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"[ABSTRAKGangguan depresi mayor merupakan suatu gangguan kejiwaan ditandai dengankemurungan, ketiadaan gairah hidup, perasaan tidak berguna dan putus asa danmengalami minimal empat dari gejala berikut yaitu perubahan berat badan dannafsu makan, perubahan tidur dan aktivitas, tidak ada energi, rasa bersalah,masalah dalam berfikir dan membuat keputusan, berfikir berulang tentangkematian dan bunuh diri tampa riwayat episode manik, campuran atau hipomanik,sekurang-kurangnya telah dirasakan selama 2 minggu. Survei kesehatan mentaldunia pada 17 negara menemukan sekitar 1 dari 20 orang dilaporkan menderitaepisode depresi setiap tahunnya, paling sering terjadi adalah gangguan depresimayor. Pengobatan dengan farmakoterapi golongan antidepresan hanyamenunjukkan efektifitas 60-70% disertai efek samping yang serius sehinggaberbagai modalitas terapi dikembangkan, salah satunya akupunktur. Penelitian inibertujuan untuk mengetahui efektivitas terapi kombinasi akupunktur denganantidepresan dibandingkan kombinasi akupunktur sham dengan antidepresanterhadap perubahan skor Hamilton Rating Scale for Depression (HAM-D 17)pada penderita gangguan depresi mayor. Uji klinis acak tersamar tunggaldilakukan pada 48 pasien gangguan depresi mayor dialokasikan ke dalamkelompok kombinasi akupunktur dengan antidepresan dan kelompok kombinasiakupunktur sham dengan antidepresan. Penilaian kemajuan terapi digunakan skorHAM-D 17. Hasil penelitian menunjukkan rerata skor HAM-D 17 pada kelompokkasus sebelum terapi 22,2±3,38 dan setelah terapi ke-12 turun menjadi 7,3±2,64.Sedangkan pada kelompok kontrol rerata skor HAM-D 17 sebelum terapi21,4±3,10 dan setelah terapi ke-12 turun menjadi 9,3±3,33. Terdapat perbedaanbermakna antara selisih rerata penurunan skor HAM-D 17 sebelum dan setelah 12kali terapi pada kelompok kasus 14,9±2,45 dibandingan dengan kelompok kontrol12,2±4,30 (p<0,005). Terapi kombinasi akupunktur dengan antidepresan lebihefektif mengurangi gejala gangguan depresi mayor dibandingkan kombinasiakupunktur sham dengan antidepresan.

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ABSTRACTMajor depressive disorder is a psychiatric disorder that is characterized at leastfour of the following symptoms, loss of weight and appetite, sleep disturbance andloss of interest of activity, low energy level, guilt, difficulty concentrating andmaking decisions, recurrent death or suicide, without a history of manicepisodes, mixed or hypomanic. These sings and symptoms have been felt at leastfor 2 weeks. The mental health survey conducted in 17 countries found that about1 in 20 people are reported to suffer from a depressive episode each year andmost are major depressive disorder. The effectiveness of antidepressantmedication only 60-70% with serious side effects, so that various therapeuticmodalities developed, one of which is acupuncture. This study aims to determinethe effectiveness of combination therapy of acupuncture with antidepressantscompared to combination of sham acupuncture with antidepressants in patientswith major depressive disorder and the outcome was the score Hamilton RatingScale for Depression (HAM-D 17). Single-blind randomized clinical trialconducted in 48 patients with major depressive disorder and the patients wereallocated into two groups, intervention (acupuncture with antidepressants) andcontrol (sham acupuncture with antidepressant). The mean of HAM-D 17 score inthe intervention group before treatment was 22,2±3,38 and after treatment was7,3±2,64. The mean of HAM-D 17 score in control group before treatment was21,4±3,10 and after treatment was 9,3±3,33. There was significant differencesbetween intervention and control group before and after 12 times of therapy in themean decrease of score on HAM-D 1714.9±2.45 to12.2±4.30 (p<0.005). Acombination of acupuncture therapy with antidepressants is more effective inreducing the symptoms of major depressive disorder compared to shamacupuncture combination with antidepressants, Major depressive disorder is a psychiatric disorder that is characterized at leastfour of the following symptoms, loss of weight and appetite, sleep disturbance andloss of interest of activity, low energy level, guilt, difficulty concentrating andmaking decisions, recurrent death or suicide, without a history of manicepisodes, mixed or hypomanic. These sings and symptoms have been felt at leastfor 2 weeks. The mental health survey conducted in 17 countries found that about1 in 20 people are reported to suffer from a depressive episode each year andmost are major depressive disorder. The effectiveness of antidepressantmedication only 60-70% with serious side effects, so that various therapeuticmodalities developed, one of which is acupuncture. This study aims to determinethe effectiveness of combination therapy of acupuncture with antidepressantscompared to combination of sham acupuncture with antidepressants in patientswith major depressive disorder and the outcome was the score Hamilton RatingScale for Depression (HAM-D 17). Single-blind randomized clinical trialconducted in 48 patients with major depressive disorder and the patients wereallocated into two groups, intervention (acupuncture with antidepressants) andcontrol (sham acupuncture with antidepressant). The mean of HAM-D 17 score inthe intervention group before treatment was 22,2±3,38 and after treatment was7,3±2,64. The mean of HAM-D 17 score in control group before treatment was21,4±3,10 and after treatment was 9,3±3,33. There was significant differencesbetween intervention and control group before and after 12 times of therapy in themean decrease of score on HAM-D 1714.9±2.45 to12.2±4.30 (p<0.005). Acombination of acupuncture therapy with antidepressants is more effective inreducing the symptoms of major depressive disorder compared to shamacupuncture combination with antidepressants]"

