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"Abstract

The Effect of Vitamin C and E Suplementations on Serum CReaetive Protein Level in Moderate-Severe Bum Patients.

To study the effect of vitamin C 1000 mg i.v and E 400 mg oral supplementation on serum c-reactive protein level as parameter of inflammation in bum patients.

This study was a one group pre post test that gave i. v 1000 mg vitamin C and ond 400 mg vitamin E supplementations to thirteen moderate-severe bum patients, with percentage of bum less than 60%, in bum unit Cipto Mangunkusumo Hospital. Data were collected using questionnaire, medical record, anthropometric measurement, dietary assessment using fol.lf consecutive days food record. Laboratory test for serum vitamin C, E and serum c-reactivc protein levels were evaluated before and after supplementations. Differences in mean values were assessed by Wilcoxon for the not normal distribution.

Results Among thirteen subjects, seven (53.80%) subjects were female, median of age 35 (18-55) years. Body mass index in most subjects (69.2%) were categorized as normal. The median percentages of bum injury 22 (5-57}%, and the frequency of severe bum was 61.50%, while the most cause of bum was flame (76.9%). Level of vitamin C after treatment was increased, but not significant. Level of vitamin E after treatment was significantly increased (!Pi),OI6). Level of CRP after supplementation significantly increased (!Pi).04).

Conclusion There was significantly reduced of level serum CRP after four days vitamin CI 000 mg i. v dan E 400 mg ond supplementations."

"ABSTRACT

Objective : To study the eH`ect of vitamin C 1000 mg i.v and E 400 mg oral supplementation on serum c-reactive protein level as parameter of inflammation in burn patients.

Methods: This study was a one group pre post test that gave i.v 1000 mg vitamin C and oral 400 mg vitamin E supplementations to thirteen moderate-severe burn patients, with percentage of burn less than 60%, in burn unit Cipto Mangunkusumo Hospital. Data were collected using questionnaire, medical record, anthropometric measurement, dietary assessment using four consecutive days food record. Laboratory test for serum vitamin C, E and serum c-reactive protein levels- were evaluated before and after supplementations. Differences in mean values were assessed by Wilcoxon for the not normal distribution.

Results: Among thirteen subjects, Seven (53.80%) Subjects were female, median of age 35 (18-55) years. Body mass index in most subjects (69.2%) were categorized as normal. The median percentages of burn injury 22 (5~57)%, and the frequency of severe burn was 6l.50%, while the most cause of burn was flame (76.9%). Level of vitamin C after treatment was increased, but not significant. Level of vitamin E after treatment was significantly increased (p=0,016). Level of CRP after supplementation significantly increased (p=0.04).

Conclussion: There was significantly reduced of level serum CRP after four days vitamin C1000 mg i.v dan E 400 mg oral supplementations."

"Mengetahui pengaruh suplementasi vitamin C 1000 mg i.v dan E 400 mg oral selama empat hari berturut-turut terhadap kadar malondialdehid (MDA) plasma, sebagai penanda stres oksidatif pada penderita luka bakar sedang berat. Penelitian ini merupakan one group pre post test, yang memberikan suplementasi vitamin C 1000 mg i.v dan vitamin E 400 mg oral yang pada 13 subyek penclitian, yaitu penderita luka bakar kategori sedang berat dengan tuas luka bakar kurang dari 60%, yang dirawat di Unit Luka Bakar RSUPN Cipto Mangunkusumo. Data diperoleh melalui wawancara, rekam medik, pengukuran antropometri, analisis asupan menggunakan metodefood record, dan pemeriksaan laboratorium. berupa pemeriksaan kadar vitamin Ct E serum dan MDA plasma pada sebeium dan setelah suplementasi. Analisis data untuk data berpasangan menggunakan uji t berpasangan dan uji Wileoxon, sedangkan untuk dua kelompok tidak berpasangan menggunakan uji Mann Whitney. Batas kemaknaan pada penelitian ini adalah 5%. Sebanyak 13 orang subyek penelitian~ terdiri dari perempuan 53,85%, dengan median usia 32 (18-55) tahun, sebagian besar subyek memiliki status gizi normal (61.54%). Median luas luka bakar adalah 22 (5-57)"/o, dengan kasus terbanyak adalah luka bakar berat (61.50%), dan penyebab terbanyak adalah api (76.9%). Kadar vitamin C pasca suplementasi mengalami sedikit peningkatan yang tidak bennakna. Kadar vitamin E subyek penelitian meningkat bermakna (p=O,Ol6) pasea suplementasi, walaupun masih dalam kategori rendah. Kadar MDA pada suplementasi mengalami penurunan bermakna W'(l,O 19). Simpulan: Terdapat penurunan bermakna kadar MDA plasma pada subyek penelitian setelah suplementasi vitamin C 1000 mg i.v dan vitamin E 400 mg oral selama empat hari.

