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Rikawati

Pengaruh kombinasi suplementasi vitamin E dan Vitamin C terhadap kadar malondialdehida plasma pada usia lanjut dengan hiperkolesterolemia = The effect of combined supplementation of vitamin E and C on plasma malondyaldehyde level elderly

"Mengetahui pcngaruh pemberian kombinasi suplementasi vitamin E dan C terhadap peroksidasi lipid pada usila dengan hiperkolesterolemia. Penelitian uji klinis paralel, tertutup timggai, alokasi acak, untuk membandingkan kadar malondialdehida usila 2,60 tahun dengan hiperkolesterolemia yang mendapatkan kombinasi supiementasi vitamin E 400 IU dan vitamin C 500 mg, masing~masing sebutir sehari selama 45 hari dengan kelompok yang mendapat vitamin E 400 IU dan plascbo.Terdapat 42 subyek penelitian yang berasal dari Yayasan Kebagusan, Yayasan Yasni, dan Yayasan Yakin, Pasar Minggu Jakarta Selatan yang dibagi menjadi dua kelompok masing-masing berjumlah 21 orang. Data yang diambil adalah : data dcmograti, antropometzi, data asupan makanan pada minggu pertama, ketiga dan ketujuh, kadar kolesterol LDL dan MDA plasma sebelum dan sesudah perlakuan. Uji statistik yang digunakan adalah uji t-tidak bezpasangan bila distribusi nonnal dan uji Manmwhimey bila distribusi tidak normal dengan tingkat kemaknaan p<0.05.

Sebanyak 20 subyek penelitian dad masing-masing kelompok yang dapat mengikuti penelitian sampai sclesai. Sebelum perlakuan, nilai median kadar kolesterol LDL kelompolc vitamin E+plasebo dan vitamin E+C masing- masing adalah I46.50(l30-190) mg/dL dan 146.50(l3I-196) mg/dL. Setelah 45 hari perlakuan, rerata kadar kolesterol LDL kelompok vitamin E4-plasebo (151.9.+:2.2.l mg/dl.) meningkat sedangkan kelompok vitamin B+-C (l46.8i28.21 mg/dL) menurun. Sebelum p¢rIakuan, nilai median kadar MDA plasma kelornpok vitamin E+plasebo dan rerata kadar MDA plasma kelompok vitamin E4-C masing-masing adalah 2.63(l.92-4.42) nmol/ml., dan 3.03:l:0.62 nmol/mL. Setelah 45 haii pcrlakuan rerata kadar MDA plasma kedua keiompok menunm menjadi 2.30i0.67 nmol/mL (p<0.01) pada kelompok vitamin E+plasebo dan 28810.88 nmol/mL (p=0.36) untuk kelompok vitamin E+C. Penurunan kadar MDA plasma kelompok vitamin E+plasebo lcbih besar (-0.5:!:0.55 nmol/mL) daripada kelompok vitamin E+C (-0.28(l.31-1.63) nmol/mL), tetapi dcngan uji statislik terhadap kedua nilai tersebut, tidalc berbeda bcrma!ma(p=0.09). Pembenan kombinasi vitamin E dan vitamin C pada usila dengan hiperkolesternlemia tidak dapat rnenurunkan kadar MDA plasma lcbih besar dibandingl-can dengan hanya pemberian vitamin E.

This parallel, single blind, randomization clinical trial purpose was to compare plasma malondyaldehydc level in hypercholesterolemic elderly aged more than 60 years old. Forty two people from Yayasan Kebagusan, Yayasan Yasni and Yayasan Yakin, Pasar Minggu, South Jakarta which participated the study, were divided into two groups. Twenty one elderly were supplemented with 400 IU vitamin E and 500 mg vitamin C for 45 consecutive days, while the other group was supplemented with 400 IU vitamin E and placebo. The data of demographic, anthropometric, food intake in the first, third and seventh weeks, plasma LDL and MDA levels before and alter period were taken. Statistical analyzes was performed by SPSS 11.5.
Twenty people for each group had followed the study until the end of period. Before study, LDL cholesterol median for vitamin E + placebo group and vitamin E+C group were 146.50(l30-190) mg/dL and l46.50( 130-190) mg/dL respectively. Alter 45 of days treatment, there was an increase in mean LDL cholesterol in vitamin E + placebo group 15l.9i22.1 mg/dL while in vitamin E+C group was decreased to l46.8:l:28.2l mg/dl Before study, plasma MDA level in vitamin E + placebo group and vitamin E+C group were 2.63(l.92-4.42) and 3.031052 nmol/mL, respectively. After 45 days, mean MDA plasma in vitamin E + placebo group was 2.30i0.67 nmol/mL (p<0.01) and was 2.881088 nmol/ml.. (p=0.36) in vitamin E+C group. The decreased on plasma MDA levels in vitamin E+placebo group was higher (-0,510.55 nmol/mL) than vitamin E+C (-0.28(1.3l-1.63) nmol/mL), but statistical test showed not significant different between both group (p=0.09). Combined supplementation vitamin E and vitamin C in hypercholesterolemic elderly couldnot decrease plasma MDA higher than supplementation of vitamin E alone."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2010

