Hasil Pencarian  ::  Simpan CSV :: Kembali

"This book will provide a detailed review of existing knowledge on the functional characterization of biological networks. In 15 chapters authored by an international group of prolific systems biology and bioinformatics researchers, it will organize, conceptualize, and summarize the existing core of research results and computational methods on understanding biological function from a network perspective."

"In this broad-based introduction Jonathan Pevsner presents the background theory to bioinformatics. Each chapter includes a problem set, pitfalls, boxes explaining key techniques and mathematics/​statistics principles, summary, recommended reading, and a list of freely available software."

"This book is intended as a self-contained guide to the entire field of bioinformatics, interpreted as the application of information science to biology. There is a strong underlying belief that information is a profound concept underlying biology, and familiarity with the concepts of information should make it possible to gain many important new insights into biology. In other words, the vision underpinning this book goes beyond the narrow interpretation of bioinformatics sometimes encoun- tered, which may confine itself to specific tasks such as the attempted identification of genes in a DNA sequence."

"In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure, a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities."