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"Hubungan pertumbuhan kraniofacial, tinggi badan, dan tahapan maturasi tulang servikal. Periode tumbuh kembang bermanfaat untuk mengobati pasien yang memerlukan perawatan orthodontik. Dalam periode pertumbuhan kraniofasial dapat dimodifikasi. Indikator yang dapat digunakan untuk menilai tumbuh kembang antara lain adalah tinggi tubuh dan tahap perkembangan vertebra servikalis (CVMS). Beberapa studi sebelumnya telah menunjukkan bahwa pertumbuhan kraniofasial mirip dengan pertumbuhan badan dan ada perbedaan antara anak laki-laki danperempuan. Tujuan: Mengidentifikasi korelasi antara pertumbuhan kraniofasial, tinggi tubuh dan CVMS pada anak laki-laki dan perempuan dalam kelompok Deutero-Malay berusia 10-17 tahun. Metode: Studi potong lintang dilakukan dengan sampel 158 subjek (72 lelaki dan 86 perempuan). Pertumbuhan kraniofasial dinilai dalam lima dimensi (N-Me, S-Go, S-NA, PNS-A, Go-Pog), CVMS dijelaskan oleh metode Baccetti, selanjutnya dilakukan pengukuran tinggi tubuh. Hasil: Koefisien korelasi Pearson dan Spearman menunjukkan tinggi memiliki hubungan yang lebih kuat dengan CVMS daripada dengan pertumbuhan kraniofasial pada kelompok anak laki-laki dan perempuan (r=0,838; p<0,05) (r=0,647; p<0,05). Koefisien korelasi kraniofasial tinggi (Na-Me, S-Go) dan panjang mandibula (Go-Pog) memiliki hubungan yang kuat dengan CVMS (r=0,458; r=0,465; r=0,545; p<0,05) dibandingkan dengan panjang kraniofasial (S-N, PNS-A) pada kelompok anak laki-laki dan perempuan (r=0,283; r=0,237; p<0,05). T-test mengungkapkan perbedaan ketinggian tubuh (p<0,005) dan pertumbuhan kraniofasial antara laki-laki dan perempuan pada kelompok usia 13-15 tahun (p<0,05). Tes Mann-Whitney mengungkapkan perbedaan CVMS antara anak laki-laki dan perempuan pada kelompok usia 10-17 tahun (p<0,05). Simpulan: Tinggi tubuh, tinggi kraniofasial, dan panjang mandibula berhubungan dengan CVMS.

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Growth and development period has benefit for treating patient who need orthodontic treatment. In this period craniofacial development can be modified. Indicators that can be used assess the growth and development among others are through body height and cervical vertebrae maturity stages (CVMS). Several previous studies have indicated that craniofacial growth is similar to body growth and there is gender difference between boys and girls. Objectives: Identifying correlation between craniofacial growth, body height and CVMS between gender in Deutero-Malay group aged 10-17 years old. Methods: A cross sectional study was conducted with samples of 158 subjects (72 males and 86 females). Craniofacial growth assessed in five dimensions (N-Me, S-Go, S-NA, PNS-A, Go-Pog), CVMS as described by Baccetti's method, body height was measured. Results: Pearson and Spearman's correlation coefficient revealed body height has stronger relationship with CVMS than craniofacial growth (r=0.838; p<0.05) (r= 0.647; p<0.05). Correlation coefficient craniofacial height (Na-Me, S-Go) and mandibula length (Go-Pog) have stronger relationship with CVMS (r=0.458; r=0.465; r=0.545; respectively p<0.05) than the length of craniofacial (S-N, PNS-A) in boys and girls group (r=0.283; r=0.237; p<0.05). T-test revealed difference in body height (p<0.05) and craniofacial growth between boys and girls in group age 13-15 years old (p<0.05). Mann-Whitney test revealed differences in CVMS between males and females in age 10-17 years old (p<0.05). Conclusions: Body height, craniofacial height and mandibular length were correlated with CVMS."

"ABSTRAKBinders syndrome or maxillonasal dysostosis is a rare congenital condition that primarily affects the mid face and sometimes the vertebrae. It was named after von Binder who described three cases of hypoplastic maxilla nasal complex in 1962. It can either occur as a sporadic mutation or may be inherited in an autosomal recessive pattern with incomplete penetrance. Decrease in the naso labial angle, flat forehead, dish shaped face, absence of protrusion of nasal tip, absence of nasal flare with triangular or semilunar nostrils, palpable depression in the nasal floor and a class III tendency are characteristic of the syndrome. Vertebral anomalies are seen in some patients owing to the parallel development of the nasal complex and vertebrae in the third month of intrauterine life. Prenatal diagnosis may be done using ultrasonography at 21 weeks of pregnancy. A multi disciplinary approach towards planning of treatment for individuals with Binders syndrome includes orthodontic treatment along with osteotomies and grafting to correct the nasal and mid face defects."