T32064

UI - Tesis Open Universitas Indonesia Library

Mellya Seswita

Kadar homosistein pada perempuan usia lanjut dan hubungannya dengan asupan folat = Association of folate intake and homocysteine level in elderly women

"Homosistein merupakan asam amino kelompok sulfhidril dari hasil metabolisme metionin. Faktor-faktor seperti, penuaan, defisiensi asam folat, vitamin B6 dan B12, dapat meningkatkan kadar homosistein. Telah dilakukan penelitian dengan desain studi potong lintang yang bertujuan mengetahui hubungan antara asupan folat dengan kadar homosistein pada usila perempuan. Pengumpulan data dilakukan selama bulan Desember 2012 sampai Januari 2013 di Pusaka 12 (Tomang) dan Pusaka 39 (Senen). Pengambilan subyek dilakukan dengan cara cluster random sampling, dan didapatkan 55 orang subyek yang memenuhi kriteria penelitian. Data dikumpulkan melalui wawancara meliputi usia, tingkat pendidikan, penghasilan, food frequency questionnaire (FFQ) semikuantitatif untuk menilai asupan folat, vitamin B6 dan B12.

Pengukuran antropometri yaitu berat badan (BB) dan tinggi lutut (TL) untuk menilai status gizi berdasarkan indeks massa tubuh (IMT) serta pemeriksaan laboratorium meliputi kadar homosistein. Didapatkan rerata usia 69,2±6,3 tahun. Malnutrisi terdapat pada 78,2 % subyek. Sebagian besar subyek penelitian, memiliki asupan folat, vitamin B6 dan B12 yang kurang dari angka kecukupan gizi (AKG), yaitu masing-masing 92,7%, 87,3% dan 80%. Median asupan folat berbahan kedelai 17,9(0,75–151,2)%. Median kadar homosistein 13,95(7.92–29,21)μmol/L. Hiperhomosisteinemia ringan dan sedang didapatkan sebanyak 23,6% dan 3,6%. Pada penelitian ini tidak didapatkan hubungan bermakna antara asupan folat, vitamin B6 dan vitamin B12 dengan kadar homosistein (p=0,702, p=0,624, dan p=0,658).

Homocysteine is an amino acid sulfhydryl group from the metabolism of methionine. Homocysteine levels influenced by various factors, ie aging, deficiency of folic acid, vitamin B6 and B12, can raise homocysteine level. The aim of the cross sectional study was to determine the relationship between intake of folate with homocysteine levels in elderly women. Data collection was conducted during December 2012 to January 2013 at the Pusaka 12 (Tomang) and Pusaka 39 (Senen). Subjects were obtained using cluster random sampling, and 55 subjects who met the study criteria were recruited. Data were collected through interviews include age, education level, income, and semiquantitative food frequency questionnaire (FFQ) to assess intake of folate, vitamin B6 and B12.
Anthropometric measurements of the body weight (BW) and high-knee (TL) to assess the nutritional status based on body mass index (BMI) as well as laboratory examinations include homocysteine levels. This study obtained a mean age of 69.2 ± 6.3 years. Malnutrition was occurred in 78.2% of subjects. Majority of the subjects had intakes of folate, vitamin B6 and B12 were less than the nutritional adequacy rate (RDA), which is respectively 92.7%, 87.3% and 80%. Median folate intake from soybeans 17.9 (0.75 to 151.2)%. Median levels of homocysteine 13.95 (7.92-29,21) μmol/L. Mild hyperhomocysteinemia and intermediate hyperhomocysteine were obtained as 23.6% and 3.6%. No significant association was found between intake of folate, vitamin B6 and vitamin B12 with homocysteine levels (p = 0.702, p = 0.624, and p = 0.658)."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013

T-Pdf

UI - Tesis Membership Universitas Indonesia Library

Emilia Slamat

Pengaruh Suplementasi Oral Vitamin C dan E terhadap Kadar Malondialdehida Plasma Perokok Kretek Filter di Jakarta = Effects of Vitamin C and E Suplementation on Plasma Malondialdehyde in Clove Cigarettes Smokers in Jakarta

"Mengelahui efek pemberian suplementasi vitamin C dan E terhadap kadar

malondialdehida plasma pada perokok kretek filter selama empat minggu di Jakarta.

