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Tamas Balla, editor
"In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field."
Dordrecht: [Springer, ], 2012
e20417501
eBooks  Universitas Indonesia Library
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Marco Falasca, editor
"This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway, however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated."
Dordrecht: [Springer, ], 2012
e20417294
eBooks  Universitas Indonesia Library
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Desi Heltina
"Titania nanotube (TNT)-carbon nanotube (CNT) composite had been successfully synthesized using simple mixing under acidic conditions and ultrasonic treatment. The samples were further characterized via field emission scanning electron microscopy (FESEM), X–ray diffraction (XRD), diffuse re?ectance UV-vis spectroscopy, and Brunauer-Emmett-Teller (BET) analysis. The TNT–CNT composite’s ability to degrade phenol, a model of industrial waste, was tested. The effects of CNT composition and calcination temperature on the phenol degradation performance of TNT-CNT composite were investigated. The results show that the TNT-CNT composite exhibits higher photocatalytic activity than TNT or CNT alone. The crystallinity of the catalyst is not the only parameter affecting the photocatalytic activity. Rather, the specific surface area, bandgap, and morphology of the catalyst must also be considered."
Depok: Faculty of Engineering, Universitas Indonesia, 2015
UI-IJTECH 6:7 (2015)
Artikel Jurnal  Universitas Indonesia Library
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Tamas Balla, editor
"In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization."
Dordrecht: [, Springer], 2012
e20417495
eBooks  Universitas Indonesia Library
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Erin Caroline
"Metilen biru merupakan pewarna organik berbahaya dari limbah industri tekstil yang menyebabkan permasalahan lingkungan yang serius. Degradasi metilen biru dapat dilakukan melalui proses fotokatalisis dengan semikonduktor berbasis oksida logam seperti NiO dan CuBi2O4. Pada penelitian ini, NiO disintesis melalui metode sol-gel, sedangkan CuBi2O4 disintesis melalui metode solvotermal. Nanokomposit NiO/CuBi2O4 telah berhasil dikembangkan dengan memodifikasi NiO dan CuBi2O4 melalui metode grinding-annealing, yang dikonfirmasi oleh hasil karakterisasi XRD, FTIR, TEM, dan UV-Vis DRS. Penurunan nilai energi celah pita NiO dari 3,39 eV akibat keberadaan CuBi2O4 dapat diamati. Energi celah pita NiO pada NiO/CuBi2O4 1:1, 1:2, dan 2:1 yang diperoleh dari hasil karakterisasi UV-Vis DRS adalah 2,95 eV, 2,89 eV, dan 3,15 eV. Selain itu, aktivitas fotokatalitik NiO, CuBi2O4, dan NiO/CuBi2O4 sebagai katalis juga dievaluasi melalui degradasi metilen biru di bawah radiasi sinar tampak selama 3 jam. Hasil menunjukkan bahwa modifikasi NiO dengan CuBi2O4 dapat meningkatkan aktivitas fotokatalitik. Persentase fotodegradasi metilen biru dengan 10 mg katalis NiO/CuBi2O4 2:1 adalah 74,12% dengan konstanta laju sebesar 6,07×10–3 menit–1, yang lebih tinggi dibandingkan NiO dan CuBi2O4 tanpa modifikasi

Methylene blue is a hazardous organic dye from textile industrial effluents which causes serious environmental problems. Degradation of methylene blue could be carried out through photocatalysis process using metal oxide-based semiconductors such as NiO and CuBi2O4. In this study, NiO was synthesized by sol-gel method, while CuBi2O4 was synthesized by solvothermal method. NiO/CuBi2O4 nanocomposite was successfully developed by modifying NiO and CuBi2O4 through grinding-annealing method, which was confirmed by the results of XRD, FTIR, TEM, and UV-Vis DRS characterization. The decrease in bandgap energy value of NiO from 3.39 eV due to the presence of CuBi2O4 could be observed. The bandgap energies of NiO in NiO/CuBi2O4 1:1, 1:2, and 2:1 obtained from the results of UV-Vis DRS characterization were 2.95 eV, 2.89 eV, and 3.15 eV. Furthermore, the photocatalytic activity of NiO, CuBi2O4, and NiO/CuBi2O4 as catalysts were also evaluated by methylene blue degradation under visible light irradiation for 3 hours. The results showed that modification NiO with CuBi2O4 could enhance the photocatalytic activity. The percentage of methylene blue photodegradation using 10 mg NiO/CuBi2O4 2:1 catalyst was 74.12% with a rate constant of 6.07×10–3 min–1, which was higher than NiO and CuBi2O4 without modification."
