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"Mengetahui pengaruh suplementasi vitamin C 1000 mg i.v dan E 400 mg oral selama empat hari berturut-turut terhadap kadar malondialdehid (MDA) plasma, sebagai penanda stres oksidatif pada penderita luka bakar sedang berat. Penelitian ini merupakan one group pre post test, yang memberikan suplementasi vitamin C 1000 mg i.v dan vitamin E 400 mg oral yang pada 13 subyek penclitian, yaitu penderita luka bakar kategori sedang berat dengan tuas luka bakar kurang dari 60%, yang dirawat di Unit Luka Bakar RSUPN Cipto Mangunkusumo. Data diperoleh melalui wawancara, rekam medik, pengukuran antropometri, analisis asupan menggunakan metodefood record, dan pemeriksaan laboratorium. berupa pemeriksaan kadar vitamin Ct E serum dan MDA plasma pada sebeium dan setelah suplementasi. Analisis data untuk data berpasangan menggunakan uji t berpasangan dan uji Wileoxon, sedangkan untuk dua kelompok tidak berpasangan menggunakan uji Mann Whitney. Batas kemaknaan pada penelitian ini adalah 5%. Sebanyak 13 orang subyek penelitian~ terdiri dari perempuan 53,85%, dengan median usia 32 (18-55) tahun, sebagian besar subyek memiliki status gizi normal (61.54%). Median luas luka bakar adalah 22 (5-57)"/o, dengan kasus terbanyak adalah luka bakar berat (61.50%), dan penyebab terbanyak adalah api (76.9%). Kadar vitamin C pasca suplementasi mengalami sedikit peningkatan yang tidak bennakna. Kadar vitamin E subyek penelitian meningkat bermakna (p=O,Ol6) pasea suplementasi, walaupun masih dalam kategori rendah. Kadar MDA pada suplementasi mengalami penurunan bermakna W'(l,O 19). Simpulan: Terdapat penurunan bermakna kadar MDA plasma pada subyek penelitian setelah suplementasi vitamin C 1000 mg i.v dan vitamin E 400 mg oral selama empat hari.

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To study the effect of vitamin C 1000 mg i.v and E 400 mg oral supplementation on plasma malondialdehyde level as parameter of oxidative stress in bum patients.

This study was a one group pre post test that gave i.v 1000 mg vitamin C and omi 400 mg vitamin E supplementations to thirteen moderate-severe bum patient$. with percentage of bum less than 60%, in burn unit Cipto Mangunkusurno HospitaL Data were collected using questionnaire, medical record, anthropometric measurement. dietary assessment using four consecutive days food record. Laboratory test for serum vitamin C, B and plasma malondialdehyde levels were evaluated before and after supplementations. Differences in mean values were assessed by paired t-test for normal distribution data or Wilcoxon fur the not normal distribution. Mann Whitney was used for unpaired data. Values of p < O~OS were considered to indicate statistical significance.

Results Among thirteen subjects. seven (53.80%) subjects were female, median of age 32 (18-55) years. Body mass indek in most subjects (61.54%) were categorized as normal. The median percentages of bum injury 22 (5-51)%, and the frequency of severe bum was 61.50%, while the most cause of bum was flame (76,9%). Level of vitamin C after treatment was increased, but not significant. Level of vitamin E after treatment was significantly increased (p=O,Ol6). Level of MDA after supplementation significantly reduced (Jl 0,0l9).

Conclusion There was significantly reduced of level plasma MDA after four days vitamin CIOOO mg i.v danE 400 mg oral supplementations. "