Penelitian ini merupakan uji klinis paralel, acalg tersamar tunggal antara kelompok

yang inendapat suplementasi vitamin C dan E (P) dengan kelompok yang mendapat

plasebo (K). Sebanyak 40 orang perokok kretek filterr di rumah makan, Jakarta Utara

memenuhi ln-iteria dan diikutkan dalam penelitian Dilakukan randomisasi blolc untuk

menentukan kclompok perlakuan dan kontrol. Kelompok perlakuan mendapatkan

suplementasi vitamin C 500 mg dan E 400 IU/hari selama empat minggu, dan

kclompok kontrol mendapat plasebo. Data yang dikumpulkan meliputi data demograti

(usia, konsumsi rokok, indeks Brinkman, tekanan dan lg kadar glukosa darah puasa,

kadar kolesterol tétal), IMT, analisis asupan zat gizi, kadar malondialdehida plasma.

Analisis data menggunakan uji t tidak berpasangan atau uji Mann Whimsy dengan

batas kemaknaan p <0,05.

Karakteristik demografi subyek pada awal penelitian meliputi usia, konsumsi rokok,

indeks Brinkman, tel-canan damh, Radar glukosa darah puasa, kadar kolesterol total,

IMT , analisis asupan zat gizi, kadar malondialdchida plasma antara kelompok

perlakuan dan kontrol homogen. Rerata kadar MDA plasma awal pada kelompok

perlakuan dan pada kelompok kontrol 1,39i0,19 vs 1,34=b=0,09 nmol/mL. Pada akhir

perlakuan, rerata kadar MDA plasma sabesar 1,18=l=0,22 pada kelompok perlakuan dan

1,3 1=k0,13 nmol/mL kelompok kontrol, berbeda bermakna (p <0,03‘7).

Setelah suplementasi vitamin C 500 mg dan E 400 IU/hari selama empat minggu

tcrdapat perbedaan bermakna renta kadar MDA plasma antara kedua kelompok.

Abstract

To investigate the effects of vitamin C and E supplementation on plasma

malondialdehycle in clove cigarettes smokers during four weeks in Jakarta

This is a parallel randomized single-blind clinical study between interventional

group with vitamin C and E supplementation (P) and control group with has

placebo (K). Forty clove cigarettes smokers in Rmtaurant, Jakarta had fulfilled

the criteria and recruited in the research. Subjects were allocated by block

randomization into intervention and control group. Intervention group treated

with vitamin C 500 mg and vitamin E 400 IU daily for 4 weeks, while control

group treated with placebo. Data collection includes demographic characteristic

(age, smoking habits, Brinkman index, blood pressure, blood glucose, total

cholesterol), body mass index (BMI), daily nutrient analysis, plasma MDA.

Statistical analysis using unpairod t-test or Mann Whitney test with significant

level at p < 0,05.

Demographic characteristic (age, smoking habits, Brinlcman index, blood

pressure, blood glucose, total cholesterol), body mass index (BMI), daily

nutrient analysis, plasma MDA between both groups were homogen. Initial

plasma MDA in the intervention group. and control were l,39=|=0,l9 vs

l,34=l=0,09 nmol/tnL. After intervention plasma MDA were l,l8=k0,22 in the

intervention group and 1,3l£),13 nmol/mL in control group (p <0,03'7).

