Hasil Pencarian  ::  Simpan CSV :: Kembali

"This book addresses patient-specific modeling. It integrates computational modeling, experimental procedures, imagine clinical segmentation and mesh generation with the finite element method (FEM) to solve problems in computational biomedicine and bioengineering. Specific areas of interest include cardiovascular problems, ocular and muscular systems and soft tissue modeling. "

"This book reviews the frontier of research and clinical applications of patient specific modeling, and provides a state-of-the-art update as well as perspectives on future. "

"Introduction to computational modeling in organizations, virtual organizations, the impact of organizational interventions on behaviors, examining the fit between empirical data and theoretical simulations, modeling faking on personality teste, simulating effects of pay-for-performance systems on pay-performance relationships, information distribution, participation, and group decision, computational modeling with petri nets, pressures to uniformity and the evolution of cultural norms, modeling change in fields of organizations, organizational adaptation in volatile environments, and lessons learned and insights gained."

"Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis. Higher time and length scale processes, such as molecular evolution, have also greatly benefited from new breeds of computational approaches. This book provides an overview of the established computational methods used for modeling biologically and medically relevant systems."

"The thesis focuses on the control of blood glucose devices and design of implantable devices, and offers valuable insights on diabetes mellitus and related physiology and treatments. Diabetes mellitus is a widespread chronic disease in the modern world that affects millions of people around the globe. In Singapore, one in ten of the population has diabetes, and the severity of the problem has prompted the country’s prime minister to talk about the disease at the National Day Rally in 2017. Designing an artificial pancreas that can provide effective blood glucose control for individuals with diabetes is one of the most challenging engineering problems. The author reports on research into the development of an implantable artificial pancreas that can regulate blood glucose levels by delivering appropriate dosages of insulin when necessary. By sensing blood glucose and injecting insulin directly into the vein, the implantable device aims to remove delays that occur with subcutaneous blood glucose sensing and insulin delivery. Preliminary in-vitro and in-vivo experimental results suggest that the implantable device for blood glucose control could be a clinically viable alternative to pancreas transplant."

"The field of mathematical biology is growing rapidly. Questions about infectious diseases, heart attacks, cell signaling, cell movement, ecology, environmental changes, and genomics are now being analyzed using mathematical and computational methods. A Course in Mathematical Biology: Quantitative Modeling with Mathematical and Computational Methods is the only book that teaches all aspects of modern mathematical modeling and that is specifically designed to introduce undergraduate students to problem solving in the context of biology."

"ABSTRACTPurposeGeriatric surgery poses specific challenges due to patient vulnerability in relation to aging. We analyzed perioperative challenges concerning super-elderly patients with breast cancer.MethodsBetween 2013 and 2018, 908 patients with breast cancer were treated surgically. Of these, two patient groups were compared: Group A (≥ 85 years old, n = 34, 3,7%) and Group B (75-84 years old, n = 136, 15%).ResultsIn Groups A and B, 26,4% and 36,8% of patients lived alone, respectively. Group A patients had higher rates of psychiatric and cardiovascular disease (32,4% and 41,2%) than Group B (8,8% and 16,2%) (p = 0,0009 and p = 0,0031, respectively). There was no marked difference in the type of surgery or length of hospital stay between groups, and most complications involved surgical site disorders. Postoperatively, Group A had a higher rate of delirium (29,4%) than Group B (3,7%) (p < 0,0001). The 30-day postoperative mortality rate was 0, and 76,5% of Group A and 45,6% of Group B patients received no adjuvant therapy (p = 0,0024).ConclusionsAge alone does not constitute a contraindication for appropriate surgery, although there are some challenges necessary to consider for super-elderly patients."

"State-of-the-technology tools for designing, optimizing, and manufacturing new materials Integrated computational materials engineering (ICME) uses computational materials science tools within a holistic system in order to accelerate materials development, improve design optimization, and unify design and manufacturing."

"Perkembangan teknik dan perangkat radioterapi yang sangat pesat membuat AAPM TG-51dan TRS 398 selaku protokol dosimetri konvensional menjadi kurang relevan untuk digunakan. Pada tahun 2008, Alfonso, dkk. kemudian memperkenalkan formalisme baru untuk menghasilkan faktor koreksi kualitas berkas lapangan nonstandar, baik statik maupun komposit untuk meminimalisir perbedaan antara kondisi kalibrasi dan aktual. Tujuan utama penelitian ini adalah mempelajari dan menentukan faktor koreksi lapangan komposit kpcsr,msr dan kclin,pcsr dari pesawat Tomotherapy pada kasus kanker kepala dan leher, pelvis, dan otak, serta mengimplementasikannya pada proses DQA. Pengukuran faktor koreksi dilakukan pada Exradin A1SL dan A16, menggunakan film EBT3 sebagai dosimeter referensi. Hasil dari penelitian ini menunjukkan bahwa nilai faktor koreksi kpcsr,msr pada kedua detektor meningkat seiring dengan peningkatan jaw, penurunan kompleksitas lapangan, dan peningkatan nilai pitch. Beberapa hal fisis yang mempengaruhi nilai faktor koreksi antara lain homogenitas target, volume averaging effect, thread effect, dan perbedaan besar rekombinasi umum pada jaw yang berbeda. Hasil ini menunjukkan bahwa nilai faktor koreksi kpcsr,msr bersifat spesifik dan bergantung pada parameter pembuatan lapangan. Oleh karenanya, lapangan pcsr sebaiknya ditentukan sesuai dengan kondisi klinis yang digunakan. Implementasi faktor koreksi kclin,pcsr untuk DQA pada kasus kanker kepala dan leher menunjukkan adanya perubahan deviasi antara dosis terkalkulasi dan terukur hingga 3 .

