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Audrey Haryanto

Korelasi antara kadar vitamin D serum dengan kadar hsCRP pada usia lanjut = Correlation between serum vitamin D level and hsCRP in elderly

"Prevalensi penyakit kardiovaskuler (PKV) meningkat seiring dengan proses penuaan. Aterosklerosis yang menyebabkan terjadinya inflamasi dan diikuti peningkatan kadar C-reactive protein (CRP). Vitamin D merupakan vitamin yang memiliki efek antiinflamasi dan dapat menurunkan kadar hsCRP. Penelitian ini merupakan penelitian dengan desain potong lintang yang bertujuan untuk mengetahui korelasi antara kadar vitamin D dengan kadar hsCRP pada usia lanjut (usila). Penelitian dilakukan di Pusat Santunan Keluarga (Pusaka) 12 di Tomang dan Pusaka 39 di Senen pada pertengahan bulan Desember 2012 sampai bulan Januari 2013. Pengambilan subyek dilakukan dengan cara cluster random sampling, dan didapatkan 71 orang subyek yang memenuhi kriteria penelitian. Data dikumpulkan melalui wawancara meliputi data usia, asupan vitamin D dengan metode Food Frequency Questionnaire (FFQ) semikuantitatif serta total skor pajanan sinar matahari mingguan. Pengukuran antropometri untuk menilai status gizi dan pemeriksaan laboratorium yang meliputi kadar vitamin D dan hsCRP. Didapatkan median usia 69 (60-85) tahun dan 80,3% subyek adalah perempuan. Malnutrisi terdapat pada 71,8 % subyek. Asupan vitamin D menunjukkan 98,6% subyek memiliki asupan vitamin D kurang dari Angka Kecukupan Gizi (AKG) Indonesia. Sebanyak 97,2% subyek memiliki skor pajanan sinar matahari rendah. Nilai rerata kadar vitamin D 38,02±12,94 nmol/L dan 78% subyek tergolong defisiensi vitamin D. Nilai median kadar hsCRP 1,5 (0,1-49,6) mg/L, dan 67,6% subyek tergolong risiko PKV sedang dan tinggi. Didapatkan korelasi positif tidak bermakna antara kadar vitamin D serum dengan kadar hsCRP pada usila (r=0,168, p=0,162).

The prevalence of cardiovascular disease (CVD) increases in the elderly. Atherosclerosis is a major cause of CVD which stimulate inflammation and followed by increase production of C-reactive protein (CRP). Vitamin D is a vitamin which has anti-inflammatory effects and may reduce level of hsCRP. The aim of this cross sectional study was to find the correlation between serum vitamin D level and hsCRP in elderly. Data collection was conducted during December 2012 to January 2013 on 2 selected Pusaka, Pusaka 12 (Tomang) and Pusaka 39 (Senen). Subjects were obtained using cluster random sampling method. A total of 71 elderly subjects had met the study criteria. Data were collected through interviews including age, vitamin D intake and weekly score of sunlight exposure. Anthropometry measurements to assess the nutritional status and laboratory examination i.e blood levels of vitamin D and hsCRP. Majority of the subjects were female (80,3%), median age was 69 (60-85) years. Malnutrition was occured in 71.8% of the subjects. Intake of vitamin D showed 98.6% of the subjects were less than recommended dietary allowances (RDA). Majority of the subjects had low score of sunlight exposure (97,2%). Mean of vitamin D levels 38,02±12,94 nmol/L, while 78% the of subjects were categorized as vitamin D deficiency. Median of hsCRP levels 1,5 (0,1-49,6) mg/L, while 67,6% subjects were at moderate and high risk of CVD. No significant correlation was found between serum vitamin D levels and hsCRP levels (r=0,168, p=0,162)."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013

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Yusi Deviana Nawawi

Korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di panti wreda = Correlation between vitamin D serum levels with physical performance among elderly individuals in nursing homes

"Usia lanjut berisiko tinggi mengalami defisiensi vitamin D, sedangkan vitamin D memiliki efek protektif terhadap massa otot. Penurunan massa otot dan fungsinya disebut dengan sarkopenia. Prevalensi sarkopenia sangat tinggi pada usia lanjut yang tinggal di panti wreda, kondisi ini disebabkan gaya hidup sedentari pada penghuni panti wreda. Deteksi dini sarkopenia dapat dilakukan dengan mengukur fungsi otot, salah satunya adalah mengukur performa fisik dengan tes short physical performance battery (SPPB). Penelitian potong lintang ini bertujuan untuk melihat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di lima panti wreda yang terdaftar di Kota Tangerang Selatan. Pengambilan subjek dilakukan dengan cara proportional random sampling, didapatkan 100 usila yang memenuhi kriteria penelitian. Pemeriksaan kadar vitamin D menggunakan kadar kalsidiol serum dengan metode chemiluminescence immunoassay (CLIA). Pemeriksaan massa otot menggunakan bioelectric impedance analysis Tanita SC-330. Analisis korelasi menggunakan uji nonparametrik. Didapatkan nilai tengah usia subjek adalah 74,89 tahun dan 72% subjek adalah perempuan. Terdapat 85% subjek memiliki asupan vitamin D yang kurang dan 94% subjek memiliki skor pajanan sinar matahari yang rendah, serta seluruh subjek masih memiliki massa otot yang normal. Nilai tengah kadar vitamin D serum adalah 15,50(4-32) ng/mL, dengan 72% subjek mengalami defisiensi vitamin D. Nilai tengah performa fisik adalah 9(3-12) dan sebanyak 47% subjek mengalami performa fisik yang buruk. Hasil penelitian ini menunjukkan bahwa tidak terdapat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di panti wreda (r=0,130; p=0,196).