After supplementation of vitamin C 500 mg/day and vitamin E 400 IU/day

during 4 weeks, showed significantly differences average of plasma MDA

between two groups."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2010

T31625

UI - Tesis Open Universitas Indonesia Library

Moore, Thomas

Vitamin A/Thomas Moore

New York : Elsevier, 1957

615.328 MOO v

Buku Teks Universitas Indonesia Library

Eka Surya Septiawan

Pengaruh Pemberian Asupan Multivitamin B1, B6, Dan B12 Terhadap Kejadian Kelelahan Kerja = Effect of Multivitamins B1, B6, And B12 Intake on The Incidence of Worker Fatigue

"Latar belakang: Kelelahan yang muncul akibat aktivitas kerja dapat menyebabkan morbiditas dan mortalitas di kalangan pekerja di dunia. Hal ini mempengaruhi kinerja fisik dan mental selama jam kerja, yang muncul dalam berbagai tanda dan gejala. Vitamin B1, B6, dan B12 menjadi salah satu pendekatan farmakologis untuk mengatasi masalah kelelahan. Namun, hanya sedikit penelitian yang menjelaskan mengenai efek dari konsumsi multivitamin ini bagi orang dengan intensitas kerja yang tinggi. Oleh karena itu, penelitian ini dilakukan untuk mengeksplorasi pengaruh multivitamin B1, B6, dan B12 terhadap kelelahan pada pekerja.

Metode: Penelitian ini merupakan penelitian berbasis bukti dengan menggunakan artikel penelitian terkait dari lima database terkemuka. Artikel penyaringan artikel dilakukan dengan menghilangkan judul dan abstrak yang tidak relevan, memilih artikel dengan bahasa Inggris dan bahasa Indonesia, menggunakan metode Randomized Control Trial, Systematic Review, serta menjelaskan tentang kelelahan. Artikel dengan data yang tidak lengkap dan eksperimen non-manusia dikeluarkan dari penelitian. Semua artikel yang diperoleh dianalisis lebih lanjut dengan menggunakan pedoman dari Centre for Evidence-Based Medicine Universitas Oxford.

Hasil: Didapatkan tiga studi yang valid dan relevan dengan metode Randomized Control Trial (RCT), studi pertama oleh Clarissa et. al. dengan 24 sampel didapatkan adanya pengaruh pemberian asupan vitamin B1, B6 dan B12 terhadap terjadinya kelelahan otot pada fase anaerob dengan nilai RRR 36% dan ARR 29,17% (p = 0.035). Studi kedua oleh Dodd et. al. dengan 82 sampel didapatkan pemberian multivitamin B1, B6 dan B12 meningkatkan oksidasi karbohidrat untuk energi saat latihan (p = 0.0001 untuk kelelahan mental, p = 0.029 untuk kelelahan fisik) dengan nilai RRR 29% untuk kelelahan mental, 17% untuk kelelahan fisik, dan didapatkan nilai ARR 10% untuk kelelahan mental, 10% untuk kelelahan fisik. Sedangkan studi ketiga oleh Ferorelli et. al didapatkan terjadi penurunan gejala kelelahan yang signifikan pada 50 sampel yang diberikan vitamin B1, B6 dan B12 (p < 0.00001) dengan nilai RRR 34% dan nilai ARR 34%.

Kesimpulan: Ketiga artikel menunjukkan hasil positif mengenai pemberian multivitamin B1, B6, dan B12 dalam mengurangi kelelahan. Namun, studi terkait pemberian vitamin B dengan kelelahan masih sangat terbatas, dan jumlah sampel yang kecil dalam studi yang ada maka pemberian vitamin B1, B6 dan B12 belum direkomendasikan sebagai terapi adjuvant untuk menurunkan kelelahan pada pekerja. Tatalaksana okupasi lebih diutamakan dalam penanganan pekerja dengan kelelahan.

