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Stefani Andini Harsetyowati
"Latar Belakang : Dentin hipersensitif (DH) sering pada pasien dengan peradangan periodontal kronis, karena permukaan akar terpapar akibat proses penyakit. Penggunaan pasta gigi saat menyikat gigi terbukti efektif menghilangkan plak gigi sebagai penyebab utama peradangan periodontal.
Tujuan: Menganalisis peran penyikatan gigi dengan pasta gigi yang mengandung sodium bicarbonate, sodium fluoride dan potassium nitrate terhadap DH disertai peradangan periodontal. Metode: Uji eksperimental klinis, membandingkan dua kelompok dengan perbedaan perlakuan.
Hasil: Terdapat penurunan sensitifitas dan peradangan periodontal pada kedua kelompok.
Kesimpulan: Penurunan tingkat sensitifitas lebih besar pada kelompok penelitian.

Background : Dentine Hypersensitivity is commonly found in patient with periodontal inflammation, due to exposed root surface as a result of disease process. Usage of toothpaste while brushing teeth is proven effective at removing plaque as major cause of inflammation.
Objective: Analyze the role of tooth brushing using toothpaste containing sodium bicarbonate, sodium fluoride and potassium nitrate for dentine hypersensitivity with periodontal inflammation.
Methods: Experimental clinical trial comparing two treatment groups with differences.
Results: There is decreased sensitivity and inflammation in both groups.
Conclusion: Greater decreased sensitivity is found in study group.
"
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2014
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Ferry Jaya
"Penelitian bertujuan mengetahui pengaruh besar tekanan dan lama scrubbing terhadap kuat rekat geser self adhering flowable composite pada dentin. Self adhering flowable composite diaplikasikan dengan tekanan scrubbing 1, 2, dan 3 gram masing-masing selama 15, 20, dan 25 detik. Resin komposit diaplikasikan secara inkremental. Polimerisasi dengan sinar selama 20 detik. Kuat rekat geser diuji menggunakan Testing Machine dan dianalisa dengan ANOVA diikuti Post Hoc Test Bonferroni. Daerah patahan diobservasi menggunakan SEM. Kuat rekat geser tertinggi pada tekanan scrubbing 3 gram selama 25 detik. Perbedaan besar tekanan dan waktu saat scrubbing mempengaruhi kuat rekat geser self adhering flowable composite pada dentin.

Effect of different scrubbing pressure and duration on shear bond strength of self adhering flowable composite to dentin was evaluated. Self adhering flowable composite was applied on dentin with 1, 2, and 3 grams pressure for 15, 20, and 25 seconds. Composite was constructed incrementally. Polymerization for 20 seconds. Shear bond strength was tested with a Testing Machine and analyzed by ANOVA and Bonferroni. Fractured area was observed with a SEM. The highest shear bond strength was obtained in 3 grams scrubbing pressure for 25 seconds. The different scrubbing pressure and duration influenced shear bond strength of self adhering flowable composite to dentin.
"
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2012
T31132
UI - Tesis Open  Universitas Indonesia Library
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Habli Daviq
"Latar Belakang: Silver Diamine Fluoride (SDF) dan Propolis Fluoride (PPF) merupakan varnish yang memiliki sifat antibakteri dan dapat mencegah demineralisasi dan memicu remineralisasi Tujuan: Penelitian ini bertujuan untuk menganalisis kekerasan dentin setelah aplikasi varnish SDF dan PPF selama 30 hari dan 60 hari. Metode: Enam spesimen dentin gigi premolar dengan ukuran 4x4x2 mm diaplikasikan varnish SDF (38%) dan PPF (10%) kemudian setiap spesimen direndam dalam tube berisi aquadem lalu dikocok dengan kecepatan 45 rpm selama 30 menit setiap hari. Dan dilakukan uji kekerasan menggunakan Vickers microhardness tester setelah 30 dan 60 hari. Hasil: Nilai kekerasan dentin setelah 30 hari aplikasi SDF ialah 67 ± 2,83 VHN dan PPF ialah 61,00 ± 2,44 VHN. Sedangkan nilai kekerasan dentin setelah 60 hari aplikasi SDF ialah 69,00 ± 2,82 VHN dan PPF ialah 73,25 ± 1,71 VHN. Kesimpulan: Varnish SDF dan PPF efektif meningkatkan kekerasan dentin.

