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"Sebagian besar industri otomotif masih menggunakan thinner yang mengandung VOC (terdiri dari benzene, toluene, xylene dan lain-lain). Efek kesehatan dari VOC diantaranya adalah iritasi pada hidung dan tenggorokan dan serta kerusakan paru-paru (Ismail, 2011). Pajanan thinner kepada pekerja secara terus menerus dapat mengakibatkan iritasi saluran napas dan gangguan fungsi paru pada pekerja. Penelitian ini adalah penelitian cross sectional yang bertujuan untuk mengetahui hubungan antara pajanan thinner dengan gangguan fungsi paru-paru setelah dikontrol variabel confounding pada pekerja bagian painting di industri otomotif. Setelah dikontrol dengan penggunaan APD, perilaku merokok dan terpajan sedikit thinner dan zat kimia lain diketahui bahwa risiko pekerja yang terpajan sebagian thinner untuk mengalami gangguan fungsi paru adalah 1,87 (95% CI = 0,74-4,71). Pada pekerja yang terpajan thinner penuh memiliki resiko untuk mengalami gangguan fungsi paru sebesar 3,23 (95% CI = 1,36-7,59). Semakin besar pajanan terhadap thinner maka semakin tinggi resiko untuk terkena gangguan fungsi paru. Berdasarkan hasil penelitian tersebut maka disarankan agar perusahaan melakukan upaya promosi kesehatan untuk meminimalkan risiko terjadinya gangguan fungsi paru pada pekerja pengecatan mobil.

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Most of the auto industry still use paint thinner containing VOCs (consisting of benzene, toluene, xylene, etc.). Health effects of VOCs include irritation of the nose and throat and impaired lung function (Ismail, 2011). Exposure paint thinner to workers continuously can cause respiratory irritation and lung function impairment in workers. This study is a cross-sectional study aimed to determine the relationship between exposure of thinner with impaired lung function after controlled confounding variable on painting workers in the automotive industry. After controlled by using mask variable, smoking behavior and exposure to a little thinner plus other chemicals, known that the risk for the paired exposed of thinner to suffer lung problems was 1.87 (95% CI = 0.74 to 4.71). In workers exposed to thinner at risk for developing impaired lung function of 3.23 (95% CI = 1.36 to 7.59). Greater and greater exposure to paint thinner, the risk for developing lung problems is higher. Based on the findings, it is recommended that companies conduct health promotion efforts to minimize the risk of impaired lung function in painting workers."

"This book delivers a concise compendium to the diagnosis and management of occupational and environmental lung diseases, incorporating evidence-based guidelines where available. Each chapter provides an updated review and a practical approach to different occupational and environmental lung diseases. With rapidly changing technology, new conditions and exposures will undoubtedly emerge. Clinicians need to remain vigilant about assessing the potential link between lung diseases and environmental exposures, and this book provides a practical guide to recognize, diagnose, and prevent occupational and environmental lung diseases. "

"Latar Belakang : Industri pemotongan batu memiliki potensi bahaya berupa debu batu yang dihasilkan dari proses pemotongan batu. Debu batu berpotensi besar masuk dan mengendap di saluran napas pekerja yang terpajan debu batu tersebut. Dalam penelitian ini ingin diketahui hubungan pajanan debu batu dan faktor lainnya dengan gangguan fungsi paru. Metode Penelitian : Desain penelitian cross sectional dengan analisis regresi logistik. Subjek penelitian diambil secara cluster sampling. Tingkat pajanan debu batu ditentukan dengan metode semikuantitatif dan faktor-faktor lainnya dengan kuesioner. Pemeriksaan fungsi paru dilakukan dengan menggunakan alat spirometer. Hasil : Subjek penelitian adalah 70 pekerja laki-laki industri pemotongan batu informal dengan masa kerja lebih dari 5 tahun. Sebanyak 21,4% subjek mengalami gangguan fungsi paru, dengan gangguan fungsi paru restriksi sebanyak 14,3% dan gangguan fungsi paru obstruksi sebanyak 7,1%. Faktor risiko yang berhubungan bermakna dengan gangguan fungsi paru adalah tingkat pajanan debu batu. Faktor umur, pendidikan, status gizi, kebiasaan olahraga, kebiasaan merokok, masa kerja, kebiasaan menggunakan alat pelindung diri (APD) dan penyediaan APD tidak memperlihatkan hubungan bermakna dengan gangguan fungsi paru. Subjek dengan tingkat pajanan debu batu tinggi mempunyai risiko 5,889 kali mengalami gangguan fungsi paru dibandingkan subjek dengan tingkat pajanan debu batu rendah [ odds rasio suaian (ORa) = 5,889; interval kepercayaan (CI) 95% = 1,436-24,153)]. Kesimpulan : Didapatkan hubungan bermakna antara tingkat pajanan debu batu dengan gangguan fungsi paru. Perlu dilakukan pengendalian terhadap pajanan debu batu untuk mencegah risiko gangguan fungsi paru pada pekerja industri pemotongan batu.

