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"Irritable bowel syndrome (IBS) merupakan kelainan fungsional saluran cerna berupa rasa nyeri atau tidak nyaman di abdomen yang timbul bersamaan dengan minimal dua dari tiga gejala, yaitu perbaikan keluhan setelah defekasi, perubahan frekuensi defekasi, atau perubahan konsistensi feses. IBS menjadi masalah kesehatan karena tata laksana yang belum optimal sehingga berbagai modalitas terapi dikembangkan, salah satunya akupunktur tanam benang. Penelitian ini bertujuan untuk mengetahui pengaruh terapi kombinasi akupunktur tanam benang dan medikamentosa terhadap gejala dan kualitas hidup penderita IBS. Uji klinis acak tersamar ganda dengan pembanding dilakukan pada 50 penderita IBS yang dialokasikan ke dalam kelompok kombinasi akupunktur tanam benang dan medikamentosa atau kelompok akupunktur sham dan medikamentosa. Skor IBS Symptom Severity Scale (IBS-SSS) dan IBS Quality of Life (IBS-QoL) digunakan untuk mengukur keluaran penelitian. Hasil penelitian menunjukkan perbedaan bermakna rerata skor IBS-SSS sebesar 71,60 lebih rendah (p = 0,000; 95% IK: - 96,36 sampai -30,15) dan skor IBS-QoL sebesar 13,08 lebih rendah (p = 0,000; 95% IK: -16,92 sampai -9,25) pada kelompok terapi kombinasi akupunktur tanam benang dan medikamentosa dibandingkan dengan kelompok akupunktur sham dan medikamentosa. Kesimpulan penelitian adalah terapi kombinasi akupunktur tanam benang dan medikamentosa lebih efektif mengurangi gejala dan meningkatkan kualitas hidup penderita IBS.

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IBS is a functional gastrointestinal disorder characterized by abdominal pain or discomfort associated with improvement with defecation and/or change of frequency or form of stool. Current medical treatments of IBS patients are still unsatisfying, hence other modalities are continuously being improved such as acupoint-catgut embedment.

The aim of this study was to establish the effect of acupoint-catgut embedment combined with medical treatment on symptoms and quality of life of IBS patients. A double blind randomized controlled trial involved 50 IBS patients randomly allocated into catgut embedding therapy with medication group or medication only group. Catgut embedding therapy was given three times at ST 25 Tianshu, ST 36 Zusanli, and ST 37 Shangjuxu every 10 days. IBS-SSS and IBS-QoL were used to measure the primary outcome.

There was a statistically significant difference between groups at one month; with IBS-SSS and IBS-QoL were 71.60 (p = 0,000; 95% CI: -96,36 to -30,15) and 13.08 point (p = 0,000; 95% CI: -16,92 to -9,25) lower in catgut embedding therapy with medication group. The results suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of IBS patients."

