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"Proses penuaan kulit secara ekstrinsik dipengaruhi oleh radiasi UV, merokok, gizi buruk, polusi udara, dan stres fisik. Dermoscopic photoaging scale (DPAS) adalah metode non-invasif untuk menilai penuaan foto. Penelitian ini bertujuan untuk mengevaluasi prevalensi penuaan kulit akibat paparan sinar UV pada personel militer pria berusia 30-42 tahun, dengan membandingkan kelompok infanteri dan administrasi yakni kelompok kesehatan militer (CKM) menggunakan DPAS. Selain itu, hubungan antara prevalensi penuaan, konsumsi alkohol, dan kebiasaan merokok akan diteliti. Penelitian ini adalah penelitian deskriptif analitik dengan desain potong lintang. Kriteria penuaan foto dinilai berdasarkan DPAS. Hasil dari penelitian ini yaitu sebanyak 40 subjek penelitian, semuanya memiliki skor DPAS total > 1, dengan kriteria yang paling sering ditemukan adalah ephelides/lentigines, yellow papules, dan superficial wrinkles. Tidak ada hubungan yang signifikan secara statistik antara kebiasaan merokok dan skor DPAS di setiap wilayah wajah. Setelah melakukan penelitian, peneliti memiliki kesimpulan bahwa berdasarkan metode DPAS, tidak ada perbedaan prevalensi penuaan foto di kedua kelompok. Namun, skor total DPAS (StDPAS) infanteri lebih tinggi daripada StDPAS kelompok CKM, dengan perbedaan signifikan pada skor DPAS di wilayah pipi kanan dan pipi kiri dibandingkan dengan wilayah wajah lainnya.

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The extrinsic process of skin aging influenced by UV radiation, smoking, poor nutrition, air pollution, and physical stress. Dermoscopic photoaging scale (DPAS) is a non-invasive method to assess photoaging. This study aims to evaluate the prevalence of UV-induced skin aging in male military personnel aged 30-42, comparing infantry and administration groups in this research represented by military medical service group using DPAS. Additionally, the relationship between aging prevalence, alcohol consumption, and smoking habits will be examined. This is a descriptive analytic research with cross-sectional design. Photoaging criteria was assessed based on DPAS. The results of this research are a total of 40 research subjects, all had a total DPAS score > 1, with the most frequently found criteria being ephelides/lentigines, yellow papules, and superficial wrinkles. There was no statistically significant association between smoking habits and DPAS scores in each facial region. After doing this research, the writer concludes that based on DPAS method, there is no prevalence difference of photoaging in both groups. But the infantry's DPAS total score (TsDPAS) was greater than military medical service’s TsDPAS, with a significant difference in the DPAS score in the right and left cheek regions compared to other facial regions."

"[ABSTRAKLatar belakang. Rekomendasi Global Alliance dalam penanganan AVS meliput antibiotik, asam retinoat, dengan atau tanpa BPO. Resistensi obat menjadi perhatian utama pada penggunaan antibiotik jangka panjang dalam terapi akne vulgaris sedang. Kombinasi antibiotik dan BPO direkomendasikan untuk mengatasi masalah tersebut. Pada tipe kulit IV-V hiperpigmentasi pasca akne merupakan masalah yang sering dikeluhkan. Tujuan. Membandingkan efektivitas, efek samping dan kejadian hiperpigmentasi pasca inflamasi penggunaan BPO sebagai paduan terapi lini pertama AVS pada tipe kulit IV-V Fitzpatrick. Metode. Penelitian analitik dengan desaain uji klinis acak tersamar ganda membandingkan dua sisi wajah. Subyek diberikan paduan terapi lini pertama. Sisi wajah perlakuan diberikan gel BPO 2,5% sedangkan kelompok kontrol gel plasebo. Hasil. Pada minggu ke-2,4,6,8 didapatkan penurunan persentase total lesi sebesar 51,47%, 71%, 75%, 82,84% pada kelompok BPO dan 30%, 53,75%, 62,28, 71% pada kelompok plasebo (p<0,001 .) Efek samping dan kejadian HPI pada minggu ke 2,4,6 dan 8 tidak berbeda bermakna. Kesimpulan. Penggunaan BPO sebagai bagian dari paduan terapi lini pertama AVS lebih efektif, tidak meningkatkan efek samping ataupun kejadian HPI.Kata kunci. akne vulgaris, gel BPO 2,5%,

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ABSTRACTBackground. Global alliance recommendation for moderate acne treatment are antibiotic, retinoic acid with or without benzoyl peroxide. Drug resistance become the most common problem due to longterm use of antibiotic in acne treatment. Combination of antibiotic and BPO is recommeded to overcome this problem. In patient with skin type IV-V post acne hyperpigmentation is one of the most significant complaint. Aim. To compare efectivity, side effect and post inflammatory hyperpigmentation of BPO 2,5% gel as a part of first line therapy regiment in patient with skin type IV-V. Method. This is an analytic study with randomized control trial design comparing both half-face (split-face). Subjects were given first line therapy regiment. Half-face was given BPO 2,5% gel twice daily while other half face with placebo. Result. Total lesions reduction in BPO group on week 2,4,6,8 were 51,47%, 71%, 75%, 82,84% respectively and 30%, 53,75%, 62,28, 71% in placebo group respectively. Conclusion. BPO as a part of first line therapy regiment for moderate acne is more effective, with no increase of side effect nor post inflammatory hyperpigmentation compared to placebo., Background. Global alliance recommendation for moderate acne treatment are antibiotic, retinoic acid with or without benzoyl peroxide. Drug resistance become the most common problem due to longterm use of antibiotic in acne treatment. Combination of antibiotic and BPO is recommeded to overcome this problem. In patient with skin type IV-V post acne hyperpigmentation is one of the most significant complaint. Aim. To compare efectivity, side effect and post inflammatory hyperpigmentation of BPO 2,5% gel as a part of first line therapy regiment in patient with skin type IV-V. Method. This is an analytic study with randomized control trial design comparing both half-face (split-face). Subjects were given first line therapy regiment. Half-face was given BPO 2,5% gel twice daily while other half face with placebo. Result. Total lesions reduction in BPO group on week 2,4,6,8 were 51,47%, 71%, 75%, 82,84% respectively and 30%, 53,75%, 62,28, 71% in placebo group respectively. Conclusion. BPO as a part of first line therapy regiment for moderate acne is more effective, with no increase of side effect nor post inflammatory hyperpigmentation compared to placebo.]"