Elderly individuals have a risk of vitamin D deficiency, whereas vitamin D has a protective effect on muscle mass. Decrease in muscle mass and function is called sarcopenia. The prevalence of sarcopenia is very high in the elderly who live in nursing homes, this condition is due to the sedentary lifestyle. Early detection of sarcopenia can be done by measuring physical performance with short physical performance battery (SPPB) test. This cross-sectional study aimed to explore the correlation between vitamin D serum levels with physical performance among elderly individuals in five nursing homes registered in South Tangerang. A hundred subjects who fulfilled study criteria gathered using proportional random sampling method. Examination of vitamin D levels using calcidiol serum with the chemiluminescence immunoassay (CLIA) method. Muscle mass was measured using bioelectric impedance analysis Tanita type SC-330. Nonparametric correlation was used for correlation analysis. Median age of subjects was 74.89 years old and 72% were female. Eighty-five percent of subjects had low vitamin D intake, 94% of subjects had low sun exposure score, and all subjects had normal muscle mass. Mean level of vitamin D serum was 15.50 (4-32) ng/mL, with 72% of subjects had vitamin D deficiency. Mean score of physical performance was 9(3-12) and 47% of subjects had low physical performance. This study showed that there was no correlation found between vitamin D serum levels with physical performance among elderly individuals in nursing homes (r=0.130; p=0.196)."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019

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Isa Rosalia Ruslim

Korelasi antara asupan vitamin D dan skor paparan sinar matahari dengan kadar kalsidiol serum pada ibu hamil trimester 1 di Jakarta = Correlation between vitamin d intake and sun exposure score with serum calcidiol on first trimester pregnant women in Jakarta

"Hipovitaminosis D selama masa kehamilan dapat menimbulkan komplikasi selama kehamilan dan pada janin. Selain itu data mengenai status vitamin D pada ibu hamil terutama trimester 1 di Indonesia masih terbatas. Oleh karena itu penelitian ini dilakukan untuk mengetahui kadar kalsidiol serum pada ibu hamil trimester 1 dan korelasinya dengan asupan vitamin D dan skor paparan sinar matahari.

Penelitian ini menggunakan metode studi potong lintang pada ibu hamil sehat usia 20-35 tahun dengan usia kehamilan <12 minggu. Hasil penelitian menunjukkan rerata usia subyek 27,36+3,91 tahun dengan median usia kehamilan 9 minggu. Sebagian besar subyek berpendidikan tinggi (68,1%), status bekerja (70,2%) dengan pendapatan >UMP (59,6%) dan rerata IMT 23,74+3,83 kg/m2. Asupan lemak, protein, dan kalsium subyek

Median skor paparan sinar matahari adalah 14 (0-42) dengan median lama paparan 17,41 (0-85,71) menit. Terdapat perbedaan bermakna antara kadar kalsidiol serum dengan kelompok lama paparan sinar matahari 5-30 menit dan >30 menit (p=0,033). Rerata kadar kalsidiol serum 39,26+10,25 nmol/mL (insufisiensi) dengan 100% subyek memiliki kadar kalsidiol serum < 80 nmol/L yang menggambarkan keadaan hipovitaminosis D.

Tidak terdapat korelasi antara kadar kalsidiol serum dengan skor paparan sinar matahari (r=0,087; p=0,562), dan asupan vitamin D (r=-0,049; p=0,745). Kesimpulan yang didapatkan dari penelitian adalah seluruh ibu hamil trimester 1 di Jakarta mengalami hipovitaminosis D sehingga perlu segera diatasi melalui konseling dan edukasi gizi.

Vitamin D deficiency could be related to several complications to pregnancy`s outcomes, both for mother and fetus. Besides, there is limited data regarding to vitamin D status among pregnant women in Indonesia especially during the first trimester. Therefore this study was performed to determine serum calcidiol on the first trimester of pregnancy and its correlation to vitamin D intake and sun exposure score.
The methode in this study was cross-sectional study among healthy pregnant women aged 20-35 years old on their first trimester of pregnancy. Average age of the subjects was 27.36±3.91 years old with median gestational age of 9 weeks. Most of the subjects was well educated (68.1%), working (70.2%) with monthly income equal and more than the province minimum salary (59.6%), and with BMI average of 23.74±3.83 kg/m2. Mostly the subjects had fat, protein, and calcium intake below its RDA with the average intake of 44.49±22.22 g/day; 45.07±19.35 g/day; 661.93±405.91 mg/day, respectively. Vitamin D intake was mostly below its RDA with a median of 2.9 mcg/day and ranged from 0.3 to 15.6 mcg/day.
The median score of sun exposure score was 14 that ranged from zerro to 42, with a median for its duration of 17.41 minutes that ranged from zerro to 85.71 minutes. In this study, there was significant differences between serum calcidiol and sun exposure duration in 5-30 minutes and more than 30 minutes groups (p=0,033). As the main finding, it reveals that the average of serum calcidiol was 39.26±10.25 nmoL/mL or classified as insufficient where all of the subjects (100%) had serum calcidiol less than 80 nmol/L (hypovitaminosis D).
However, there were no significant correlations between serum calcidiol with sun exposure score and vitamin D intake (r=0.087 and p=0.562; r=-0,049 and p=0.745, respectively). In conclusion, all of the pregnant women in Jakarta, especially in their first trimester had low vitamin D status. Therefore, intervention is needed, i.e. through prenatal counselling and nutrition education regarding to natural sources of vitamin D."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013