"ABSTRAK Gastroesophageal reflux disease (GERD) merupakan suatu kondisi patologis yang disebabkan oleh refluks kandungan lambung ke dalam esofagus. GERD memiliki dampak yang besar terhadap penderitanya baik secara fisik, psikologik, sosial maupun ekonomi. Penurunan kualitas hidup dan produktifitas kerja sering ditemukan pada penderita GERD. Berbagai terapi farmakologis telah dikembangkan, namun belum memberikan hasil yang optimal. Hal tersebut mendorong pengembangan modalitas terapi lain, salah satunya akupunktur tanam benang. Penelitian ini bertujuan untuk mengetahui efektifitas terapi kombinasi akupunktur tanam benang dan medikamentosa terhadap gejala dan kualitas hidup penderita GERD. Uji klinis acak tersamar ganda dengan pembanding dilakukan terhadap 52 penderita GERD yang dialokasikan secara acak ke dalam kelompok kombinasi akupunktur tanam benang dan medikamentosa (kelompok perlakuan) atau kelompok akupunktur sham dan medikamentosa (kelompok kontrol). Akupunktur tanam benang dilakukan pada titik CV12 Zhongwan, ST36 Zusanli dan BL21 Weishu sebanyak 2 kali dengan interval 15 hari. Skor GERDQ, RQS dan SF-36 digunakan untuk mengukur keluaran terapi. Hasil penelitian menunjukkan bahwa penurunan skor GERDQ pada kelompok perlakan lebih besar dari kelompok kontrol (p<0,001) dan peningkatan skor RQS serta peningkatan skor seluruh komponen SF-36 pada kelompok perlakuan lebih besar dibanding kelompok kontrol (p<0,001). Kesimpulan penelitian adalah terapi kombinasi akupunktur tanam benang dan medikamentosa lebih efektif dalam mengurangi gejala dan meningkatkan kualitas hidup penderita GERD dibandingkan dengan terapi medikamentosa saja ABSTRACT Gastroesophageal reflux disease (GERD) is a pathological condition caused by reflux of gastric contents into the esophagus. It has been shown that GERD has significant impact on patients either physically, psychologically, socially or economically. Impaired of quality of life and working productivity are common in GERD patients. Various pharmacological therapies have been developed, but not yet provide optimal results. It encourages the development of other therapeutic modalities, such as acupoint catgut embedment. The aim of this study was to establish the effect of acupoint catgut embedment combine with medical treatment on symptom and quality of life of GERD patients. A double-blind randomized controlled trial involved 52 GERD patients randomly allocated into catgut embedding therapy with medication group (treatment group) or medication only group (control group). Catgut embedding therapy was given 2 times at CV12 Zhongwan, ST36 Zusanli and BL21 Weishu every 15 days. GERDQ, RQS and SF-36 were used to measure the primary outcomes. The result shown, the decreased of GERDQ scores at treatments group significant higher than control groups (p<0,001), the increased of RQS score and all of SF-36 components scores at treatment group significant higher than control group (p<0,001). The result suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of GERD patients.;Gastroesophageal reflux disease (GERD) is a pathological condition caused by reflux of gastric contents into the esophagus. It has been shown that GERD has significant impact on patients either physically, psychologically, socially or economically. Impaired of quality of life and working productivity are common in GERD patients. Various pharmacological therapies have been developed, but not yet provide optimal results. It encourages the development of other therapeutic modalities, such as acupoint catgut embedment. The aim of this study was to establish the effect of acupoint catgut embedment combine with medical treatment on symptom and quality of life of GERD patients. A double-blind randomized controlled trial involved 52 GERD patients randomly allocated into catgut embedding therapy with medication group (treatment group) or medication only group (control group). Catgut embedding therapy was given 2 times at CV12 Zhongwan, ST36 Zusanli and BL21 Weishu every 15 days. GERDQ, RQS and SF-36 were used to measure the primary outcomes. The result shown, the decreased of GERDQ scores at treatments group significant higher than control groups (p<0,001), the increased of RQS score and all of SF-36 components scores at treatment group significant higher than control group (p<0,001). The result suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of GERD patients.;Gastroesophageal reflux disease (GERD) is a pathological condition caused by reflux of gastric contents into the esophagus. It has been shown that GERD has significant impact on patients either physically, psychologically, socially or economically. Impaired of quality of life and working productivity are common in GERD patients. Various pharmacological therapies have been developed, but not yet provide optimal results. It encourages the development of other therapeutic modalities, such as acupoint catgut embedment. The aim of this study was to establish the effect of acupoint catgut embedment combine with medical treatment on symptom and quality of life of GERD patients. A double-blind randomized controlled trial involved 52 GERD patients randomly allocated into catgut embedding therapy with medication group (treatment group) or medication only group (control group). Catgut embedding therapy was given 2 times at CV12 Zhongwan, ST36 Zusanli and BL21 Weishu every 15 days. GERDQ, RQS and SF-36 were used to measure the primary outcomes. The result shown, the decreased of GERDQ scores at treatments group significant higher than control groups (p<0,001), the increased of RQS score and all of SF-36 components scores at treatment group significant higher than control group (p<0,001). The result suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of GERD patients.;Gastroesophageal reflux disease (GERD) is a pathological condition caused by reflux of gastric contents into the esophagus. It has been shown that GERD has significant impact on patients either physically, psychologically, socially or economically. Impaired of quality of life and working productivity are common in GERD patients. Various pharmacological therapies have been developed, but not yet provide optimal results. It encourages the development of other therapeutic modalities, such as acupoint catgut embedment. The aim of this study was to establish the effect of acupoint catgut embedment combine with medical treatment on symptom and quality of life of GERD patients. A double-blind randomized controlled trial involved 52 GERD patients randomly allocated into catgut embedding therapy with medication group (treatment group) or medication only group (control group). Catgut embedding therapy was given 2 times at CV12 Zhongwan, ST36 Zusanli and BL21 Weishu every 15 days. GERDQ, RQS and SF-36 were used to measure the primary outcomes. The result shown, the decreased of GERDQ scores at treatments group significant higher than control groups (p<0,001), the increased of RQS score and all of SF-36 components scores at treatment group significant higher than control group (p<0,001). The result suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of GERD patients.;Gastroesophageal reflux disease (GERD) is a pathological condition caused by reflux of gastric contents into the esophagus. It has been shown that GERD has significant impact on patients either physically, psychologically, socially or economically. Impaired of quality of life and working productivity are common in GERD patients. Various pharmacological therapies have been developed, but not yet provide optimal results. It encourages the development of other therapeutic modalities, such as acupoint catgut embedment. The aim of this study was to establish the effect of acupoint catgut embedment combine with medical treatment on symptom and quality of life of GERD patients. A double-blind randomized controlled trial involved 52 GERD patients randomly allocated into catgut embedding therapy with medication group (treatment group) or medication only group (control group). Catgut embedding therapy was given 2 times at CV12 Zhongwan, ST36 Zusanli and BL21 Weishu every 15 days. GERDQ, RQS and SF-36 were used to measure the primary outcomes. The result shown, the decreased of GERDQ scores at treatments group significant higher than control groups (p<0,001), the increased of RQS score and all of SF-36 components scores at treatment group significant higher than control group (p<0,001). The result suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of GERD patients."

