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"Telah dilakukan penelitian terhadap pengaruh infeksi Fasciola gigantica yang diradiasi pada marmot. Marmot dibagi menjadi empat kelompok. Tiga kelompok diinfeksi dengan metaserkaria F.gigantica yang diradiasi 20Gy, 40 Gy, dan 60 Gy, sedangkan satu kelompok lagi sebagai kontrol positif. Setiap ekor marmot diinfeksi dengan 50 metaserkaria F.giganctica hidu[. Penelitian dilakukan sebanyak tiga kali. Pengamatan pada setiap ulangan dilakukan selama 12 minggu. Hasil penelitian menunjukkan bahwa pada kelompok kontrol dapat dipanen ulang dengan rataan 3,9%. Infeksi oleh cacing hati pada marmot masih dapat ditemukan hingga dosis radiasi 40Gy. "

"The previous studies had shown that Indonesian thin-tailed (ITT) sheep are more resistant to infection with fasciola gigantica than the Merino sheep...."

"Latar Belakang Uji latih jantung beban (ULJB) merupakan modalitas diagnostik PJKO yang telah lama digunakan. Meskipun demikian, perannya semakin semakin tergantikan oleh karena tingginya angka positif palsu, khususnya pada respons iskemik sugestif positif. Tujuan studi ini adalah untuk menyusun sebuah model algoritme prediksi menggunakan kecerdasan buatan untuk mendeteksi PJKO pada populasi respons iskemik sugestif positif.Metode Pasien yang menjalani ULJB dengan hasil respons iskemik sugestif positif dan angiografi koroner invasif dalam rentang 1 tahun pasca ULJB diikutsertakan dalam studi ini. Populasi studi dibagi secara acak menjadi kelompok latihan (80%) dan uji (20%) untuk membuat algoritme prediktif. Total 16 dari 122 fitur yang digunakan, meliputi informasi klinis, faktor risiko dan EKG saat ULJB. Algoritme yang digunakan meliputi support vector machine, logistic regression, random forest, k-nearest neighbor, naive Bayesian, Adaboost, decision tree dan extreme gradient boosting. Hasil Sebanyak 124 dari 513 pasien dengan respons iskemik sugestif positif ikutserta dalam studi ini. Algoritme random forest memiliki nilai akurasi yang paling tinggi 0,75±0,05 dengan indeks Youden 0,37 serta AUC 0,7±0,14. Sebanyak 86(69,35%) populasi terbukti memiliki stenosis signifikan.Kesimpulan ULJB dengan bantuan kecerdasan buatan dapat mendeteksi adanya PJKO pada pasien dengan sindroma koroner kronik dengan respons iskemik sugestif positif.

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Background Treadmill stress testing (TST) used to be an established diagnostic modalities in diagnosing obstructive coronary artery disease (OCAD) among patients with chronic coronary syndrome (CCS). Nevertheless, it has high false positive rate especially especially those with suggestive positive ischemic response (SPIR). We aim to develop an predictive model based on machine learning to detect OCAD among those with SPIR.

Method Patients who underwent TST and coronary angiography (CAG) within 1 year interval were enrolled into the study. They were randomly splitted into training (80%) and testing (20%) dataset for model development. Sixteen out of 122 features were used, including clinical information, risk factor and ECG parameter during TST. Several algorithm were used in model development including support vector machine, logistic regression, random forest, k-nearest neighbor, naive Bayesian, Adaboost, decision tree dan extreme gradient boosting.

Result 124 out of 513 patients with SPIR were enrolled in this study. Random forest algorithm achieved the highest accuracy (0,75±0,05) with Youden index of 0,37 and AUC 0,7±0,14. A total of 86(69,35%) patients had OCAD based on CAG.

Conclusion Machine learning based predictive model can diagnosed OCAD among CCS patients with SPIR."

"Peningkatan keandalan dan penurunan biaya penyaluran sistem tenaga listrik tenus diupayakan. Dalam daflar penggunaan isolator saluran udara di Indonesia, isolator porselen merupakan isolator yang menempati posisi pertama dibandingkon dengan pemakaian isolator lainnya. Padahal isolator parselenmempunyai bebarapa kelemahan, diantaranya proses produksi yang lama dan biaya produksi yang tidak. sedikit. Isalalor Epoxy Resin sebagai isolator dari jenis cycloaliphatic silica powder filled menjadi atlematif dalam pemakaian isolator di luar ruangan. Kelebihan isolator ini antara lain, harga yang relatif lebih murah, proses fabrikasi yang lebih mudah, sifat mekanis yang kuat dan ringan serta yang utama yaitu didukung oleh sifat isolasi yang mendukung dalam penggunaannya sebagai isolator. Sedangkan kekurangannya adalah terjadi penurunan unjuk kerja isolator ini pada lingkungan yang ekstrim dan berplutan. Untuk itu penulis terdorong untuk melakukan pengujian dengan judul "Analisis Pengaruh Debit Embun Terhadap tegangan Kritis Flashover pada isolator Epoxy Resin dengan Variasi Polutan Buatan". Adapun polutan yang dtgunakan adalah NaCI, CaC03, Carbon dan Semen dengan musing-masing divariasikan bobot nya sebesar 100 gr, 3()0 gr dan 500 gr. Sedangkan debit embun yang digunakan sebesar 16,7 ml/menit untuk tipe 1, 24 m/lmenit untuk tipe 11 dan 32 ml/menit untuk tipe III. Dari hasil pengujian menunjukkan bahwa vanrasi debit embun tidak…"