Background: Silver Diamine Fluoride (SDF) and Propolis Fluoride (PPF) had antibacterial properties on silver and propolis contents. The fluoride content present in both varnishes could inhibit demineralization and promote remineralization Objective: This study analyzed the dentin microhardness after 30 and 60 days application of Sodium diamine fluoride (SDF) and propolis fluoride (PPF). Methods: Six dentin blocks were allocated and divided into control groups and treatment groups with SDF (38%) and PPF (10%). Each dentin block in the treatment group received a topical application of various fluoridebased varnishes and was submerged in aquadem and shaken for 30 minutes at 45 rpm every day. The dentin hardness was analyzed by a Vickers microhardness tester. Results: Dentin microhardness after 30 days application of SDF varnish was 67 ± 2,83 VHN and PPF varnish was 61,00 ± 2,44 VHN. While, Dentin microhardness after 60 days application of SDF varnish was 69,00 ± 2,82 VHN and PPF varnish was 73,25 ± 1,71 VHN Conclusion: SDF and PPF were effective for dentin remineralization and increase dentin microhardness.
"
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2017
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Grace Riska
"Latar Belakang: Salah satu material remineralisasi yang banyak digunakan adalah semen ionomer kaca (SIK). Namun dentin terdemineralisasi sesudah aplikasi SIK memiliki sifat mekanis yang berbeda dan lebih rendah daripada dentin normal karena remineralisasi yang terjadi adalah remineralisasi interfibril. Material carboxymethyl chitosan (CMC) bertindak sebagai analog protein nonkolagen yang mampu menstabilisasi nanocluster amorphous calcium phosphate (ACP) dalam proses remineralisasi intrafibril. Tujuan: Mengetahui pengaruh aplikasi modifikasi SIK-CMC5% dan SIK-CMC10% pada dentin terdemineralisasi terhadap kekerasan mikro, fasa mineral dan derajat kristalinitas dentin. Metode: Material SIK dilakukan pencampuran dengan CMC pada rasio 5% dan 10% menghasilkan SIK-CMC5% dan SIK-CMC10%. Kemudian, demineralisasi pada kavitas dentin terdemineralisasi dilakukan dengan aplikasi material SIK, SIK-CMC5% dan SIK-CMC10%. Akar gigi direndam dalam cairan phosphate-buffered saline selama 14 hari. Remineralisasi dentin dievaluasi dari kekerasan mikro melalui uji Vickers dan penilaian fasa mineral dan derajat kristalinitas dentin dari uji X-Ray Diffraction (XRD). Hasil: Kekerasan mikro dentin pada kelompok SIK-CMC5% dan SIK-CMC10% meningkat dibandingkan pada kelompok SIK. Pembentukan kristal hidroksiapatit ditemukan pada sampel SIK dan SIK-CMC, dengan derajat kristalinitas tertinggi pada sampel SIK-CMC10%. Kesimpulan: Semen Ionomer Kaca modifikasi Carboxymethyl Chitosan 10% lebih efektif dalam meningkatkan nilai kekerasan mikro dan mempengaruhi pembentukan fasa mineral kristal hidroksiapatit dan derajat kristalinitas.