"Tujuan penelitian ini adalah menilai kadar GSH plasma setelah suplementasi vitamin C 1000 mg intravena dan 400 mg vitamin E secara oral selama empat hari berturut-turut pada luka bakar sedang berat. Penelitian eksperimen ini dengan satu kelompok pre-post test dengan usia 18-59% tahun pada kasus luka bakar sedang berat kurang dari 60%. Dari 16 kasus yang memenuhi kriteria, diperoleh 12 kasus sehagai subjek penelitian sesuai dengan sampel yang diharapkan. Penyebab luka bakar terbanyak adalah api (75%) dan sebagian besar subyek menriliki BMI nonnal (67%) dengan rata-rata 22,04 ± 1,89 kglm2 ? Kadar vitamin C sebelurn suplementasi adalah 17,79(10,16-32,88)p.mol/L dan sesudah suplementasi adalah 18,33(9,10-37,02) p.mol/ L (p = 0,239), Nilai rata-rata serum kadar vitamin E meningkat signifikan, yaitu 9,06 ± 1,56 p.mol I L sebelurn suplementasi dan 15,50 (6,28-27,17) p.mol/L setelah suplementasi (p = 0,019). Nilai rata-rata dan kisaran kadar GSH plasma sebelum suplementasi adalah 0,54±0,11 Jlll I mL, Nilai rata-rata tingkat GSH setelah suplemen adalah l ,07 (0,94-1,68) g /mL.lni menunjukkan bahwa suplementasi vitamin C dan vitamin E bisa meningkatkan kadar GSH secara signifikan (p = 0,002). Terdapat perbedaan yang signifikan pada perubahan kadar vitamin C, vitamin E, dan GSH sebelum dan sesudah perlakuan antara luka bakar sedang dan luka bakar berat.

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The aimed of the study is to assess the levels of GSH after supplementation of vitamin C 1000 mg iv and 400 mg vitamin E orally for four consecutive days on a moderate to severe bums. This experimental studies with one group pre-post test involved 18-590/o years aged patients with moderate to severe burns less than 60%, From 16 cases required the criteria, there were 12 cases as the subject of research in accordance with the expected sample. The most causes of burns is fire (75%) and most of subjects have a nominal BMl (67%) with average 22.04 ± 1.89 kg /m2 ? Median value of vitamin C levels before supplementation was 17.79(10.16-32.88) and after supplementation was 18.33(9.10-37.02) ~mol/L (lr= 0.239). Average value of serum vitantin E levels increased significantly, which are 9.06 ± 1.56 mol/L befure supplementation and 15.50(6.28-27.17) mol/L after supplementation (p= 0.019). Median value and range of plasma GSH levels before supplementation was 0.54±0.11 ;tg/mL. Median value of GSH levels after supplementation was 1.07 (0.94-1.68) flgimL. This is show that the supplementation of vitamin C and vitamin E may increased GSH levels significantly (p = 0.002). There were no significant differences in changes in levels of vitamin C, vitamin E, and GSH before and after treatment among the study subjects with moderate and severe burns."

"ABSTRACT

Objective : To study the eH`ect of vitamin C 1000 mg i.v and E 400 mg oral supplementation on serum c-reactive protein level as parameter of inflammation in burn patients.

Methods: This study was a one group pre post test that gave i.v 1000 mg vitamin C and oral 400 mg vitamin E supplementations to thirteen moderate-severe burn patients, with percentage of burn less than 60%, in burn unit Cipto Mangunkusumo Hospital. Data were collected using questionnaire, medical record, anthropometric measurement, dietary assessment using four consecutive days food record. Laboratory test for serum vitamin C, E and serum c-reactive protein levels- were evaluated before and after supplementations. Differences in mean values were assessed by Wilcoxon for the not normal distribution.

Results: Among thirteen subjects, Seven (53.80%) Subjects were female, median of age 35 (18-55) years. Body mass index in most subjects (69.2%) were categorized as normal. The median percentages of burn injury 22 (5~57)%, and the frequency of severe burn was 6l.50%, while the most cause of burn was flame (76.9%). Level of vitamin C after treatment was increased, but not significant. Level of vitamin E after treatment was significantly increased (p=0,016). Level of CRP after supplementation significantly increased (p=0.04).

Conclussion: There was significantly reduced of level serum CRP after four days vitamin C1000 mg i.v dan E 400 mg oral supplementations."