"ABSTRAKDepresi merupakan suatu gangguan kejiwaan pada alam perasaan, yang ditandai dengan kesedihan, hilangnya minat atau kebahagiaan, perasaan bersalah, gangguan tidur dan nafsu makan, perasaan lelah dan konsentrasi yang kurang baik. Tiga terapi utama untuk depresi yaitu psikoterapi, farmakoterapi dan electroconvulsive therapy (ECT). Selective Serotonin Re-uptake Inhibitor (SSRI) merupakan terapi antidepresan yang paling sering dipakai. Efektifitas farmakologis antidepresan hanya mencapai 60%-70%. Sebagian pasien depresi tidak merespons penuh, mengalami relaps, atau menderita efek samping yang tidak diharapkan sehingga memerlukan pengembangan terapi pilihan lain, seperti laserpunktur.Penelitian ini bertujuan untuk mengetahui efektivitas terapi kombinasi laserpunktur dengan antidepresan dan psikoterapi dibandingkan dengan terapi kombinasi laserpunktur sham dengan antidepresan dan psikoterapi terhadap perubahan skor Hamilton Rating Scale for Depression 17 (HAM-D 17) dan kadar serotonin penderita depresi. Uji klinis acak tersamar tunggal pada 33 penderita depresi dialokasikan kedalam kelompok perlakuan dan kontrol. Terdapat penurunan skor HAM-D 17 yang bermakna (p<0.001) setelah 8 kali terapi laserpunktur dan peningkatan kadar serotonin yang bermakna (p=0,004) setelah terapi.Penelitian ini menunjukkan terapi kombinasi laserpunktur dengan antidepresan dan psikoterapi efektif mengurangi gejala depresi dan meningkatkan kadar serotonin lebik baik dibandingkan terapi kombinasi laserpunktur sham dengan antidepresan dan psikoterapi saja.

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ABSTRACT

Depression is a psychiatric disorder in mood, which is characterized by sadness, loss of interest or happiness, feeling guilty or worthless, sleep or appetite disorders, feeling tired and lack of concentration. There are three main treatment for depression are psychotherapy, pharmacotherapy and electroconvulsive therapy (ECT). The effectiveness of pharmacological antidepressant only reach 60% to 70%. The majority of depressed patients do not respond fully, relapse, or suffer side effects are not expected to require the development of therapies other options, one of which laserpuncture.

This study aims to determine the effectiveness of combination therapy with antidepressants and psychotherapy laserpuncture compared with sham laserpuncture combination therapy with antidepressants and psychotherapy to change in Hamilton Rating Scale for Depression 17 (HAM-D 17) and the serotonin levels of people with depression. Single-blind randomized clinical trial was conducted on 33 patients with depression were allocated into intervention and control groups.

The results showed there is a decrease in HAM-D 17 were significantly (p <0.001). There is a significant increase serotonin levels (p = 0.004). Conclusion of the study is laserpuncture combination therapy with antidepressants and psychotherapy are effective in reducing symptoms of depression and elevating cortisol level compared to sham laserpuncture combination therapy with antidepressants and psychotherapy."

"Hingga saat ini masalah depresi masih tetap merupakan topik yang menarik dan hangat. Hal ini disebabkan karena masalahnya yang besar dan kompleks; meliputi antara lain gambaran klinis, klasifikasi diagnosis, distribusi kasus dan penanganannya.Penelitian yang dilakukan di Eropa dan Amerika menunjukkan sekitar 8-11 % pria dan 18-23 % wanita akan mengalami episode depresi disuatu saat dalam perjalanan hidupnya (5,22). WHO (World Health Organi zation) memperkirakan depresi dialami oleh 3 % penduduk dunia - 100.000.000 jiwa - dan menurut Sartorius (1979), dari tahun ke tahun angka tersebut akan terus meningkat (12,16).Khusus di Indonesia, penderita depresi secara klinis diperkirakan minimal 3.000.000 jiwa (Kusumanto S., Iskandar Y., 1985). Namun bila ditinjau menurut data yang ada, baik di Rumah Sakit Umum maupun Rumah Sakit Jiwa, ternyata angka depresi sangat kecil. Hal ini mungkin disebabkan karena masih banyak pasien, atau bahkan para dokter yang tidak mengenal dan menyangkal bahwa seseorang menderita depresi (15). Dalam pada itu data menunjukkan bahwa dari seluruh pasien yang berkunjung ke dokter, 10 % diantaranya terdiri dari pasien depresi dan separuhnya merupakan depresi dalam bentuk tersamar (12,18,21)."