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To study the effect of vitamin C 1000 mg i.v and E 400 mg oral supplementation on plasma malondialdehyde level as parameter of oxidative stress in bum patients.

This study was a one group pre post test that gave i.v 1000 mg vitamin C and omi 400 mg vitamin E supplementations to thirteen moderate-severe bum patient$. with percentage of bum less than 60%, in burn unit Cipto Mangunkusurno HospitaL Data were collected using questionnaire, medical record, anthropometric measurement. dietary assessment using four consecutive days food record. Laboratory test for serum vitamin C, B and plasma malondialdehyde levels were evaluated before and after supplementations. Differences in mean values were assessed by paired t-test for normal distribution data or Wilcoxon fur the not normal distribution. Mann Whitney was used for unpaired data. Values of p < O~OS were considered to indicate statistical significance.

Results Among thirteen subjects. seven (53.80%) subjects were female, median of age 32 (18-55) years. Body mass indek in most subjects (61.54%) were categorized as normal. The median percentages of bum injury 22 (5-51)%, and the frequency of severe bum was 61.50%, while the most cause of bum was flame (76,9%). Level of vitamin C after treatment was increased, but not significant. Level of vitamin E after treatment was significantly increased (p=O,Ol6). Level of MDA after supplementation significantly reduced (Jl 0,0l9).

Conclusion There was significantly reduced of level plasma MDA after four days vitamin CIOOO mg i.v danE 400 mg oral supplementations. "

"Tujuan penelitian ini adalah menilai kadar GSH plasma setelah suplementasi vitamin C 1000 mg intravena dan 400 mg vitamin E secara oral selama empat hari berturut-turut pada luka bakar sedang berat. Penelitian eksperimen ini dengan satu kelompok pre-post test dengan usia 18-59% tahun pada kasus luka bakar sedang berat kurang dari 60%. Dari 16 kasus yang memenuhi kriteria, diperoleh 12 kasus sehagai subjek penelitian sesuai dengan sampel yang diharapkan. Penyebab luka bakar terbanyak adalah api (75%) dan sebagian besar subyek menriliki BMI nonnal (67%) dengan rata-rata 22,04 ± 1,89 kglm2 ? Kadar vitamin C sebelurn suplementasi adalah 17,79(10,16-32,88)p.mol/L dan sesudah suplementasi adalah 18,33(9,10-37,02) p.mol/ L (p = 0,239), Nilai rata-rata serum kadar vitamin E meningkat signifikan, yaitu 9,06 ± 1,56 p.mol I L sebelurn suplementasi dan 15,50 (6,28-27,17) p.mol/L setelah suplementasi (p = 0,019). Nilai rata-rata dan kisaran kadar GSH plasma sebelum suplementasi adalah 0,54±0,11 Jlll I mL, Nilai rata-rata tingkat GSH setelah suplemen adalah l ,07 (0,94-1,68) g /mL.lni menunjukkan bahwa suplementasi vitamin C dan vitamin E bisa meningkatkan kadar GSH secara signifikan (p = 0,002). Terdapat perbedaan yang signifikan pada perubahan kadar vitamin C, vitamin E, dan GSH sebelum dan sesudah perlakuan antara luka bakar sedang dan luka bakar berat.

