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"ExpDesign Studio facilitates more efficient clinical trial design. This book introduces pharmaceutical statisticians, scientists, researchers, and others to ExpDesign Studio software for classical and adaptive designs of clinical trials. It includes the Professional Version 5.0 of ExpDesign Studio software that frees pharmaceutical professionals to focus on drug development and related challenges while the software handles the essential calculations and computations. After a hands-on introduction to the software and an overview of clinical trial designs encompassing numerous variations, Classical and adaptive clinical trial designs using ExpDesign Studio:* Covers both classical and adaptive clinical trial designs, monitoring, and analyses* Explains various classical and adaptive designs including groupsequential, sample-size reestimation, dropping-loser, biomarker-adaptive, and response-adaptive randomization designs* Includes instructions for over 100 design methods that have been implemented in ExpDesign Studio and step-by-step demos as well as real-world examples* Emphasizes applications, yet covers key mathematical formulations* Introduces readers to additional toolkits in ExpDesign Studio that help in designing, monitoring, and analyzing trials, such as the adaptive monitor, graphical calculator, the probability calculator, the confidence interval calculator, and more* Presents comprehensive technique notes for sample-size calculation methods, grouped by the number of arms, the trial endpoint, and the analysis basis Written with practitioners in mind, this is an ideal self-study guide for not only statisticians, but also scientists, researchers, and professionals in the pharmaceutical industry, contract research organizations (CROs), and regulatory bodies. It's also a go-to reference for biostatisticians, pharmacokinetic specialists, and principal investigators involved in clinical trials. "

"This book will examine current issues and controversies in the design of clinical trials, including topics in adaptive and sequential designs, the design of correlative genomic studies, the design of studies in which missing data is anticipated. Each chapter will be written by an expert conducting research in the topic of that chapter. As a collection, the chapters would be intended to serve as a guidance for statisticians designing trials."

"ABSTRAKApartemen tipe studio merupakan hunian dengan ruang terbatas. Keterbatasan tersebut terkadang tidak sesuai dengan kebutuhan penghuni yang menempatinya sehingga dapat menimbulkan permasalahn didalam hunian. Oleh sebab itu penghuni dituntut untuk dapat beradaptasi dengan ruang terbatas tersebut. Berdasarkan hal tersebut, skripsi ini bertujuan untuk mengetahui apakah penghuni apartemen tipe studio dapat memenuhi kebutuhannya dengan melakukan adaptasi di dalam ruang yang terbatas dan apakah dengan beradaptasi kebutuhan penghuni terpenuhi. Hal tersebut ditinjau berdasarkan kebutuhan, aktivitas, dan penggunaan furnitur. Berdasarkan hasil pengamatan diketahui bahwa pengaturan pembagian area untuk masing-masing fungsi ruang dan pemilihan furnitur yang tepat dapat memberi pengaruh besar terhadap permasalahan keterbatasan ruang.

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ABSTRACTStudio-Type Apartment is a limited space of living. Sometimes the limitation is not suitable with the resident needs and can cause a living problem. Therefor, the resident is forced to adapt with the available limited space. Based on that, the purpose of this thesis is to know whether or not the resident of Studio Apartment can fulfill their needs through adaptation towards this limited space. This issue is observed and analyzed base on the activity spatial needs and the used of the furniture. Based on the observation, it is known that the setting of area divisions for each function and the exact furniture that is used can give a big impact to limited-space problem."

"When hero policeman Grant Cliveden dies from a poisoning in the Old Bailey, it threatens to shake the country to its core. The evidence points to one man. Jimmy Knight has been convicted of multiple offences before and defending him will be no easy task. Not least because this is trainee barrister Adam Green's first case. But it will quickly become clear that Jimmy Knight is not the only person in Cliveden's past with an axe to grind. The only thing that's certain is that this is a trial which will push Adam - and the justice system itself "

"Ninety cannabis-dependent adults seeking treatment were randomly assigned to receive cognitive-behavioral therapy, abstinence-based voucher incentives, or their combination. Treatment duration was 14 weeks, and outcomes were assessed for 12 months posttreatment. Findings suggest that (a) abstinence-based vouchers were effective for engendering extended periods of continuous marijuana abstinence during treatment, (b) cognitive-behavioral therapy did not add to this during-treatment effect, and (c) cognitive-behavioral therapy enhanced the posttreatment maintenance of the initial positive effect of vouchers on abstinence. This study extends the literature on cannabis dependence, indicating that a program of abstinence-based vouchers is a potent treatment option. Discussion focuses on the strengths of each intervention, the clinical significance of the findings, and the need to continue efforts toward development of effective interventions."