"Tujuan penelitian ini adalah menilai kadar GSH plasma setelah suplementasi vitamin C 1000 mg intravena dan 400 mg vitamin E secara oral selama empat hari berturut-turut pada luka bakar sedang berat. Penelitian eksperimen ini dengan satu kelompok pre-post test dengan usia 18-59% tahun pada kasus luka bakar sedang berat kurang dari 60%. Dari 16 kasus yang memenuhi kriteria, diperoleh 12 kasus sebagai subjek penelitian sesuai dengan sampel yang diharapkan. Penyebab luka bakar terbanyak adalah api (75%) dan sebagian besar subyek memiiiki BMI (67%) dengan rata-ma 22,04 i 1,89 kg/mz. Kam vitamin C sebelum suplementasi adalah l7,79(10,l6-32,88)pmol I L dan sesudah suplemcntasi adalah 18,33(9,l0-37,02) pmol I L (p = 0,239). Niiai rata-rata serum kadar vitamin E meningkat signitikan, yaitu 9,06 1 1,56 nmol / L sebelum supiementasi dan 15,50 (6,28~27,17) pmol / L setelah suplementasi (p = 0,019). Nilai rata-rata dan kisaran kadar GSH plasma sebelum suplementasi adalah 0,54:t0,ll pg / mL. Nilai rata~rata tingkat GSH setelah suplemen adalah 1,07 (0,94-l,68) pg / mL. Ini menunjukkan bahwa suplcmcntasi vitamin C dan vitamin E bisa meningkatkan kadar GSH secara signifikan (p = 0,002). Terdapat perbedaan yang sigfinikan pada perubahan kadar vitamin C, vitamin E, dan GSH sebelum dan sesudah perlakuan antara luka bakar sedang dan luka bakar berat.

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The aimed of the study is to assess the levels of GSH after supplementation of vitamin C 1000 mg iv and 400 mg vitamin E orally for four consecutive days on a moderate to severe bums. This experimental studies with one group pre-post test involved 18-59% years aged patients with moderate to severe burns less than 60%. From I6 cases required the criteria., there were 12 cases as the subject of research in accordance with the expected sample. The most causes of bums is Ere (75%) and most of subjects have a normal BMI (67%) with average 22.04 i 1.89 kg /mz. Median value of vitamin C levels before supplementation was l7.79(l0.I6-3288) pmol/L and after supplementation was l8.33(9.l0-37.02) |imolfL (p= 0239). Average value of serum vitamin E levels increased significantly, which are 9.06 -L 1.56 pmol/L before supplementation and l5.50(6.28-2'/.l7) nmol/I. alter supplementation (p= 0.0l9). Median value and range of plasma GSH levels before supplementation was 0.540.ll pg,lmL. Median value of GSH levels after supplementation was l.07 (0.94-1.68) ug/mL. This is show that the supplementation of vitamin C and vitamin E may increased GSH levels significantly (p = 0.002). There were no significant differences in changes in levels of vitamin C, vitamin E, and GSH before and after treatment among the study subjects with moderate and severe bums."

"Abstract

The Effect of Vitamin C and E Suplementations on Serum CReaetive Protein Level in Moderate-Severe Bum Patients.

To study the effect of vitamin C 1000 mg i.v and E 400 mg oral supplementation on serum c-reactive protein level as parameter of inflammation in bum patients.

This study was a one group pre post test that gave i. v 1000 mg vitamin C and ond 400 mg vitamin E supplementations to thirteen moderate-severe bum patients, with percentage of bum less than 60%, in bum unit Cipto Mangunkusumo Hospital. Data were collected using questionnaire, medical record, anthropometric measurement, dietary assessment using fol.lf consecutive days food record. Laboratory test for serum vitamin C, E and serum c-reactivc protein levels were evaluated before and after supplementations. Differences in mean values were assessed by Wilcoxon for the not normal distribution.

Results Among thirteen subjects, seven (53.80%) subjects were female, median of age 35 (18-55) years. Body mass index in most subjects (69.2%) were categorized as normal. The median percentages of bum injury 22 (5-57}%, and the frequency of severe bum was 61.50%, while the most cause of bum was flame (76.9%). Level of vitamin C after treatment was increased, but not significant. Level of vitamin E after treatment was significantly increased (!Pi),OI6). Level of CRP after supplementation significantly increased (!Pi).04).

Conclusion There was significantly reduced of level serum CRP after four days vitamin CI 000 mg i. v dan E 400 mg ond supplementations."