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The aimed of the study is to assess the levels of GSH after supplementation of vitamin C 1000 mg iv and 400 mg vitamin E orally for four consecutive days on a moderate to severe bums. This experimental studies with one group pre-post test involved 18-590/o years aged patients with moderate to severe burns less than 60%, From 16 cases required the criteria, there were 12 cases as the subject of research in accordance with the expected sample. The most causes of burns is fire (75%) and most of subjects have a nominal BMl (67%) with average 22.04 ± 1.89 kg /m2 ? Median value of vitamin C levels before supplementation was 17.79(10.16-32.88) and after supplementation was 18.33(9.10-37.02) ~mol/L (lr= 0.239). Average value of serum vitantin E levels increased significantly, which are 9.06 ± 1.56 mol/L befure supplementation and 15.50(6.28-27.17) mol/L after supplementation (p= 0.019). Median value and range of plasma GSH levels before supplementation was 0.54±0.11 ;tg/mL. Median value of GSH levels after supplementation was 1.07 (0.94-1.68) flgimL. This is show that the supplementation of vitamin C and vitamin E may increased GSH levels significantly (p = 0.002). There were no significant differences in changes in levels of vitamin C, vitamin E, and GSH before and after treatment among the study subjects with moderate and severe burns."

"Tujuan penelitian ini adalah menilai kadar GSH plasma setelah suplementasi vitamin C 1000 mg intravena dan 400 mg vitamin E secara oral selama empat hari berturut-turut pada luka bakar sedang berat. Penelitian eksperimen ini dengan satu kelompok pre-post test dengan usia 18-59% tahun pada kasus luka bakar sedang berat kurang dari 60%. Dari 16 kasus yang memenuhi kriteria, diperoleh 12 kasus sebagai subjek penelitian sesuai dengan sampel yang diharapkan. Penyebab luka bakar terbanyak adalah api (75%) dan sebagian besar subyek memiiiki BMI (67%) dengan rata-ma 22,04 i 1,89 kg/mz. Kam vitamin C sebelum suplementasi adalah l7,79(10,l6-32,88)pmol I L dan sesudah suplemcntasi adalah 18,33(9,l0-37,02) pmol I L (p = 0,239). Niiai rata-rata serum kadar vitamin E meningkat signitikan, yaitu 9,06 1 1,56 nmol / L sebelum supiementasi dan 15,50 (6,28~27,17) pmol / L setelah suplementasi (p = 0,019). Nilai rata-rata dan kisaran kadar GSH plasma sebelum suplementasi adalah 0,54:t0,ll pg / mL. Nilai rata~rata tingkat GSH setelah suplemen adalah 1,07 (0,94-l,68) pg / mL. Ini menunjukkan bahwa suplcmcntasi vitamin C dan vitamin E bisa meningkatkan kadar GSH secara signifikan (p = 0,002). Terdapat perbedaan yang sigfinikan pada perubahan kadar vitamin C, vitamin E, dan GSH sebelum dan sesudah perlakuan antara luka bakar sedang dan luka bakar berat.

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The aimed of the study is to assess the levels of GSH after supplementation of vitamin C 1000 mg iv and 400 mg vitamin E orally for four consecutive days on a moderate to severe bums. This experimental studies with one group pre-post test involved 18-59% years aged patients with moderate to severe burns less than 60%. From I6 cases required the criteria., there were 12 cases as the subject of research in accordance with the expected sample. The most causes of bums is Ere (75%) and most of subjects have a normal BMI (67%) with average 22.04 i 1.89 kg /mz. Median value of vitamin C levels before supplementation was l7.79(l0.I6-3288) pmol/L and after supplementation was l8.33(9.l0-37.02) |imolfL (p= 0239). Average value of serum vitamin E levels increased significantly, which are 9.06 -L 1.56 pmol/L before supplementation and l5.50(6.28-2'/.l7) nmol/I. alter supplementation (p= 0.0l9). Median value and range of plasma GSH levels before supplementation was 0.540.ll pg,lmL. Median value of GSH levels after supplementation was l.07 (0.94-1.68) ug/mL. This is show that the supplementation of vitamin C and vitamin E may increased GSH levels significantly (p = 0.002). There were no significant differences in changes in levels of vitamin C, vitamin E, and GSH before and after treatment among the study subjects with moderate and severe bums."