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Dyah Saptarini

Hubungan antara kadar vitamin D serum dengan derajat akne vulgaris pada remaja sekolah menengah atas usia 15-18 Tahun = The relationship between vitamin D serum level and the degree of acne vulgaris in high school adolescents aged 15-18 years

Akne vulgaris (AV) adalah penyakit inflamasi yang kronis pada bagian pilosebasea. Pada umumnya akne terjadi pada masa pubertas, dewasa muda, dan banyak terjadi pada remaja. AV mempengaruhi 85% dewasa muda usia 12-25 tahun dan secara konsisten menduduki “the top three most prevalence skin condition“ dalam populasi umum Salah satu faktor yang mempengaruhi timbulnya akne vulgaris dan yang masih menjadi perebatan adalah faktor nutrisi. Dengan menggunakan cut-off <20 ng/mL, prevalensi defisiensi vitamin D bervariasi antara 6-70% di Asia Tenggara, hasil penelitian di Malaysia lebih dari setengah (58%) jumlah remaja memiliki 25(OH)D <50 nmol/L. Penelitian ini merupakan studi potong lintang yang membandingkan nilai rerata kadar vitamin D serum antara dua kelompok derajat akne pada remaja siswa sekolah menengah atas usia 15-18 tahun di kota Depok. Jumlah subjek total 60 orang terbagi dalam 2 kelompok, 30 orang kelompok akne vulgaris ringan (AVR) dan 30 orang akne vulgaris sedang-berat (AVS). Rerata kadar vitamin D serum subjek adalah 17,29±6,77 ng/ml. Sebanyak 21 subjek (35%) berada pada kondisi sufisiensi vitamin D dan 39 subjek (65%) berada dalam kondisi insufisiensi-defisiensi (terdiri dari 43,3% insufisiensi, 21,7% defisiensi). Kadar rerata vitamin D serum pada kelompok AVR 15,45±6,7 ng/ml dan pada AVS 19,13±6,8 ng/ml dengan p=0,034.

Kesimpulan : hasil penelitian ini menunjukkan ada hubungan yang bermakna antara kadar vitamin D serum dengan akne vulgaris. vitamin D serum.

Acne vulgaris is a chronic inflammatory disease as a part of pilosebaceus. In general acne occurs during puberty, but it can also occur in young adults, and many occur in adolescents. Acne vulgaris affects 85% of young adults aged 12-25 years and consistently occupies "the top three most prevalence skin conditions" in the general population. One of the factors that influence acne vulgaris and which is still a debate pro and contra are nutritional factors. This study aims to find a relationship between vitamin D serum level and the degree of acne in adolescents. Previous researches that linked vitamin D levels with acne was not conclusive, especially in adolescents. This is a cross-sectional study that compares the mean values of serum vitamin D levels between two groups of acne levels in adolescents of high school students aged 15-18 years in the city of Depok. The total number of subjects was 60 people divided into 2 groups, 30 people in the group of mild acne vulgaris and 30 people with moderate-severe acne vulgaris. The mean of vitamin D level of the subject serum was 17.29 ± 6.77 ng / ml. The mean of vitamin D serum level in the mild group was 15.45 ± 6.7 ng / ml and moderate group was 19.13 ± 6.8 ng / ml with p = 0.034. A significant association was found between serum vitamin D levels and the degrees of acne vulgaris.

Conclusion: there is a significant relationship between serum vitamin D levels and degree of acne vulgaris. The mean of vitamin D level are lower in mild acne group than in moderate group

Depok: Fakultas Kedokteran Universitas Indonesia, 2019

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Ade Gautama

Korelasi Antara Kadar Vitamin D dan Penanda Fungsi Ginjal pada Subjek Dewasa di Kawasan Urban Kampung Jakarta dan Tangerang = Correlation Between Vitamin D Serum Level and Kidney Function Parameter in Adult Subjects of Urban Kampung Area Around Jakarta and Tangerang

"Latar belakang: Masyarakat kawasan urban kampung di Indonesia memiliki risiko lingkungan berupa gorong-gorong yang gelap dan ventilasi yang tidak adekuat. Hal ini menjadi risiko kadar vitamin D yang tidak optimal (serum 25OHD <20 ng/mL dan >100 ng/mL). Kadar vitamin D yang tidak optimal juga bisa menjadi risiko penurunan fungsi ginjal. Oleh karena itu penelitian ini dilakukan untuk mengetahui korelasi antara kadar vitamin D dan penanda fungsi ginjal pada masyarakat kawasan urban kampung Jakarta dan Tangerang.