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Background : Stone cutting industry have a potential hazard in stone dust resulted from stone cutting process. Stone dust has a significant potential to enter and settle inside exposed worker’s respiratory tract. This study aims to identify the relationship between stone dust exposure and other factors with lung function disorder.

Method : This study was a cross-sectional study with logistic regression analysis. Study’s subjects were taken with cluster sampling method. Level of stone dust exposure was determined by semi-quantitative method and the other factors were identified by a questionnaire. Lung function was tested with a spirometer.

Results : Study’s subject was 70 male informal stone cutting industry workers with more than 5 years of service. In this study, it was found that lung function disorders was 21.4%, which restrictive lung function disorder was 14.3% and the obstructive lung function disorder was 7.1%. Risk factor significantly related to lung function disorder was stone dust level of exposure. Age, education, nutritional status, exercise habit, smoking habit, length of employment, habit of using personal protective equipment (PPE) and provision of PPE showed no significant relationship with lung function disorder. Subjects with high level of stone dust exposure had 5.889 times the risk of lung function disorder compared to subjects with low level of stone dust exposure [adjusted odds ratio(ORa) = 5.889; 95% confidence interval (CI) = 1.436 - 24.153)].

Conclusion : The level of stone dust exposure significantly related to lung function disorder. Control measures are needed for stone dust exposure to prevent the risk of lung function disorder in stone cutting industry workers."

"Penelitian ini membahas mengenai gangguan fungsi paru yang terjadi pada pekerja bengkel yang terpajan dengan uap cat untuk mengetahui gambaran gangguan fungsi paru disana. Penelitian ini adalah penelitian semi kuantitatif dengan metode cross-sectional terhadap 25 pekerja yang diukur fungsi parunya menggunakan spirometri dan diwawancara dengan menggunakan kuesioner. Hasil keseluruhan survei terhadap 25 pekerja bengkel body repair terdapat 1 orang dari bagian color matching dan 6 orang dari bagian painting yang mengalami gangguan fungsi paru.

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This study focused about lung function disorders in workers of X body repair workshop who exposed by car spray to find out the overview of lung function disorders. This study is a semi-quatitative study with cross-sectional method to the 25 workers. The lung function is assessed by spirometry and were interviewed by using quiestionnaire. The results showed that 1 worker in color matching and 6 workers in painting suffer lung function disorders."