"ABSTRAKTujuanMengetahui pengaruh suplementasi vitamin C 1000 mg i.v dan E 400 mg oral selama empat hari berturut-turut terhadap kadar malondialdehid (MDA) plasma. sebagai penanda stres oksidatif pada penderita luka bakar sedang berat.Penelitian ini merupakan one group pre post tes yang memberikan suplementasi vitamin C t 000 mg i.v dan vitamin E 400 mg oral yang pada 13 subyek penelitian yaitu penderita luka bakar kategorl sedang berat dengan luas luka bakar kurang dari 60%, yang dirawat di Unit Luka Bakar RSUPN Cipto Mangunkusumo. Data diperoleh melalui wawancara, rekam medik, pengukuran antropometri analisis asupan menggunakan metode food record, dan pemeriksaan laboratorium, berupa pemeriksaan kadar vitamin C, E serum dan MDA plasma pada sebelum dan setelah suplementasi. Analisis data untuk data berpasangan menggunakan uji t berpasangan dan uji Wilcoxon, sedangkan untuk dua kelompok tidak berpasangan menggunakan uji Mann Whitney. Batas kemaknaan pada penelitian ini ada1ah 5o/a.Sebanyak 13 orang subyek penelitian, terdiri dari perempuan 53.85o/o, dengan median usia 32 (18 55) subyek memiliki status gizi normal (61.54%), Median luas Juka bakar adalah 22 (5-57)%, dengan kasus terbanyak adalah luka bakar berat (61.50%), dan penyebab terbanyak adalah api (76.9%). Kadar vitamin C pasca suplementasi menga!ami sedikit peningkatan yang tidak bermakna. Kadar vitamin E subyek penelitian meningkat bermakna (p=0,016) pasca suplementasi, walaupun masih dalam kategori rendah. Kadar MDA pasca supiementasi mengalami penurunan bermakna(p=O,Ol9)."

"Mengetahui pcngaruh pemberian kombinasi suplementasi vitamin E dan C terhadap peroksidasi lipid pada usila dengan hiperkolesterolemia. Penelitian uji klinis paralel, tertutup timggai, alokasi acak, untuk membandingkan kadar malondialdehida usila 2,60 tahun dengan hiperkolesterolemia yang mendapatkan kombinasi supiementasi vitamin E 400 IU dan vitamin C 500 mg, masing~masing sebutir sehari selama 45 hari dengan kelompok yang mendapat vitamin E 400 IU dan plascbo.Terdapat 42 subyek penelitian yang berasal dari Yayasan Kebagusan, Yayasan Yasni, dan Yayasan Yakin, Pasar Minggu Jakarta Selatan yang dibagi menjadi dua kelompok masing-masing berjumlah 21 orang. Data yang diambil adalah : data dcmograti, antropometzi, data asupan makanan pada minggu pertama, ketiga dan ketujuh, kadar kolesterol LDL dan MDA plasma sebelum dan sesudah perlakuan. Uji statistik yang digunakan adalah uji t-tidak bezpasangan bila distribusi nonnal dan uji Manmwhimey bila distribusi tidak normal dengan tingkat kemaknaan p<0.05. Sebanyak 20 subyek penelitian dad masing-masing kelompok yang dapat mengikuti penelitian sampai sclesai. Sebelum perlakuan, nilai median kadar kolesterol LDL kelompolc vitamin E+plasebo dan vitamin E+C masing- masing adalah I46.50(l30-190) mg/dL dan 146.50(l3I-196) mg/dL. Setelah 45 hari perlakuan, rerata kadar kolesterol LDL kelompok vitamin E4-plasebo (151.9.+:2.2.l mg/dl.) meningkat sedangkan kelompok vitamin B+-C (l46.8i28.21 mg/dL) menurun. Sebelum p¢rIakuan, nilai median kadar MDA plasma kelornpok vitamin E+plasebo dan rerata kadar MDA plasma kelompok vitamin E4-C masing-masing adalah 2.63(l.92-4.42) nmol/ml., dan 3.03:l:0.62 nmol/mL. Setelah 45 haii pcrlakuan rerata kadar MDA plasma kedua keiompok menunm menjadi 2.30i0.67 nmol/mL (p<0.01) pada kelompok vitamin E+plasebo dan 28810.88 nmol/mL (p=0.36) untuk kelompok vitamin E+C. Penurunan kadar MDA plasma kelompok vitamin E+plasebo lcbih besar (-0.5:!:0.55 nmol/mL) daripada kelompok vitamin E+C (-0.28(l.31-1.63) nmol/mL), tetapi dcngan uji statislik terhadap kedua nilai tersebut, tidalc berbeda bcrma!ma(p=0.09). Pembenan kombinasi vitamin E dan vitamin C pada usila dengan hiperkolesternlemia tidak dapat rnenurunkan kadar MDA plasma lcbih besar dibandingl-can dengan hanya pemberian vitamin E.