"ABSTRAK Detrusor underactivity DU adalah berkurangnya kekuatan dan/atau durasi kontraksi yang mengakibatkan pengosongan kandung kemih yang memanjang atau inkomplit. Sebanyak enam pasien dengan diagnosis DU diinklusikan dalam penelitian ini. Akupunktur tanam benang dilakukan dengan menggunakan polydioxanone PDO yang ditusukkan di titik akupunktur BL33 dan CV3 dengan teknik penetrating needling. Akupunktur tanam benang dilakukan sebanyak satu kali. Transcutaneous tibial nerve stimulation TTNS dilakukan sebanyak 3 kali seminggu selama 4 minggu. Hasilnya penelitian menunjukkan tidak terdapat perbedaan bermakna antara rerata volume berkemih sebelum 72,00 70,48 dan setelah 158,17 139,58 akupunktur tanam benang dan TTNS, p = 0,115, namun didapatkan peningkatan dengan rerata 86,17 110,80. Tidak terdapat perbedaan bermakna antara nilai PVR sebelum 164,00 173,69 dan setelah 74,83 126,28 terapi, p = 0,151, namun didapatkan penurunan sebesar 89,17 129,07. Tidak terdapat perbedaan bermakna antara rerata Qmax sebelum 4,12 3,28 dan setelah 12,35 9,20 , p = 0,085, namun didapatkan peningkatan sebesar 8,23 9,41. Terdapat perbedaan bermakna antara skor kualitas hidup sebelum dan setelah terapi dengan p = 0,017. Kesimpulan : akupunktur tanam benang dan TTNS dapat meningkatkan volume berkemih, menurunkan PVR, dan meningkatkan Qmax penderita DU, dan dapat memperbaiki kualitas hidup penderita DU secara signifikan. ABSTRACT Detrusor underactivity DU is a contraction of reduced strength and/or duration resulting in prolonged and/or incomplete bladder emptying. A total of six DU patients were included in this research. We did thread-embedding acupuncture by inserting polydioxanone PDO into BL33 and CV3 acupuncture points with penetrating needling techniques. Thread-embedding acupuncture was given once. Transcutaneous tibial nerve stimulation TTNS was given 3 times in a week during 4 weeks. The results showed no significant differences between before and after treatment on voided volume 72,00 70,48 and 158,17 139,58 , p = 0,115, but there was improvement with mean 86,17 110,80. There was no significant difference between before and after treatment on PVR 164,00 173,69 and 74,83 126,28 , p = 0,151, but there was improvement with mean 89,17 129,07. There was no significant difference between before and after treatment on Qmax 4,12 3,28 and 12,35 9,20 , p = 0,085, but there was improvement with mean 8,23 9,41. There was significant difference between before and after treatment on quality of life scoring with p = 0,017. Conclusion : thread embedding acupuncture and TTNS increase voided volume, and Qmax, decrease PVR, improve quality of life in in detrusor underactivity patients significantly "

"Luka bakar didefinisikan sebagai kerusakan jaringan yang terjadi akibat aksi panas baik secara langsung maupun tidak langsung. Meskipun telah banyak kemajuan yang dibuat dalam terapi luka bakar, namun penyembuhan luka yang lambat masih menjadi tantangan dalam perawatan luka bakar. Akupunktur manual dapat mempercepat penyembuhan luka bakar melalui efek anti-inflamasi, meningkatkan re-epitelisasi dan angiogenesis. Sedangkan laser akupunktur merupakan terapi yang menggunakan laser enersi rendah untuk merangsang titik akupunktur. Penelitian ini menilai pengaruh akupunktur manual dan laser akupunktur terhadap kecepatan penyembuhan luka bakar yang diamati secara makroskopik dan mikroskopik. Tiga puluh enam tikus Wistar jantan dibagi secara acak kedalam kelompok kontrol (n=12), kelompok akupunktur manual (n=12), dan kelompok laser akupunktur (n=12). Setelah dilakukan induksi luka bakar, pengukuran luka dan perlakuan diberikan setiap dua hari sekali selama 14 hari. Separuh jumlah dari setiap kelompok diterminasi pada hari ke-7 dan separuh sisanya diterminasi pada hari ke-14 untuk dilakukan pengamatan mikroskopik. Pada pengukuran penutupan luas luka hari ke-14, didapatkan perbedaan bermakna (p=0,009) antara kelompok akupunktur manual (66,96 ± 9,17) dibandingkan kelompok kontrol (49,93 ± 9,15), dan perbedaan yang bermakna (p=0,009) antara kelompok laser akupunktur (72,48 ± 14,62) dibandingkan kelompok kontrol. Namun tidak didapatkan perbedaan bermakna (p=0,451) antara kelompok akupunktur manual dan laser akupunktur. Pada penilaian skoring mikroskopik hari ke-14 didapatkan perbedaan yang bermakna (p<0,001) antara kelompok akupunktur manual (16,17 ± 1,17) dibandingkan kelompok kontrol (10,33 ± 1,21), dan perbedaan yang bermakna (p=0,004) antara kelompok laser akupunktur (17,83 ± 1,47) dibandingkan kelompok kontrol. Namun tidak didapatkan perbedaan bermakna (p=0,058) antara kelompok akupunktur manual dan laser akupunktur. Hasil penelitian menunjukkan bahwa baik terapi akupunktur manual ataupun laser akupunktur dapat digunakan sebagai terapi tambahan untuk mempercepat penyembuhan luka bakar.