Metode: Studi potong lintang pada subjek dewasa kawasan urban kampung Jakarta dan Tangerang di tahun 2019-2020. Kemudian dilakukan penyesuaian dengan kriteria inklusi dan eksklusi. Lalu, dilakukan pengambilan darah untuk pengukuran kadar vitamin D juga nilai penanda fungsi ginjal.

Hasil: Pada 161 subjek dewasa di urban kampung Jakarta dan Tangerang diperoleh nilai median kadar vitamin D 24,46 ng/mL (10,04 – 52,55 ng/mL), kadar kreatinin serum 0,7 mg/dL (0,5 – 6,7 mg/dL), kadar ureum 20,6 mg/dL (11,9 – 50,5 mg/dL), dan nilai eGFR (CKD-EPI) 97,854 ml/min/1,73m2 (5,52 – 121,92 ml/min/1,73 m2). Hasil analisis menggunakan uji Spearman menunjukkan tidak terdapat korelasi antara kadar vitamin dengan kadar ureum, kreatinin, dan nilai eGFR.

Kesimpulan: Tidak terdapat korelasi antara kadar vitamin D dan penanda fungsi ginjal baik dengan eGFR, kadar kreatinin serum, maupun kadar ureum pada masyarakat yang tinggal di kawasan urban kampung Jakarta dan Tangerang.

Background: Individuals who live in urban kampung have the environmental risk factors of dark alleyways and inadequate ventilations. These increase the risk of subjects in developing vitamin D deficiency and later may decrease the kidney function. Therefore, this study is performed to identify the correlation between vitamin D serum levels and kidney function markers in adults of urban kampung area around Jakarta and Tangerang.
Methods: Cross-sectional study performed in adults of urban kampung areas around Jakarta and Tangerang in 2019-2020. We recruited participants using predetermined inclusion and exclusion criteria. Afterward, blood sample were drawn to quantify vitamin D serum level and kidney function markers of the subjects.
Results: From 161 adult subjects in urban kampung around Jakarta and Tangerang, the vitamin D serum level median is 24,46 (10,04 – 52,55) ng/mL, the serum creatinine median is 0,7 (0,5 – 6,7) mg/dL, the urea serum level median is 20,6 (11,9 – 50,5) mg/dL, and the median of eGFR score (CKD-EPI), is 97,854 (5,52 – 121,92) ml/min/1,73 m2. Analysis using Spearman shows that there is no correlation between vitamin D serum level with urea serum level, serum creatinine, and eGFR score.
Conclusion: There are no correlation between vitamin D serum level and kidney function markers in individuals who live in urban kampung area around Jakarta and Tangerang."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021

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Purwita Wijaya Laksmi

Korelasi antara konsentrasi vitamin D dan mobilitas fungsional dasar pada perempuan usia lanjut = The correlation between vitamin D serum concentration and basic functional mobility of institutionalized elderly women

"Pendahuluan: Pada usia lanjut (usila) terjadi perubahan dalam berjalan dan keseimbangan, penurunan kekuatan otot rangka, dan perlambatan integrasi sensorik dan motorik oleh sistem saraf pusat. Di sisi lain, usila rentan terhadap defisiensi vitamin D yang diketahui berkaitan dengan sistem muskuloskeletal dalam koridor fungsi mobilitas seseorang untuk melaksanakan aktivitas sehari-hari. Belem. ada penelitian mengenai konsentrasi vitamin D dan korelasinya dengan mobilitas fungsional perempuan usila.

Tujuan: Menentukan konsentrasi vitamin D serum, hasil nilai uji the timed up and go (TUG), dan korelasi antara konsentrasi vitamin D serum dan nilai uji TUG perempuan usi la

Metode: Penelitian di tiga panti werdha di DK1 Jakarta dan satu panti werdha di Bekasi ini dilakukan dengan desain korelatif secara potong lintang yang dilakukan pada bulan Januari 2005 terhadap perempuan berusia 60 tahun atau lebih. Uji TUG digunakan untuk menilai mobilitas fungsional dasar dengan mengukur berapa detik waktu yang diperlukan subyek untuk melakukan aktivitas berturut-turut: bangkit dari kursi bertinggi duduk 46 cm dengan sandaran lengan dan punggung, berjalan sejauh tiga meter, berbalik arah kembali menuju kursi, dan duduk kembali. Konsentrasi vitamin D serum diukur dengan metode ELBA. Sebagai variabel perancu adalah usia, indeks massa tubuh, dan konsentrasi ion kalsium serum yang diukur dengan metode NOVA.