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This parallel, single blind, randomization clinical trial purpose was to compare plasma malondyaldehydc level in hypercholesterolemic elderly aged more than 60 years old. Forty two people from Yayasan Kebagusan, Yayasan Yasni and Yayasan Yakin, Pasar Minggu, South Jakarta which participated the study, were divided into two groups. Twenty one elderly were supplemented with 400 IU vitamin E and 500 mg vitamin C for 45 consecutive days, while the other group was supplemented with 400 IU vitamin E and placebo. The data of demographic, anthropometric, food intake in the first, third and seventh weeks, plasma LDL and MDA levels before and alter period were taken. Statistical analyzes was performed by SPSS 11.5.

Twenty people for each group had followed the study until the end of period. Before study, LDL cholesterol median for vitamin E + placebo group and vitamin E+C group were 146.50(l30-190) mg/dL and l46.50( 130-190) mg/dL respectively. Alter 45 of days treatment, there was an increase in mean LDL cholesterol in vitamin E + placebo group 15l.9i22.1 mg/dL while in vitamin E+C group was decreased to l46.8:l:28.2l mg/dl Before study, plasma MDA level in vitamin E + placebo group and vitamin E+C group were 2.63(l.92-4.42) and 3.031052 nmol/mL, respectively. After 45 days, mean MDA plasma in vitamin E + placebo group was 2.30i0.67 nmol/mL (p<0.01) and was 2.881088 nmol/ml.. (p=0.36) in vitamin E+C group. The decreased on plasma MDA levels in vitamin E+placebo group was higher (-0,510.55 nmol/mL) than vitamin E+C (-0.28(1.3l-1.63) nmol/mL), but statistical test showed not significant different between both group (p=0.09). Combined supplementation vitamin E and vitamin C in hypercholesterolemic elderly couldnot decrease plasma MDA higher than supplementation of vitamin E alone."

"Endometriosis merupakan penyakit inflamasi kronis pada organ reproduksi wanita dengan gejala utama nyeri pelvis kronis, dismenore, dan dispareunia yang dapat disebabkan oleh stres oksidatif akibat rendahnya kadar antioksidan, seperti vitamin C, sehingga terjadi kerusakan sel. Levonorgestrel adalah terapi hormonal yang sering digunakan untuk meredakan rasa nyeri pada endometriosis, tetapi dapat memperberat proses inflamasi, sehingga dibutuhkan suatu terapi adjuvan, seperti propolis yang mengandung antioksidan yang tinggi. Penelitian ini menggunakan desain uji klinis dengan alokasi acak dan tersamar ganda. Subjek penelitian adalah 24 wanita yang sedang mendapatkan terapi implan levonorgestrel dan diminta untuk menerima propolis atau plasebo dua kali sehari dengan dosis 1 tetes/10 kg berat badan (kgBB) per kali. Sampel darah kemudian diambil pada 4 minggu setelah intervensi dan dilakukan pemisahan serum. Pengukuran kadar vitamin C serum dilakukan dengan metode spektrofotometri dan analisis statistik dilakukan dengan uji t tidak berpasangan apabila data berdistribusi normal. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan antara kedua kelompok (p<0,001), yaitu kadar vitamin C serum lebih tinggi pada kelompok propolis (0,202+0,057) dibandingkan kelompok plasebo (0,069+0,028). Dengan demikian, pemberian propolis meningkatkan kadar vitamin C serum pada pasien endometriosis setelah intervensi 4 minggu. 