"ABSTRAK Latar belakang : Penelitian ini merupakan studi awal untuk mengukur kapasitasdifusi paru DLCO-SB ipada pasien PPOK di RSUP Persahabatan Jakarta untukmengetahui prevalens penurunan nilai DLCO pada pasien PPOK.Metode : Penelitian ini menggunakan desain studi potong lintang (cross sectional study) pada pasien PPOK yang berkunjung di Poliklinik Asma-PPOK RSUPPersahabatan Jakarta. Dilakukan uji spirometri dan DLCO pada pasien PPOKyang diambil secara konsekutif antara bulan Mei-Juli 2015. Komorbiditas jugadicatat.Hasil : Uji Spirometri and DLCO dilakukan pada 65 subjek didapatkan 7 subjek (10,8%) termasuk kedalam PPOK Grup A, 19 subjek (29,2%) PPOK Grup B, 21subjek (32,3%) PPOK grup C dan 18 subjek (27,7%) PPOK grup D. rerata usia64,15 (45-89) tahun;rerata VEP1% 46,05%, rerata nilai DLCO 19,42ml/menit/mmHg dan rerata DLCO % adalah 72.00%. prevalens penurunanDLCO pasien PPOK adalah 56,92% (37/65 subjek) sedangkan 28 subjek dengannilai DLCO normal. Ditemukan 15 subjek (23,07%) dengan penurunan ringan, 18subjek (27.69%) penurunan sedang dan 4 subjek (6,15%) dengan penurunan berat.Ditemukan 47 subjek (72,3%) memiliki komorbid. Terdapat hubungan bermaknaantara grup PPOK, derajat spirometri, VEP1, IMT dan komorbiditas dengan nilaihasil uji DLCO. Tidak terdapat hubungan bermakna antara nilai DLCO denganjenis kelamin, umur, riwayat merokok, Indeks Brinkmann, obstruksi-restriksi danlama terdiagnosis PPOK.Kesimpulan : Proporsi penurunan nilai DLCO pada pasien PPOK adalah 56,92%. Terdapat hubungan bermakna antara grup PPOK, derajat spirometri,VEP1, IMT dan riwayat TB dengan nilai hasil uji DLCO. Tidak terdapathubungan bermakna antara nilai DLCO dengan jenis kelamin, umur, riwayatmerokok, Indeks Brinkmann, obstruksi-restriksi, komorbid dan lama terdiagnosisPPOK.ABSTRACT Background and the aim of study : This is a preliminary study to measureDLCO-SB in COPD patients in Persahabatan Hospital. The aim of the study is toknow the magnitude of disturbance in diffusing capacity of the lung in COPDpatients.Methods : This was a cross sectional study in which COPD patients attending COPD-Asthma clinic in Persahabatan Hospital Jakarta were performed spirometryand DLCO-SB consecutively between May 2015?July 2015. Comorbiditiesconditions were also recorded.Results : Spirometry and DLCO-SB measurement were conducted on 65 COPDsubjects of which 7 subjects (10.8%) were COPD Group A, 19 subjects (29.2%)were Group B, 21 subjects (32.3%) were COPD group C and 18 subjects (27.7%)were COPD group D. The mean age was 64.15 (45-89); mean FEV1% was46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO%was 72.00%. The prevalence of decreasing in diffusing capacity of the lung inCOPD patients was 56.92% (37 subjects) While 28 subjects were normal. Therewere 15 subjects (23.07%) with mild decrease in DLCO, 18 subjects (27.69%)were moderate decrease and 4 subjects (6.15%) with severe decrease. 47 subjects(72.3%) had comorbid conditions. There was significant correlation between grupCOPD, GOLD COPD grade, VEP1, BMI and comorbidities with magnitude ofdecreasing DLCO value. There was no correlation between DLCO value with sex,smoking history, Brinkmann index, age, obstruction-mix criteria, length of COPDperiod. Conclusion : The proportion of decreasing in DLCO in COPD patients are56.92%. There is significant correlation among the group of COPD, GOLDCOPD grade, VEP1, BMI and previous TB history with magnitude of decreasingDLCO value. There is no correlation between DLCO value with sex, smokinghistory, brinkmann index, age, obstruction-mix criteria, comorbidities and lengthof COPD period. ;Background and