Hasil Pencarian  ::  Simpan CSV :: Kembali

"Pragelatinisasi pati singkong ftalat (PPSFt) merupakan salah satu hasil modifikasi pati singkong. Modifikasi pati dilakukan untuk meningkatkan sifat fungsional eksipien. Pada penelitian ini, telah dibuat dan dikarakterisasi PPSFt dari pati singkong. Proses modifikasi pati singkong dimulai dengan gelatinisasi sempurna dan esterifikasi dengan asam ftalat anhidrida. PPSFt yang dihasilkan dikarakterisasi sifat fisik, kimia, dan fungsionalnya. Kemudian, PPSFt diformulasikan sebagai polimer pembentuk matriks dalam tablet lepas lambat dengan ketoprofen sebagai model obat. Tablet lepas lambat dibuat dengan metode granulasi basah. Tablet lepas lambat dievaluasi dan dipelajari profil pelepasan obatnya. Hasil penelitian menunjukkan derajat substitusi PPSFt sebesar 0,0541, lebih larut dalam medium basa, memiliki kemampuan mengembang yang baik, dan kekuatan gel yang tinggi yaitu 31,90 gf. Seluruh tablet lepas lambat yang diformulasikan memenuhi evaluasi keseragaman ukuran, keseragaman bobot, kekerasan, dan keregasan tablet. Profil pelepasan ketoprofen dari tablet lepas lambat yang mengandung PPSFt sebagai pembentuk matriks (F1, F2, dan F3) memenuhi persyaratan sediaan enterik, yaitu hanya melepaskan 3-4 % ketoprofen dalam medium asam. Dalam medium basa, ketiga formula menunjukkan profil pelepasan obat lepas lambat, yaitu profil pelepasan obat orde nol. Oleh karena itu, formula tablet lepas lambat dapat digunakan sebagai sediaan lepas lambat untuk pemakaian 16 jam (F1 dan F2) dan 32 jam (F3).

---

PCSPh is one of modified cassava starch. Starch modification were to improve the functional properties of excipient. In this study, PCSPh was prepared from cassava starch and then characterized. Cassava starch was carried out by gelatinization and esterification using phthalic anhydride acid. PCSPh properties were characterized physically, chemically, and functionally. PCSPh was formulated in sustained release tablet as matrix with ketoprofen as a model drug. Furthermore, sustained release tablet was prepared by wet granulation method. Drug release profile of sustained release tablet were evaluated and studied.

As results, the degree of substitution PCSPh in aqueous medium was 0.0541, more soluble in alkaline medium, have good Swelling index, and the gel strength in akuadest was 31.90 gf. All sustained release tablet were formulated have uniform size, uniform weight, good hardness and good friability. In addition, drug release of sustained release tablet used PPSPh as matrix (F1, F2, F3) was release 3-4% in HCl solution (pH 1,2). In phosphate solution, the third formula were follow zero order kinetics. This study suggested that tablet could be applied as enteric sustained release tablet and could retard drug release up to 16 hours (F1, F2) and 32 hours (F3) in phosphate solution (pH 7,4)."

"Plastik merupakan bahan yang banyak digunakan dalam peralatan keseharaian. Penambahan zat tertentu pada alat berbahan plastik ini diketahui dapat menambah kualitas, yaitu lebih elastis, kuat dan tahan lama. Salah satu bahan aditif yang biasa digunakan yaitu ftalat. Senyawa ftalat dapat berpotensi menghasilkan terjadinya DNA adduct. Penelitian ini mempelajari mengenai pembentukan 8-OHdG akibat paparan senyawa ftalat dan logam Cu (II) secara in vitro dan in vivo pada tikus (Rattus novergicus). Pembentukan 8-OHdG dianalisa secara in vitro dengan menggunakan HPLC, dengan variasi pH, waktu inkubasi dan perbandingan konsentrasi. Sedangkan secara in vivo pada tikus, sampel darah dianalisa menggunakan ELISA Kit dan sampel urin menggunakan instrumen LC-MS/MS. Secara umum, konsentrasi 8-OHdG paling besar pada sampel 2-dG diinkubasi dengan kombinasi larutan H₂O₂, ftalat, dan Cu (II). Pada studi in vitro dengan variasi pH menunjukkan konsentrasi 8-OHdG yang lebih tinggi pada pH 7,4; pada variasi waktu inkubasi lebih besar kosentrasi 8-OHdG pada 32 jam; dan pada variasi konsentrasi lebih besar pada perbandingan 1:20. Hasil studi in vivo menggunakan ELISA Kit, konsentrasi 8-OHdG yang terbentuk menunjukkan nilai paling besar pada sampel darah kelompok tikus terpapar ftalat kombinasi Cu (II) yaitu 5,26 ppb; kelompok tikus terpapar ftalat sebesar 4,29 ppb; dan kelompok tikus kontrol (tanpa paparan) sebesar 2,58 ppb. Sedangkan uji in vivo menggunakan LC-MS/MS pada sampel urin tikus juga menunjukkan konsentrasi 8-OHdG paling besar pada tikus kelompok ftalat kombinasi Cu (II) sebesar 174,1 ppb; dan tikus kelompok ftalat sebesar 156,5 ppb.