"ABSTRAKTujuanMengetahui pengaruh suplementasi vitamin C 1000 mg i.v dan E 400 mg oral selama empat hari berturut-turut terhadap kadar malondialdehid (MDA) plasma. sebagai penanda stres oksidatif pada penderita luka bakar sedang berat.Penelitian ini merupakan one group pre post tes yang memberikan suplementasi vitamin C t 000 mg i.v dan vitamin E 400 mg oral yang pada 13 subyek penelitian yaitu penderita luka bakar kategorl sedang berat dengan luas luka bakar kurang dari 60%, yang dirawat di Unit Luka Bakar RSUPN Cipto Mangunkusumo. Data diperoleh melalui wawancara, rekam medik, pengukuran antropometri analisis asupan menggunakan metode food record, dan pemeriksaan laboratorium, berupa pemeriksaan kadar vitamin C, E serum dan MDA plasma pada sebelum dan setelah suplementasi. Analisis data untuk data berpasangan menggunakan uji t berpasangan dan uji Wilcoxon, sedangkan untuk dua kelompok tidak berpasangan menggunakan uji Mann Whitney. Batas kemaknaan pada penelitian ini ada1ah 5o/a.Sebanyak 13 orang subyek penelitian, terdiri dari perempuan 53.85o/o, dengan median usia 32 (18 55) subyek memiliki status gizi normal (61.54%), Median luas Juka bakar adalah 22 (5-57)%, dengan kasus terbanyak adalah luka bakar berat (61.50%), dan penyebab terbanyak adalah api (76.9%). Kadar vitamin C pasca suplementasi menga!ami sedikit peningkatan yang tidak bermakna. Kadar vitamin E subyek penelitian meningkat bermakna (p=0,016) pasca suplementasi, walaupun masih dalam kategori rendah. Kadar MDA pasca supiementasi mengalami penurunan bermakna(p=O,Ol9)."

"Mengetahui pcngaruh pemberian kombinasi suplementasi vitamin E dan C terhadap peroksidasi lipid pada usila dengan hiperkolesterolemia. Penelitian uji klinis paralel, tertutup timggai, alokasi acak, untuk membandingkan kadar malondialdehida usila 2,60 tahun dengan hiperkolesterolemia yang mendapatkan kombinasi supiementasi vitamin E 400 IU dan vitamin C 500 mg, masing~masing sebutir sehari selama 45 hari dengan kelompok yang mendapat vitamin E 400 IU dan plascbo.Terdapat 42 subyek penelitian yang berasal dari Yayasan Kebagusan, Yayasan Yasni, dan Yayasan Yakin, Pasar Minggu Jakarta Selatan yang dibagi menjadi dua kelompok masing-masing berjumlah 21 orang. Data yang diambil adalah : data dcmograti, antropometzi, data asupan makanan pada minggu pertama, ketiga dan ketujuh, kadar kolesterol LDL dan MDA plasma sebelum dan sesudah perlakuan. Uji statistik yang digunakan adalah uji t-tidak bezpasangan bila distribusi nonnal dan uji Manmwhimey bila distribusi tidak normal dengan tingkat kemaknaan p<0.05. Sebanyak 20 subyek penelitian dad masing-masing kelompok yang dapat mengikuti penelitian sampai sclesai. Sebelum perlakuan, nilai median kadar kolesterol LDL kelompolc vitamin E+plasebo dan vitamin E+C masing- masing adalah I46.50(l30-190) mg/dL dan 146.50(l3I-196) mg/dL. Setelah 45 hari perlakuan, rerata kadar kolesterol LDL kelompok vitamin E4-plasebo (151.9.+:2.2.l mg/dl.) meningkat sedangkan kelompok vitamin B+-C (l46.8i28.21 mg/dL) menurun. Sebelum p¢rIakuan, nilai median kadar MDA plasma kelornpok vitamin E+plasebo dan rerata kadar MDA plasma kelompok vitamin E4-C masing-masing adalah 2.63(l.92-4.42) nmol/ml., dan 3.03:l:0.62 nmol/mL. Setelah 45 haii pcrlakuan rerata kadar MDA plasma kedua keiompok menunm menjadi 2.30i0.67 nmol/mL (p<0.01) pada kelompok vitamin E+plasebo dan 28810.88 nmol/mL (p=0.36) untuk kelompok vitamin E+C. Penurunan kadar MDA plasma kelompok vitamin E+plasebo lcbih besar (-0.5:!:0.55 nmol/mL) daripada kelompok vitamin E+C (-0.28(l.31-1.63) nmol/mL), tetapi dcngan uji statislik terhadap kedua nilai tersebut, tidalc berbeda bcrma!ma(p=0.09). Pembenan kombinasi vitamin E dan vitamin C pada usila dengan hiperkolesternlemia tidak dapat rnenurunkan kadar MDA plasma lcbih besar dibandingl-can dengan hanya pemberian vitamin E.