the aim of study : This is a preliminary study to measureDLCO-SB in COPD patients in Persahabatan Hospital. The aim of the study is toknow the magnitude of disturbance in diffusing capacity of the lung in COPDpatients.Methods : This was a cross sectional study in which COPD patients attending COPD-Asthma clinic in Persahabatan Hospital Jakarta were performed spirometryand DLCO-SB consecutively between May 2015?July 2015. Comorbiditiesconditions were also recorded.Results : Spirometry and DLCO-SB measurement were conducted on 65 COPDsubjects of which 7 subjects (10.8%) were COPD Group A, 19 subjects (29.2%)were Group B, 21 subjects (32.3%) were COPD group C and 18 subjects (27.7%)were COPD group D. The mean age was 64.15 (45-89); mean FEV1% was46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO%was 72.00%. The prevalence of decreasing in diffusing capacity of the lung inCOPD patients was 56.92% (37 subjects) While 28 subjects were normal. Therewere 15 subjects (23.07%) with mild decrease in DLCO, 18 subjects (27.69%)were moderate decrease and 4 subjects (6.15%) with severe decrease. 47 subjects(72.3%) had comorbid conditions. There was significant correlation between grupCOPD, GOLD COPD grade, VEP1, BMI and comorbidities with magnitude ofdecreasing DLCO value. There was no correlation between DLCO value with sex,smoking history, Brinkmann index, age, obstruction-mix criteria, length of COPDperiod. Conclusion : The proportion of decreasing in DLCO in COPD patients are56.92%. There is significant correlation among the group of COPD, GOLDCOPD grade, VEP1, BMI and previous TB history with magnitude of decreasingDLCO value. There is no correlation between DLCO value with sex, smokinghistory, brinkmann index, age, obstruction-mix criteria, comorbidities and lengthof COPD period. ;Background and the aim of study : This is a preliminary study to measureDLCO-SB in COPD patients in Persahabatan Hospital. The aim of the study is toknow the magnitude of disturbance in diffusing capacity of the lung in COPDpatients.Methods : This was a cross sectional study in which COPD patients attending COPD-Asthma clinic in Persahabatan Hospital Jakarta were performed spirometryand DLCO-SB consecutively between May 2015?July 2015. Comorbiditiesconditions were also recorded.Results : Spirometry and DLCO-SB measurement were conducted on 65 COPDsubjects of which 7 subjects (10.8%) were COPD Group A, 19 subjects (29.2%)were Group B, 21 subjects (32.3%) were COPD group C and 18 subjects (27.7%)were COPD group D. The mean age was 64.15 (45-89); mean FEV1% was46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO%was 72.00%. The prevalence of decreasing in diffusing capacity of the lung inCOPD patients was 56.92% (37 subjects) While 28 subjects were normal. Therewere 15 subjects (23.07%) with mild decrease in DLCO, 18 subjects (27.69%)were moderate decrease and 4 subjects (6.15%) with severe decrease. 47 subjects(72.3%) had comorbid conditions. There was significant correlation between grupCOPD, GOLD COPD grade, VEP1, BMI and comorbidities with magnitude ofdecreasing DLCO value. There was no correlation between DLCO value with sex,smoking history, Brinkmann index, age, obstruction-mix criteria, length of COPDperiod. Conclusion : The proportion of decreasing in DLCO in COPD patients are56.92%. There is significant correlation among the group of COPD, GOLDCOPD grade, VEP1, BMI and previous TB history with magnitude of decreasingDLCO value. There is no correlation between DLCO value with sex, smokinghistory, brinkmann index, age, obstruction-mix criteria, comorbidities and lengthof COPD period. "