Background. Fatigue emergence due to working activity could lead morbidity and mortality among workers in the world. It affected to the physical and mental performance during working hours, which appeared in various sign and symptoms. Vitamin B1, B6, and B12 were being a pharmacological approach to address fatigue problem. However, only few studies explained regarding the effects of these multivitamin consumption for people with high intensities of working. Therefore, this study was carried out to explore the effect of multivitamin B1, B6, and B12 intake on the incidence of fatigue among workers.
Methods. This study was an evidence-based report using related research articles from five reputable databases. The article screening has employed by eliminating irrelevant title and abstract, selected articles with English and Bahasa Indonesia, used randomized Control Trial, Systematic Review, and explaining fatigue. Articles with incomplete data and non-human experiments were excluded from study. All obtained articles were analysed further using guideline from the Centre for Evidence-Based Medicine, University of Oxford.
Results. Three valid and relevant studies were obtained with the Randomised Control Trial (RCT) method, the first study by Clarissa et. al. with 24 samples found the effect of vitamin B1, B6 and B12 intake on the occurrence of muscle fatigue in the anaerobic phase with an RRR value of 36% and ARR 29.17% (p = 0.035). The second study by Dodd et. al. with 82 samples found that giving multivitamins B1, B6 and B12 increased carbohydrate oxidation for energy during exercise (p = 0.0001 for mental fatigue, p = 0.029 for physical fatigue) with an RRR value of 29% for mental fatigue, 17% for physical fatigue, and obtained an ARR value of 10% for mental fatigue, 10% for physical fatigue. While the third study by Ferorelli et. al found a significant reduction in fatigue symptoms in 50 samples given vitamins B1, B6 and B12 (p < 0.00001) with an RRR value of 34% and an ARR value of 34%.
Conclusion. The three articles showed positive results regarding multivitamins B1, B6, and B12 intake in reducing fatigue. However, studies related to the administration of vitamin B with fatigue are still very limited, and the sample size is small in the existing studies, so the vitamins B1, B6 and B12 intake has not been recommended as adjuvant therapy to reduce fatigue in workers. Occupational management takes priority in handling workers with fatigue."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024

SP-pdf

UI - Tugas Akhir Universitas Indonesia Library

Eka Surya Septiawan

Pengaruh Pemberian Asupan Multivitamin B1, B6, Dan B12 Terhadap Kejadian Kelelahan Kerja = Effect of Multivitamins B1, B6, And B12 Intake on The Incidence of Worker Fatigue

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024

SP-pdf

UI - Tugas Akhir Universitas Indonesia Library

Rikawati

Pengaruh kombinasi suplementasi vitamin E dan C terhadap kadar malondial dehida plasma pada usia lanjut dengan hiperkolesterolemia

"Penelitian uji klinis paralel, tertutup tunggal, alokasi acak, untuk membandingkan kadar malondialdehida usila 260 tahtm dcngan hiperkolestcrolcmia yang mendapatkan kombinasi suplementasi vitamin E 400 IU dan vitamin C 500 mg, masing-masing sebutir sehari selama 45 hari dengan kelompok yang mendapat vitamin E 400 IU dan plasebo.Terdapat 42 subyek penelitian yang herasal dari Yayasan Kebagusan, Yayasan Yasni, dan Yayasan Yakin, Pasar Minggu Jakarta Selatan yang dibagi menjadi dua kelompok masing-masing benjurnlah 21 orang. Data yang diambil adalah : data demografi, antropometri, data asupan makanan pada minggu pertama, ketiga dan ketujuh, kadar kolesterol LDL dan MDA plasma sebclum dan sesudah perlakuan. Uji statistik yang digunakan adalah uji t-tidak berpasangan bila distribusi normal dan uji Mann-whitney bila distrihusi tidak nom1aI dcngan tingkat kernaknaan p<0.05.

Sebanyak 20 subyek penelitian dari masing-masing kelompok yang dapat mengikuti penelitian sampai selesai. Sebeltun perlakuan, nilai median kadar kolesterol LDL kelompok vitamin E+plasebo dan vitamin E4-C masing- masing adalah l46.50(l30-190) mg/dL dan l46.50(l3l-196) mg/dL. Setelah 45 hari perlakuan, rerata kadar kolesterol LDL kelompok vitamin E+plasebo (151.9:l:22.l mg/dl.) meningkat sedangkan kelompok vitamin E+C (l46.8:b28.2l mg/dL) menurun. Sebelum perlakuan, nilai median kadar MDA plasma kelompok vitamin E+plasebo dan rerata kadar MDA plasma kelompok vitamin E-+C masing-musing adalah 2.63(l .92-4.42) nmol/mL dan 3.03=h0.62 nmol/mL. Setelah 45 hari perlakuan rerata kadar MDA plasma kedua kelompok mcnurun menjadi 2.30:h0.67 nmol/mL (p<0.0l) pada kelompok vitamin E+plasebo dan 2.88i:0.88 mnol/mL (p=0.36) untuk kelompok vitamin E+C. Penurunan kadar MDA plasma kelompok vitamin E+plaseb0 lebih besar (-0.5=\=0.55 nmol/mL) daripada kclompok vitamin E+C (-0.28(1.3l-1.63) nmol/mL), tetapi dengan uji statistik terhadap kedua nilai tersebut, tidak berbeda berma.kna(p=0.09). Pemberian kombinasi vitamin E dan vitamin C pada usila dengan hiperkolesterolemia tidak dapat menurunkan kadar MDA plasma lebih besar dibandingkan dcngan hanya pemberian vitamin E. Usia lanjut, hipcrkolcstcrolcmia, vitamin E, vitamin C, malondiaidehida.