"Penyakit Paru Obstruktif Kronik (PPOK) kini telah menjadi penyebab kematian terbanyak keempat di dunia. Masih tingginya angka mortalitas pada tatalaksana PPOK mengharuskan pengembangan modalitas terapi yang terus-menerus. Penelitian ini bertujuan untuk mengetahui pengaruh terapi kombinasi akupunktur tanam benang dan medikamentosa terhadap indeks BODE pasien PPOK. Uji klinis acak tersamar ganda dengan pembanding dilakukan terhadap 48 pasien yang dialokasikan ke dalam kelompok kasus (kombinasi akupunktur tanam benang dan medikamentosa) atau kelompok kontrol (kelompok akupunktur sham dan medikamentosa). Akupunktur tanam benang dilakukan pada titik BL13 Feishu, BL43 Gaohuangshu, BL20 Pishu, BL23 Shenshu dan ST40 Fenglong sebanyak 2 kali dengan interval 15 hari. Indeks BODE sebagai keluaran primer dinilai pada hari ke-1 dan hari ke-30. Hasil penelitian menunjukkan perbedaan yang bermakna secara statistik maupun klinis antar kedua kelompok. Rerata penurunan indeks BODE 1,83 lebih rendah pada kelompok kasus dibandingkan dengan kelompok kontrol (p =0,000). Disimpulkan bahwa terapi kombinasi akupunktur tanam benang dan medikamentosa lebih efektif menurunkan Indeks BODE dibandingkan dengan medikamentosa saja.