Hasil: Dari 42 perempuan usila-yang memenuhi kriteria inklusi dan eksklusi penelitian, 30 orang yang ditentukan secara random propotsional diikutsertakan dalam penelitian. Rerata (SB) konsentrasi vitamin D adalah 68,0 (SB 21,1) nmol/L, dengan konsentrasi <50 nmol/L sebesar 23,3%, nilai uji TUG 10,7 (SB 2,1) detik, IMT 22,3 (SB 3,7) kglm2, dan usia 70,2 (SB 6,4) tahun, sedangkaiu median (minimal-maksimal) konsentrasi ion kalsium serum adalah 1,095 (1,030-1,230) mmol/L. Konsentrasi vitamin D serum belum menunjukkan korelasi yang bermakna dengan TUG (r = -0,008; p = 0,968). Antara variabel perancu dan TUG juga belum menunjukkan korelasi yang bermalma. Hasil korelasi dengan TUG untuk indeks massa tubuh r = 0,014; p = 0,942, konsentrasi ion kalsium serum p = 0,287;p = 0,124, dan usia r = 0,315;p = 0,09.

Simpulan: Rerata konsentrasi vitamin D serum perempuan usila dalam penelitian ini adalah 68,0 (SB 21,1) nmollL, 23,3% mengalami defisiensi vitamin D sedangkan sisanya memiliki konsentrasi vitamin D serum normal. Rerata basil nilai uji TUG perempuan usila yang diteliti adalah 10,7 (SB 2,1) detik, sebagian besar (60%) memiliki basil nilai uji TUG 10-<20 detik yang menunjukkan kemandirian _untuk berbagai . aktivitas. Konsentrasi vitamin D serum belum menunjukkan korelasi yang bermakna dengan mobilitas fungsional dasar perempuan usila, semakin tinggi konsentrasi vitamin D serum tidak diikuti dengan semakin sedikit waktu yang diperlukan untuk melakukan.uji TUG; proporsi subyek dengan nilai uji TUG <10 detik (mobilitas fungsional dengan kemandirian penuh), lebih sedikit pads responden yang mengalami defisiensi vitamin D.

Background: In elderly there are changes both in gait and balance, muscle strength decline, and slowing of sensory and motoric integration by central nervous system. On the other hand, elderly are susceptible to vitamin D deficiency which is known associated with musculosceletal system in the light of functional mobility in order to perform daily Iiving activities independently. Study on vitamin D and its correlation with basic functional mobility in elderly women has not been conducted yet.
Objective: to determine vitamin D serum concentration, the timed up and go (TUG) test score, and the correlation between vitamin D serum concentration and TUG test score of elderly women.
Method: a correlative cross sectional study of institutionalized elderly women age 60 years old or greater was conducted in three nursing homes in DKI Jakarta and one nursing home in Bekasi in January 2005. TUG test was.performed to evaluate basic functional mobility by measuring the time in seconds to stand from 46 cm height armchair, walk three meters, turn around, and return to full sitting in chair. Vitamin D serum concentration was measured by ELISA method. Calcium ion serum concentration that was measured by NOVA method, age and body mass index (BMI) were confounding variables.
Result: Of forty-two elderly women who met the inclusion and exclusion criteria, thirty subjects which proportional randomly assigned were participated in this study. Mean (SD) vitamin D serum concentration was 68.0 (SD 21.1) nmoUL, with concentration S50 nmolIL was 23.3%, TUG score was 10.7 (SD 2.1) seconds, BMI was 223 (3.7) kglm2, age was 70.2 (SD 6.4) years, and median (minimal-maximal) ionized calcium serum concentration was 1.095 (1.030-1.230) mmolfL. Vitamin D serum concentration had not shown significant correlation yet with TUG (r = -0.008; p = 0.968). There were also no significant correlation among the confounding variables and TUG. The correlation with TUG for BMI r = 0.014; p = 0.942, ionized calcium serum concentration p = 0.287; p = 0.124, and age r=0.315;p=0.09.
Conclusion: The mean vitamin D serum concentration of elderly women in this study was 68.0 (SD 21.1) nmolIL, 23.3% had vitamin D deficiency, while the rest of other subjects still had normal vitamin D serum concentration. The mean TUG score of elderly women in this study was 10.7 (SD 2.1) seconds, more than half (60%) had TUG score 10-<20 seconds which means they were mostly independent to perform daily living activities. Vitamin D serum concentration had not shown significant correlation yet with basic functional mobility of elderly women, the higher vitamin D serum concentration was not followed by lesser time to perform TUG test; the proportion of subjects with TUG score <10 seconds (freely mobile in functional mobility) were lesser in vitamin D deficiency respondents."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2005

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Rizka Farah Hilma

Hubungan Antara Kadar Serum Vitamin D (25-Hydroxyvitamin D) dan Kadar Plasma Reseptor Vitamin D Dengan Indeks Bakteri Pada Pasien Kusta = Association between Serum Level of Vitamin D (25-Hydroxyvitamin D) and Plasma Level of Vitamin D Receptor with Bacteriological Index in Leprosy Patients

