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"Pharmacotherapy: A Pathophysiologic Approach is written to help advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories. This edition is enriched by more than 300 expert contributors, and every chapter has been revised and updated to reflect the latest evidence-based information and recommendations. Important features such as Key Concepts at the beginning of each chapter, Clinical Presentation tables that summarize disease signs and symptoms, and Clinical Controversies boxes that examine the complicated issues faced by students and clinicians in providing drug therapy make this text an essential learning tool for students, patient-focused pharmacists, and other health care providers."

"The most comprehensive, widely used, and evidence-based pharmacotherapy text available Hailed by Doody's Review Service as "one of the best in pharmacy" Pharmacotherapy: A Pathophysiologic Approach is unmatched in its ability to help students develop a mastery of evidence-based medicine for optimum patient outcomes. The eighth edition will feature the addition of SI units throughout and an increased number of global examples and clinical questions. Features Unparalleled guidance in the development of pharmaceutical care plans Full-color presentation Key Concepts in each chapter Critical Presentation boxes summarize common disease signs and symptoms Clinical Controversies boxes examin complicated issues you face when providing drug therapy NEW material added to the online learning center EXPANDED evidence-based recommendations EXPANDED coverage of timely issues such as palliative care and pain medicine Therapeutic recommendations in each disease-specific chapte"

"Summary: "The most comprehensive, widely used, and evidence-based pharmacotherapy text available Hailed by Doody's Review Service as "one of the best in pharmacy" Pharmacotherapy: A Pathophysiologic Approach is unmatched in its ability to help students develop a mastery of evidence-based medicine for optimum patient outcomes. The eighth edition will feature the addition of SI units throughout and an increased number of global examples and clinical questions. Features Unparalleled guidance in the development of pharmaceutical care plans Full-color presentation Key Concepts in each chapter Critical Presentation boxes summarize common disease signs and symptoms Clinical Controversies boxes examin complicated issues you face when providing drug therapy NEW material added to the online learning center EXPANDED evidence-based recommendations EXPANDED coverage of timely issues such as palliative care and pain medicine Therapeutic recommendations in each disease-specific chapter""

"Inflamasi yang tidak terkontrol menjadi penyebab kematian yang signifikan di seluruh dunia dan merupakan faktor penting dalam kasus COVID-19 yang parah. EmponEmpon (EE), merupakan jamu tradisional Indonesia secara empiris diyakini mampu menyembuhkan COVID-19 yang parah. Namun, mekanisme kerja senyawa utama dalam mengobati keparahan COVID-19 masih belum jelas. Penelitian ini bertujuan mengidentifikasi senyawa utama EE dan mekanisme molekulernya dalam mengendalikan inflamasi pada COVID-19. Senyawa EE diidentifikasi menggunakan KNApSAcK, protein/target yang terhubung senyawa dikumpulkan menggunakan database: ChemBL, GeneCard, dan Traditional Chinese Medicine Systems Pharmacology (TCMSP), sedangkan target terhubung penyakit dikumpulkan menggunakan GeneCard database. Analisis protein-protein interaction (PPI) dibangun menggunakan String, analisis Gene Ontology (GO) dan Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment menggunakan ShinyGO 0.8. Jaringan interaksi senyawa-target-pathway divisualisasikan dan dianalisis menggunakan Cytoscape 3.10. Analisis penambatan molekul menggunakan PyRx 0.98 serta analisis molecular dynamics simulation (MD) menggunakan NAMD. Diperoleh sebanyak 336 senyawa dalam EE, 28 senyawa diantaranya memenuhi kriteria penyaringan berdasarkan bobot molekul (BM): 200-500 dalton, Oral bioavailability (OB) ≥ 30%, drug-likeness (DL) ≥ 0.18, tidak menghambat CYP2D6 di hati, toksisitas ≥ III. sebanyak 578 target EE diidentifikasi terlibat dalam inflamasi dan COVID-19. Analisis GO dan KEGG mengungkap bahwa aksi farmakologi EE melalui berbagai jalur, termasuk jalur kanker, lipid dan aterosklerosis, serta COVID-19. Analisis PPI diperoleh sebanyak 6 target yang memainkan peran essensial dalam mengendalikan inflamasi dan mengobati COVID-19, yaitu: MAPK3, EGFR, AKT1, PTGS2, TNF dan IL-6. Analisis penambatan molekul menunjukkan bahwa α-amyrin, Biochanin-A, Delphinidin, Sesamin, Isorhamnetin, Guaiacin, dan Ellagic acid adalah senyawa yang mampu terikat kuat pada MAPK3, EGFR, AKT1, PTGS2, TNF dan IL-6; hasil ini diperkuat oleh analisis MD yang mengkonfirmasi bahwa interaksi antara senyawa dengan kompleks target esensialnya stabil. Temuan ini memberikan landasan teoritis mekanisme EE dalam mengendalikan inflamasi pada COVID-19, yang dapat digunakan untuk mengembangkan jamu berbasis EE