"Globalisasi merupakan fenomena yang bersifat omnipresent dan oleh karena itu setiap negara mau tidak mau dan bisa tidak bisa harus menjadi bagian dari fenomena itu. Perwujudan yang nyata dari globalisasi,termasuk dalam bidang pendidikan adalah liberalisasi perdagangan....."

"Diabetes mellitus (DM) is one of the public health problems worldwide, including in Indonesia. Cardiovascular disease was the main cause of death (75-80%) in DM, three-fourths of this death was caused by coronary heart disease (CHD). Approximately 34.2% of patients with acute coronary syndrome (ACS) receiving care at ICCU of Dr. Cipto Mangunkusumo General Hospital (RSCM) suffered from DM. Mortality rates of ACS in DM patients were still high and ACS prognosis in DM patients were still unfavorable. There are many factors playing a part in atherosclerosis and ACS incidence in DM patients, such as metabolic disorders due to hyperglycemia and the fomration of advanced glycation end product (AGE), oxidative stress, atherogenic dyslipidemia in DM in the form of high triglyceride level and low HDL cholesterol as well as an increase in small dense LDL, and insulin resistance. In addition, other risk factors of CHD frequently encountered with DM were hypertension, obesity, thrombocytc hyperaggregation and hypercoagulation. The management ofthis disease which was based on the control of risk factors was not yet satisfactory.Inflammatory response played an important role in pathogenesis of atherosclerosis, beginning with early lesion up to acute coronary syndrome. Increase in inflammatory responses (hsCRP) could predict cardiovascular event and predict post-ACS prognosis. Studies in DM population showed an increase in inflammation. ln-depth studies on inflammatory responses in ACS DM patients have not yet been reported. In normal condition, there was a balance of proinflammatory and antiinflammatory cytokines. The ratio of proinflammatory and antiinflammatory cytokines in ACS, particularly DM patients has not been studied. The relationship between metabolic factor (blood glucose, glyco Hb and lipid) and inflammatory response in ACS DM patients has not yet also been studied.Currently, the effort to decrease inflammatory response is made, among others, by aspirin, statin hypolipidemic medication and insulin sensitizer. Although aspirin and statin were used routinely in ACS patients and have proved to reduce inflammation, morbidity and mortality rates of ACS patients were still high. Thus, we would like to observe whether an addition of other medications in standard therapy could reduce inflammation better. Curcumin in experimental animals-and humans) showed -hypolipidemic effect (decrease 'in absorption and increase in catabolism) and hypoglycemia (effect on PPAR-7). Curcumin also demonstrated antiinflammatory effect. In this study we would like to observe the effects of curcumin on both metabolic factors and inflammatory responses in ACS patients.PROBLEM IDENTIFICATIONThe above elaboration showed a discrepancy associated with inflammatory response in DM ACS patients. Up to now, the relationship of metabolic factor and inflammatory response in DM ACS has not been clear yet. Likewise, the effects of curcumin on metabolic factor and inflammatory response in ACS have not yet been identified.OBJECTIVESTo evaluate inflammatory responses in DM ACS and its relationship with metabolic factors (glucose, blood; glyco Hb, total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride); to evaluate the ratio of proinflammatory and antiinflammatory cytokines (IL-6/IL-10) in ACS DM patients, and to identify the effects of curcumin on metabolic factors and inflammatory responses in ACS patients.SETTINGThe study was conducted at ICCU of RSCM, ICCU of Persahabatan, ICCU of RS MMC and ICCU of Medistra Hospital, Cardiology Polyclinic, Department of Internal Medicine, Faculty of Medicine University of Indonesia! RSCM and Integrated Cardiac Service Poiyclinic of RSCM.STUDY SUBJECTSACS patients (DM and non-DM) and CHD (DM and non-DM).DESIGNThere were two studies: l. Observational design to observe inflammatory responses (hscRP, IL-6, IL-IO, VCAM and ICAM) in DM ACS, non-DM ACS, DM CI-ID, and non-DM CHD; to evaluate the relationship between metabolic factors (fasting blood glucose, blood glucose 2 hours PP, glyco Hb, total cholesterol, LDL cholesterol, HDI.. cholesterol and triglyceride) and inflammatory responses (hsCRP, IL-6, IL-10, VCAM and ICAM) in ACS DM. 2. Interventional study which was a double-blind randomized trial to evaluate the effects of curcumin at escalating doses (low dose 3:-:IS mglday, moderate dose 3x30 mg/day and high dose 3x60 mg/day on metabolic factors (fasting blood glucose. blood glucose 2 hours PP and glyco Hb) and the effects of curcumin at escalating doses on inflammatory responses (hsCRP, ll.-6, VCAM and ICAM) in ACS patients.RESULTSIn observational study, |46 subjects were analyzed, consisting of 84 ACS patients, (30 DM ACS patients and 54 non-DM ACS), and 62 CHD (25 DM CHD patients and 37 non-DM CHD patients). The results of the study in the four groups of patients showed: 1. Inflammatory response in DM ACS was higher than in DM CHD (hsCRP, p=0.00; II..-6, p=0.00; IL-10, p=0.00) and non-DM ACS (ICAM, P=0.03). 2. The ratio of proinflammatory and antiinflammatory cytokines (IL-6/II..-10) in DM ACS did not differ from that of DM CHD (p=0.2l) and non-DM ACS (p=0.5 l). 3. There was a relationship between metabolic factors and inflammatory responses in DM ACS: triglyceride and ll.-6 (r=O.39, p=0.03) and II..-I0 (r=0.37, p=o.o4).In interventional study we performed randomization in 75 ACS patients divided into four groups, consisting of low-dose curcumin group of 15 patients, moderate-dose curcumin group of 15 patients, high-dose curcumin group of IS patients, and placebo group of 30 patients. The results of the study in these four groups showed: l. Low-dose curcumin showed a decrease in hsCRP in one week ofthe first month after intervention, there was a significant difference liom that of placebo (p=0.04). Low-dose, moderate-dose, high-dose curcumin groups showed a decrease in IL-6, but was not significantly different from placebo. Low-dose, moderate-dose, high-dose curcumin did not show a decrease in VCAM and ICAM after intervention of 2 months. 2. Low-dose curcumin group tended to experience a decrease in glyco Hb level after intervention of 2 months (p=0.06); however, it was not significantly different from that of placebo. 3. There was a tendency that low-dose curcumin reduced total cholesterol and LDI. cholesterol; however, it was not significantly different from that of placebo. There was a tendency that low-dose curcumin increased HDL cholesterol; however, it was not significantly different from that of placebo. 4. There was a tendency that the pattern of escalating doses had some effects in inflammatory responses and metabolic factors, in which low-dose curcumin showed the best effects, followed by moderate-dose and finally high- dose curcumin.CONCLUSIONSIn this study, inflammatory responses in DM ACS patients were higher than those in DM CHD and non-DM ACS patients. There was no difference in the ratio of proinflammatory and antiinflammatory cytokines (IL-6fIL-IO) in DM ACS compared with DM CHD and non-DM ACS. ln addition, the present study identified some of the relationships between metabolic factors and inflammatory responses. Low-dose curcumin reduced hsCRP in one week of the first month after the intervention in ACS patients. There was a tendency that low-dose curcumin reduced glyco Hb level in ACS."