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Endometriosis is a chronic inflammatory reproductive disease in women which main symptoms are chronic pelvic pain, dysmenorrhea, and dyspareunia that can be triggered by oxidative stress due to decreased antioxidants, such as vitamin C that may cause cell damage. Levonorgestrel is a hormonal therapy that is commonly used for endometriosis to relieve pain but it can worsen the inflammatory process, so an adjuvant therapy is needed, such as propolis that contains high antioxidant level. This study used clinical trial design with random allocation and double-blinded. The study subject is 24 women that receive levonorgestrel therapy and were asked to consume propolis or placebo randomly two times a day with a dose of 1 drop/10 kg body weight (kgBW) per time. Blood samples were then taken after 4 weeks and serum separation was performed. Serum vitamin C levels were measured using spectrophotometric method and statistical analysis used independent t-test if the data were normally distributed. The result showed that there is a significant difference between the two groups (p<0,001), in which the concentration of serum vitamin C is higher in the propolis group (0,202+0,057) compared to the placebo group (0,069+0,028). In conclusion, the administration of propolis results in significantly higher serum vitamin C concentration after 4-week intervention."

"Serat asbes yang terinhalasi masuk ke dalam alveolus menyebabkan terjadinya peningkatan produksi reactive oxigen spesies (ROS) yang dapat memicu terjadinya reaksi inflamasi. Interleukin 6 merupakan penanda reaksi inflamasi akibat pajanan serat asbes. Vitamin C dan E merupakan antioksidan yang bekerja sebagai scavenger ROS. Vitamin C juga dapat menghambat aktivitas faktor transkripsi NFқB. Vitamin E selain dapat menghambat aktivitas faktor transkripsi JAK/STAT3 dan NFқB, juga dapat menghambat aktivitas COX2 dan LOX5. Penelitian potong lintang di sekretariat serikat buruh pabrik asbes X Kabupaten Karawang bulan Oktober 2014 dilakukan untuk menilai korelasi asupan vitamin C, E dengan kadar interleukin 6 pada pekerja pabrik asbes. Lima puluh dua pekerja pabrik asbes berhasil menyelesaikan protokol penelitian. Hasilnya menunjukkan tidak terdapat korelasi bermakna (p >0,05) antara asupan vitamin C dengan kadar IL-6 dan antara asupan vitamin E dengan kadar IL-6. Terdapat korelasi positif antara kadar vitamin C dengan kadar IL-6 (r = 0,31) dengan p <0,05, namun tidak terdapat korelasi antara kadar vitamin E dengan kadar IL-6.

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Asbestos fibers that are inhaled into the alveoli cause increased production of reactive oxygen species (ROS) which may trigger inflammation reaction. Interleukin 6 (IL-6) is a marker of inflammation reaction caused by asbestos fibers exposure. Vitamin C and vitamin E are antioxidants acting as ROS scavengers. Vitamin C can also inhibit the activity of transcription factor NFқB. Vitamin E can inhibit the activities of transcription factors JAK/STAT3 and NFқB as well as the activities of COX2 and LOX5.

A cross-sectional sudy at a labor union secretariat in Karawang Regency in October 2014 was conducted to evaluate the correlations between intakes and levels of vitamin C and vitamin E and level of IL-6 in asbestos factory workers. Fifty two asbestos factory workers finished the study. The result showed no significant correlation between vitamin C intake and IL-6 level or between vitamin E intake and IL-6 level. There was a moderate positive correlation between vitamin C level and IL-6 level (r = 0.31, p <0.05), but there was no correlation between vitamin E level and IL-6 level."