"Penelitian ini bertujuan untuk mengetahui perbandingan efektifitas biaya antara Puskesmas yang menerapkan PAL dengan yang tidak menerapkan PAL dalam penanganan Tuberkulosis Paru di Wilayah Kota Administratif Jakarta Timur, dengan melakukan perhitungan menggunakan metode Activity Based Costing (ABC) untuk mendapatkan biaya per aktifitas. Penilaian efektifitas berdasarkan perbandingan antara penjumlahan komponen biaya pada masing-masing alternatif dengan output penelitian yang meliputi efektifitas pengobatan, Quality Adjusted Life Years (QALY's) serta Kegagalan/drop out yang dapat dihindari. Hasil penelitian menunjukkan bahwa Puskesmas PAL lebih efektif dalam penanganan Tuberkulosis Paru berdasarkan output kegagalan/drop out yang dapat dihindari.

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This research purposes to compare cost effectivity between Center of Health which implements PAL and Non PAL in treatment Pulmonary Tuberculosis on administrative district East Jakarta. It uses Activity Based Costing (ABC) method to obtain cost per activity. The effectivity evaluation is based on comparison between total cost component at each alternatives with output consists of medical treatment effectiveness, Quality Adjusted Life Years (QALY's) and prevented failure/drop out. The result shows that Puskesmas with PAL is more effective in Pulmonary Tuberculosis treatment based on prevented failure/drop out."

"Industri keramik saat ini sedang berkembang dengan pesat, berdasarkan data dari depnaker Tangerang bahwa khusus didaerah ini diperkirakan sekitar ribuan tenaga kerja yang bekerja di industri keramik. Seperti telah diketahui bahwa industri keramik adalah industri yang menghasilkan banyak debu baik dari mulai pengolahan bahan baku, glosir maupun pengepakan.Pemajanan debu keramik dalam kurun waktu lama walaupun dengan konsentrasi kecil telah diketahui akan memberikan dampak negatif terhadap kelainan fungsi paru. Walaupun ada beberapa faktor lain yang ikut memperberat terjadinya kelainan.Penelitian ini bertujuan untuk mengetahui sejauh mana gangguan fungsi paru yang terjadi terhadap tenaga kerja di industri keramik " A " akibat pajanan debu keramik ditempatnya bekerja.Penelitian dilakukan dengan metode wawancara, pemeriksaan fisik, pemeriksaan faal paru yang di lakukan dengan memakai alat spirometri dan pengukuran kadar debu total lingkungan. Namun banyak keterbatasan - keterbatasan yang penulis hadapi, dimana tidak dapat diukurnya kadar debu respirable maupun ukuran dari partikel debu.Selain itu dalam penelitian ini penulis dibantu oleh pihak lain terutama dalam hal pengukuran faal paru dilapangan, sehingga beberapa kesalahan terjadi pada saat pemeriksaan. Sebagai dampaknya banyak hasil uji fast pan" responden yang tidak seperti yang diharapkan. Dari penelitian ini diperoleh hasil konsentrasi debu yang berada di bawah nilai ambang batas serta pekerja yang selalu memakai alat pelindung diri ( masker ) selama bekerja, sehingga kedua parameter tersebut tidak berdampak terhadap kelainan fungsi paru.Namun dicoba mencari hubungan dengan beberapa variabel lain yang kurang lebih dapat mempengaruhi gangguan fungsi paru seperti umur pekerja, masa kerja, status gizi dan kebiasaan merokok.Dari hasil penelitian ini diperoleh hubungan antara usia pekerja, status gizi pekerja dan kebiasaan merokok dari pekerja.Dengan adanya keterbatasan - keterbatasan yang telah disebutkan sebaiknya dilakukan pengukuran debu respirable, ukuran pertikel debu dan persiapan yang baik sebelum melakukan uji faal paru. Sehingga hasil yang diperoleh akan sesuai seperti yang diharapkan dari penelitian ini.Daftar bacaan : 44 ( 1984 - 1999)

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Relation between Exposure of Ceramic Dust to Lung Function Disorder Workers in Ceramic Industrial " A " in Tangerang Regency, Banten 2004Ceramic industrial is have develops year and years, in Tangerang regency we can found about 1 millions workers in ceramic industrial.

Ceramic industrial is industri that product very much dust in workplace, like product department until packing department .

Exposure of ceramic dust in long time although in small concentration can make lung function disorder , but there are some variable can make this disorther more heavy.

This research was want to know how the ceramic dust in the future can make lung function disorder to teh workers in teh workplace.

This research use questioner method, physical examination, lung function test with use spirometry test and measured dust concentration that exposure of the workers.