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Chronic Obstructive Pulmonary Disease (COPD) is now becoming the fourth leading cause of death in the world. Since high level of mortality following COPD medication, continous research to improve treatment modalities keeps on progressing. This study aimed to establish the effect of acupoint-catgut embedment combined with medical treatment on BODE index of COPD patient. A double blind randomized controlled trial has been conducted on 48 patient allocated into acupoint-catgut embedment with medication group (case group) or sham acupuncture with medication group (control group). Acupoint-catgut embedment was done on BL13 Feishu, BL43 Gaohuangshu, BL20 Pishu, BL23 Shenshu and ST40 Fenglong, 2 times with interval 15 days. BODE index as primary outcome was assessed on day-1 and day-30. The result shown statistically and clinically important difference between groups. BODE index was reduced 1,83 point lower in case group (p = 0,000). By that result, acupoint-catgut embedment combined with medical treatment is concluded more effective than medical treatment solely in reducing BODE index."

"Latar Belakang: Penyakit refluks gastroesofageal GERD adalah suatu kondisi patologis akibat refluks isi lambung ke dalam esofagus. GERD merupakan penyakit yang ditimbulkan oleh berbagai faktor dengan prevalensi yang semakin meningkat di seluruh dunia. Interleukin 6 IL-6 adalah sitokin pro inflamasi ditemukan pada mukosa esofagus pasien GERD dan berkaitan dengan gangguan motorik otot esofagus. Akupunktur tanam benang telah lama dikenal sebagai salah satu terapi tambahan dalam menangani GERD. Penelitian ini bertujuan untuk mengetahui pengaruh terapi kombinasi akupunktur tanam benang dan medikamentosa terhadap kadar IL-6 serum pasien penyakit refluks gastroesofageal.Metode: Uji klinis acak tersamar tunggal dilakukan pada 40 pasien GERD yang dialokasikan ke dalam kelompok akupunktur tanam benang dan medikamentosa atau kelompok akupunktur sham dan medikamentosa. Akupunktur tanam benang dilakukan pada titik CV12 Zhongwan, ST36 Zusanli, BL21 Weishu sebanyak 2 kali dengan interval 15 hari. Kadar IL-6 dalam plasma darah secara ELISA digunakan untuk mengukur keluaran penelitian.Hasil penelitian: Tidak ada perbedaan signifikan pada kadar IL-6 sebelum terapi di kedua grup. Pada akhir terapi didapatkan penurunan kadar IL-6 pada kelompok akupunktur tanam benang dan penurunan kadar IL-6 pada kelompok sham, namun secara statistik tidak ada perbedaan bermakna antara kedua kelompok p = 0.14.Kesimpulan: Akupunktur tanam benang belum terbukti secara statistik mempengaruhi kadar IL-6 pada pasien GERD. Kata kunci : GERD, akupunktur tanam benang, IL-6.

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Backgrounds: Gastroesophageal reflux disease GERD is a pathological condition due to reflux of stomach contents into the esophagus. GERD is multifactorial disorder with increase in prevalence worldwide. Interleukin 6 IL 6 is a pro inflammatory cytokine that is commonly found in esophageal mucosa of GERD patients and associated with esophageal motor disorders. Acupoint catgut embedment has long been known as an adjunctive therapy for GERD. This study aimed to establish the effect of acupoint catgut embedment combined with medication on IL 6 serum levels of patients with GERD.

Methods: A single blind, randomized controlled trial involved 40 GERD patients randomly allocated to catgut embedding therapy plus medication or sham acupuncture with medication. Catgut embedding therapy was given two times at CV12 Zhongwan, ST36 Zusanli, BL21 Weishu every 15 days. Serum levels of IL 6 were measured by ELISA as research output.