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Burns are defined as tissue damage that occurs as a result of the direct or indirect action of heat. Although many advanced treatments have been made in burn therapy, slow wound healing remains a challenge in burn treatment. Acupuncture can accelerate burn healing through its anti-inflammatory effect, increasing re-epithelialization and angiogenesis. While laser acupuncture is a therapy that uses low energy lasers to stimulate acupuncture points. This study assessed the effect of manual acupuncture and laser acupuncture on the speed of wound healing which were observed macroscopically and microscopically. Thirty-six male Wistar rats were randomly divided into control group (n=12), acupuncture group (n=12), and laser acupuncture group (n=12). After burn induction, wound measurements and treatments were given every two days for 14 days. Half of the numbers from each group were terminated on the 7th day and the remaining half were terminated on the 14th day for microscopic observation. On the 14th day of measurement of wound closure, there was a significant difference (p=0.009) between the acupuncture group (66.96 ± 9.17) compared to the control group (49.93 ± 9.15), and a significant difference (p =0.009) between laser acupuncture group (72.48 ± 14.62) compared to control group. However, there was no significant difference (p=0.451) between acupuncture and laser acupuncture groups. On the 14th day of microscopic scoring, there was a significant difference (p<0.001) between the acupuncture group (16.17 ± 1.17) compared to the control group (10.33 ± 1.21), and a significant difference (p = 0.004) between the laser acupuncture group (17.83 ± 1.47) versus the control group. However, there was no significant difference (p=0.058) between acupuncture and laser acupuncture groups. The results showed that either acupuncture therapy or laser acupuncture could be used as an adjunct therapy to accelerate burn healing."

"ABSTRAKLatar belakang:Migren adalah serangan nyeri kepala primer, bersifat spesifik,paroksismal, dengan atau tanpa aura, dengan manifestasi subjektif baik sebelummaupun sesudah serangan, merupakan nyeri kepala tipe kronik dengan gejala rekurensi,menyerang usia produktif dan dapat menyebabkan penurunan produktivitas kerja hingga80%, sehingga akan mempengaruhi kualitas hidup dan kehidupan perekonomian danpendidikan secara global yang mengarah kepada kerugian bagi penderita migren daninstitusi tempat penderita migren bersekolah ,bekerja serta dalam kehidupan keluargapenderita. Dengan tingginya angka prevalensi dan disabilitas pada penderita migren,dilain pihak sampai saat ini pengobatan yang tepat terhadap migren belum didapatkansecara maksimal maka diperlukan pendalaman dalam pengobatan maupun pencegahanmigren sangat dibutuhkan., dan sampai saat ini belum didapatkan obat yang pasti, baikterhadap pencegahan dan pengobatan, sehingga perlu dikembangkan terapi yang dapatmemberikan pertolongan yang lebih akurat pada penderita migrenTujuan penelitian ini adalah menilai keberhasilan dalam penatalaksanaan migren dalammengurangi frekuensi serangan, mengurangi intensitas serangan dan mengurangi durasiserangan dari minggu ke-0,ke-4 hingga ke-8. Metode: Uji klinis acak tersamar tunggaldengan kontrol dilakukan terhadap 34 subjek dengan migren yang dialokasikan secaraacak kedalam kelompok manual akupunktur (n=17), serta kelompok medikamentosa(n=17). Penilaian menilai frekuensi, durasi dan intensitas serangan migren yang dinilaipada saat sebelum perlakuan, minggu ke-4 dan minggu ke-8 dari baseline. Hasil: Hasilpenelitian menunjukkan terdapat perbedaan bermakna antara kedua kelompok padarerata jumlah frekuensi (p=0,040), durasi (p=0,012) dan intensitas (p=0,003) seranganmigren pada minggu ke-4 dibandingkan dengan medikamentosa. Serata terdapatperbedaan yang bermakna antara kedua kelompok pada rerata jumlah jumlah frekuensi(p=0,029), durasi (p=0,001) dan intensitas (p<0,001) serangan migren pada minggu ke-8. Kesimpulan: Intervensi akupunktur manual dapat menurunkan frekuensi, durasi danintensitas serangan migren lebih baik dibandingkan dengan preventif farmakologi asamvalproat pada minggu ke-4 dan minggu ke-8.