"Salah satu peran sistem imunitas terhadap infeksi M.leprae adalah respons makrofag melalui interaksinya dengan vitamin D dan reseptor vitamin D (RVD). Interaksi vitamin D dengan RVD pada berbagai sel imun akan menstimulasi ekspresi katelisidin. Penelitian ini bertujuan untuk menganalisis kadar serum 25-hydroxyvitamin D (25(OH)D) dan kadar plasma RVD serta hubungannya dengan IB pada pasien kusta. Penelitian ini berupa observasional-analitik dengan desain potong lintang. Sebanyak 28 subjek penelitian (SP) menjalani pemeriksaan slit-skin smear kemudian diagnosis kusta ditegakkan berdasarkan tanda kardinal kusta. Penelitian ini juga menilai kecukupan pajanan matahari menggunakan kuesioner pajanan matahari mingguan. Kadar serum 25(OH)D diperiksa dengan metode chemiluminescent immunoassay (CLIA) dan kadar plasma RVD dilakukan dengan metode enzyme linked immunosorbent assay (ELISA). Median kadar serum 25(OH)D adalah 12,68 ng/ml (4,88 – 44,74). Median kadar plasma RVD adalah 1,36 ng/ml (0,26 – 8,04). Berdasarkan analisis regresi multivariat, tidak terdapat hubungan antara IB dengan kadar serum 25(OH)D dan kadar plasma RVD (R square = 0,055). Tedapat korelasi positif kuat antara kadar serum 25(OH)D dengan skor pajanan sinar matahari (r = 0,863; p < 0,001).

One of many immunity system’s roles against M. leprae infection is macrophage response through its interaction with vitamin D and vitamin D receptor (VDR). The interaction between vitamin D and VDR in various immune cells will stimulate the expression of cathelicidin. The objective is to analyze the serum level of 25-hydroxyvitamin D₃ (25(OH)D) and plasma level of VDR as well as their association with IB in leprosy patients. This observational analytic study was performed with cross-sectional design. A total of 28 subjects underwent a slit-skin smear examination and then the diagnosis of leprosy was made based on the cardinal signs. This study also assessed the patient’s sun exposure with weekly sun exposure questionnaire. Serum 25(OH)D level was assessed with chemiluminescent immunoassay (CLIA) method and RVD plasma level was measured by enzyme linked immunosorbent assay (ELISA). Median serum level of 25(OH)D was 12.68 ng/ml (4.88 – 44.74). Median plasma level of VDR was 1.36 ng/ml (0.26 – 8.04). Based on multivariate regression analysis, there was no significant association between BI and serum level of 25(OH)D and plasma level of VDR (R square = 0.055). There was strong positive correlation between serum level of 25(OH)D and sun exposure score (r = 0.863; p < 0.001)."

Depok: Fakultas Kedokteran Universitas Indonesia, 2022

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Napitupulu, Luther Holan Parasian

Korelasi antara asupan vitamin d dengan kadar vitamin D dalam darah pada ibu hamil trimester pertama di Jakarta = Corellation between vitamin d intake and value of vitamin D in blood on firs trimester pregnancy in Jakarta

"Vitamin D adalah salah satu mikronutrien yang penting bagi manusia terlebih lagi pada ibu hamil. Di beberapa Negara kekurangan vitamin D menjadi masalah yang terabaikan terutama di negara Asia Tenggara termasuk di Indonesia. Ibu hamil yang kekurangan vitamin D dapat berisiko lebih tinggi untuk mengalami pre eklampsia. Pada bayi yang lahir dari ibu yang mengalami kekurangan vitamin D dapat lahir dengan berat badan yang rendah dan kedepannya dapat mengalami gangguan pada organ penting seperti otak dan tulang. Oleh karena itu, pencegahan harus dilakukan sedini mungkin dari trsimester pertama. Namun terbatasnya fasilitas untuk mengukur tersebut mendorong untuk mencari tahu faktor yang berperan penting dalam kadar vitamin D seperti asupan harian.

Penelitian ini dilakukan dengan menggunakan desain studi cross-sectional. Data yang digunakan dalam penelitian ini merupakan data sekunder dari penelitian yang dilakukan oleh Fakultas Kedokteran Universitas Indonesia pada tahun 2013 sampai 2014 dengan subjek ibu hamil trimester pertama yang tinggal di Jakarta.

Metode penelitian menggunakan pengukuran 25-hidroxivitamin D terstandar untuk memperoleh kadar vitamin D dalam darah subjek serta food-frequency questionnaire (FFQ) untuk mengetahui asupan harian vitamin D subjek. Data yang diperoleh kemudian diolah menggunakan piranti lunak SPSS for Windows 20.0 lalu dianalisis dengan uji Spearman. Didapatkan bahwa persentase subjek hipovitaminosis vitamin D adalah sebesar 43,5% (27 orang, n = 62) dan seluruh subjek memiliki asupan vitamin D harian yang rendah.

Hasil penelitian menunjukkan bahwa tidak ditemukan adanya korelasi antara asupan harian vitamin D dengan kadar 25-hidroxivitamin D. Banyak faktor lain yang mempengaruhi misalnya adalah sinar matahari.

