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"This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors? own laboratories."

"This completely updated second edition of Radiation exposure and image quality in x-ray diagnostic radiology provides the reader with detailed guidance on the optimization of radiological imaging. The basic physical principles of diagnostic radiology are first presented in detail, and their application to clinical problems is then carefully explored. The final section is a supplement containing tables of data and graphical depictions of X-ray spectra, interaction coefficients, characteristics of X-ray beams, and other aspects relevant to patient dose calculations. In addition, a complementary CD-ROM contains a user-friendly Excel file database covering these aspects that can be used in the reader’s own programs. "

"Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes w."

"This book offers an overview of state-of-the-art in non amplified DNA detection methods and provides chemists, biochemists, biotechnologists and material scientists with an introduction to these methods. In fact all these fields have dedicated resources to the problem of nucleic acid detection, each contributing with their own specific methods and concepts. This book will explain the basic principles of the different non amplified DNA detection methods available, highlighting their respective advantages and limitations. Non-amplified DNA detection can be achieved by adopting different techniques. Such techniques have allowed the commercialization of innovative platforms for DNA detection that are expected to break into the DNA diagnostics market. The enhanced sensitivity required for the detection of non amplified genomic DNA has prompted new strategies that can achieve ultrasensitivity by combining specific materials with specific detection tools. Advanced materials play multiple roles in ultrasensitive detection. Optical and electrochemical detection tools are among the most widely investigated to analyze non amplified nucleic acids. Biosensors based on piezoelectric crystal have been also used to detect unamplified genomic DNA. The main scientific topics related to DNA diagnostics are discussed by an outstanding set of authors with proven experience in this field."

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ABSTRACTOral bacteria are the first human microbiome to encounter the food we eat. To date, most research has focused on the role of oral bacteria in the development and progression of caries and periodontal disease; however, little is known about the microbial communities that maintain a healthy oral cavity. This book, Oral Microbial Communities: Genomic Inquiry and Interspecies Communication, helps readers understand how multispecies microbial communities function to maintain and promote oral health as well as disease. It explores the immense opportunities presented by readily accessible, genetically tractable, genome-sequenced oral species that naturally form multispecies communities. Emphasizing the use of genomic inquiry to probe questions, Oral Microbial Communities examines multispecies community interactions, spatiotemporal organization, and gene function. Readers will find coverage of all the major microbe species currently under investigation by leading oral microbiologists. In particular, the book highlights model systems that study oral bacterial interactions, including biofilm growth using saliva as the source of nutrition."

"A rapid and simple to amplify genomic DNA sequences nanking mini-Tn5 transposon insertion was developed....."

"Algoritma pencarian string telah menjadi topik yang ramai dibicarakan di dunia komputer sejak berpuluh-puluh tahun yang lalu. Banyak para ahli yang mencoba menemukan algoritma pencarian string yang dapat memberikan hasil yang tepat dalam waktu singkat. Algoritma-algoritma baru bermunculan untuk memperbaiki kinerja algoritma pencarian string yang telah ada sebelumnya. Pentingnya sebuah algoritma pencarian string yang mampu memberikan hasil yang tepat dalam waktu yang relatif cepat memang sangat beralasan. Mengingat manipulasi string sangat diperlukan dalam dunia komputer. Banyak hal yang dapat dilakukan dengan adanya algoritma pencarian string yang handal. Permasalahan yang sering berkaitan dengan pengolahan string adalah mengenai ukuran data yang sangat besar dan juga pola atau karakteristik string yang berbedabeda. Ukuran data yang sangat besar jelas memberikan pengaruh yang besar terhadap waktu serta space yang dibutuhkan untuk melakukan pencarian. Sedangkan karakteristik dari string yang akan diproses berpengaruh terhadapkematangan sebuah algoritma pencarian string. Algoritma yang dapat bekerja dengan baik pada string umum (string yang terdiri dari banyak jenis karakter serta tidak memiliki pola tertentu) belum tentu dapat memberikan hasil yang sama apabila diterapkan pada string yang khusus. String khusus yang dimaksudkan di sini adalah string yang hanya terdiri dari karakter-karakter tertentu saja ataupun string yang memiliki pola tertentu. Salah satu string khusus yang berbeda dari string yang akrab dengan kehidupan manusiasehari-hari adalah string yang berisi informasi DNA mahluk hidup. Jenis string ini hanya terdiri dari empat karakter inti, yaitu A, C, G, dan T. Hanya dari empat karakter tersebut, dapat tersusun milyaran informasi DNA yang berbeda-beda. Pencarian string pada data DNA (data genomic), merupakan suatu permasalahan yang patut diberikan perhatian khusus. Karena penelitian mengenai DNA mahluk hidup merupakan suatu penelitian yang mendatangkan banyak sekali manfaat bagi seluruh mahluk hidup. Manfaat dari proses pencarian atau pencocokan string pada data genomic antara lain adalah untuk mengetahui kemiripan suatu mahluk hidup dengan mahluk hidup lain ataupun juga mengetahui manfaat dari suatu protein SK-661-Pencarian string dgn...DesianaNurulM.;FASILKOM;2007 iv tertentu dengan melakukan perbandingan dengan protein-protein yang terdapat di bank data protein. Oleh karena itu, sangat beralasan jika algoritma pencarian string untuk data genomic yang dapat memberi kan hasil yang tepat dalam waktu yang singkat sangat diperlukan."