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"This book covers quality measurement, control, and improvement in combinatorial chemistry. Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable." To this end, "Analysis and purification methods in combinatorial chemistry" describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's "Chemical analysis" series, this text has four parts covering: various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis; high-throughput analytical methods used to analyze the quality of libraries; high-throughput purification techniques; and, analytical methods applied in post-synthesis and post-purification stages.Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques."

"Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process."

"This book reviews the fundamentals, covers the classical topics (paths, flows, matching, matroids, NP-completeness, approximation algorithms) in detail, and proceeds to advanced and recent topics, some of which have not appeared in a textbook before. This fifth edition has again been updated, revised, and significantly extended, with more than 60 new exercises and new material on various topics, including Cayley's formula, blocking flows, faster b-matching separation, multidimensional knapsack, multicommodity max-flow min-cut ratio, and sparsest cut. Thus, this book represents the state of the art of combinatorial optimization."

"Combinatorial data analysis (CDA) refers to a wide class of methods for the study of relevant data sets in which the arrangement of a collection of objects is absolutely central. The focus of this monograph is on the identification of arrangements, which are then further restricted to where the combinatorial search is carried out by a recursive optimization process based on the general principles of dynamic programming (DP). The authors provide a comprehensive and self-contained review delineating a very general DP paradigm or schema that can serve two functions. First, the paradigm can be applied in various special forms to encompass all previously proposed applications suggested in the classification literature. Second, the paradigm can lead directly to many more novel uses. An appendix is included as a user's manual for a collection of programs available as freeware. The incorporation of a wide variety of CDA tasks under one common optimization framework based on DP is one of the book's strongest points. The authors include verifiably optimal solutions to nontrivially sized problems over the array of data analysis tasks discussed."