As long as this research was have some weakness, where ever we cannot measure teh respirabel dust concentration or dimension of teh dust.

And this research , when lung function test was measured, there is some problem with person whose measured teh test.

Dust of ceramic in ceramic industrial " A" was very small concentration (< 10 mg/m3 ), and used teh personal protective device when workers in the work place , so we can found the lung function disorder because of ceramic dust. There is no correlation between dust concentration in work place with lung function disorder.

But there are some variables in this cases have correlation with lung function test, this correlation not significant to make lung function disorder.

There are the weakness that we have explained before , in research furthermore we must measure respirable dust, dimension of dust and arrange the method of lung function test before with the result we can have good outcome later.

Bibliography : 44 ( 1984 -1999 )"

"Tesis ini menganalisis sistem pencatatan dan pelaporan Practical Approach to Lung Health (PAL) pada 6 Puskesmas di Kabupaten Bogor pada tahun 2013. Penelitian ini menggunakan pendekatan kualitatif dengan wawancara mendalam pada 11 informan dan memeriksa laporan PAL selama bulan Januari-April 2013 pada 6 Puskesmas dengan memperhatikan ketepatan waktu laporan, kelengkapan laporan, dan keakuratan. Hasil penelitian menunjukkan bahwa ada perbedaan dalam beberapa faktor input, proses dan output dalam pelaksanaan pencatatan dan pelaporan PAL di Puskesmas yang diteliti. Puskesmas yang memenuhi indikator tampak lebih terorganisasi dengan adanya Tim PAL yang disahkan oleh Kepala Puskesmas, semua pihak tampak berkerjasama dalam melaksanakan pencatatan dan pelaporan PAL setiap hari, dan mempunyai komitmen yang tinggi baik Kepala Puskesmas, kordinator PAL, pelaksana harian dan petugas pencatatan dan pelaporan. Untuk itu, masih dibutuhkan perbaikan secara komprehensif dan terintegrasi melibatkan banyak pihak yang terkait sistem pencatatan dan pelaporan PAL di Puskesmas Kabupaten Bogor.

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This thesis discusses Recording and Reporting System of Practical Approach to Lung Health (PAL) in 6 Primary Health Center (Puskesmas) at Bogor District 2013. This research uses qualitative method by conducting in-depth interview to 11 key informants and checking PAL report for 6 Puskesmas since January until April 2013, by considering the timeliness, the completeness of the report, and accuracy. The result shows that there are differences in input, process and output in the the implementation of recording and reporting system. Puskesmas that meet the indicator are more organized with the PAL team authorized by the Head of Puskesmas, all parties cooperate in implementing the PAL recording and reporting every day, and everybody has commitment. Therefore, it is need to have comprenhensive and integrated improvements by involving others stakeholders related to recording and reporting PAL system in Puskesmas."