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ABSTARCTMigraine is a primary headache attack, specific, paroxysmal, with or without aura, with subjective manifestations both before and after the attack, a chronictype of headache with symptoms of recurrence, attacks at productive age and can cause a decrease in work productivity up to 80%, so that it will affect the quality of life, economic life and education globally which leads to losses for migraine sufferers andinstitutions where migraine sufferers attend school, work and in the lives of sufferersfamilies. With the high prevalence and disability rates for migraine sufferers, on theother hand, the right treatment for migraine has not yet been obtained to the maximum,it is necessary to deepen the treatment and prevention of migraine is needed, and untilnow there has been no definitive cure, both for prevention and treatment, so it isnecessary to develop therapies that can provide more accurate relief for migrainesufferers. The purpose of this study is to assess the success in managing migraine inreducing the frequency of attacks, reducing the intensity of attacks and reducing theduration of attacks from weeks 0, 4 to 8. Methods: A randomized controlled trial withcontrol was conducted on 34 subjects with migraine who were randomly allocated intothe manual group of acupuncture (n = 17), as well as the medicine group (n = 17). Theassessment of frequency, duration and intensity of migraine attacks assessed at the timebefore treatment, at the fourth and eight week from baseline. Results: The resultsshowed there were significant differences between the two groups in the mean numberof frequencies (p = 0.040), duration (p = 0.012) and intensity (p = 0.003) of migraineattacks at the fourth week. There were significant differences between the two groups inthe average number of frequencies (p= 0.029), duration (p=0.001) and intensity(p<0.001) of migraine attacks at the eight week. Conclusion: Manual acupunctureinterventions can reduce the frequency, duration and intensity of migraine attacksbetter than the use of valproic acid in the fourth and eight week."

"Pendahuluan: COVID-19 merupakan penyakit yang disebabkan oleh infeksi virus SARS-CoV-2. Gejala klinis COVID-19 yang paling sering dialami adalah demam dan batuk. Infeksi SARS-CoV-2 ke dalam tubuh pejamu akan menimbulkan respon imun dari pejamu yang akan menyebabkan terjadinya inflamasi sistemik. Hal ini dapat dilihat dari peningkatan berbagai penanda inflamasi, salah satunya adalah C-Reactive Protein (CRP). Saat ini belum ada terapi spesifik yang efektif untuk mengatasi COVID-19. Akupunktur yang merupakan modalitas terapi non-farmakologi yang telah terbukti dapat memberikan efek anti-inflamasi. Saat ini belum ada penelitian uji klinis akupunktur yang meneliti penanda inflamasi terhadap pasien COVID-19 yang telah dipublikasi. Tujuan penelitian ini adalah untuk mengetahui bagaimana efektivitas akupunktur dalam menurunkan kadar CRP dan memperbaiki gejala batuk yang dialami pasien COVID-19 gejala ringan-sedang.Metode: Sebuah penelitian pilot dengan desain studi uji klinis acak tersamar tunggal. Dua puluh dua pasien COVID-19 terkonfirmasi melalui pemeriksaan RT-PCR yang memiliki gejala ringan-sedang yang sedang dirawat inap di rumah sakit dikelompokan dalam dua kelompok: kelompok perlakuan yang mendapat terapi standar dan intervensi akupunktur manual dan kelompok kontrol yang mendapat terapi standar. Intervensi akupunktir manual dilakukan setiap 2 hari dengan total 6 sesi terapi. Sebelum intervensi dilakukan pengukuran kadar CRP dan penentuan onset batuk dan setelah 6 sesi akupunktur dilakukan dilakukan pengukuran kadar CRP dan penentuan periode lama batuk. Hasil: Terjadi penurunan rerata kadar CRP pada kedua kelompok (p=0,397). Penurunan kadar CRP pada kelompok perlakuan lebih besar dibandingkan kelompok kontrol. Gejala batuk lebih singkat pada kelompok perlakuan dibandingkan pada kelompok kontrol dan perbedaan ini bermakna secara statistik (p = 0,01).Kesimpulan: Kombinasi akupunktur manual dan terapi standar menurunkan kadar CRP dan penurunannya lebih besar dibandingkan dengan terapi standar. Namun, penurunan kadar CRP tidak bermakna secara statistik. Dan mempersingkat gejala batuk yang dialami pasien COVID-19 gejala ringan-sedang secara bermakna.

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Introduction: COVID-19 is a disease that caused by infection of SARS-CoV-2. The most common clinical symptoms of COVID-19 are fever and cough. SARS-CoV-2 infection into the host's body will cause an immune response which will cause systemic inflammation. This can be seen from the increase in various inflammatory markers, one of which is C-Reactive Protein (CRP). Currently there is no specific therapy that is effective for curing COVID-19. Acupuncture is a non-pharmacological therapeutic modality that has been shown to provide anti-inflammatory effects. Currently, there are no published studies of acupuncture clinical trials examining inflammatory markers in COVID-19 patients. The purpose of this study was to determine how effective acupuncture in reducing CRP levels and improving cough symptoms experienced by COVID-19 with mild-moderate symptoms patients.