"Tujuan: Tujuan dari penelitian ini adalah untuk mengevaluasi korelasi antara polimorfisme gen Bone Morphogenetic-2 (BMP-2) rs1005464 dan rs235768 dengan pertumbuhan dan perkembangan kraniofasial pada maloklusi skeletal kelas I, II, dan III; dan untuk mengetahui kerentanan Bone Morphogenetic Protein-2 (BMP-2) terhadap tipe wajah dan arah pertumbuhan. Bahan dan Metode: Populasi subjek terdiri dari 150 pasien ortodontik dewasa yang menjalani perawatan ortodontik di Klinik Spesialis Ortodontik Fakultas Kedokteran Gigi dan Mulut Universitas Indonesia. Subjek dibagi menjadi beberapa kelompok berdasarkan kasus maloklusi skeletal kelas I, II, dan III; tipe wajah (mesofacial, dolichofacial, brachyfacial) dan arah pertumbuhan wajah (normal, hyperdivergent, hypodivergent) dikonfirmasi dengan radiografi sefalometrik lateral. Ekstraksi DNA dilakukan dengan potongan rambut subjek, metode polymerase chain reaction, dan Sanger sequencing digunakan untuk menganalisis subjek. Koefisien korelasi Pearson dan regresi logistik berganda dihitung untuk menganalisis korelasi dan kerentanan BMP-2 rs1005464 dan rs235768, pohon filogenetik dibuat untuk mengevaluasi evolusi gen. Hasil: Distribusi genotip BMP-2 rs1005464 dan rs235768 menunjukkan distribusi yang konsisten, menunjukkan bahwa varian tersebut dapat menjadi bioindikator genetik pola pertumbuhan dan perkembangan kraniofasial. Koefisien korelasi Pearson menunjukkan bahwa BMP-2 rs1005464 dan rs235768 berkorelasi signifikan dan kerentanan dengan pasien maloklusi skeletal kelas I, II, dan III. Sanger sequencing menunjukkan adanya distribusi yang konsisten polimorfisme gen BMP-2 rs1005464 dan rs235768 dan pohon filogenetik menunjukkan BMP-2 rs1005464 memiliki kecenderungan maloklusi skeletal kelas I dan III sedangkan BMP-2 rs235768 terhadap maloklusi skeletal kelas II. Kesimpulan: Studi ini menunjukkan bahwa BMP-2 rs1005464 dan rs235768 berkorelasi signifikan, dan kerentanan terhadap pola pertumbuhan dan perkembangan Kraniofasial pada Maloklusi Skeletal kelas I, II, dan III.

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Objectives:The purpose of this study was to evaluate the correlation between Bone Morphogenetic-2 (BMP-2) gene polymorphisms rs1005464 and rs235768 with craniofacial growth and development in skeletal malocclusion classes I, II, and III; and to determine the susceptibility of Bone Morphogenetic Protein-2 (BMP-2) against the facial types and growth direction. Materials and Methods: The subject population consisted of 150 adult orthodontic patients who underwent orthodontic treatment at the Orthodontic Clinic Specialist for the Dental Oral Education University of Indonesia. Subjects were divided into groups based on cases of skeletal malocclusion classes I, II, and III; facial types (mesofacial, dolichofacial, brachyfacial) and the direction of facial growth (normal, hyperdivergent, hypodivergent) were confirmed by lateral cephalometric radiograph. DNA extraction was carried out by haircuts of the subjects, polymerase chain reaction method, and Sanger sequencing was used to analyze the subjects. Pearson correlation coefficients and multiple logistic regression were calculated to analyze the correlation and susceptibility of BMP-2 rs1005464 and rs235768, a phylogenetic tree was made to evaluate the evolution of the gene. Result: The genotyping distribution of BMP-2 rs1005464 and rs235768 showed a consistent distribution, indicating that these variants can be a genetic bioindicator of the growth pattern and development of craniofacial. Pearson correlation coefficients indicated that the BMP-2 rs1005464 and rs235768 were significantly correlated and susceptibility with skeletal malocclusion classes I, II, and III patients. Sanger sequencing showed there was a consistent distribution of gene polymorphisms of BMP-2 rs1005464 and rs235768 and the phylogenetic tree shows BMP-2 rs1005464 has a tendency to skeletal malocclusion classes I and III while the BMP-2 rs235768 against skeletal malocclusion class II. Conclusion: This study indicated that the BMP-2 rs1005464 and rs235768 are significantly correlated, and susceptibility to growth patterns and development of Craniofacial in Skeletal Malocclusion classes I, II, and III."

""Mineralized Tissues in Oral and Craniofacial Science" is a major comprehensive update on knowledge in the field of mineralized tissues in the oral and craniofacial region. Drs. McCauley and Somerman assembled an international team of researchers and clinicians, offering a global perspective on the current knowledge in this field. Basic and clinical correlates reinforce the significance of research to clinical diagnoses and therapies, written in a manner that lends easily to their use for case study teaching venues.Section 1 features the many aspects of bone in the craniofacial region, including embryology, cell biology, and stem cell biology. Section 2 focuses on teeth-tooth development, dentin, enamel, cementum, and tooth regeneration. Section 3 discusses the interaction between bones and teeth, including those associated with inflammatory processes, periodontal ligaments, biomechanics, and other impact factors-such as nutrition, metabolic bone diseases and therapeutic modalities.The novel approach of linking the basic principles of the cell and molecular biology of hard tissues to clinical correlates will appeal to readers at all levels of their research careers, both students and faculty; faculty interested in a comprehensive text for reference; and clinicians interested in the biologic aspects of bones and teeth."