"Latar Belakang: Jumlah kasus KPKBSK diperkirakan 85% dari seluruh kasus kanker paru dan 40% diantaranya adalah jenis adenokarsinoma. Sebanyak 10%-30% pasien adenokarsinoma mengalami mutasi EGFR dan mendapatkan terapi EGFR-TKI. Mayoritas pasien KPKBSK memiliki respons dan toleransi baik terhadap terapi EGFR- TKI tetapi sebagian kecil pasien mengalami penyakit paru interstisial akibat EGFR- TKI. Penelitian ini bertujuan untuk mengetahui proporsi gambaran penyakit paru interstisial pada pasien KPKBSK dengan terapi EGFR-TKI di RSUP Persahabatan.Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendeketan kohort retrospektif yang dilakukan bulan Januari 2021 hingga Juni 2022. Subjek penelitian adalah pasien KPKBSK yang mendapatkan terapi EGFR-TKI. Subjek penelitian dipilih sesuai kriteria inklusi dan eksklusi. Pengambilan data melalu data sekunder berupa rekam medis dan hasil CT scan toraks pasien yang kontrol di poliklinik onkologi RSUP Persahabatan.Hasil: Pada penelitian ini diperoleh 73 subjek penelitian, pasien KPKBSK dengan mutasi EGFR yang mendapatkan terapi EGFR-TKI di RSUP Persahabatan. Sebanyak 12 dari 73 subjek penelitian mengalami gambaran ILD yang dievaluasi berdasarkan CT scan toraks RECIST I dan II dengan karakteristik jenis kelamin laki-laki (22,2%), kelompok usia 40-59 tahun (19,4%), perokok (24,1%), indeks brinkman berat (42,9%) dan mendapatkan terapi afatinib (26,1%). Proporsi gambaran ILD pada pasien KBPKBSK dengan terapi EGFR-TKI adalah opasitas retikular (58,3%), parenchymal band (33,3%), ground-glass opacities (25%), traction bronchiectasis (25%) dan crazy paving pattern (8,3%). Hasil analisis bivariat dan multivariat menunjukkan tidak terdapat perbedaan antara faktor-faktor seperti jenis kelamin, usia, jenis EGFR-TKI, riwayat merokok, indeks brinkman, riwayat penyakit paru dan tampilan status terhadap gambaran ILD.Kesimpulan: Gambaran ILD pada pasien KPKBSK dengan terapi EGFR-TKI meliputi opasitas retikular, parenchymal band, ground-glass opacities, traction bronchiectasis dan crazy paving pattern. Tidak terdapat perbedaan bermakna secara statistik antara faktor-faktor yang memengaruhi terhadap gambaran ILD.

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Background: The number of cases of NSCLC is estimated around 85% of all lung cancer cases and 40% among them are adenocarcinoma. Approximately 10%-30% of adenocarcinoma patients have EGFR mutations and receive EGFR-TKI therapy. The majority of NSCLC patients have a good response and tolerance to EGFR-TKI therapy, but a small group of patients experience EGFR-TKI induced interstitial lung disease. This study aims to determine the proportion of features of interstitial lung disease ini NSCLC patients treated with EGFR-TKI at Persahabatan Hospital.

Methods: This study was an analytic observational with a retrospective cohort approach that was conducted from January 2021 until June 2022. The subject were NSCLC patients who received EGFR-TKI treatment. The inclusion and exclusion criteria were used to determine which subjects will be included in the study. Data collection through secondary data from medical record and chest CT scan results of patients controlled at oncology polyclinic at Persahabatan Hospital.

Result : In this study, there were 73 subjects of NSCLC with EGFR mutations and received EGFR-TKI therapy at Persahabatan Hospital. There were 12 out of 73 subjects had ILD features which were evaluated based on RECIST I and II chest CT scan with predominant of male (22.2%), age group 40-59 years old (19.4%), smokers (24.1%), severe Brinkman index (42.9%) and received afatinib (26.1%). The proportion of ILD features in NSCLC patients with EGFR-TKI therapy are reticular opacities (58.3%), parenchymal bands (33.3%), ground-glass opacities (25%), traction bronchiectasis (25%) and crazy paving pattern (8.3%). The results of bivariate and multivariate analyzes showed that there was no differences between factors such as sex, age, type of GEFR-TKI, smoking history, Brinkman index, history of lung disease and performance status with features of ILD.

Conclusion: Features of ILD in NSCLC patients with EGFR-TKI therapy include reticular opacities, parenchymal bands, ground-glass opacities, traction bronchiectasis and crazy paving pattern. There is no statistically significa"