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Uncontrolled inflammation is a significant cause of death worldwide and is an essential factor in severe cases of COVID-19. Empon-Empon (EE), a traditional Indonesian herbal medicine, is empirically believed to be able to cure severe COVID-19. However, the mechanism of action of the main compound in treating the severity of COVID-19 is still unclear. This study aims to identify the main compounds of EE and their molecular mechanisms in controlling inflammation in COVID-19. EE compounds were identified using KNApSAcK, and compound-related proteins/targets were collected using ChemBL, GeneCard, and Traditional Chinese Medicine Systems Pharmacology (TCMSP) databases. In a while, disease-linked targets were collected using the GeneCard database. Protein-protein interaction (PPI) analysis was built using String, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment using ShinyGO 0.8. The compound-target-pathway interaction network was visualized and analyzed using Cytoscape 3.10. Molecular docking analysis using PyRx 0.98 and molecular dynamics simulation (MD) analysis using NAMD. A total of 336 compounds were obtained in EE, 28 of which met the screening criteria based on molecular weight (BM): 200-500 daltons, Oral bioavailability (OB) ≥ 30%, drug-likeness (DL) ≥ 0.18, does not inhibit CYP2D6 in the liver, toxicity ≥ III. A total of 578 EE targets were identified as being involved in inflammation and COVID-19. GO and KEGG analyses revealed the pharmacological actions of EE through various pathways, including cancer, lipid and atherosclerosis, and COVID-19 pathways. PPI analysis revealed six essential targets in controlling inflammation and treating COVID19, namely MAPK3, EGFR, AKT1, PTGS2, TNF, and IL-6. Molecular docking analysis showed that α-amyrin, Biochanin-A, Delphinidin, Sesamin, Isorhamnetin, Guaiacin, and Ellagic acid were compounds that were able to bind strongly to MAPK3, EGFR, AKT1, PTGS2, TNF, and IL-6; these results were confirmed by MD analysis which confirmed that the interaction between the compound and its essential target complex was stable. These findings provide a theoretical basis for the mechanism of EE in controlling inflammation in COVID-19, which can be used to develop EE-based herbal medicine."

"With its concise, straightforward approach, this text puts nursing pharmacology concepts and essential drug calculation skills into a contemporary nursing context to prepare you for real-world drug administration responsibilities. Revised and updated with the most current information-including Prototype Drug Charts, detailed Nursing Process summaries, and NCLEX Study Questions-this 7th edition makes pharmacology more understandable than ever."

"Penelitian ini merupakan penelitian kualitatif dengan pendekatan fenomenologi yang bertujuan untuk memahami berbagai pengalaman ILWHA (Injecting Drug User Living with HIV/AIDS) dalam menjalani terapi ARV pada saat terapi rumatan metadon. Partisipan dalam penelitian ini berjumlah 6 orang yang telah menjalani terapi ARV lebih dari 3 bulan dan sedang menjalani terapi rumatan metadon. Partisipan dipilih dengan cara purposive sampling. Pengumpulan data adalah dengan wawancara mendalam dan analisis serta sintesis menggunakan metode ?Colaizzi?s?. Hasil penelitian menunjukan pengalaman ILWHa dalam menjalani terapi ARV pada saat terapi rumatan metadon yang diungkapkan secara mendalam dengan berbagai penjelasan yang penuh emosi dan digambarkan dengan pernyataan-pernyataan tematik. Penelitian ini menyimpulkaan setiap ILWHA mengalami kebuaran dan lebih fungsional dalam hidup. Setiap ILWHA mengalami: 1)beban fisik akibat efek ARVdan gejala putus obat, 2)beban psikologi, yaitu ketidakberdayaan, kecemasan dan gangguan mood, 3)beban sosial, yaitu stigma dan diskriminasi serta kehilangan kesempatan bekerja. Menjalani terapi ARV pada saat terapi rumatan metadon merupakan proses pembelajaran dan dijalani dengan kepasrahan. Terdapat berbagai kebutuhan pelayanan kesehatan yaitu pelayanan yang terintegrasi antara ARV dan metadon, informasi penanggulangan efek ARV dan gizi serta informasi HIV, ARV dan emtadon bagi masyarakat. . Berdasarkan hal tersebut, perawat medikal bedah perlu memahami aspek fisik, psikologis, dan sosial serta kedinamisan ILWHA dalam terapi ARV pada saat terapi rumatan metadon selain itu juga perlu mengidentifikasi dan mengembangkan lebih lanjut kebutuhan pelayanan kesehatan pada ILWHA yang sedang menjalani terapi ARV.

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This is a qualitative research with phenomenological approach which was aimed to understand ILWHA experiences in receiving ARV therapy during methadone maintenance therapy. Six participants who have had received ARV therapy for more than 3 months and were undergoing methadone maintenance therapy were chosen using purposive sampling. Data was collected with a deep interview and further was analyzed and synthesized with Colaizzi?s. The results showed ILWHA experiences in receiving ARV therapy during methadone maintenance therapy were expressed in depth with various emotional explanations and were described with thematic statements. The conclusion of this research was every ILWHA experiences fitness and more functional in live. Every ILWHA experiences: 1) physical burden as the effect of ARV and drug withdrawal, 2) psychological burden, including helplessness, anxiety and mood disturbance, 3) social burden, such as stigma, discrimination and losing opportunity to work. Receiving ARV therapy during methadone maintenance therapy is a learning process and should be through in a sincere heart. There are health service needs such as integrated service between ARV and methadone, information of ARV effects, nutrition, and knowledge related to HIV, ARV and methadone for community. Based on this fact, medical surgical nurses need to understand physical, psychological and social aspects and ILWHA dynamicity in receiving ARV therapy during methadone maintenance therapy. The nurses are also necessary to identify and develop a further nursing care needs among ILWHA who are receiving ARV."