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This parallel, single blind, randomization clinical trial purpose was to compare plasma malondyaldehydc level in hypercholesterolemic elderly aged more than 60 years old. Forty two people from Yayasan Kebagusan, Yayasan Yasni and Yayasan Yakin, Pasar Minggu, South Jakarta which participated the study, were divided into two groups. Twenty one elderly were supplemented with 400 IU vitamin E and 500 mg vitamin C for 45 consecutive days, while the other group was supplemented with 400 IU vitamin E and placebo. The data of demographic, anthropometric, food intake in the first, third and seventh weeks, plasma LDL and MDA levels before and alter period were taken. Statistical analyzes was performed by SPSS 11.5.

Twenty people for each group had followed the study until the end of period. Before study, LDL cholesterol median for vitamin E + placebo group and vitamin E+C group were 146.50(l30-190) mg/dL and l46.50( 130-190) mg/dL respectively. Alter 45 of days treatment, there was an increase in mean LDL cholesterol in vitamin E + placebo group 15l.9i22.1 mg/dL while in vitamin E+C group was decreased to l46.8:l:28.2l mg/dl Before study, plasma MDA level in vitamin E + placebo group and vitamin E+C group were 2.63(l.92-4.42) and 3.031052 nmol/mL, respectively. After 45 days, mean MDA plasma in vitamin E + placebo group was 2.30i0.67 nmol/mL (p<0.01) and was 2.881088 nmol/ml.. (p=0.36) in vitamin E+C group. The decreased on plasma MDA levels in vitamin E+placebo group was higher (-0,510.55 nmol/mL) than vitamin E+C (-0.28(1.3l-1.63) nmol/mL), but statistical test showed not significant different between both group (p=0.09). Combined supplementation vitamin E and vitamin C in hypercholesterolemic elderly couldnot decrease plasma MDA higher than supplementation of vitamin E alone."

"Mengelahui efek pemberian suplementasi vitamin C dan E terhadap kadarmalondialdehida plasma pada perokok kretek filter selama empat minggu di Jakarta.Penelitian ini merupakan uji klinis paralel, acalg tersamar tunggal antara kelompokyang inendapat suplementasi vitamin C dan E (P) dengan kelompok yang mendapatplasebo (K). Sebanyak 40 orang perokok kretek filterr di rumah makan, Jakarta Utaramemenuhi ln-iteria dan diikutkan dalam penelitian Dilakukan randomisasi blolc untukmenentukan kclompok perlakuan dan kontrol. Kelompok perlakuan mendapatkansuplementasi vitamin C 500 mg dan E 400 IU/hari selama empat minggu, dankclompok kontrol mendapat plasebo. Data yang dikumpulkan meliputi data demograti(usia, konsumsi rokok, indeks Brinkman, tekanan dan lg kadar glukosa darah puasa,kadar kolesterol tétal), IMT, analisis asupan zat gizi, kadar malondialdehida plasma.Analisis data menggunakan uji t tidak berpasangan atau uji Mann Whimsy denganbatas kemaknaan p <0,05.Karakteristik demografi subyek pada awal penelitian meliputi usia, konsumsi rokok,indeks Brinkman, tel-canan damh, Radar glukosa darah puasa, kadar kolesterol total,IMT , analisis asupan zat gizi, kadar malondialdchida plasma antara kelompokperlakuan dan kontrol homogen. Rerata kadar MDA plasma awal pada kelompokperlakuan dan pada kelompok kontrol 1,39i0,19 vs 1,34=b=0,09 nmol/mL. Pada akhirperlakuan, rerata kadar MDA plasma sabesar 1,18=l=0,22 pada kelompok perlakuan dan1,3 1=k0,13 nmol/mL kelompok kontrol, berbeda bermakna (p <0,03‘7).Setelah suplementasi vitamin C 500 mg dan E 400 IU/hari selama empat minggutcrdapat perbedaan bermakna renta kadar MDA plasma antara kedua kelompok.