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2022
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UI - Skripsi Membership  Universitas Indonesia Library
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Luthfiah
"Pewarna sintesis merupakan salah satu bahan pencemar lingkungan perairan karena sifatnya yang sulit terurai dan persisten sehingga dapat menghambat penetrasi cahaya matahari masuk ke dalam air dan menyebabkan penurunan aktivitas fotosintesis. Fotokatalitik dilakukan untuk mendegradasi pewarna sintesis dengan menggunakan CuBi2O4 yang memiliki energi celah pita sebesar 1.75 eV. Namun, rekombinasi pasangan e-/h+ pada CuBi2O4 dapat terjadi akibat celah pita yang sempit serta karena memiliki sifat mobilitas pembawa muatan yang buruk. Untuk mengurangi rekombinasi pasangan e-/h+ pada CuBi2O4 ditambahkan Ag sehingga efisiensi degradasi fotokatalitik meningkat. CuBi2O4 disintesis melalui metode solvotermal sedangkan Ag/CuBi2O4 disintesis melalui metode presipitasi-reduksi dengan rasio mol prekursor Ag:CuBi2O4 (1:1), (2:1), dan (1:2). Hasil sintesis CuBi2O4 dan nanokomposit Ag/CuBi2O4 dikarakterisasi dengan XRD, TEM, FTIR, dan Spektroskopi UV-Vis DRS. Kemampuan fotokatalitik Ag/CuBi2O4 untuk mendegradasi metilen biru dianalisis dengan variasi jenis katalis, variasi massa katalis (5 mg, 10 mg, dan 15 mg), variasi waktu iradiasi, dan variasi kondisi (adsorpsi dan fotolisis). Hasil degradasi metilen biru oleh CuBi2O4 dan Ag/CuBi2O4 dianalisis dengan Spektroskopi UV-Vis. Hasil penelitian menunjukkan bahwa penambahan Ag pada CuBi2O4 meningkatkan aktivitas fotokatalitik. Persentase degradasi metilen biru yang terbesar terjadi pada 10 mg Ag/CuBi2O4 (2:1) yaitu sebesar 82,51% dengan konstanta laju sebesar 9,07 x 10-3 menit-1.

Synthetic dyes are one of the pollutants in the aquatic environment because they are difficult to decompose and are persistent, so they can inhibit the penetration of sunlight into the water and cause a decrease in photosynthetic activity. Photocatalytic was performed to degrade synthetic dyes using CuBi2O4 which has a band gap energy of 1.75 eV. However, recombination of the e-/h+ pair on CuBi2O4 can occur due to the narrow band gap and because it has poor charge carrier mobility. In order to reduce the recombination of e-/h+ pairs in CuBi2O4, Ag was added so that the efficiency of photocatalytic degradation increased. CuBi2O4 was synthesized by the solvothermal method while Ag/CuBi2O4 was synthesized by the precipitation-reduction method with the mole ratio of Ag:CuBi2O4 precursors (1:1), (2:1), and (1:2). The CuBi2O4 and Ag/CuBi2O4 nanocomposites produced were characterized by XRD, TEM, FTIR, and UV-Vis DRS. The photocatalytic ability of Ag/CuBi2O4 nanocomposites in degrading methylene blue was analyzed with various catalyst types, catalyst mass variations (5 mg, 10 mg, and 15 mg), irradiation time variations, and conditions variations (adsorption and photolysis). Degradation results of methylene blue by CuBi2O4 and Ag/CuBi2O4 were analyzed by UV-Vis spectroscopy. The results showed that the addition of Ag into CuBi2O4 increased the photocatalytic activity. The greatest percentage of methylene blue degradation occurred at 10 mg Ag/CuBi2O4 (2:1) which was 82,51% with a rate constant of 9.07 x 10-3 min-1."
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2023
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UI - Skripsi Membership  Universitas Indonesia Library
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Harsono
"Titania nanotube dengan dopan karbon (C-TiNT) telah berhasil disentesis dan diuji untuk degradasi fenol. Sintesis dilakukan dengan dua tahap yaitu pembentukan titania nanotube dengan metode hydrothermal dan pemberian dopan karbon pada fotokatalis TiO2 nanotube. Pemberian dopan karbon dilakukan dengan dua metode post treatment yaitu kalsinasi dan hydrothermal. Selain itu, juga dilakukan variasi jenis sumber dopan karbon yaitu glukosa dan 1-propanol. Karakterisasi dilakukan dengan menggunakan analisis SEM-EDS, XRD, dan DRS.
Hasil SEM menunjukkan hasil morfologi nanotube telah terbentuk dan terdapat dopan karbon didalamnya. Analisis XRD menunjukkan pada semua katalis terbentuk kristal anatase 100% dengan ukuran kristal 7 - 10 nm. Karakterisasi DRS menunjukkan bahwa katalis nanotube dengan dopan karbon memberikan respon yang baik pada panjang gelombang cahaya tampak dengan nilai band gap 3,0 eV hingga 3,20 eV. Hasil pengujian terhadap fenol menunjukkan katalis C-TiNT mampu mendegradasi fenol dengan kinerja 60% hingga 80%. Nilai ini jauh lebih baik dibandingkan dengan TiO2 nanopartikel yang hanya mampu mendegradasi fenol dengan kinerja sebesar 33%.