---

Plastic is a material that is widely used in everyday appliances. The addition of certain substances to plastic tools is known to add quality, namely more elastic, strong and durable. One of the additives commonly used is phthalate. Phthalate compounds can potentially produce DNA adducts. This research studies the formation of 8-OHdG due to exposure to phthalate compounds and Cu (II) metal in vitro and in vivo in rats (Rattus novergicus). The formation of 8-OHdG was analyzed in vitro using HPLC, with variations in pH, incubation time and concentration ratio. While in vivo in rats, blood samples were analyzed using ELISA Kit and urine samples using LC-MS/MS instrument. In general, the concentration of 8-OHdG was greatest in 2-dG samples incubated with a combination of H2O2, phthalate, and Cu (II) solutions. In vitro studies with variations in pH showed higher concentrations of 8-OHdG at pH 7.4; at variations in incubation time the concentration of 8-OHdG was greater at 32 hours; and at variations in concentration greater at a ratio of 1:20. The results of the In vivo study using ELISA Kit, the concentration of 8-OHdG formed showed the greatest value in the blood samples of the rat group exposed to phthalate combined with Cu (II), which was 5.26 ppb; the rat group exposed to phthalate was 4.29 ppb; and the control rat group (without exposure) was 2.58 ppb. While the In vivo test using LC-MS/MS on rat urine samples also showed the highest concentration of 8-OHdG in rats of the Cu (II) phthalate combination group at 174.1 ppb; and rats of the phthalate group at 156.5 ppb."

"Ftalat merupakan senyawa kimia sintetis yang digunakan sebagai plasticizer dalam industri plastik. Besarnya penggunaan plastik sehari-hari dalam kehidupan manusia menyebabkan terjadinya paparan ftalat pada manusia. Ftalat yang diinduksi oleh spesies oksigen reaktif (ROS) dapat menyebabkan terjadinya kerusakan DNA. Penelitian ini bertujuan untuk mendeteksi pembentukan DNA Adduct 8-OHdG akibat adanya paparan senyawa ftalat dan ion Timbal(II) secara In Vitro dan In Vivo. Uji In Vitro dilakukan melalui proses inkubasi senyawa 2-dG (2-deoksiguanosin) dengan H2O2, ftalat dan Pb(II). DNA adduct 8-OHdG yang terbentuk secara In Vitro dianalisis menggunakan instrumen HPLC fase terbalik dengan detektor UV-Vis. Uji In Vivo dilakukan dengan menggunakan hewan uji tikus Rattus norvegicus< yang diberikan ftalat dan Pb(II) dengan dosis sebesar 100 mg/L hari dan 0,78 mg/L hari. Analisis 8-OHdG yang terbentuk secara In Vivo dilakukan menggunakan ELISA Kit dan LC-MS/MS. Hasil dari penelitian ini didapatkan bahwa paparan dari kombinasi ftalat dan Pb(II) memberikan efek sinergis terhadap pembentukan 8-OHdG. Pada kondisi pH yang 7,4, waktu inkubasi yang lebih lama dan konsentrasi xenobiotik yang semakin besar akan meningkatkan jumlah pembentukan 8-OHdG.