Results: There were no significant differences in the baseline levels of pro inflammatory IL 6 mediators between groups. After one month treatment, the median levels of IL 6 were statistically insignificant decreased in catgut embedding therapy plus medication vs sham acupuncture and medication p 0.14.

Conclusion: The results suggest that catgut embedding therapy has not been proven statistically influencing the levels of IL 6 in patients with GERD. Keywords GERD, catgut embedding therapy, IL 6."

"Prevalensi asma di Indonesia cukup tinggi (4,5%) dan beban yang diakibatkannya menyebabkan konsekuensi sosial ekonomi. Peningkatan risiko terjadinya efek samping yang mengiringi pengobatan jangka lama pada asma mendorong pengembangan modalitas terapi lain salah satunya adalah akupunktur tetapi belum ada penelitian akupunktur pada asma yang menilai efeknya pada derajat keterkontrolan asma menggunakan alat ukur yang valid. Penelitian ini bertujuan mengetahui efektivitas terapi kombinasi akupunktur tanam benang dan medikamentosa terhadap derajat keterkontrolan asma menggunakan skor ACT, pengaruhnya terhadap perubahan faal paru dan efek samping yang dapat timbul pada tindakan akupunktur tanam benang pada pasien asma bronkial derajat persisten sedang yang terkontrol sebagian dan tidak terkontrol. Uji klinis acak dan tersamar ganda dengan pembanding dilakukan pada 52 penderita asma bronkial derajat persisten sedang yang terkontrol sebagian dan tidak terkontrol yang dialokasikan secara acak menjadi kelompok terapi kombinasi akupunktur tanam benang dan medikamentosa (kelompok kasus) atau kelompok terapi medikamentosa (kelompok kontrol). Hasil penelitian menunjukkan perbedaan bermakna perubahan skor ACT dan persentasi perubahan nilai APE sebelum dan sesudah perlakuan lebih tinggi pada kelompok kasus dibanding kelompok kontrol (p < 0,05). Persentasi perubahan nilai VEP1, KVP dan VEP1/KVP sebelum dan sesudah perlakuan lebih tinggi pada kelompok kasus dibanding kelompok kontrol namun perbedaan tersebut tidak bermakna secara statistik (p > 0,05). Kesimpulan penelitian adalah terapi kombinasi akupunktur tanam benang dan medikamentosa lebih efektif dibanding terapi medikamentosa saja dalam meningkatkan derajat keterkontrolan asma pada pasien asma bronkial derajat persisten sedang yang terkontrol sebagian dan tidak terkontrol.

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Asthma prevalence in Indonesia is quite high (4,5%) and the resulting burden caused socio-economic consequences. An increased risk of side effects that accompany long term treatment of asthma encourage the development of other therapeutic modalities one of which is acupoint catgut embedment but there is no studies of acupuncture in asthma that assess its effect on the degree of asthma control using a valid measurement tools.

The aim of this study was to establish the effectiveness of acupoint catgut embedment combined with medical treatment on asthma control using Asthma Control Test (ACT), to establish its effect on measurement result of lung function and to monitor the side effects that may occur. This study is a randomized, double-blind and controlled clinical trial involving 52 patients with partially controlled and uncontrolled moderate persistent bronchial asthma that are allocated into groups of catgut embedding method combined with medication (case group) and group of medication (control group).

The results showed a statistically significant difference in the change of ACT scores and PEF before and after treatment higher in case group compared to control group (p < 0,05). The change of FEV1, FVC and FEV1/FVC before and after treatment were higher in case group compared to control group but the differences were not statistically significant (p > 0,05).

The conclucion of this study is acupoint catgut embedment combined with medical treatment is more effective than medication treatment alone in improving asthma control in patients with partially controlled and uncontrolled moderate persistent bronchial asthma."