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AbstractTo investigate the effects of vitamin C and E supplementation on plasmamalondialdehycle in clove cigarettes smokers during four weeks in JakartaThis is a parallel randomized single-blind clinical study between interventionalgroup with vitamin C and E supplementation (P) and control group with hasplacebo (K). Forty clove cigarettes smokers in Rmtaurant, Jakarta had fulfilledthe criteria and recruited in the research. Subjects were allocated by blockrandomization into intervention and control group. Intervention group treatedwith vitamin C 500 mg and vitamin E 400 IU daily for 4 weeks, while controlgroup treated with placebo. Data collection includes demographic characteristic(age, smoking habits, Brinkman index, blood pressure, blood glucose, totalcholesterol), body mass index (BMI), daily nutrient analysis, plasma MDA.Statistical analysis using unpairod t-test or Mann Whitney test with significantlevel at p < 0,05.Demographic characteristic (age, smoking habits, Brinlcman index, bloodpressure, blood glucose, total cholesterol), body mass index (BMI), dailynutrient analysis, plasma MDA between both groups were homogen. Initialplasma MDA in the intervention group. and control were l,39=|=0,l9 vsl,34=l=0,09 nmol/tnL. After intervention plasma MDA were l,l8=k0,22 in theintervention group and 1,3l£),13 nmol/mL in control group (p <0,03'7).After supplementation of vitamin C 500 mg/day and vitamin E 400 IU/dayduring 4 weeks, showed significantly differences average of plasma MDAbetween two groups."

"Penelitian uji klinis paralel, tertutup tunggal, alokasi acak, untuk membandingkan kadar malondialdehida usila 260 tahtm dcngan hiperkolestcrolcmia yang mendapatkan kombinasi suplementasi vitamin E 400 IU dan vitamin C 500 mg, masing-masing sebutir sehari selama 45 hari dengan kelompok yang mendapat vitamin E 400 IU dan plasebo.Terdapat 42 subyek penelitian yang herasal dari Yayasan Kebagusan, Yayasan Yasni, dan Yayasan Yakin, Pasar Minggu Jakarta Selatan yang dibagi menjadi dua kelompok masing-masing benjurnlah 21 orang. Data yang diambil adalah : data demografi, antropometri, data asupan makanan pada minggu pertama, ketiga dan ketujuh, kadar kolesterol LDL dan MDA plasma sebclum dan sesudah perlakuan. Uji statistik yang digunakan adalah uji t-tidak berpasangan bila distribusi normal dan uji Mann-whitney bila distrihusi tidak nom1aI dcngan tingkat kernaknaan p<0.05. Sebanyak 20 subyek penelitian dari masing-masing kelompok yang dapat mengikuti penelitian sampai selesai. Sebeltun perlakuan, nilai median kadar kolesterol LDL kelompok vitamin E+plasebo dan vitamin E4-C masing- masing adalah l46.50(l30-190) mg/dL dan l46.50(l3l-196) mg/dL. Setelah 45 hari perlakuan, rerata kadar kolesterol LDL kelompok vitamin E+plasebo (151.9:l:22.l mg/dl.) meningkat sedangkan kelompok vitamin E+C (l46.8:b28.2l mg/dL) menurun. Sebelum perlakuan, nilai median kadar MDA plasma kelompok vitamin E+plasebo dan rerata kadar MDA plasma kelompok vitamin E-+C masing-musing adalah 2.63(l .92-4.42) nmol/mL dan 3.03=h0.62 nmol/mL. Setelah 45 hari perlakuan rerata kadar MDA plasma kedua kelompok mcnurun menjadi 2.30:h0.67 nmol/mL (p<0.0l) pada kelompok vitamin E+plasebo dan 2.88i:0.88 mnol/mL (p=0.36) untuk kelompok vitamin E+C. Penurunan kadar MDA plasma kelompok vitamin E+plaseb0 lebih besar (-0.5=\=0.55 nmol/mL) daripada kclompok vitamin E+C (-0.28(1.3l-1.63) nmol/mL), tetapi dengan uji statistik terhadap kedua nilai tersebut, tidak berbeda berma.kna(p=0.09). Pemberian kombinasi vitamin E dan vitamin C pada usila dengan hiperkolesterolemia tidak dapat menurunkan kadar MDA plasma lebih besar dibandingkan dcngan hanya pemberian vitamin E. Usia lanjut, hipcrkolcstcrolcmia, vitamin E, vitamin C, malondiaidehida.