---

The rapid development of radiation therapy techniques and devices cause TG 51 and TRS 398 as conventional dosimetry protocols become less relevant for clinical dosimetry. In 2008, Alfonso, et al. introduced new formalism to produce correction factors for nonstandard field static and composite field to minimize the difference between calibration and actual conditions. The purpose of this work is to investigate and determine the correction factor of composite field from Tomotherapy for several cases H N, pelvis and brain cancer, and to implement it in DQA process. Measurements were performed using Exradin A1SL and A16, using EBT3 film as reference dosimeter. The results indicate that the value of kpcsr,msr on both detectors increased with increasing field width, decreasing field complexity, and increasing pitch value. Several factors that affect the correction factor were indicated in this work target homogeneity, volume averaging effect, thread effect, and large difference of general recombination on different jaws. These results show that kpcsr,msr is specific and depends on the parameters of composite field. Therefore, the pcsr field should be determined according to the parameters used in clinical conditions. Implementation of kclin,pcsr for DQA in H N cancer showed a change in deviation between the calculated and measured doses up to 3 ."

"Halcyon 2.0 memiliki EPID yang dapat digunakan untuk Patient-Specific Quality Assurance (PSQA) dan selalu merekam dosis transit selama penyinaran. PSQA merupakan metode untuk menilai kesesuaian hasil perencanaan radioterapi dengan pengukuran, sedangkan dosis transit memiliki kaitan terhadap distribusi dosis pasien. Penelitian ini menganalisis hasil PSQA pada Halcyon 2.0 dan dosis transit setiap fraksi pada kasus nasofaring, servik, dan payudara. Analisis dilakukan berdasarkan metode pengukuran dan evaluasi yang direkomendasikan TG-218. Selain itu, analisis dosis transit dilakukan pada setiap fraksi dan fluence map fraksi pertama dijadikan sebagai baseline. Nilai tolerance limit dan action limit Halcyon 2.0 memenuhi kriteria dari TG-218. Metode dan kriteria gamma index yang direkomendasikan TG-218 memiliki performa baik. Berbeda hal, nilai GPR dosis transit kasus nasofaring terjadi penurunan lebih curam dibandingkan kasus servik dan payudara, hal yang sama untuk korelasi berat badan dengan GPR. Penurunan GPR dari memiliki korelasi dengan berat badan, terutama untuk kasus nasofaring. Selain itu, kasus payudara tidak memiliki subjek dengan korelasi signifikan (p < 0,05) antara GPR dengan berat badan. Kesimpulan dari penelitian ini, berdasarkan metode TG-218 Halcyon 2.0 memiliki hasil PSQA yang baik. Nilai GPR untuk ketiga kasus mengalami penurunan seiring bertambahnya waktu dan memiliki kaitan terhadap berat badan.

---

Halcyon 2.0 has an EPID that can be used for Patient-Specific Quality Assurance (PSQA) and continuously records transit doses during irradiation. PSQA is a method for assessing the suitability of the results of radiotherapy planning with measurements, while the transit dose has a bearing on the patient's dose distribution. This study analyzed PSQA results on Halcyon 2.0 and transit doses for each fraction in the nasopharynx, cervix, and breast cases. The analysis was carried out based on the measurement and evaluation methods recommended by TG-218. In addition, transit dose analysis was carried out for each fraction, and the fluence map of the first fraction was used as a baseline. The tolerance limit and action limit values of Halcyon 2.0 meet the criteria of TG-218. The method and gamma index criteria recommended by TG-218 have good performance. In contrast, the transit dose GPR values for nasopharyngeal cases decreased more steeply than cervical and breast cases, the same for the correlation of body weight with GPR. The decrease in GPR correlates with body weight, especially for nasopharyngeal cases. In addition, no breast cases had a significant correlation (p <0.05) between GPR and body weight. The conclusion of this study, based on the TG-218 Halcyon 2.0 method, has good PSQA results. The GPR values for the three cases decreased over time and were related to body weight."