor yang berpengaruh Metode Studi potong lintang terhadap 110 anak epilepsi usia 1 bulan 18 tahun yang datang ke Poliklinik EEG Kiara RSCM dari bulan Mei hingga September 2015 Faktor faktor yang dianggap berpengaruh dianalisis secara multivariat dengan uji regresi logistik Hasil Proporsi munculnya gelombang epileptiform sebesar 48 110 43 6 Pada analisis bivariat didapatkan faktor yang berpengaruh terhadap munculnya gelombang epileptiform adalah lama anak terbangun hingga dilakukannya pemeriksaan EEG p 0 034 OR 2 449 IK95 1 071 5 599 dan jarak kejang terakhir dengan EEG p 0 005 OR 3 037 IK95 1 386 6 626 Pada analisis multivariat didapatkan faktor yang paling berpengaruh terhadap kejadian gelombang epileptiform adalah jarak kejang terakhir dengan EEG p 0 016 OR 2 671 IK95 1 198 5 957 Simpulan Jarak kejang terakhir dengan pemeriksaan EEG kurang dari 3 hari dan deprivasi tidur parsial selama 6 jam merupakan faktor terjadinya gelombang epileptiform pada EEG anak dengan epilepsi ABSTRACT Background Top of Form EEG is an important modality in the multi axial diagnosis of epilepsy and therapy Sensitivity of EEG was low so efforts were made to improve it Factors related to the occurence of epileptiform waves has been studied in adult patients but no specific studies in children Top of Form Objectives Determine proportion of epileptiform waves in the EEG of children with epilepsy and identify the factors related to the occurence of epileptiform waves Methods This is a cross sectional study on 110 children with epilepsy aged 1 month 18 years old who came to the EEG outpatient clinic at Kiara Cipto Mangunkusumo hospital from May to September 2015 Related factors was analyzed using multivariate Results The proportion of epileptiform waves was 48 110 43 6 Results in bivariate analysis revealed related factors were the duration of awakeness p 0 034 OR 2 499 95 CI 1 071 5 599 and the duration of last seizure until EEG done p 0 005 OR 3 037 95 CI 1 386 6 626 In the multivariate analysis duration of last seizure until EEG done was the most related factors to the occurence of epileptiform waves p 0 016 OR 2 671 95 CI 1 198 5 957 Conclusion Factors related to the occurence of epileptiform waves are duration of last seizure until EEG done less than 3 days and patial deprivation for 6 hours ;Background Top of Form EEG is an important modality in the multi axial diagnosis of epilepsy and therapy Sensitivity of EEG was low so efforts were made to improve it Factors related to the occurence of epileptiform waves has been studied in adult patients but no specific studies in children Top of Form Objectives Determine proportion of epileptiform waves in the EEG of children with epilepsy and identify the factors related to the occurence of epileptiform waves Methods This is a cross sectional study on 110 children with epilepsy aged 1 month 18 years old who came to the EEG outpatient clinic at Kiara Cipto Mangunkusumo hospital from May to September 2015 Related factors was analyzed using multivariate Results The proportion of epileptiform waves was 48 110 43 6 Results in bivariate analysis revealed related factors were the duration of awakeness p 0 034 OR 2 499 95 CI 1 071 5 599 and the duration of last seizure until EEG done p 0 005 OR 3 037 95 CI 1 386 6 626 In the multivariate analysis duration of last seizure until EEG done was the most related factors to the occurence of epileptiform waves p 0 016 OR 2 671 95 CI 1 198 5 957 Conclusion Factors related to the occurence of epileptiform waves are duration of last seizure until EEG done less than 3 days and patial deprivation for 6 hours ;Background Top of Form EEG is an important modality in the multi axial diagnosis of epilepsy and therapy Sensitivity of EEG was low so efforts were made to improve it Factors related to the occurence of epileptiform waves has been studied in adult patients but no specific studies in children Top of Form Objectives Determine proportion of epileptiform waves in the EEG of children with epilepsy and identify the factors related to the occurence of epileptiform waves Methods This is a cross sectional study on 110 children with epilepsy aged 1 month 18 years old who came to the EEG outpatient clinic at Kiara Cipto Mangunkusumo hospital from May to September 2015 Related factors was analyzed using multivariate Results The proportion of epileptiform waves was 48 110 43 6 Results in bivariate analysis revealed related factors were the duration of awakeness p 0 034 OR 2 499 95 CI 1 071 5 599 and the duration of last seizure until EEG done p 0 005 OR 3 037 95 CI 1 386 6 626 In the multivariate analysis duration of last seizure until EEG done was the most related factors to the occurence of epileptiform waves p 0 016 OR 2 671 95 CI 1 198 5 957 Conclusion Factors related to the occurence of epileptiform waves are duration of last seizure until EEG done less than 3 days and patial deprivation for 6 hours , Background Top of Form EEG is an important modality in the multi axial diagnosis of epilepsy and therapy Sensitivity of EEG was low so efforts were made to improve it Factors related to the occurence of epileptiform waves has been studied in adult patients but no specific studies in children Top of Form Objectives Determine proportion of epileptiform waves in the EEG of children with epilepsy and identify the factors related to the occurence of epileptiform waves Methods This is a cross sectional study on 110 children with epilepsy aged 1 month 18 years old who came to the EEG outpatient clinic at Kiara Cipto Mangunkusumo hospital from May to September 2015 Related factors was analyzed using multivariate Results The proportion of epileptiform waves was 48 110 43 6 Results in bivariate analysis revealed related factors were the duration of awakeness p 0 034 OR 2 499 95 CI 1 071 5 599 and the duration of last seizure until EEG done p 0 005 OR 3 037 95 CI 1 386 6 626 In the multivariate analysis duration of last seizure until EEG done was the most related factors to the occurence of epileptiform waves p 0 016 OR 2 671 95 CI 1 198 5 957 Conclusion Factors related to the occurence of epileptiform waves are duration of last seizure until EEG done less than 3 days and patial deprivation for 6 hours ]"