Vitamin D is one of the important micronutrients for humans especially pregnant women. In some countries, deficiency of vitamin D is one of neglected health problem, especially in South-East countries including Indonesia. Pregnancy women with deficiency vitamin D may be higher risk for having preeclampsia. In infants born from mother who have deficiency vitamin D may be born with low birth weight. Some important organs development will interference such as brain and bone. Therefore, prevention from deficiency vitamin D should be conducted as early as possible from first trimester pregnancy. But there are limitation in vitamin D measurement facilities so these research purpose is to elaborate the others factor that influencing vitamin D in blood and the most important factor is diet vitamin D. These research aims to determine whether a correlation between vitamin D intake and value of vitamin D in blood.
Running a cross-sectional study design, this research uses secondary data from a former research by Faculty Medicine of University Indonesia conducted in 2013 ? 2014 with pregnant women living in Jakarta.
The research method comprised a 25-hydroxyvitamin D measurement and the usage of food-frequency questionnaire (FFQ) to obtain subject's vitamin D in blood and vitamin D intake respectively. Using SPSS for Windows 20.0 software, data is then analyzed by Spearman, resulting 43.5% (n = 62) of subjects being hypovitaminosis D (<10 ng/mL) and the whole subjects receiving under the boundary value of vitamin D (12 mcg/day).
This research shows that no correlation could be found between vitamin d intake and value of vitamin D in blood."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015

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UI - Skripsi Membership Universitas Indonesia Library

Amelia Jessica

Korelasi antara kadar serum vitamin D dengan derajat keparahan pada pasien stroke iskemik = Severity stroke patients in correlation vitamin D levels

"Latar Belakang: Stroke iskemik merupakan penyebab kematian terbanyak kedua dan penyebab utama disabilitas di seluruh dunia. Beberapa faktor risiko yang sudah diketahui diantaranya pola hidup, penyakit komorbid, usia, jenis kelamin, dan ras. Namun, kadar serum vitamin D yang kurang ternyata juga dikaitkan dengan penyakit neurodegeneratif, serta luaran klinis yang lebih buruk. Penelitian ini dilakukan untuk mengetahui korelasi kadar serum vitamin D dengan derajat keparahan pada stroke iskemik yang dinilai berdasarkan NIHSS. Pada penelitian ini juga akan menilai asupan vitamin D serta pajanan sinar matahari.

Metode: Penelitian ini merupakan studi potong lintang pada pasien stroke iskemik di RSUPN dr. Cipto Mangunkusumo dan RS Universitas Indonesia. Karakteristik subjek penelitian berupa usia, jenis kelamin, faktor risiko, penyakit komorbid dengan komplikasi, asupan protein, asupan lemak, asupan vitamin D, pajanan sinar matahari, kadar serum vitamin D, serta derajat keparahan. Dilakukan analisis korelasi kadar serum vitamin D dengan derajat keparahan berdasarkan NIHSS.

Hasil: Terdapat 59 subjek dengan diagnosis stroke iskemik dengan rerata usia 63 tahun dan mayoritas laki-laki (62,7%). Faktor risiko terbanyak adalah hipertensi (83,1%), berat badan lebih dan obesitas (64,4%), merokok (57,6%), dan diabetes melitus (42,4%). Penyakit komorbid dengan komplikasi tersering yang ditemukan adalah gangguan jantung (35,6%). Sebanyak 79,7% subjek penelitian memiliki asupan protein yang kurang, sedangkan asupan lemak seluruhnya tergolong cukup. Sebagian besar (52,5%) subjek penelitian memiliki status asupan vitamin D kurang, 5 orang mengonsumsi suplementasi vitamin D secara rutin, derajat pajanan sinar matahari rendah (89,8%). Sebanyak 59,3% memiliki status kadar serum vitamin D defisiensi dengan derajat keparahan terbanyak adalah skor NIHSS 5-15 (76,3%). Terdapat korelasi antara asupan vitamin D dengan derajat keparahan stroke iskemik (r -0,307, p 0,018).

Kesimpulan: Kadar serum vitamin D memiliki korelasi dengan derajat keparahan stroke iskemik (r -0,469, p <0,001). Kadar serum vitamin D yang kurang berbanding terbalik dengan skor NIHSS yang didapatkan pada penderita stroke iskemik onset akut.

Background: Ischemic stroke is the second leading cause of death and the leading cause of disability worldwide. Some of the known risk factors include lifestyle, comorbid diseases, age, gender, and race. However, deficient serum vitamin D levels are also associated with neurodegenerative diseases, as well as worse clinical outcomes. This study was conducted to determine the correlation of serum vitamin D levels with severity in ischemic stroke as assessed by the NIHSS. This study will also assess vitamin D intake and sunlight exposure.
Methods: This study is a cross-sectional study on ischemic stroke patients at RSUPN dr. Cipto Mangunkusumo and University of Indonesia Hospital. Characteristics of the study subjects included age, gender, risk factors, comorbid diseases with complications, protein intake, fat intake, vitamin D intake, sun exposure, serum vitamin D levels, and severity. Correlation analysis of serum vitamin D levels with severity based on NIHSS was conducted.
Results: There were 59 subjects with a diagnosis of ischemic stroke with an average age of 63 years and the majority were male (62.7%). The most common risk factors were hypertension (83.1%), overweight and obesity (64.4%), smoking (57.6%), and diabetes mellitus (42.4%). Comorbid disease with the most common complication found were cardiac disorders (35.6%). A total of 79.7% of the study subjects had insufficient protein intake, while the fat intake was entirely considered adequate. Most (52.5%) of the study subjects had deficient vitamin D intake status, 5 people took vitamin D supplementation regularly, the degree of sun exposure was low (89.8%). A total of 59.3% had vitamin D deficiency serum level status with the most severity being NIHSS score 5-15 (76.3%). There was a correlation between vitamin D intake and ischemic stroke severity (r -0,307, p 0,018).
Conclusion: Serum vitamin D levels have a correlation with ischemic stroke severity (r -0,469, p <0,001). Insufficient serum vitamin D levels are inversely proportional to the NIHSS score obtained in patients with acute onset ischemic stroke."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024