---

Phthalates are synthetic chemical compounds used as plasticizers in the plastics industry. The magnitude of the daily use of plastic in human life causes exposure to phthalates in humans. Phthalates induced by reactive oxygen species (ROS) can cause DNA damage. This study aims to detect the formation of DNA adduct 8-OHdG due to exposure to phthalate and lead (II) ions In Vitro and In Vivo. The In Vitro test was carried out through the incubation process of 2-dG (2-deoxyguanosine) with H2O2, Phthalates and Pb(II). DNA adduct 8-OHdG produced In Vitro was analyzed using a reversed phase HPLC instrument with a UV-Vis detector. The In Vivo test was carried out using Rattus norvegicus rats which were given phthalates and lead (II) at a dose of 100 mg/L kg and 0,78 mg/L kg. Analysis of the 8-OHdG formed In Vivo was carried out using the ELISA Kit and LC-MS/MS. The results of this study found that exposure to the combination of Phthalates and Pb(II) gave a synergistic effect on the formation of 8-OHdG. In conditions pH 7,4, longer incubation time and greater concentration of xenobiotics will increase the amount of 8-OHdG formation."

"Penelitian ini bertujuan untuk mensintesis ester sukrosa dari asam lemak hasil hidrolisis minyak kelapa sawit dengan sukrosa menggunakan lipase Candida rugosa EC 3.1.1.3. Lipase yang digunakan diimobilisasi secara adsorbsi pada matriks silka gel 60. Proses imobilisasi menggunakan tris buffer HCl 0,1M pH 7, waktu adsorbsi 3 jam, dan variasi silika gel sebanyak 100, 250, 500, 750, dan 1000 mg. Nilai % loading ditentukan dengan metode Lowry. Hasil pengujian efisiensi lipase terimobilisasi melalui reaksi hidrolisis minyak sawit dengan nilai efisiensi imobilisasi mencapai 80,59% untuk jumlah silika gel sebanyak 500 mg. Reaksi esterifikasi optimum pada, suhu37oC, perbandingan rasio sukrosa:asam lemak 1:80, dan waktu reaksi 8 jam. Nilai % konversi asam lemak pada keadaan optimum sebesar 2,90%. Penggunaan molecular sieve yang bertujuan meningkatkan % konversi memberikan dampak penurunan % konversi.

---

The aim of this study is to synthesize sucrose ester from fatty acid obtained from hydrolyzed palm oil and sucrose using Candida rugosa lipase EC 3.1.1.3. Lipase was immobilized in matrix silica gel 60. Immobilization was carried out in condition at pH 7 using Tris buffer HCl 0.1M, for 3 hours, and varying the amount of matrix 100, 250, 500, 750, and 1000 mg. % loading was determined by Lowry method.

The results of determining the efficiency of immobilized lipase reached 80.59% with a total amount of silica gel 500 mg. The optimum conditions for esterification are at 37oC, ratio sucrose : fatty acid 1:80, and for 8 hours incubation.. The highest % conversion in this condition reached 2,90%. The addition of molecular sieve, which aims to increase the % conversion, lead to lowered % conversion."

"Tujuan koproses adalah meningkatkan fungsionalitas bahan secara sinergis dan menutupi sifat yang tidak diinginkan dari masing-masing eksipien. Pada penelitian ini tujuan dilakukannya koproses adalah untuk meningkatkan fungsi pati sebagai bahan matriks tablet dalam industri farmasi dikombinasi dengan metilselulosa untuk menghasilkan sediaan lepas lambat. Koproses PPS-MC dibuat dengan cara mengkombinasikan PPS dan MC dengan rasio 2:1, 3:1, dan 4:1 kemudian dikarakterisasi. Koproses PPS-MC yang dipilih sebagai matriks tablet adalah perbandingan 2:1, 3:1 dan 4:1. PPS-MC koproses 2:1, 3:1 dan 4:1 dapat digunakan sebagai bahan matriks tablet yang memperlambat pelepasan obat selama 40 jam."