Background: One of the widely used remineralization materials is glass ionomer cement (GIC). However, demineralized dentine after GIC application has different and lower mechanical properties than normal dentin because the remineralization that occurs is interfibril remineralization. Carboxymethyl chitosan (CMC) acts as noncollagenous protein analog that can stabilize amorphous calcium phosphate (ACP) nanoclusters in intrafibril remineralization. Objective: To determine the effect of the application of modified GIC-CMC5% and GIC-CMC10% on the microhardness, mineral phase and degree of crystallinity of demineralized dentin. Methods: GIC material was mixed with CMC at ratio 5% and 10% to produce GIC-CMC5% and GIC-CMC10%. Remineralization of demineralized dentin cavity was carried out by applying GIC, GIC-CMC5% and GIC-CMC10% for 14 days. Remineralization was evaluated from microhardness value through Vickers test and assessment of mineral phase and degree of dentin crystallinity from X-Ray Diffraction (XRD) test. Results: Dentin microhardness in the GIC-CMC5% and GIC-CMC10% was increasing compared to the CIC group. The formation of hydroxyapatite crystals was found in the GIC and GIC-CMC samples with the highest degree of crystallinity in the GIC-CMC10% sample. Conclusion: Modified Glass Ionomer Cement with 10% Carboxymethyl Chitosan is more effective in increasing the microhardness value and affecting the formation of the hydroxyapatite crystalline mineral phase and the degree of crystallinity."
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2023
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Albert
"[ABSTRAK
Latar Belakang: Hipersensitif dentin dipengaruhi oleh akumulasi plak pada
permukaan gigi dan penetrasi bakteri pada tubulus dentin. Tujuan: Menganalisis
proporsi serotipe c Streptococcus mutans dan tingkat keasaman di dalam plak
dan saliva penderita resesi gingiva yang hipersensitif dentin dengan penderita
resesi gingiva yang non hipersensitif. Metode: Tiga puluh enam sampel plak dan
saliva dibagi dalam dua kelompok yaitu kelompok hipersensitif dan non
hipersensitif. Dilakukan ekstrak DNA sampel, pengukuran pH sampel dan
evaluasi amplifikasi serotipe c Streptococcus mutans dengan alat Real Time
PCR. Hasil: Proporsi serotipe c Streptococcus mutans di dalam plak dan
saliva tidak berbeda pada penderita resesi gingiva dengan hipersensitif
dentin maupun non hipersensitif, Kesimpulan: Proporsi serotipe c
Streptococcus mutans plak dan saliva tidak mempengaruhi hipersensitif
dentin.

ABSTRACT
Background: dentin hypersensitivity is affected by the accumulation of plaque
on the tooth surface and penetration of bacteria in the dentinal tubules.
Objective: To analyze the proportion of serotype c Streptococcus mutans and the
level of acidity in plaque and saliva of patients with hypersensitive dentin and
non hypersensitive. Methods: Thirty-six plaque and saliva samples were divided
into two groups: the hypersensitive and non-hypersensitive. Extract the sample
DNA, measure the acidity levels and evaluate serotype c Streptococcus mutans
amplification with Real Time PCR. Results: The proportion of serotype c
Streptococcus mutans in plaque and saliva is not significantly different in the
patients with gingival recession both hypersensitive and non-hypersensitive,
Conclusions: The proportion of serotype c Streptococcus mutans in plaque and
saliva are equally well both in hypersensitive and non hypersensitive cases.;Background: dentin hypersensitivity is affected by the accumulation of plaque
on the tooth surface and penetration of bacteria in the dentinal tubules.
Objective: To analyze the proportion of serotype c Streptococcus mutans and the
level of acidity in plaque and saliva of patients with hypersensitive dentin and
non hypersensitive. Methods: Thirty-six plaque and saliva samples were divided
into two groups: the hypersensitive and non-hypersensitive. Extract the sample
DNA, measure the acidity levels and evaluate serotype c Streptococcus mutans
amplification with Real Time PCR. Results: The proportion of serotype c
Streptococcus mutans in plaque and saliva is not significantly different in the
patients with gingival recession both hypersensitive and non-hypersensitive,
Conclusions: The proportion of serotype c Streptococcus mutans in plaque and
saliva are equally well both in hypersensitive and non hypersensitive cases., Background: dentin hypersensitivity is affected by the accumulation of plaque
on the tooth surface and penetration of bacteria in the dentinal tubules.