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The eH'ect of combined supplementation of vitamin E and C on plasma Malondyaldehyde level elderly with hypercholesterolemic. To know the effect of combined supplementation of vitamin E and C in lipid peroxidation in hypercholesterolemic elderly. This parallel, single blind, randomization clinical trial purpose was to compare plasma malondyaldehyde level in hypercholesterolemic elderly aged more than 60 years old. Forty two people Hom Yayasan Kebagusan, Yayasan Yasni and Yayasan Yakin, Pasar Minggu, South Jakarta which participated the study, were divided into two groups. Twenty one elderly were supplemented with 400 IU vitamin E and 500 mg vitamin C for 45 consecutive days, while the other group was supplemented with 400 IU vitamin E and placebo. The data of demographic, anthropometrics, food intake in the first, third and seventh weeks, plasma LDL and MDA levels before and aller period were taken. Statistical analyzes was perfonned by SPSS 11.5.

Twenty people for each group had followed the study until the end of period. Before study, LDL cholesterol median for vitamin E + placebo group and vitamin E+C group were l46.SO(I30-190) mg/dL and l46.50{l30»l90) mg/dL respectively. After 45 of days treatment, there was an increase in mean LDL cholesterol in vitamin E + placebo group l5l.9:l:22.l mg/dl, while in vitamin E+C group was decreased to l46.8i28.2I mg/dL. Before study, plasma MDA level in vitamin E -I- placebo group and vitamin E+C group were 2.63(l .92-4.42) and 3.03i0.62 nmol/mL, respectively. Alter 45 days, mean MDA plasma in vitamin E + placebo group was 2.30-£0.67 nmol/mL (p<0.0l) and was 2.88:t0.88 nmol/mL (p=0.36) in vitamin E+C group. The decreased on plasma MDA levels in vitamin Er*-placebo group was higher (-0510.55 nmol/mL) than vitamin E+C (-0.28(l.31-1.63) nmol/mL), but statistical test showed not significant different between both group (p=0.09). Combined supplementation vitamin E and vitamin C in hypercholesterolemic elderly eouldnot decrease plasma MDA higher than supplementation of vitamin E alone."

"Tujuan : Mengetahui korelasi antara kadar vitamin C plasma dengan kadar MDA dan monosit pada penderita DM tips 2Tempat : Poliklinik Metabolik dan Endokrin Departemen Ilmu Penyakit Dalam RSUPN Dr. Cipta Mangunkusumo/Fakultas Kedokteran Universitas Indonesia, JakartaMetodologi : Penelitian potong lintang pada 52 orang pasien DM tipe 2. Data yang diambil meliputi data umum dan demografi, lama menderita DM, status gizi, komplikasi, asupan vitamin C dan pemeriksaan laboratorium meliputi kadar vitamin C, MDA plasma, jmlah monosit dan kadar HbAic. Uji korelasi dilakukan dengan mcnggunakan uji Pearson dan Spearman-RankHasil : Subyek terdiri dari 37 prang perempuan dan 15 orang pria, dengan rerata usia 49,88 ± 5,87 tahun. Sebanyak 46,2% subyek berpendidikan rendah, 75% berada di bawah Upah Minimum Propinsi (UMP), median lama menderita DM 48 (1- 228) bulan dan 78,8% telah mengalami komplikasi. Rerata IMT 26,11 + 4,85 kg/m2 dan 69,3% tcrmasnk kategori BB lebih. Sebanyak 40,4% tergolong dalam kelompok dengan asupan vitamin C kurang. Median kadar-vitamin C plasma 21,14 (1,89 - 0,86) pmo11L dan 52% tergolong ke dalam kelompok dengan kadar vitamin C rendah dan defisiensi. Median kadar MDA plasma 0,37 (0,03 - 0,86) [anon dart 90,4% subyek tergolong dalam kelompok dengan MDA normaL Rerata jutnlah monosit 7,13 ± 1,78% dan 75% mempunyai kadar monosit normal. Terdapat korelasi bermakna (p=0,02) antara asupan vitamin C dengan kadar vitamin C plasma, dan antara kadar HbA,c dcngan kadar MDA plasma (p=0,02). Variabel lain yang diteliti tidak mempcrlihatkan korelasi yang bermaknaKesimpulan: Antara kadar vitamin C dengan kadar MDA plasma dan jumlah monosit tidak didapatkan korelasi yang bermakna. Didapatkan korelasi bermakna antara asupan vitamin C dengan kadar vitamin C plasma dan antara kadar HbA1c dengan kadar MDA plasma."