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"In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. "

"Traditional systems of medicine are fast emerging as viable alternatives to modern medical science. Further, in recent years the emphasis on botanicals as source for drug discovery and development has been realized globally. Added to this, the safer profile of herbal drugs combined with their low costs make them ideal targets for newer drugs. As in the modern system of medicine, viz. allopathy, herbal drugs form an inseparable part of the management of various disorders. The concept of scientific validation of the basis of traditional uses of herbal medicines has given birth to a new concept of reverse pharmacology, and interactions between traditional and modern systems of medicine are being increasingly encouraged. Recent Advances in Herbal Drug Research and Therapy showcases some of these crucial and emerging issues relating to herbal drugs. This compilation is a judicious combination of research and conventional aspects on the subject of herbal drugs, their pharmacology and therapeutic applications. Some very relevant general and systemic pharmacological as well as toxicological aspects have been highlighted by some of the leading experts in this field. The book will be of interest to students, scientists, teachers and other health professionals in the area of pharmacology, toxicology and allied health sciences."

"Systems biology in cancer research and drug discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology, (i) in understanding aberrant signaling in cancer, (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways, (iii) in unwinding microRNAs complexity, and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. "

"This comprehensive resource covers the fundamentals, formulation, and biopharmaceutical issues of lipid-based drug delivery. It presents the principles of lipid absorption and covers formulation issues, such as dissolution testing and stability testing, and physiological and biopharmaceutical issues, including the role of specific enzymes, the evaluation of transport systems in the body, and the mechanisms governing the transport of water-insoluble drugs."

"Written for busy professionals at the forefront of new drug development, "Drug delivery" gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery. Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures. It begins with an in-depth review of key fundamentals, such as physiochemical and biological barriers; drug delivery pathways; metabolism; drug formulation; pharmacokinetic and pharmacodynamic issues; and more. The remainder of the book is devoted to the systematic examination, including overviews, timely examples, and extensive references, of a host of specific subjects."

"Epidermal growth factor receptor variant III (EGFRvIII) is a mutant EGFR lacking 267 amino acids (exon-2 throught 7) within its extracellular domain, resulting in the formation of a new epitope as a tumor-Antibodies ..."