A variety of carbon doped on titania nanotube (C-TiNT) have already syntesied well as investigeted for phenol degradation. Synthesis has been conducted in two steps. First step was synthesis of titania nanotube by using hydrothermal method. Second step was incorporated carbon doped to the photocatalyst TiO2 nanotube. Carbon doped was also given by using two methods of post treatment. They are calcination and hydrothermal methods. In addition, we also examined two carbon sources of dopan. They are glucose and 1-Propanol. The prepared samples were characterized with SEM-EDS, XRD, and DRS.
The SEM result showed that nanotube morphology was already exist and contained with carbon. XRD analysis showed existence of anatase crystalline phase reached 100%, and size of crystal was around 7-10nm. DRS result showed good response to visible light range (λ > 400nm) which has band gap value at 3,0 eV-3,20 eV. The results of phenol degradation showed those photocatalyst have performance in range 60% - 80%.This result is much better compared to TiO2 nanoparticle which only degradated 33% of phenol.
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Depok: Fakultas Teknik Universitas Indonesia, 2013
S44409
UI - Skripsi Membership  Universitas Indonesia Library
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Safira Ramadhani Firdaus
"Pada penelitian ini, nanokomposit alginat/CMC/ZnO telah berhasil disintesis dan didukung dengan karakterisasi menggunakan FTIR, XRD, SEM, EDX, TEM, dan UV-DRS. Alginat dan CMC merupakan biopolimer yang memiliki keunggulan masing-masing dan dapat membentuk komposit dengan sifat yang baik jika digabungkan serta didukung oleh semikonduktor ZnO. Nanokomposit yang diperoleh memiliki band gap 2.94 eV dengan ukuran partikel ZnO sekitar 58 nm. Nanokomposit alginat/CMC/ZnO diaplikasikan untuk uji aktivitas fotokatalitik dari larutan zat warna congo red. Aktivitas fotokatalitik dilakukan dengan sinar UV, matahari, sinar tampak, dan tanpa menggunakan sinar. Keadaan optimum reaksi fotokatalisis diperoleh dengan berat nanokomposit 60 mg, pH larutan pada daerah pH 3, rasio alginat dan CMC (1:1), dan lama reaksi selama 110 menit. Hasil degradasi yang paling baik diperoleh dengan menggunakan sinar matahari. Produk degradasi diuji dengan menggunakan LC-MS lalu diperoleh hasil degradasi yang mendekati senyawa air karena pada hasil degradasi terdapat adanya puncak pada waktu retensi 1.23 yang mengindikasikan bahwa zat warna belum sepenuhnya terdegrasi menjadi senyawa air. Untuk proses fotokatalisis, telah dipelajari studi kinetika dimana reaksi yang berjalan mengikuti kinetika orde satu dengan nilai R2 yaitu 0.9885 dan konstanta laju k sebesar 0.0058 menit-1 dan proses adsorpsi mengukuti isoterm Langmuir dengan R2 sebesar 0.9875. Nanokomposit yang diperoleh dapat menjadi solusi untuk mengurangi limbah zat warna dan bersifat biodegradable sehingga ramah terhadap lingkungan.

In this study, nanocomposite alginate/CMC/ZnO was successfully synthesized and supported by characterization using FTIR, XRD, SEM, EDX, TEM, and UV-DRS. Alginate and CMC are biopolymers that have their advantages and able to form composites with good properties when combined and supported by ZnO semiconductors. The nanocomposite obtained has a band gap of 2.94 eV with a particle size of ZnO of around 58 nm. Alginate/CMC/ZnO nanocomposite was applied to test the photocatalytic activity of a solution of congo red dyes. Photocatalytic activity is carried out with UV light, sun, visible light, and without using light. The optimum condition of the photocatalytic reaction was obtained by weight of 60 mg nanocomposite, pH of the solution at pH 3, alginate and CMC ratio (1: 1), and reaction time for 110 minutes. The best degradation results are obtained using sunlight. The degradation products were tested using LC-MS and then the degradation results were approached due to the water compound because at the degradation results there were peaks at the retention time of 1.23 indicating that the dyestuffs had not been fully degradaded into water compounds. For the photocatalytic process, kinetics studies have been conducted in which the reaction that follows the first order kinetics with the value R2 is 0.9885 and the k constant rate is 0.0058 minutes-1 and the adsorption process follows the Langmuir isotherm with R2 of 0.9875. Nanocomposite can reduce dyestuff waste and be biodegradable so that it is environmentally friendly.