"ABSTRAKDalam bidang kriminal, pengenalan sidik jari membutuhkan banyak waktu dan tenaga, karena itu Lerbagai cara otomatisasi dilakukan untuk mempermudah serta mempercepat proses pengenalan sidik jari tersebut. Salah satu teknik otomatisasi untuk pengenalan sidik jari ini adalah dengan menggunakan komputer dan pemanfaatan aplikasi dad jaringan saraf buatan.Dalam skripsi ini digunakan proses otomatisasi dengan menggunakan gabungan dari proses-proses pengolahan citra dan jaringan saraf buatan. Citra sidik jari hasil scanning diolah dan diproses sehingga didapatkan ciri-ciri sidik jari bersangkutan, berupa kode arah rata-rata dan jumlah bifurkasi. Ciri-ciri ini kcmudian dimasukkan ke dalam suatu sistem jaringan saraf buatan untuk- proses pelatihan sehingga jaringan saraf tersebut dapat digunakan sebagai standar pembanding untuk proses identifikasi.Jaringan saraf yang dirancang dan diterapkan dalam skripsi ini adalah salah satu dari topologi jaringan saraf mulliiayer dengan algoritma pelatihan propagasi balik, karena dari hasil yang diperoleh telah menunjukkan proses pengenalan yang cukup akurat dan memakan waktu yang singkat.

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