Objective: To analyze the proportion of serotype c Streptococcus mutans and the
level of acidity in plaque and saliva of patients with hypersensitive dentin and
non hypersensitive. Methods: Thirty-six plaque and saliva samples were divided
into two groups: the hypersensitive and non-hypersensitive. Extract the sample
DNA, measure the acidity levels and evaluate serotype c Streptococcus mutans
amplification with Real Time PCR. Results: The proportion of serotype c
Streptococcus mutans in plaque and saliva is not significantly different in the
patients with gingival recession both hypersensitive and non-hypersensitive,
Conclusions: The proportion of serotype c Streptococcus mutans in plaque and
saliva are equally well both in hypersensitive and non hypersensitive cases.]"
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2014
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Adeline Clarissa
"Latar Belakang : Penambahan fluor ke dalam proses PILP memiliki potensi meningkatkan remineralisasi intrafibril dan ekstrafibril kolagen dentin. Tujuan : Penelitian ini bertujuan untuk mengetahui pengaruh penambahan fluor dalam proses PILP terhadap remineralisasi intrafibril dan ekstrafibril kolagen dentin. Metode : 8 sampel blok dentin dibagi ke dalam 4 kelompok: Kelompok 1 demineralized dentin sebagai kontrol, kelompok 2 demineralized dentin disimpan dalam larutan remineralisasi PILP yang ditambahkan fluor 5 ppm, kelompok 3 demineralized dentin disimpan dalam larutan remineralisasi PILP yang ditambahkan fluor 25 ppm, kelompok 4 demineralized dentin disimpan dalam larutan remineralisasi PILP tanpa fluor (0 ppm) Kemudian seluruh sampel disimpan dalam shaking incubator pada suhu 37°C selama 14 hari. Selanjutnya dilakukan pemeriksaan dengan TEM/SAED untuk melihat remineralisasi intrafibril dan ekstrafibril kolagen dentin dan kristalinitas kristal yang dihasilkan. Hasil : Terjadi remineralisasi intrafibril dan ekstrafibril kolagen dentin pada kelompok perlakuan 2, 3, dan 4. Remineralisasi intrafibril dan ekstrafibril terlihat paling padat pada kelompok 2. Terdapat perbedaan kristalinitas kristal di antara kelompok 1, 2, 3, dan 4. Kesimpulan: Penambahan fluor 5 ppm ke dalam proses PILP menghasilkan remineralisasi intrafibril dan ekstrafibril kolagen dentin. Remineralisasi yang dihasilkan berupa kristal apatit dengan tingkat kristalinitas yang padat.

Background: Fluoride addition into PILP process has the potential to increase intrafibrillar and extrafibrillar dentin collagen remineralization. Objective: This research aim to evaluate the influence of fluoride addition into PILP process towards intrafibrillar and extrafibrillar dentin collagen remineralization. Methods: 8 dentin blocks were divided into 4 sample groups. Group 1 (demineralized dentin) as control group, group 2 is demineralized dentin that were soaked in PILP process with 5 ppm fluoride addition, group 3 is demineralized dentin that were soaked in PILP process with 25 ppm fluoride addition, and group 4 is demineralized dentin that were soaked in PILP process with no fluor (0 ppm) addition. All of the samples were incubated in shaking incubator at 37o C for 14 days. Result: Intrafibrillar and extrafibrillar dentin collagen remineralization occurred in group 2, 3, and 4. The most dense intrafibrillar and extrafibrillar dentin collagen remineralization was seen in group 2. There are differences of crystal's crystallinity between group 1, 2, 3, and 4. Conclusion: 5 ppm fluoride addition into PILP process produced intrafibrillar and extrafibrillar dentin collagen remineralization. The remineralization were consisted by high-density apatite crystals."
Depok: Fakultas Kedokteran Gigi Universitas Indonesia, 2019
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Dimas Mahardika Generosa
"ABSTRAK
Latar belakang: Ketahanan ikatan antara resin komposit dengan
dentin merupakan penentu keberhasilan restorasi resin komposit.
Tujuan: Menganalisis EBA terhadap kekuatan ikat resin-dentin.