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Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2019
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UI - Skripsi Membership  Universitas Indonesia Library
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Didit Ardi Maulana
"Penelitian ini bertujuan untuk mensintesis nano-komposit Ag/TiO2 untuk dikaji kemampuannya dalam mendegradasi mikroplastik dalam air, dilanjutkan dengan memvariasikan konsentrasi serta ukuran dari partikel mikroplastik sebagai polutan di dalam air minum. Mikroplastik polietilena dipilih sebagai sampel pada penelitian ini. Variasi konsentrasi mikroplastik yang digunakan yaitu 100, 500, dan 1000 ppm dengan ukuran partikel awal 100-150 mikrometer. Sedangkan variasi ukuran mikroplastik yang digunakan yaitu 100-125, 125-150, dan 150-250 mikrometer dengan konsentrasi awal 100 ppm. Pengaduk magnetik digunakan pada kecepatan putar 2000 rpm selama proses irradiasi dengan lampu UV. Penambahan dopan Ag memberikan efek yang cukup baik dalam mendegradasi mikroplastik, dimana persentase degradasi mencapai 100% dalam waktu 120 menit irradiasi pada konsentrasi awal 100 ppm dan ukuran partikel 100-150 mikrometer. Dengan konsentrasi awal 100 ppm diperoleh persen degradasi terbaik pada ukuran partikel 125-150 mikrometer, dimana degradasi 100% dicapai pada waktu irradiasi selama 90 menit.

The aim of this research is to synthesize Ag/TiO2 nano-composites to study their ability to degrade microplastics in water, followed by varying the concentration and size of microplastic particles as pollutants in drinking water. Polyethylene microplastics were selected as samples in this study. The variation of microplastic concentrations used are 100, 500, and 1000 ppm with an initial particle size of 100-150 micrometers. While the microplastic size variations used are 100-125, 125-150, and 150-250 micrometers with initial concentrations of 100 ppm. Magnetic stirrers are used at a rotational speed of 2000 rpm during the irradiation process with a UV lamp. The addition of Ag dopant has a fairly good effect in microplastic degradation, where the percentage of degradation reaches 100% within 120 minutes of irradiation at an initial concentration of 100 ppm and particle size of 100-150 micrometers. With an initial concentration of 100 ppm obtained the best percent degradation at particle size 125-150 micrometers, where 100% degradation was achieved at 90 minutes of irradiation."
Depok: Fakultas Teknik Universitas Indonesia, 2020
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UI - Skripsi Membership  Universitas Indonesia Library
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Sitanggang, Ida Frisca Royani
"Nanokomposit selulosa/Ag3PO4/ZnO untuk fotokatalisis degradasi metil jingga telah disintesis dan dikarakterisasi menggunakan FTIR, XRD, UV-DRS dan SEM. Penambahan Ag3PO4 pada ZnO dapat menurunkan energi band gap ZnO dari 3.21 eV menjadi 3.19 eV. Pada penelitian ini, ZnO akan bertindak sebagai sisi aktif katalis, Ag3PO4 bertindak sebagai sensitizer yang dapat meningkatkan kemampuan katalis untuk menyerap sinar visible, sedangkan selulosa bertindak sebagai support katalis. Proses fotokatalisis degradasi metil jingga dilakukan di bawah sinar UV dan visible selama 1 jam. Kondisi optimum yang diperolah adalah ketika proses fotokatalisis dilakukan pada pH 6, menggunakan jumah katalis 45 mg, dengan rasio komposit pada ZnO/Ag3PO4 1:2, dan rasio selulosa pada nanokomposit selulosa/Ag3PO4/ZnO 1:2:1.  Nilai efisiensi fotodegradasi metil jingga yang paling tinggi adalah sebesar 81.05%. Reaksi ini mengikuti kinetika pseudo orde satu dan proses adsorpsi yang terjadi mengikuti model isoterm adsorpsi Langmuir.

Cellulose/Ag3PO4/ZnO nanocomposite for photocatalytic degradation of methyl orange have been synthesized and characterized by FTIR, XRD, UV-DRS, and SEM. The addition of Ag3PO4 to ZnO can reduce the band gap energy from 3.21 eV to 3.19 eV. In this work, ZnO acts as an active site, Ag3PO4 acts as sensitizer that can increase the ability of catalyst to absorb visible light, and cellulose acts as a catalyst support. The photocatalysis degradation of methyl orange was observe under UV and light illumination for an hour. The optimum condition obtained was when the photocatalyst was conducted at pH 6 using 45 mg catalyst with composite ratio ZnO/Ag3PO4 1:2, and cellulose ratio on cellulose/Ag3PO4/ZnO nano composite 1:2:1. The highest photodegradation efficiency of methyl orange is 81.05%. This reaction fits well to the pseudo-first order kinetics and Langmuir adsorption isotherm model."
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2020
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UI - Skripsi Membership  Universitas Indonesia Library
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