The eH'ect of combined supplementation of vitamin E and C on plasma Malondyaldehyde level elderly with hypercholesterolemic. To know the effect of combined supplementation of vitamin E and C in lipid peroxidation in hypercholesterolemic elderly. This parallel, single blind, randomization clinical trial purpose was to compare plasma malondyaldehyde level in hypercholesterolemic elderly aged more than 60 years old. Forty two people Hom Yayasan Kebagusan, Yayasan Yasni and Yayasan Yakin, Pasar Minggu, South Jakarta which participated the study, were divided into two groups. Twenty one elderly were supplemented with 400 IU vitamin E and 500 mg vitamin C for 45 consecutive days, while the other group was supplemented with 400 IU vitamin E and placebo. The data of demographic, anthropometrics, food intake in the first, third and seventh weeks, plasma LDL and MDA levels before and aller period were taken. Statistical analyzes was perfonned by SPSS 11.5.
Twenty people for each group had followed the study until the end of period. Before study, LDL cholesterol median for vitamin E + placebo group and vitamin E+C group were l46.SO(I30-190) mg/dL and l46.50{l30»l90) mg/dL respectively. After 45 of days treatment, there was an increase in mean LDL cholesterol in vitamin E + placebo group l5l.9:l:22.l mg/dl, while in vitamin E+C group was decreased to l46.8i28.2I mg/dL. Before study, plasma MDA level in vitamin E -I- placebo group and vitamin E+C group were 2.63(l .92-4.42) and 3.03i0.62 nmol/mL, respectively. Alter 45 days, mean MDA plasma in vitamin E + placebo group was 2.30-£0.67 nmol/mL (p<0.0l) and was 2.88:t0.88 nmol/mL (p=0.36) in vitamin E+C group. The decreased on plasma MDA levels in vitamin Er*-placebo group was higher (-0510.55 nmol/mL) than vitamin E+C (-0.28(l.31-1.63) nmol/mL), but statistical test showed not significant different between both group (p=0.09). Combined supplementation vitamin E and vitamin C in hypercholesterolemic elderly eouldnot decrease plasma MDA higher than supplementation of vitamin E alone."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2010

T33930

UI - Tesis Open Universitas Indonesia Library

Agnes Riyanti Inge Permadhi

Pengaruh suplementasi vitamin B6, B12 dan asam folat terhadap kadar homosistein plasma pada lansia

"Tujuan : Mengetahui pengaruh suplementasi vitamin B6, B12 dan asam folat terhadap kadar homosistein plasma pada lansia dalam rangka mengurangi risiko terjadinya aterosklerosis.

Tempat : Panti werdha Santa Anna - Jakarta.

Bahan dan cara : penelitian eksperimental pra dan pasca suplementasi vitamin B6 (10 mg), B12 (400 µg) dan asam folat (1 mg) yang diberikan per oral, sekali sehari selama 6 minggu, terhadap 10 subyek lansia (60 tahun) yang telah memenuhi kriteria penerimaan dan penolakan. Data yang dikumpulkan meliputi data non nutrisi, data nutrisi, data antropametri, status vitamin B6, kadar vitamin B12 serum dan asam folat serum dan kadar homosistein plasma.

Hasil : Pada pra suplementasi, diketahui prevalensi subyek dengan hiperhomosisteinemia tipe ringan sebesar 70%. Prevalensi defisiensi vitamin B6 (KA ASATE>I,40), 812 (<258 pmol/L) dan asam folat (<15 nmo/L) adalah 30%,30% dan 90%. Prevalensi defisiensi vitamin B6, B12 dan asam folat pada subyek dengan hiperhomosisteinemia adalah 14%, 43% dan 85%. Pada pasca suplementasi didapatkan perbaikan pada seluruh hasil pemeriksaan laboratorium secara bermakna (p<0,05) yaitu penurunan KA ASATE 11,68%, kenaikan kadar vitamin B12 serum 111,75%, kenaikan kadar asam folat serum 139,05% dan penurunan kadar homosistein plasma 36,68%.