Methods: A pilot study with an experimental study design single blind randomized clinical trial. Twenty-two COVID-19 patients confirmed by RT-PCR examination who had mild-moderate symptoms who were being hospitalized were divided into two groups: the treatment group who received standard therapy and manual acupuncture intervention and the control group who received standard therapy. Manual acupuncture intervention was performed every 2 days for a total of 6 therapy sessions. Before the intervention, the CRP level was measured and the onset of the cough was determined and after 6 acupuncture sessions, the CRP level was measured and the period of cough was determined.

Results: There was a decrease in the mean of CRP levels in both groups (p = 0.397). The decrease in CRP levels in the treatment group was greater than the control group. Cough symptoms were shorter in the treatment group than in the control group and this difference was statistically significant (p = 0.01).

Conclusion: The combination of manual acupuncture and standard therapy reduced CRP levels and the decrease was greater than that of standard therapy. However, the reduction in CRP levels was not statistically significant. And shorten the cough symptoms experienced by mild-moderate COVID-19 patients significantly."

"Pendahuluan: Peningkatan kadar kolesterol didalam plasma darah atau hiperlipidemia merupakan faktor predisposisi terjadinya aterosklerosis. Faktor risiko diet tinggi lemak amat mempengaruhi tingginya kadar kolesterol darah. Permasalahan kepatuhan dalam perubahan diet dan efek samping obat penurun kolesterol menjadi alasan perlunya terapi pilihan lain yang aman dan efektif. Penelitian menunjukkan bahwa elektroakupunktur pada titik ST40 Fenglong dapat digunakan sebagai terapi untuk memperbaiki kadar kolesterol darah. Salah satu modalitas akupunktur yang sedang berkembang adalah laser akupunktur. Tujuan penelitian ini adalah untuk mengetahui bagaimana efektivitas laser akupunktur dibandingkan dengan elektroakupunktur pada titik ST40 Fenglong dalam memperbaiki kadar kolesterol otal, indeks aterogenik, dan berat lemak dinding abdomen pada tikus model diet tinggi lemak. Metode: Desain studi ini adalah studi eksperimental dengan randomised control group posttest only. Dua puluh empat tikus Wistar jantan, usia 10 minggu dengan berat badan 200–250 gram dibagi menjadi 4 kelompok yaitu: kelompok diet normal, kelompok diet tinggi lemak tanpa perlakuan akupunktur, kelompok diet tinggi lemak dengan elektroakupunktur dan kelompok diet tinggi lemak dengan laser akupunktur. Elektroakupunktur dan laser akupunktur dilakukan 3 kali seminggu dengan total 12 sesi. Dilakukan pengukuran kadar kolesterol total, indeks aterogenik, dan berat lemak dinding abdomen setelah 12 sesi.Hasil: Rerata kadar kolesterol total, indeks aterogenik, dan berat lemak dinding abdomen pada kelompok tikus model diet tinggi lemak yang mendapat laser akupunktur lebih rendah dibandingkan pada kelompok tikus model diet tinggi lemak yang mendapat elektroakupunktur, namun tidak berbeda bermakna secara statistik (p > 0,05). Kesimpulan: Laser akupunktur memiliki kecenderungan lebih baik dalam mencegah peningkatan kolesterol total, indeks aterogenik, dan peningkatan berat lemak dinding abdomen akibat konsumsi diet tinggi lemak dibandingkan dengan elektroakupunkturIntroduction: Hyperlipidemia is an increased concentration of fat in blood plasma and is a predisposing factor for atherosclerosis. Risk factor such as high-fat diet greatly affect blood cholesterol levels. The problem of adherence to diet changes and cholesterol medication side effects are reasons to look for other alternative therapies that are safe and effective. Research shows that electroacupuncture at the ST40 Fenglong point can be used as a therapy to improve blood cholesterol levels. One of the acupuncture modalities is laser acupuncture. The purpose of this study was to determine the effectiveness of laser acupuncture compared to electroacupuncture at the ST40 Fenglong point for improving total cholesterol levels, atherogenic index, and abdominal wall fat weight in high fat diet model rats. Methods: This study was an experimental study with posttest only randomized control group. Twenty-four male Wistar rats, aged 10 weeks with a body weight of 200–250 grams were divided into 4 groups: the normal diet group, the high-fat diet without acupuncture treatment group, the high-fat diet with electroacupuncture group and the high-fat diet with laser acupuncture group. Electroacupuncture and laser acupuncture treatments were performed 3 times a week for a total of 12 sessions. Total cholesterol levels, atherogenic index, and abdominal wall fat weight were measured after 12 sessions.Results: The mean total cholesterol levels, atherogenic index, and weight of abdominal wall fat in the high-fat diet model group which received laser acupuncture treatment was lower than that in the high-fat diet group which received electroacupuncture group, but did not significantly differ (p> 0.05). Conclusion: Compared to electroacupuncture, laser acupuncture has a better tendency at preventing increases in total cholesterol level, atherogenic index, and abdominal wall fat weight due to high-fat diet consumption."