"Obesitas merupakan salah satu masalah kesehatan di Indonesia, dan merupakan salah satu faktor yang berhubungan dengan penurunan kualitas hidup dan faktor resiko perkembangan berbagai penyakit lainnya. Obesitas juga berhubungan dengan status inflamasi kronik yang berperan dalam perkembangan disfungsi metabolik dan sindrom metabolik. Akupunktur diketahui dapat membantu menurunkan berat badan dengan cara menekan nafsu makan dan mengurangi resiko sindrom metabolik.Penelitian ini bertujuan untuk mengetahui efektifitas terapi kombinasi akupunktur tanam benang catgut dan intervensi diet terhadap kadar Tumor Necrosis Factor-α (TNF-α) dan lingkar perut pada pasien obesitas. Uji klinis acak tersamar ganda dengan pembanding dilakukan pada 36 pasien obesitas yang dialokasikan secara acak menjadi kelompok terapi kombinasi akupunktur tanam benang catgut dan intervensi diet (kelompok kasus) atau kelompok akupunktur sham dan intervensi diet (kelompok kontrol).Hasil penelitian menunjukkan terdapat perbedaan bermakna kadar TNF-α awal dengan akhir dalam kelompok kasus (p < 0,01) dan terdapat perbedaan bermakna selisih lingkar perut awal dan akhir antara kedua kelompok (p < 0,01; IK 95% 1,68 sampai 6,13). Kesimpulan penelitian ini terapi kombinasi akupunktur tanam benang catgut dan intervensi diet memiliki pengaruh terhadap kadar TNF-α plasma darah dan lingkar perut pada pasien obesitas.

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Obesity is a health problem in Indonesia and associated with decreased quality of life and a risk factor for the development of other diseases. Obesity is also associated with chronic inflammatory status that play a role in the development of metabolic dysfunction and metabolic syndrome. Acupuncture is known to help you lose weight by suppressing appetite and reducing the risk of metabolic syndrome.

The aim of this study was to establish the effectiveness of acupoint catgut embedding therapy combined with dietary intervention on tumor necrosis factor-α (TNF-α) levels and abdominal circumference in obese patients. This study is a randomized, double-blind and controlled clinical trial involving 36 obese patients that are allocated into groups of catgut embedding method combined with dietary intervention (case group) or sham acupuncture combined with dietary intevention (control group).

The results showed there was significant difference in TNF-α levels within case group (p < 0,01) and there were significant differences in abdominal circumference changes between the two groups (p < 0.01; 95% CI: 1.68 to 6.13). The conclusion of this study is acupoint catgut embedment combined with dietary intervention has effects on TNF-α levels of blood plasma and abdominal circumference in obese patients."

"Obesitas merupakan suatu keadaan dengan akumulasi lemak yang tidak normal atau berlebihan di jaringan adiposa sehingga dapat mengganggu kesehatan. Diperkirakan lebih dari 500 juta orang dewasa di seluruh dunia mengalami obesitas dan 1,5 miliar mengalami masalah kelebihan berat badan. Pada obesitas terdapat peningkatan jaringan adiposa dimana jaringan adiposa dapat mensintesis dan mensekresi sitokin pro-inflamasi seperti interleukin-6 (IL-6). Akupunktur telah lama dikenal sebagai salah satu terapi tambahan dalam menangani obesitas. Akupunktur dapat menurunkan respon inflamasi pada jaringan adiposa dengan menurunkan infiltrasi makrofag ke dalam jaringan adiposa pada obesitas sehingga jumlah makrofag yang merupakan sumber produksi adipokin pro-inflamasi menjadi lebih sedikit. Penelitian ini bertujuan untuk mengetahui pengaruh terapi akupunktur tanam benang catgut dan intervensi diet terhadap perubahan kadar IL-6 dan indeks massa tubuh pada pasien obesitas. Uji klinis acak tersamar ganda dilakukan pada 36 pasien obesitas yang dialokasikan ke dalam kelompok akupunktur tanam benang catgut dan intervensi diet atau kelompok akupunktur tanam benang sham dan intervensi diet. Akupunktur tanam benang dilakukan 2 kali pada titik CV12 Zhongwan, ST25 Tianshu, CV6 Qihai, dan SP6 Sanyinjiao setiap 2 minggu. Kadar IL-6 dalam plasma darah dan indeks massa tubuh digunakan untuk mengukur keluaran penelitian. Hasil penelitian menunjukkan perbedaan bermakna rerata kadar IL-6 awal dengan akhir dalam kelompok akupunktur tanam benang catgut (p = 0.01; 95% IK: 0.03 sampai 0.23) dan rerata selisih IMT lebih rendah 0.33 pada kelompok akupunktur tanam benang catgut dibandingkan dengan kelompok akupunktur tanam benang sham (p = 0.02; 95% IK: 0.05 sampai 0.61). Kesimpulan penelitian adalah terapi kombinasi akupunktur tanam benang catgut dan intervensi diet lebih efektif dalam menurunkan kadar IL-6 dan indeks massa tubuh pada pasien obesitas.