Kesimpulan : Suplementasi vitamin B6, B12 dan asam folat terbukti secara efektif dan elision dapat memperbaiki status vitamin dan menurunkan kadar homosistein plasma secara bermakna pada seluruh subyek penelitian.

Objective : To identify the effect of vitamin B6, B12 and folate supplementation to plasma homocysteine concentration of elderly people in respect of minimizing atherosclerosis risks.

Place :Panri werdha Santa Anna - Jakarta.

Materials and Methods :Experimental study of pre and post oral supplementation of vitamin B6 (10 mg), B12 (400 }1g) and folate (1 mg), once a day for 6 weeks continuously applied to 10 elderly subjects NO years) passing through pre-defined inclusion criteria. Relevant information and data was collected through questionnaire, field observation and laboratory measurement which comprise of ages, sex, education, anthropometrics, dietary intake, food frequency amount, food habits, vitamin B6, B12 and folate status and finally plasma homocysteine concentration.

Results :During pre-supplementation, 70% of subjects was classified as moderate hyperhomocysteinemia. Cut off points to define deficiency vitamin status are erytrocyte aspartate aminotransferase activity coefficient (EAST-AC) >1,40 for vitamin B6 , serum vitamin B12 and folate concentrations were <258 pmol/L and <15 nmol/L respectively. The overall prevalence of deficiencies vitamin B6, B12 and folate status were 30%, 30% and 90% respectively. The prevalence of deficiencies vitamin B6, B12 and folate status in hyperhomocysteinemia subjects were 14%, 43% and 85% respectively. During post supplementation, no more vitamins deficiencies subjects was detected. Post supplementation laboratory measurement indicate the following significant improvement (p<0,05) on EAST-AC reduction 11,68%, serum vitamin B12 concentration improvement to 111,75%, serum folate concentration improvement to 139,05% and reduction of plasma homocysteine concentration of 36,68%.

Conclusion :Supplementation of vitamin B6, B12 and folate are effectively and significantly improve both vitamin status and plasma homocysteine concentration level of all subjects."

Depok: Universitas Indonesia, 1999

T-Pdf

UI - Tesis Membership Universitas Indonesia Library

Marya Warascesaria Haryono

Pengaruh suplementasi vitamin C dan E terhadap kadar GSH plasma pada kasus luka bakar sedang berat = The effect of vitamin c and e supplementation on level of plasma GSH of moderate and severe burn

"Tujuan penelitian ini adalah menilai kadar GSH plasma setelah suplementasi vitamin C 1000 mg intravena dan 400 mg vitamin E secara oral selama empat hari berturut-turut pada luka bakar sedang berat. Penelitian eksperimen ini dengan satu kelompok pre-post test dengan usia 18-59% tahun pada kasus luka bakar sedang berat kurang dari 60%. Dari 16 kasus yang memenuhi kriteria, diperoleh 12 kasus sehagai subjek penelitian sesuai dengan sampel yang diharapkan. Penyebab luka bakar terbanyak adalah api (75%) dan sebagian besar subyek menriliki BMI nonnal (67%) dengan rata-rata 22,04 ± 1,89 kglm2 ? Kadar vitamin C sebelurn suplementasi adalah 17,79(10,16-32,88)p.mol/L dan sesudah suplementasi adalah 18,33(9,10-37,02) p.mol/ L (p = 0,239), Nilai rata-rata serum kadar vitamin E meningkat signifikan, yaitu 9,06 ± 1,56 p.mol I L sebelurn suplementasi dan 15,50 (6,28-27,17) p.mol/L setelah suplementasi (p = 0,019). Nilai rata-rata dan kisaran kadar GSH plasma sebelum suplementasi adalah 0,54±0,11 Jlll I mL, Nilai rata-rata tingkat GSH setelah suplemen adalah l ,07 (0,94-1,68) g /mL.lni menunjukkan bahwa suplementasi vitamin C dan vitamin E bisa meningkatkan kadar GSH secara signifikan (p = 0,002). Terdapat perbedaan yang signifikan pada perubahan kadar vitamin C, vitamin E, dan GSH sebelum dan sesudah perlakuan antara luka bakar sedang dan luka bakar berat.