Metode: 48 sampel dentin dibagi menjadi 6 kelompok. Kemudian
seluruh kelompok di ukur kekuatan ikat gesernya menggunakan UTM.
Data dianalisa statistik dengan uji hipotesis Kruskal Wallis yang
dilanjutkan dengan uji Mann Whitney. Hasil: Median tertinggi
kelompok 3, sedangkan median terendah kelompok 5. Kesimpulan:
Ekstrak biji anggur yang diaplikasikan sebelum etsa dapat
meningkatkan kekuatan ikat gesek namun tidak dapat menghambat
biodegradasinya.ABSTRACT
Background: Resilience of resin-dentin bonding known as one of
success composite resin restoration determinants. Aim: To analyze the
effect of grape seed extract on resin-dentin shear bond strength.
Methods: 48 dentin sample were divided into 6 groups. Shear bond
strengths measured using UTM. Statistical analysis was done by
Kruskal Wallis test and Mann Whitney test. Results: The highest
median value was highest on group 3, and the lowest was group 5.
Conclusion: Grape seed extract can improve the shear bond strength
but not have effect on reducing the biodegradation.
;Background: Resilience of resin-dentin bonding known as one of
success composite resin restoration determinants. Aim: To analyze the
effect of grape seed extract on resin-dentin shear bond strength.
Methods: 48 dentin sample were divided into 6 groups. Shear bond
strengths measured using UTM. Statistical analysis was done by
Kruskal Wallis test and Mann Whitney test. Results: The highest
median value was highest on group 3, and the lowest was group 5.
Conclusion: Grape seed extract can improve the shear bond strength
but not have effect on reducing the biodegradation.
"
Fakultas Kedokteran Gigi Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Meilisa Rachmawati
"Latar Belakang: Saat ini perawatan pulpa vital mengacu pada konsep minimal intervensi, yaitu dengan meninggalkan lapisan affected dentin saat ekskavasi karena masih terdapat ikatan silang kolagen sehingga dapat dilakukan upaya remineralisasi. Remineralisasi melalui aplikasi material bioaktif Mineral Trioxide Aggregate (MTA) belum dapat menghasilkan karakteristik dentin menyerupai dentin normal karena pembentukan mineral hanya terjadi pada ruang ekstrafibrillar. Penggunaan material analog protein non kolagen dibutuhkan untuk menstabilkan nano Amorphous Calcium Phosphate (ACP) agar dapat memasuki ruang intrafibrillar, salah satunya menggunakan Carboxymethyl Chitosan (CMC).
Tujuan: mengevaluasi remineralisasi dentin pada permukaan dentin terdemineralisasi setelah aplikasi material MTA dan material modifikasi MTA-CMC dengan melihat morfologi permukaan dan komposisi ion pada dentin.
Metode: remineralisasi dilakukan melalui aplikasi material MTA, MTA-CMC 5% dan 10% selama 14 hari pada permukaan sampel dentin yang terdemineralisasi. Pengamatan morfologi dilakukan dengan Scanning Electron Microscope (SEM) dan konfirmasi komposisi ion dengan Energy Dispersive X-ray Spectroscopy (EDX).
Hasil: terdapat perbedaan morfologi pada permukaan dentin setelah dilakukan remineralisasi melalui aplikasi MTA, MTA-CMC 5%, dan MTA-CMC 10% selama 14 hari yang dievaluasi menggunakan SEM. Hasil analisis EDX mengonfirmasi adanya peningkatan kandungan kalsium dan fosfor pada permukaan dentin yang diremineralisasi dengan material MTA-CMC.
Kesimpulan: remineralisasi melalui aplikasi material modifikasi MTA-CMC dapat memengaruhi morfologi permukaan dan komposisi ion pada permukaan dentin yang terdemineralisasi.

Background: Vital pulp treatment refers to the concept of minimal intervention by preserving the affected dentin layer in the excavation process because there are still collagen cross-linked to induce remineralization. Remineralization through the application of bioactive material Mineral Trioxide Aggregate (MTA) produce different dentin characteristics to normal dentin because mineral formation only occurs in the extrafibrillar space. The use of non-collagen protein analog materials is needed to stabilize the nano Amorphous Calcium Phosphate (ACP) to get into the intrafibrillar space, one of which is Carboxymethyl Chitosan (CMC).