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Obesity is a condition with abnormal fat accumulation or excessive adipose tissue so it can disturb our health. It is estimated that over 500 million adults worldwide are obese and 1.5 billion are having problems with overweight. In obese there is an increased adipose tissue which can synthesize and secrete pro-inflammatory cytokines such as interleukine-6 (IL-6). Acupuncture has long been known as an adjunctive therapy for obesity. Acupuncture can reduce inflammatory responses in adipose tissue by reducing macrophage infiltration into adipose tissue in obesity so that the number of macrophages, which are the source of production of proinflammatory adipokines become fewer. A double blind randomized controlled trial involved 36 obesity patients randomly allocated into catgut embedding acupuncture group with diet intervention or sham embedding acupuncture group with diet intervention. Catgut embedding therapy was given two times at CV12 Zhongwan, ST25 Tianshu, CV6 Qihai, and SP6 Sanyinjiao every two weeks. Interleukine-6 level in blood plasma and body mass index (BMI) is used to measure research output. There was a statistically significant difference within catgut embedding group with levels of IL-6 (p = 0.01; 95% CI: 0.03 to 0.23) and lower mean BMI difference of 12.33 in catgut embedding group compared with sham embedding group (p = 0.02; 95% CI: 0.05 to 0.61). The result suggest that acupoint-catgut embedding therapy combined with diet intervention is more effective in reducing IL-6 levels and BMI in obese patients."

"Obesitas merupakan suatu keadaan dengan akumulasi lemak yang tidak normal atau berlebihan di jaringan adiposa sehingga dapat mengganggu kesehatan. Diperkirakan lebih dari 500 juta orang dewasa di seluruh dunia mengalami obesitas dan 1,5 miliar mengalami masalah kelebihan berat badan. Pada obesitas terdapat peningkatan jaringan adiposa dimana jaringan adiposa dapat mensintesis dan mensekresi sitokin pro-inflamasi seperti interleukin-6 (IL-6). Akupunktur telah lama dikenal sebagai salah satu terapi tambahan dalam menangani obesitas. Akupunktur dapat menurunkan respon inflamasi pada jaringan adiposa dengan menurunkan infiltrasi makrofag ke dalam jaringan adiposa pada obesitas sehingga jumlah makrofag yang merupakan sumber produksi adipokin pro-inflamasi menjadi lebih sedikit. Penelitian ini bertujuan untuk mengetahui pengaruh terapi akupunktur tanam benang catgut dan intervensi diet terhadap perubahan kadar IL-6 dan indeks massa tubuh pada pasien obesitas. Uji klinis acak tersamar ganda dilakukan pada 36 pasien obesitas yang dialokasikan ke dalam kelompok akupunktur tanam benang catgut dan intervensi diet atau kelompok akupunktur tanam benang sham dan intervensi diet. Akupunktur tanam benang dilakukan 2 kali pada titik CV12 Zhongwan, ST25 Tianshu, CV6 Qihai, dan SP6 Sanyinjiao setiap 2 minggu. Kadar IL-6 dalam plasma darah dan indeks massa tubuh digunakan untuk mengukur keluaran penelitian. Hasil penelitian menunjukkan perbedaan bermakna rerata kadar IL-6 awal dengan akhir dalam kelompok akupunktur tanam benang catgut (p = 0.01; 95% IK: 0.03 sampai 0.23) dan rerata selisih IMT lebih rendah 0.33 pada kelompok akupunktur tanam benang catgut dibandingkan dengan kelompok akupunktur tanam benang sham (p = 0.02; 95% IK: 0.05 sampai 0.61). Kesimpulan penelitian adalah terapi kombinasi akupunktur tanam benang catgut dan intervensi diet lebih efektif dalam menurunkan kadar IL-6 dan indeks massa tubuh pada pasien obesitas.