"Latar Belakang: Aktivasi mediator inflamasi diketahui menyebabkan kelahiran preterm. Sitokin dan penanda inflamasi yang terbentuk berhubungan dengan imun tubuh. Vitamin D diketahui berperan pada modulasi respon sistem imunitas tubuh. Penelitian ini ingin mengetahui hubungan antara kadar vitamin D serum ibu dan tali pusat, dengan IL-6 tali pusat dan C Reactive Protein (CRP) darah bayi prematur.Metode: Penelitian ini merupakan studi analitik dengan desain potong lintang pada subjek ibu hamil 28-34 minggu yang mengalami kelahiran prematur didahului KPD dan bayi yang dilahirkannya, di Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo dan Rumah Sakit Umum Pusat Persahabatan, Jakarta pada bulan Januari 2017 sampai Agustus 2018. Subjek diambil secara consecutive sampling. Variabel data adalah kadar serum vitamin D ibu dan tali pusat, kadar serum IL-6 tali pusat dan kadar CRP darah bayi. Dilakukan kategorisasi dikotomi dan polikotomi (tiga) kadar vitamin D dan dicari hubungannya dengan kadar IL-6 tali pusat dan CRP darah bayi, menggunakan uji Mann-Whitney dan Kruskal Wallis.Hasil: Sebanyak 70 subjek telah memenuhi kriteria penelitian. Pada kategori dikotomi vitamin D ibu, kadar IL-6 tali pusat dan CRP bayi dari kelompok kadar vitamin D kurang, sedikit lebih tinggi (3,89 pg/ml dan 0,45 mg/dl) dibandingkan kelompok kadar vitamin D normal (3,29 pg/ml dan 0,30 mg/dl), tetapi perbedaan tersebut tidak bermakna (IL-6 p=0,771 dan CRP p = 0,665). Pada kategori polikotomi vitamin D ibu, kadar IL-6 tali pusat dan CRP bayi dari kelompok ibu vitamin D defisiensi, lebih tinggi (20,31 pg/ml dan 0,50 mg/dl) dibandingkan kelompok ibu vitamin D insufisiensi (3,34 pg/mL dan 0,45 mg/dl) dan kelompok ibu vitamin D normal (3,29 pg/mL dan 0,30 mg/dl), tetapi perbedaan tersebut tidak bermakna (IL-6 p=0,665 dan CRP p = 0,899). Pada kategori dikotomi maupun polikotomi vitamin D tali pusat, didapatkan perbedaan tidak bermakna yang terbalik dari kadar IL-6 tali pusat dan CRP bayi.Simpulan: Tidak didapatkan hubungan antara kadar serum vitamin D ibu dan tali pusat dengan kadar serum IL-6 tali pusat dan CRP darah bayi prematur.

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Background: Activation of inflammatory mediators is known to cause preterm birth. Cytokines and inflammatory markers formed are associated with the body's immune system. Vitamin D is known to play a role in modulating the body's immune system response. This study aimed to find out the relationship between the levels of serum of maternal and umbilical cord vitamin D, with umbilical cord IL-6 and C Reactive Protein (CRP) in premature infants.Method: This research was an analytic study with a cross-sectional design on the subject of 28-34 weeks pregnant women who experience preterm birth preceded by premature rupture of membranes and their babies, at dr. Cipto Mangunkusumo and Persahabatan General Hospital, Jakarta, from January 2017 to August 2018. Data variables were the levels of serum of maternal and umbilical cord vitamin D, umbilical cord IL-6 and CRP in premature infants. Vitamin D levels were divided into dichotomy and polycotomy categories, and found out their relationship to the levels of IL-6 and CRP using the Mann Whitney and Kruskal Wallis tests.Result: A total of 70 subjects met the research criteria. In the maternal vitamin D dichotomy category, the umbilical cord IL-6 and infants CRP levels from the group with low level were less slightly higher (3.89 pg/ml and 0.45 mg/dl) compared to the group with normal level (3.29 pg/ml and 0.30 mg/dl), but the difference was not significant (IL-6 p = 0.771 and CRP p = 0.665). In the maternal vitamin D polycotomy category, umbilical cord IL-6 and infants CRP levels from the deficiency group were higher (20.31 pg/ml and 0.50 mg/dl) compared to the insufficiency group (3.34 pg/mL and 0.45 mg/dl) and the normal group (3.29 pg/mL and 0.30 mg/dl), but the difference was not significant (IL-6 p = 0.665 and CRP p = 0.899). In both dichotomy and polycotomy categories of umbilical cord vitamin D, we found a non-significant difference inversely related to umbilical cord IL-6 and infants CRP levels.Conclusion: There was no correlation between between the levels of serum of maternal and umbilical cord vitamin D, with umbilical cord IL-6 and C Reactive Protein (CRP) in premature infants."