"Pendahuluan: Salah satu efek samping kemoterapi yang paling sering terjadi dan meresahkan pada pasien anak adalah Chemotherapy induced nausea and vomiting (CINV). Akupunktur merupakan suatu pendekatan non farmakologi yang telah terbukti dapat menurunkan gejala CINV. Namun, aplikasi pada anak sering kali terkendala rasa takut akan jarum. Salah satu modalitas yang minimal invasif dan dapat diaplikasikan pada anak adalah press needle. Tujuan penelitian ini adalah untuk menilai efektivitas akupunktur press needle dalam mengurangi gejala CINV yang dinilai berdasarkan skor Rhodes index of nausea, vomiting, and retching (RINVR) pada pasien kanker anak yang menjalani kemoterapi.Metode: Desain studi ini adalah uji klinis acak terkontrol tunggal dengan kontrol sham. Penelitian ini diikuti oleh 60 pasien kanker anak yang menjalani kemoterapi. Subjek penelitian dialokasikan secara acak ke dalam kelompok perlakuan (n=30) dan kontrol (n=30). Pada kelompok perlakuan dilakukan pemasangan press needle pada titik PC6 Neiguan dan ST36 Zusanli, dilanjutkan dengan perangsangan akupresur minimal 3 kali sehari, sementara pasien pada kelompok kontrol mendapatkan press needle sham Plesterin® tanpa diikuti perangsangan apapun. Selama penelitian seluruh subjek tetap mendapatkan terapi anti emetik standar. Pemasangan press needle dilakukan sebelum kemoterapi dan dipertahankan hingga 3 hari pasca kemoterapi. Evaluasi mual muntah dilakukan setiap hari hingga 6 hari pasca kemoterapi menggunakan kuesioner Rhodes index of nausea, vomiting, and retching.Hasil: Terjadi penurunan skor RINVR yang signifikan antara hari kemoterapi dengan 3 hari pasca kemoterapi pada kelompok perlakuan ( p = 0,005 ). Skor RINVR pada hari pemberian kemoterapi, 3 hari dan 6 hari pasca kemoterapi pada kelompok perlakuan lebih rendah dibandingkan kelompok kontrol, namun perbedaan kedua kelompok tidak berbeda bermakna (p = 0,525, p = 0,506, p = 0,284).Kesimpulan: Akupunktur press needle mampu menurunkan skor RINVR pada pasien anak yang menjalani kemoterapi dan dapat diaplikasikan pada pasien anak karena efek sampingnya yang minimal, namun perlu dilakukan penelitian lebih lanjut untuk mengetahui waktu terapi yang sesuai.

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Background: Chemotherapy induced nausea and vomiting (CINV) are the most prevalent yet disturbing side effects of chemotherapy. Acupuncture is a non-pharmalogical approach that has been shown to reduce CINV symptoms. However, acupuncture in children is often constrained by a fear of acupuncture needles. Press needle is minimally invasive modalities that might be applied. The purpose of this study was to assess the effectiveness of press needle acupuncture in reducing CINV according to Rhodes index of nausea, vomiting, and retching (RINVR) score in pediatric cancer patients undergoing chemotherapy.

Method: The study design was a single randomized controlled trial with sham control. A total of 60 subjects were randomly allocated into treatment ( n = 30 ) and control ( n = 30) groups. Subjects in treatment group will received press needle at PC6 Neiguan and ST36 Zusanli, followed by acupressure stimulation at least 3 times a day, while patients in the control group received press needle sham Plesterin® without any further stimulation. During the study all subjects continued to receive standart anti-emetic therapy. The insertion of the press needle was performed before chemotherapy and retained up to 3 days after chemotherapy. Nausea and vomiting was evaluated everyday up to 6 days after chemotherapy using a Rhodes index of nausea, vomiting, and retching questionnaire.

Result: The RINVR score decreased significantly between the days of chemotherapy and 3 days post chemotherapy (p = 0,005) in treatment group. Comparation of RINVR score on chemotherapy days, 3 , and 6 days after chemotherapy was lower in treatment group but not significantly different between two groups ( p = 0,525, p = 0,506, p = 0,284).

Conclusion: Press needle acupuncture might be effective in reducing CINV in pediatric cancer patiens and was feasible due to its minimal side effects. Further research is needed to determine the appropriate treatment time."