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Obesity is a condition with abnormal fat accumulation or excessive adipose tissue so it can disturb our health. It is estimated that over 500 million adults worldwide are obese and 1.5 billion are having problems with overweight. In obese there is an increased adipose tissue which can synthesize and secrete pro-inflammatory cytokines such as interleukine-6 (IL-6). Acupuncture has long been known as an adjunctive therapy for obesity. Acupuncture can reduce inflammatory responses in adipose tissue by reducing macrophage infiltration into adipose tissue in obesity so that the number of macrophages, which are the source of production of pro-inflammatory adipokines become fewer. A double blind randomized controlled trial involved 36 obesity patients randomly allocated into catgut embedding acupuncture group with diet intervention or sham embedding acupuncture group with diet intervention. Catgut embedding therapy was given two times at CV12 Zhongwan, ST25 Tianshu, CV6 Qihai, and SP6 Sanyinjiao every two weeks. Interleukine-6 level in blood plasma and body mass index (BMI) is used to measure research output. There was a statistically significant difference within catgut embedding group with levels of IL-6 (p = 0.01; 95% CI: 0.03 to 0.23) and lower mean BMI difference of 12.33 in catgut embedding group compared with sham embedding group (p = 0.02; 95% CI: 0.05 to 0.61). The result suggest that acupoint-catgut embedding therapy combined with diet intervention is more effective in reducing IL-6 levels and BMI in obese patients."

"Irritable bowel syndrome (IBS) is the most common functional disorder of the gastrointestinal tract. As a result of the lack of specific diagnostic testing and absence of circumscribed biology markers of the disease, its diagnosis is based on a myriad of symptoms. The term irritable bowel syndrome was probably first coined in 1944 by Peters and Bargenf. ln 1849, Cumming described the clinical manifestations of Irritable Bowel Syndrome. Irritable bowel syndrome is defined an the basis of the recently modified Rome criteria as the presence of at least l2 weeks (not necessarily consecutive) of abdominal discomfort or pain in the preceding l2 months that cannot be explained by structural or biochemical abnormalities, and that has at least two of the following three features: pain relieved with defecation, an onset associated with a change in the frequency of bowel movements (diarrhea or constipation), or an onset associated with a change inform of stool (loose, watery, or pellet-like). The syndrome can be divided into three subcategories according to the Modmed Rome criteria ll; those with a predominant symptom of diarrhea, constipation, or constipation alternating with diarrhea. There are Several criteria for irritable bowel syndrome, one of which is the Manning criteria applied in many epidemiological and clinical studies to identify irritable bowel syndrome. However, many investigators disagree with this criteria due to a seemingly poor validity in men. In an attempt to bring order to the specialty, consensus-based approach is adopted by a group of international experts, which led to the development ofthe Rome criteria for irritable bowel syndrome (Table l). Extra-intestinal symptoms, including headache, backache, urinary and gynecologic symptoms, and fatigue, are more common in the constipation-predominant subgroup"