"ABSTRAKBanyak studiBanyak studi epidemiologi, klinis dan in vitro terakhir menunjukkan hubungan antara vitaminD dengan tuberkulosis (TB) paru. Kadar 25-hidroksivitamin D (25(OH)D) yang rendahberhubungan dengan penyakit TB paru aktif dan laten. Namun, sampai saat ini belum ada datamengenai hubungan kadar 25(OH)D dan status vitamin D dengan derajat lesi TB paru. Tujuanpenelitian ini dilakukan untuk mendapatkan hubungan antara proporsi status vitamin D dankadar 25(OH)D dengan derajat lesi TB paru ringan, sedang dan berat. Desain penelitianpotong lintang, terdiri dari 137 pasien TB paru terbagi menjadi kelompok derajat lesi TB paruringan, sedang dan berat masing-masing 46, 47 dan 44 pasien. Diagnosis TB paruberdasarkan Pedoman Nasional Pengendalian Tuberkulosis, Kementerian Kesehatan RepublikIndonesia. Derajat lesi TB paru dinilai secara radiologis berdasarkan klasifikasi dari NationalTuberculosis and Respiratory Disease Association, New York. Status vitamin D ditetapkanmenurut rekomendasi Holick. Pada ketiga kelompok dicatat data karakteristik subjek dandilakukan pemeriksaan 25(OH)D. Status vitamin D pada subjek penelitian ini didapatkansebanyak 122(89,1%) defisiensi dan 15(10,9%) insufiensi vitamin D. Proporsi defisiensi daninsufisiensi vitamin D kelompok TB paru ringan, sedang dan berat tidak didapatkanperbedaan bermakna, masing-masing dengan 84,8% dan 15,2%; 91,5% dan 8,5%; 90,9% dan9,1%. Kadar 25(OH)D kelompok TB paru ringan, sedang dan berat tidak berbeda bermakna,masing-masing dengan rerata 12,96 (SB±5,83)ng/mL, 12,42 (SB±5,13)ng/mL, dan 11,29(SB±5,61)ng/mL. Kami menyimpulkan status vitamin D dan kadar 25(OH)D tidakberhubungan dengan derajat lesi TB paru. Proporsi defisiensi dan insufisiensi vitamin Dkelompok TB paru ringan, sedang dan berat tidak didapatkan perbedaan bermakna, masingmasingdengan 84,8% dan 15,2%; 91,5% dan 8,5%; 90,9% dan 9,1%.

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ABSTRACTMost recent epidemiological, clinical and in vitro studies indicate that there is a therelationship between vitamin D and pulmonary tuberculosis (TB). Low concentration of 25-hydroxyvitamin D (25(OH)D) is associated with active and latent pulmonary TB disease.Nevertheless, there is no data about the relationship between vitamin D status andconcentrations of 25(OH)D with severity of pulmonary TB. The aim of this study was toobtain the relationship between proportions of vitamin D and concentrations 25(OH)D withmild, moderate and severe degrees of pulmonary TB lesions. This was a cross-sectional study,137 patients with pulmonary TB and 46, 47 and 44 patients each of mild, moderate and severedegree of pulmonary TB lesions, respectively. Diagnosis of pulmonary TB was based onNational Tuberculosis Control Guideline, Ministry of Health of the Republic of Indonesia.The degree of pulmonary TB lesion was radiologically assessed based on classifications of theNational Tuberculosis and Respiratory Disease Association, New York. Vitamin D status wasdefined according to Holick recommendations. Baseline characteristics of subjects wererecorded and 25(OH)D concentrations were measured in subjects of each groups. Vitamin Dstatus of the subjects were 122 (89.1%) deficiency and 15 (10.9%) insufficiency of vitamin D.The proportions of vitamin D deficiency and insufficiency at mild, moderate and severedegree of pulmonary TB lesions were also not significantly different, i.e. 84.8% and 15.2%,91.5% and 8.5%, 90.9% and 9.1%, respectively. Concentrations of 25 (OH) D in each groupof mild, moderate and severe pulmonary TB lesions were not significantly different, with amean (SD) 12.96 (5.83)ng/mL, 12.42 (5.13)ng/mL, and 11.29 (5.61)ng/mL respectively. It isconcluded that vitamin D status and serum 25 (OH) D were not related to the degree ofpulmonary TB lesion. The proportion of vitamin D deficiency and insufficiency at mild,moderate and severe degree of pulmonary TB lesions were also not significantly different, i.e.84.8% and 15.2%, 91.5% and 8.5%, 90.9% and 9.1%, respectively."