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UI - Tugas Akhir Universitas Indonesia Library

Winda Kusumadewi

Gambaran kadar serum vitamin D 25 (OH) pada orang dengan penyakit demielinisasi sistem saraf pusat = Profile of vitamin D 25 (OH) serum level in peoples with demielinating diseases of the central nervous system

"Latar Belakang. Defisiensi vitamin-D dapat terjadi pada sklerosis multipel MS dan neuromielitis optik (NMO), dan dapat berpengaruh terhadap proses imunologi. Penelitian ini bertujuan untuk mengetahui kadar serum vitamin-D-25 (OH) pada orang dengan penyakit demielinisasi sistem saraf pusat dibandingkan dengan kontrol sehat.

Metode. Penelitian potong lintang ini dilakukan di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo Jakarta pada November 2016 sampai Mei 2017. Pada sampel dikumpulkan data kebiasaan makan, suplementasi vitamin-D, paparan sinar matahari, terapi medikamentosa, jumlah relaps per tahun, dan expanded disability status scale (EDSS). Kadar serum vitamin-D-25(OH) diukur menggunakan metode direct competitive chemiluminescence immunoassay (CLIA).

Hasil. Tiga puluh dua pasien (18 MS dan 14 NMO) dan 33 kontrol diikutsertakan dalam penelitian ini. Jumlah laki-laki pada kelompok studi dan kontol adalah 12,5% dan 15,2%. Insufisiensi dan defisiensi vitamin-D-25(OH) (<30ng/mL) didapatkan pada 90,6% pasien di kelompok studi. Tidak didapatkan perbedaan kadar vitamin-D-25(OH) yang bermakna antara kelompok studi dan kontrol dengan median rentang adalah 17(5.2-71.6)ng/ml dan 15.7(5.5-34.4)ng/ml. Hasil tersebut tidak diduga, karena 50 pasien mendapatkan suplementasi vitamin D lebih dari 400IU. Terapi kortikosteroid juga ditemukan berpengaruh terhadap kadar vitamin-D-25(OH). Kadar vitamin-D-25(OH) tidak berhubungan dengan EDSS.

Kesimpulan. Insufisiensi dan defisiensi vitamin-D didapatkan pada orang dengan MS dan NMO di Jakarta, namun kadarnya tidak berhubungan dengan EDSS. Tenaga kesehatan juga perlu mewaspadai rendahnya kadar vitamin-D pada pasien yang menggunakan kortikosteroid. Kontrol normal juga memiliki kadar vitamin-D yang rendah walaupun tinggal di negara dengan paparan sinar matahari yang cukup. Temuan ini menunjukkan risiko kekurangan vitamin-D pada masyarakat yang tinggal di Jakarta.

Introduction. Vitamin-D-25(OH) deficiency is common in Multiple Sclerosis (MS) and Neuromyelitis Optic (NMO) patients and can affect the immunological process. We performed study to evaluate serum vitamin-D-25(OH) levels in MS and NMO patients compared to healthy control.
Methods. This is a cross sectional study done in Cipto Mangunkusumo Hospital Jakarta from November 2016 May 2017. We reviewed dietary recall, vitamin-D supplementation, sun exposure, medication, annual relapse rate and expanded disability status scale (EDSS). Vitamin-D-25(OH) level was measured using direct competitive chemiluminescence immunoassay (CLIA).
Results. Thirty two patients (18 MS and 14 NMO) and 33 controls were enrolled. Male patients and controls were 12,5% and 15,2%, respectively. Vitamin-D insufficiency and deficiency (<30ng mL) among patients reached 90,6% and not associated with EDSS. It was not significantly different between patients and control, with median (range) 17(5.2-71.6)ng/ml and 15.7(5.5-34.4)ng/ml respectively. The result was unexpected because 50 patients received vitamin-D supplementation. Corticosteroid used also influenced the vitamin-D levels.
Conclusion. Vitamin-D insufficiency and deficiency was common in MS and NMO patients in Jakarta but not associated with EDSS. Practitioners need to be alert to vitamin-D low level particularly in patients using corticosteroid. Healthy control also had low vitamin-D concentrations though they lived in a sufficient sun exposure country. This finding suggests a risk of vitamin-D deficiency among community living in Jakarta. "

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2017

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UI - Tesis Membership Universitas Indonesia Library

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