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"This book covers both recent advances in the design and synthesis of new drugs, as well as the myriad other issues facing a new drug candidate as it moves through the development process. Utilizing recent case studies, the authors provide valuable insights into the complexities of the process, from designing new synthetic methodologies and applying new automated techniques for finding optimal reaction conditions to selecting the final drug form and formulation."

"The essentials of drug metabolism vital to developing new therapeutic entities.Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers :- Basic concepts of drug metabolism- The role of drug metabolism in the pharmaceutical industry- Analytical techniques in drug metabolism- Common experimental approaches and protocolsDrug metabolism in drug design and development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques."

"Annotation. Gain a full understanding of the basic science andclinical use of drugs with the most up-to-date andcomprehensive pharmacology text in the health sciences400 ILLUSTRATIONS--MANY IN FULL COLOROrganized to reflect the course sequence in many pharmacology courses and in integrated curricula, Basic &​ Clinical Pharmacology covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors' many years of experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students.Coverage that spans every aspect of medical pharmacology:Encompasses every aspect of medical pharmacology including botanicals and over-the-counter drugsNew chapter on pharmacogenomics with important examplesEmphasis is placed on discussion of druggroups and prototypesClinically relevant, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effectsFull-color presentation with more than 400 illustrationsCase studies introduce clinical problems in most chaptersSummary tables and diagrams encapsulate important informationIncludes many new drugsA Generic Name/​Trade Name Table appears at the end of most chapters for easy reference when writing a chart order or prescription."

"Annotation. Gain a full understanding of the basic science andclinical use of drugs with the most up-to-date andcomprehensive pharmacology text in the health sciences400 ILLUSTRATIONS--MANY IN FULL COLOROrganized to reflect the course sequence in many pharmacology courses and in integrated curricula, Basic &​ Clinical Pharmacology covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors' many years of experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students.Coverage that spans every aspect of medical pharmacology:Encompasses every aspect of medical pharmacology including botanicals and over-the-counter drugsNew chapter on pharmacogenomics with important examplesEmphasis is placed on discussion of druggroups and prototypesClinically relevant, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effectsFull-color presentation with more than 400 illustrationsCase studies introduce clinical problems in most chaptersSummary tables and diagrams encapsulate important informationIncludes many new drugsA Generic Name/​Trade Name Table appears at the end of most chapters for easy reference when writing a chart order or prescription."

"This book discusses key statistical concepts that facilitate the inferential analysis of data collected from a group of individuals participating in a pharmaceutical clinical trial, the estimation of their clinical significance in the general population of individuals likely to be prescribed the drug if approved, and the related decision-making that occurs at both the public health level (by regulatory agencies when deciding whether or not to approve a new drug for marketing) and the individual patient level (by physicians and their patients when deciding whether or not the patient should be prescribed a drug that is on the market). These concepts include drug safety and efficacy, statistical significance, clinical significance, and benefit-risk balance."

"Summary:A range of new and innovative tools used for preformulation and formulation of medicines help optimize pharmaceutical development projects. Such tools also assist with the performance evaluation of the pharmaceutical process, allowing any potential gaps to be identified. This book considers these key research and industrial tools."