Objective: To evaluate dentin remineralization on the surface of demineralized dentin after the application of MTA and MTA-CMC modified material by looking at the surface morphology and ionic composition of the dentin.
Methods: The remineralization was carried out through the application of MTA,MTA-CMC 5%, MTA-CMC 10% materials for 14 days on the surface of demineralized dentin samples. Morphological observations were carried out by Scanning Electron Microscope (SEM) and confirmation of ion composition by Energy Dispersive X-ray Spectroscopy (EDX). Results: there were morphological differences on the dentin surface after remineralization through the application of MTA, MTA-CMC 5%, and MTA-CMC 10% for 14 days which were evaluated using SEM. The results of the EDX analysis confirmed an increase in the content of calcium and phosphorus on the dentin surface remineralized with MTA-CMC material.
Conclusion: remineralization through the application of MTA-CMC modified material can affect the surface morphology and ion composition on the demineralized dentin surface.
"
Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2022
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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"The present study investigated the effect of non-surgical periodontal therapy on serum level of anti-cardiolipin antibodies (aCLA), which are potentially involved in the pathogenesis of cardiovascular diseases in periodontal patients. Twenty volunteers (11 females and 9 males) with the mean age of 40.55 years participated in this study. Generalized chronic periodontitis was diagnosed through clinical periodontal examination at baseline visit. This examination included measuring the probing pocket depth and clinical attachment loss. Plaque index and gingival index were also recorded. After baseline examination, all the subjects received full-mouth non-surgical periodontal treatment. Subjects returned for a final visit 6 weeks after the last session of scaling for reevaluation of the periodontal parameters. At baseline and final visits 2 ml of venous blood was collected from each patient and an available commercially enzyme-linked immunosorbent assay was used for analyzing aCLA (IgM and IgG). The collected data were analyzed using the paired sample t test. Mean levels of both forms of aCLA, before and after treatment, showed statistically significant difference (P = 0.003 for IgM and P = 0.001 for IgG). In addition, study results showed significant reductions in periodontal parameters after non-surgical periodontal therapy (P < 0.001). The results of this study suggested that successful periodontal therapy can improve the serum level of one of the inflammatory biomarkers involved in the cardiovascular problems."
ODO 103:2 (2015)
Artikel Jurnal  Universitas Indonesia Library
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"Root development of permanent teeth is disturbed in survivors of childhood cancer. Cyclophosphamide (CY) is a cytostatic drug commonly used for chemotherapy in children with cancer. This study aimed to evaluate the effects of CY on the development of molar teeth until the completion of occlusion in young mice, focusing on Hertwig’s epithelial root sheath (HERS). We treated thirty-two 12-day-old ICR mice with CY (100 mg/kg; 100-CY group), and 36 control mice with saline. At 12, 14, 16, 20, 24, 27, 39, 60, and 76 days of age, the mandibular molars were removed. Soft X-ray radiographs were obtained in lateral projection. The root/crown length (R/C) ratio of the first molar was calculated. Serial sagittal sections were prepared and histomorphological hematoxylin and eosin (HE) staining and immunohistochemical (cytokeratin) studies were performed. The R/C ratio of the 100-CY group (0.78) was smaller than that of the control group (1.23) at 76 days (p < 0.05, t test). While all roots developed further after injection, microscopic examination showed that the roots of the first molars that developed in the 100-CY group were shorter than those in the control group. In addition, experimental mice showed apical closure of the roots. By 20 days after injection, the HERS had disappeared from the root surface in the 100-CY group. In conclusion, this study indicates that CY can induce a defect in HERS and cause early loss of HERS. Disruption of the epithelial sheath inhibits normal root formation, and it could cause irreversible short-root development."
ODO 103:2 (2015)
Artikel Jurnal  Universitas Indonesia Library
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