"[ABSTRAKNyeri dan kecemasan merupakan hal yang normal ketika ibu menghadapipersalinan, namun jika mengalami nyeri dan kecemasan yang berlebihan akanmenimbulkan komplikasi selama proses persalinan. Penelitian ini bertujuan untukmengetahui pengaruh paket Touching, Massage, Acupressure (T.M.A) olehkeluarga terhadap nyeri persalinan dan proses persalinan. Penelitian inimerupakan operasional research. Sampel dalam penelitian ini 94 ibu hamil yangdibagi menjadi dua kelompok yaitu 47 orang sebagai kelompok intervensi dan 47kelompok kontrol yang diambil dengan teknik consecutive sampling.Pengumpulan data menggunakan kuesioner FPRS, FAS, lembar observasi prosespersalinan dan wawancara. Hasil wawancara keluarga mengatakan bahwapengetahuan keluarga bertambah dan adanya manfaat setelah penerapan paketT.M.A. Hasil uji statistik dengan menggunakan Chi Square menunjukan bahwaada perbedaan yang bermakna pada proses persalinan (power, p=0,028);passanger p=0,006; passageway p=0,048; position p=0,048; psikologis p=0,000)dan nyeri persalinan (p=0,003) antara kedua kelompok intervensi dan kontrol. Halini menunjukan bahwa pendampingan keluarga dengan menggunakan paketT.M.A berpengaruh terhadap proses persalinan dan nyeri persalinan. Paket T.M.Adiharapkan menjadi intervensi non farmakologis dalam keperawatan untukmenurunkan nyeri dan kecemasan pada ibu bersalin.

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ABSTRAKPain and anxiety is normal when a mother facing labor. Excessive pain andanxiety will cause complications during childbirth. This research aimed to knowthe effect of touching package, Massage, Acupressure (TMA) by the family to thepain of labor and delivery process. This research operasional research. Thesample were 94 pregnant women that divided into two groups: 47 as interventiongroup and 47 control group that taken with consecutive sampling technique.Collection data using questionnaires FPRS, FAS and observation sheet deliveryprocess. The results obtained in the interview, participant said that familyknowledge has increased and they feel the benefit of the TMA package. Thequantitatif result showed there was a significant difference in labor process(power, p=0,028); passenger p=0,006; passageway p=0,048; position p=0,048;psychological response p=0,000) and pain (p=0,003) between the intervention andcontrol groups. This shows that the family what used TMA package influence onlabor process and pain. Touching package, Massage, Acupressure (TMA) isexpected as an intervention non farmakologis in decreased pain and anxietymaternal.;Pain and anxiety is normal when a mother facing labor. Excessive pain andanxiety will cause complications during childbirth. This research aimed to knowthe effect of touching package, Massage, Acupressure (TMA) by the family to thepain of labor and delivery process. This research operasional research. Thesample were 94 pregnant women that divided into two groups: 47 as interventiongroup and 47 control group that taken with consecutive sampling technique.Collection data using questionnaires FPRS, FAS and observation sheet deliveryprocess. The results obtained in the interview, participant said that familyknowledge has increased and they feel the benefit of the TMA package. Thequantitatif result showed there was a significant difference in labor process(power, p=0,028); passenger p=0,006; passageway p=0,048; position p=0,048;psychological response p=0,000) and pain (p=0,003) between the intervention andcontrol groups. This shows that the family what used TMA package influence onlabor process and pain. Touching package, Massage, Acupressure (TMA) isexpected as an intervention non farmakologis in decreased pain and anxietymaternal.;Pain and anxiety is normal when a mother facing labor. Excessive pain andanxiety will cause complications during childbirth. This research aimed to knowthe effect of touching package, Massage, Acupressure (TMA) by the family to thepain of labor and delivery process. This research operasional research. Thesample were 94 pregnant women that divided into two groups: 47 as interventiongroup and 47 control group that taken with consecutive sampling technique.Collection data using questionnaires FPRS, FAS and observation sheet deliveryprocess. The results obtained in the interview, participant said that familyknowledge has increased and they feel the benefit of the TMA package. Thequantitatif result showed there was a significant difference in labor process(power, p=0,028); passenger p=0,006; passageway p=0,048; position p=0,048;psychological response p=0,000) and pain (p=0,003) between the intervention andcontrol groups. This shows that the family what used TMA package influence onlabor process and pain. Touching package, Massage, Acupressure (TMA) isexpected as an intervention non farmakologis in decreased pain and anxietymaternal., Pain and anxiety is normal when a mother facing labor. Excessive pain andanxiety will cause complications during childbirth. This research aimed to knowthe effect of touching package, Massage, Acupressure (TMA) by the family to thepain of labor and delivery process. This research operasional research. Thesample were 94 pregnant women that divided into two groups: 47 as interventiongroup and 47 control group that taken with consecutive sampling technique.Collection data using questionnaires FPRS, FAS and observation sheet deliveryprocess. The results obtained in the interview, participant said that familyknowledge has increased and they feel the benefit of the TMA package. Thequantitatif result showed there was a significant difference in labor process(power, p=0,028); passenger p=0,006; passageway p=0,048; position p=0,048;psychological response p=0,000) and pain (p=0,003) between the intervention andcontrol groups. This shows that the family what used TMA package influence onlabor process and pain. Touching package, Massage, Acupressure (TMA) isexpected as an intervention non farmakologis in decreased pain and anxietymaternal.]"