"Latar belakang: Hampir sebagian besar pasien kanker akan memiliki keluhan kulit, rambut, dan kuku (KRK) terkait efek samping kemoterapi yang diberikan. Antrasiklin merupakan kemoterapi yang banyak digunakan pada pasien kanker. Meskipun jarang mengancam nyawa, kelainan KRK dapat menyebabkan penurunan kualitas hidup. Berbagai faktor risiko berpengaruh terhadap kelainan tersebut. Waktu timbulnya manifestasi kelainan KRK pada pasien kanker yang menjalani kemoterapi berbasis antrasiklin juga beragam munculnya. Penelitian ini bertujuan untuk menganalisis hubungan antara usia, penyakit penyerta sistemik, status gizi, ECOG, dan anemia dengan manifestasi klinis KRK pada pasien kanker yang menjalani dua siklus kemoterapi berbasis antrasiklin.Metode: Penelitian ini merupakan penelitian deskriptif analitik dengan kohort prospektif yang diikuti dalam dua siklus pertama kemoterapi berbasis antrasiklin. Sebesar 65 pasien kanker berusia di atas 18 tahun yang mendapatkan kemoterapi siklus pertama berbasis antrasiklin di RSUPN dr. Cipto Mangunkusumo. Semua SP dilakukan anamnesis, pemeriksaan dermatovenereologikus, dan dokumentasi klinis sampai sebelum kemoterapi siklus ke-3. Pencatatan faktor risiko, jenis, dan waktu timbulnya kelainan dilakukan apabila ditemukan manifestasi KRK.Hasil: Kelainan kulit terbanyak berupa xerosis dan hiperpigmentasi. Anagen effluvium ditemukan pada 89,2% pasien kemoterapi. Melanonikia dan xanthonikia ditemukan pada 87,7% pasien. Xerosis ditemukan dengan median (minimum-maximum) 7 (2-56) hari, anagen effluvium timbul dalam median (minimum-maximum) 13(1-27 hari), dan melanonikia dengan median (minimum-maximum) 23(1-65) hari. Tidak terdapat hubungan antara usia, penyakit penyerta sistemik, status gizi, status performa ECOG, dan anemia dengan manifestasi KRK pada pasien kanker yang menjalani dua siklus kemoterapi berbasis antrasiklin.Kesimpulan: Semua pasien memiliki kelainan KRK. Kelainan yang paling cepat timbul adalah xerosis, diikuti anagen effluvium, dan melanonikia. Tidak ditemukan hubungan antara usia, penyakit penyerta sistemik, status gizi, status performa ECOG, dan anemia dengan manifestasi KRK pada pasien kanker yang menjalani dua siklus kemoterapi berbasis antrasiklin.

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Background: Nearly most cancer patients experience skin, hair, and nail complaints due to chemotherapy side effects. Anthracycline-based chemotherapy is widely utilized in cancer care. While rarely life-threatening, cutaneous, hair, and nail alterations can significantly impact quality of life. Several risk factors influence these disorders. The onset timing of skin, hair, and nail manifestations varies among cancer patients undergoing anthracycline-based chemotherapy. This study analyses the association between age, systemic comorbidities, nutritional status, ECOG performance status, and anaemia with clinical manifestations of skin, hair, and nails in cancer patients undergoing two cycles of anthracycline-based chemotherapy.

Methods: This is an analytical descriptive study involving a prospective cohort followed during the first two cycles of anthracycline-based chemotherapy. A total of 65 cancer patients aged above 18, receiving the first cycle of anthracycline-based chemotherapy at RSUPN dr. Ciptomangunkusumo, were enrolled. All subjects underwent anamnesis, dermatovenereological examination, and clinical documentation before the third chemotherapy cycle. Risk factors, type, and onset time of abnormalities were recorded upon detection of skin, hair, and nail manifestations.

Results: All patients presented with skin, hair, or nail abnormalities. The most rapidly occurring abnormalities were xerosis, followed by anagen effluvium and melanonychia. No correlation was found between age, systemic comorbidities, nutritional status, ECOG performance status, and anaemia with skin, hair, and nail manifestations in cancer patients undergoing two cycles of anthracycline-based chemotherapy. Conclusions: The most frequent skin abnormalities observed were xerosis and hyperpigmentation. Anagen effluvium was detected in 89.2% of chemotherapy patients. Melanonychia and xanthonychia were found in 87.7% of patients. Xerosis had a median (min-max) onset of 7 (2-56) days, anagen effluvium manifested within a median (min- max) of 13 (1-27) days, and melanonychia with a median (min-max) onset of 23 (1-65) days. There was no association found between age, systemic comorbidities, nutritional status, ECOG performance status, and anaemia with skin, hair, and nail manifestations in cancer patients undergoing two cycles of anthracycline-based chemotherapy."