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"Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ?unit dose? and ?unit effect? with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics."

"This book addresses biometrics from a biomedical engineering point of view. Divided into five sections, it discusses topics including the influence of pathologies on various biometric modalities (e.g. face, iris, fingerprint), medical and security biometrics, behavioural biometrics, instrumentation, wearable technologies and imaging. The final chapters also present a number of case studies. "

"Planning construction of a new library facility or renovation of an existing one can be a daunting task. With the new fifth edition of his Checklist of Library Building Design Considerations, veteran library administrator and construction consultant William Sannwald guides librarians and other members of a building design team through the stages of the design process. Updated materials include# A new chapter on sustainable design, including issues of site selection, air quality, and energy and water efficiency# New sections on wireless networking, information commons and media production and presentation labs# Updated treatment of special collections and materials handling systems# A new section on disaster planning# ADA Accessibility Guidelines section reorganized to match structure of the federal statuteBecause construction projects are complex and sometimes unwieldy, Sannwald's checklist format provides a clear, concise way of itemizing the issues."