The aimed of the study is to assess the levels of GSH after supplementation of vitamin C 1000 mg iv and 400 mg vitamin E orally for four consecutive days on a moderate to severe bums. This experimental studies with one group pre-post test involved 18-590/o years aged patients with moderate to severe burns less than 60%, From 16 cases required the criteria, there were 12 cases as the subject of research in accordance with the expected sample. The most causes of burns is fire (75%) and most of subjects have a nominal BMl (67%) with average 22.04 ± 1.89 kg /m2 ? Median value of vitamin C levels before supplementation was 17.79(10.16-32.88) and after supplementation was 18.33(9.10-37.02) ~mol/L (lr= 0.239). Average value of serum vitantin E levels increased significantly, which are 9.06 ± 1.56 mol/L befure supplementation and 15.50(6.28-27.17) mol/L after supplementation (p= 0.019). Median value and range of plasma GSH levels before supplementation was 0.54±0.11 ;tg/mL. Median value of GSH levels after supplementation was 1.07 (0.94-1.68) flgimL. This is show that the supplementation of vitamin C and vitamin E may increased GSH levels significantly (p = 0.002). There were no significant differences in changes in levels of vitamin C, vitamin E, and GSH before and after treatment among the study subjects with moderate and severe burns."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2009

T32848

UI - Tesis Open Universitas Indonesia Library

Yusi Deviana Nawawi

Korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di panti wreda = Correlation between vitamin D serum levels with physical performance among elderly individuals in nursing homes

"Usia lanjut berisiko tinggi mengalami defisiensi vitamin D, sedangkan vitamin D memiliki efek protektif terhadap massa otot. Penurunan massa otot dan fungsinya disebut dengan sarkopenia. Prevalensi sarkopenia sangat tinggi pada usia lanjut yang tinggal di panti wreda, kondisi ini disebabkan gaya hidup sedentari pada penghuni panti wreda. Deteksi dini sarkopenia dapat dilakukan dengan mengukur fungsi otot, salah satunya adalah mengukur performa fisik dengan tes short physical performance battery (SPPB). Penelitian potong lintang ini bertujuan untuk melihat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di lima panti wreda yang terdaftar di Kota Tangerang Selatan. Pengambilan subjek dilakukan dengan cara proportional random sampling, didapatkan 100 usila yang memenuhi kriteria penelitian. Pemeriksaan kadar vitamin D menggunakan kadar kalsidiol serum dengan metode chemiluminescence immunoassay (CLIA). Pemeriksaan massa otot menggunakan bioelectric impedance analysis Tanita SC-330. Analisis korelasi menggunakan uji nonparametrik. Didapatkan nilai tengah usia subjek adalah 74,89 tahun dan 72% subjek adalah perempuan. Terdapat 85% subjek memiliki asupan vitamin D yang kurang dan 94% subjek memiliki skor pajanan sinar matahari yang rendah, serta seluruh subjek masih memiliki massa otot yang normal. Nilai tengah kadar vitamin D serum adalah 15,50(4-32) ng/mL, dengan 72% subjek mengalami defisiensi vitamin D. Nilai tengah performa fisik adalah 9(3-12) dan sebanyak 47% subjek mengalami performa fisik yang buruk. Hasil penelitian ini menunjukkan bahwa tidak terdapat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di panti wreda (r=0,130; p=0,196).

Elderly individuals have a risk of vitamin D deficiency, whereas vitamin D has a protective effect on muscle mass. Decrease in muscle mass and function is called sarcopenia. The prevalence of sarcopenia is very high in the elderly who live in nursing homes, this condition is due to the sedentary lifestyle. Early detection of sarcopenia can be done by measuring physical performance with short physical performance battery (SPPB) test. This cross-sectional study aimed to explore the correlation between vitamin D serum levels with physical performance among elderly individuals in five nursing homes registered in South Tangerang. A hundred subjects who fulfilled study criteria gathered using proportional random sampling method. Examination of vitamin D levels using calcidiol serum with the chemiluminescence immunoassay (CLIA) method. Muscle mass was measured using bioelectric impedance analysis Tanita type SC-330. Nonparametric correlation was used for correlation analysis. Median age of subjects was 74.89 years old and 72% were female. Eighty-five percent of subjects had low vitamin D intake, 94% of subjects had low sun exposure score, and all subjects had normal muscle mass. Mean level of vitamin D serum was 15.50 (4-32) ng/mL, with 72% of subjects had vitamin D deficiency. Mean score of physical performance was 9(3-12) and 47% of subjects had low physical performance. This study showed that there was no correlation found between vitamin D serum levels with physical performance among elderly individuals in nursing homes (r=0.130; p=0.196)."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019

T58914

UI - Tesis Membership Universitas Indonesia Library

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