Hasil Pencarian  ::  Simpan CSV :: Kembali

"Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers."

"This proceedings book presents the outcomes of the VII International Scientific Conference "Digital Transformation of the Economy: Challenges, Trends, New Opportunities", which took place in Samara, Russian Federation, on April 26-27, 2019. Organized by the Samara State University of Economics, the conference chiefly focused on digital economy issues, such as theoretical preconditions for the development of economic systems in the digital age and specific practical issues related to real-world business practice. Consisting of six chapters corresponding to the thematic areas of the conference, and written by scientists and practitioners from different regions of Russia, Kazakhstan, the Czech Republic and Germany, the book offers answers to the most pressing questions for todays business community: - How is our world changing under the influence of digital technology? - Is sustainable economic development a myth or reality in the context of digitalization? - What threats and opportunities does digitalization bring? - What are realities and prospects of digitalization in the context of business practice? - How do we create a digital infrastructure for the economy? - How should the legal environment of the economy be transformed in the context of digitalization? The conclusions and recommendations presented are not recipes for solving the existing economic problems, but instead are intended for use in further research on transformation processes in the economy and in the development of state economic policies in various countries and regions"

"Latar belakang: Penelitian ini membahas tentang penggunaan alat uji cepat (rapid test device) untuk mendeteksi Prostate-Specific Antigen (PSA) dalam cairan mani secara spesifik, sebagai upaya pengungkapan kasus kejahatan seksual.Metode: Penelitian ini merupakan penelitian potong lintang analitik. Sebanyak 45 sampel cairan mani dan urindiambil secara consecutive. Cairan mani diencerkan secara bertingkat hingga 1:5.000.000 dan urin laki-lakihingga 1:200 menggunakan akuades, sedangkan urin perempuan tidak diencerkan. Pemeriksaan dilakukan denganmenggunakan rapid test PSA.Hasil: Proporsi hasil pemeriksaan PSA yang positif pada cairan mani, urin laki-laki, dan urin perempuan berturutturut100%, 6,67%, dan 0%. Secara statistik perbedaan proporsi ini sangat bermakna. Nilai diagnostik rapid testdevice PSA untuk mendeteksi cairan mani adalah sensitivitas 100%, spesifisitas 96,67%, NDP 93,75%, NDN 100%,RKP 33,33, RKN 0, dan AUC 0,983.Kesimpulan: Rapid test PSA sangat spesifik dan sensitif untuk mendeteksi PSA dalam cairan mani. Oleh karena itu,praktisi forensik disarankan untuk menggunakan alat ini untuk mengungkap kasus kejahatan seksual.

---

AbstractBackground: This study was conducted to determine whether the rapid test device can be used to detect PSA inseminal fluid specifically, for solving sexual assault cases.Methods: A cross sectional study has been conducted. A total of 45 samples were taken consecutively. Semen wasdiluted in serially up to 1:5.000.000 and male urin up to 1:200 using distilled water, whereas female urin was notdiluted. Samples were analyzed using rapid test PSA.Results: The proportion of positive results of PSA in seminal fluid, male urin and female urin respectively was 100%,6.67%, and 0%. Statistically, these differences are highly significant. The analysis revealed that the PSA rapid testdevice was 100% sensitive and 96.67% specific to detect seminal fluid. The test also have PPV 93.75%, NPV 100%,LR(+) 33.33, LR(-) 0, and AUC 0.983.Conclusion: PSA Rapid Test is very specific and sensitive to detect PSA in seminal fluid. Therefore, this device issuggested for forensic use in sexual assault cases."

""With contributions from leading scholars in constitutional law, this volume examines how carefully designed and limited doctrines of proportionality can improve judicial decision-making, how it is applied in different jurisdictions, its role on constitutionalism outside the courts, and whether the principle of proportionality actually advances or detracts from democracy. Contributions from some of the seminal thinkers on the development of scholarship on proportionality (e.g. Alexy, Barak, and Beatty) extend their prior work and engage in an important dialogue on the topic. Some offer substantial critiques, others defend the doctrine and offer important clarifications and extensions of their prior work. Throughout, the authors engage not only with case law from around the world but also with existing scholarly treatments of the subject. Mathematical treatments are avoided, making the book accessible to readers from both 'soft' and hard' social science backgrounds"--"With contributions from leading scholars in constitutional law, this volume examines how carefully designed and limited doctrines of proportionality can improve judicial decision-making, how it is applied in different jurisdictions, its role on constitutionalism outside of courts and whether the principle of proportionality actually advances or detracts from democracy. Contributions from some of the seminal thinkers on the development of scholarship on proportionality (e.g. Alexy, Barak and Beatty) extend their prior work and engage in an important dialogue on the topic. Some offer substantial critiques, others defend the doctrine and offer important clarifications and extensions of their prior work. Throughout, the authors engage not only with case law from around the world, but also with existing scholarly treatments of the subject. Mathematical treatments are avoided, making the book accessible to readers from both 'soft' and hard' social science backgrounds"--"

""With contributions from leading scholars in constitutional law, this volume examines how carefully designed and limited doctrines of proportionality can improve judicial decision-making, how it is applied in different jurisdictions, its role on constitutionalism outside the courts, and whether the principle of proportionality actually advances or detracts from democracy. Contributions from some of the seminal thinkers on the development of scholarship on proportionality (e.g. Alexy, Barak, and Beatty) extend their prior work and engage in an important dialogue on the topic. Some offer substantial critiques, others defend the doctrine and offer important clarifications and extensions of their prior work. Throughout, the authors engage not only with case law from around the world but also with existing scholarly treatments of the subject. Mathematical treatments are avoided, making the book accessible to readers from both 'soft' and hard' social science backgrounds"--"With contributions from leading scholars in constitutional law, this volume examines how carefully designed and limited doctrines of proportionality can improve judicial decision-making, how it is applied in different jurisdictions, its role on constitutionalism outside of courts and whether the principle of proportionality actually advances or detracts from democracy. Contributions from some of the seminal thinkers on the development of scholarship on proportionality (e.g. Alexy, Barak and Beatty) extend their prior work and engage in an important dialogue on the topic. Some offer substantial critiques, others defend the doctrine and offer important clarifications and extensions of their prior work. Throughout, the authors engage not only with case law from around the world, but also with existing scholarly treatments of the subject. Mathematical treatments are avoided, making the book accessible to readers from both 'soft' and hard' social science backgrounds"--"

"This book arises as the natural continuation of the International Spring School "Advances and challenges in space-time modelling of natural events," which took place in Toledo (Spain) in March 2010. This Spring School above all focused on young researchers (Master students, PhD students and post-doctoral researchers) in academics, extra-university research and the industry who are interested in learning about recent developments, new methods and applications in spatial statistics and related areas, and in exchanging ideas and findings with colleagues."