"Sorbitan ester asam lemak merupakan surfaktan hasil esterifikasi sorbitan dengan asam lemak. Sorbitan stearat dan sorbitan oleat merupakan senyawa non-polar dan memiki gugus hidroksi sehingga berpotensi sebagai pengikat ion logam. Pada penelitian ini, disintesis sorbitan stearat dan sorbitan oleat dari sorbitol menggunakan katalis H2SO4 dan NaOH serta aplikasinya sebagai ligan terhadap ion logam Zn2 dan Pb2 pada sampel sludge Tegal. Sintesis sorbitan ester dilakukan melalui tahap dehidrasi dan tahap esterifikasi. Sorbitan ester hasil sintesis dikarakterisasi dengan FTIR dan ditentukan kadar asam lemak bebasnya. Studi pembentukan kompleks dilakukan dengan metode job menggunakan spektrofotometer UV-Vis. Konsentrasi ion logam yang terikat oleh ligan dianalisis menggunakan AAS. Sorbitan ester hasil sintesis diaplikasikan terhadap hasil destruksi basah sampel sludge Tegal dengan variasi pH dan volume larutan. Melalui penelitian ini berhasil disintesis sorbitan stearat dan sorbitan oleat dengan nilai asam 29,45 mg/g dan 65,92 mg/g serta kadar asam lemak bebas sebesar 14,94 dan 33,19 . Sorbitan stearat hasil sintesis memiliki kemampuan dalam mengikat ion logam yang paling baik dibandingkan sorbitan oleat dan Span 80 yaitu mampu mengikat 30,5 ion Zn2 dan 42 ion Pb2 dari larutan destruksi sampel sludge Tegal dengan waktu kontak 2 s, pH 1 dan perbandingan volume logam : ligan sebesar 2 : 1.

---

Sorbitan fatty acid ester is a surfactant made from esterification reaction of sorbitan and fatty acid. Sorbitan stearate and sorbitan oleate have a potential as metal ligand due to their hydroxyl groups and because of their non polar properties. In this research, synthesis of sorbitan stearate and sorbitan oleate were carried out using sorbitol and catalyzed by H2SO4 and NaOH. Synthesis of both sorbitan esters were done in two steps, the first step was dehydration of sorbitol and then esterification. The products of the reaction were characterized using FTIR and the acid values were also evaluated. Later on, the sorbitan esters ability to bind with metal ions was studied using AAS to analyze the concentration of metal ion solution. The complex formation study was done with Job`s Method using UV Vis spectrophotometers. We also studied the use of sorbitan esters as ligand for metal ions in solution of industrial sludge from Tegal. The sorbitan ester products has acid values of 25,45 mg g and 65,9 mg g for sorbitan stearate and sorbitan oleate respectfully, with 14,94 and 33,19 free fatty acids. Compared to sorbitan oleate and Span 80, the sorbitan stearate product has the best potential to be use as ligand, as it can bind up to 30,5 of Zn2 ion and 42 of Pb2 ion from destruction solution of Tegal`s industrial sludge with the optimum condition contact time 2 s, pH 1, and metal ligand volume ratio is 2 1."

"Sustained release tablet is solid oral dosage form which is designed to release drugs slowly in the body. This research was conducted to make and characterize the cross-linked excipient of coprocessed polyvinyl alcohol-amylose as matrix for sustained release tablet with diclofenac sodium as the model drug. Cross-linked excipient of coprocessed polyvinyl alcohol-amylose (CL6 Co-PVA-A) was resulted from coprocessed excipient of polyvinyl alcohol-amylose (Co-PVA-A) that have been crosslinked with sodium trimetaphosphate. Meanwhile, Co-PVA-A was originated from two excipients, which are polyvinyl alcohol and amylose that have been coprocessed with ratio 1:2, 1:1, and 2:1. Co-PVA-A and CL6 Co-PVA-A properties were characterized physically, chemically, and functionally. Co-PVA-A and CL6 Co-PVA-A were formulated with dry granulation method in sustained release tablet as matrix. Furthermore, the sustained release tablets were evaluated and the drug release profiles were studied. As results, substitution degree of CL6 Co-PVA-A 1:2, 1:1, and 2:1 are respectively 0.080; 0.069; and 0.086. Those excipients have good swelling capability and gel strength that are 5.02; 5.22; and 5.12 gf. All sustained release tablet passed the requirement of weight variation, hardness, friability, and assay. CL6 Co-PVA-A as matrices (F1, F2, and F3) showed first order (F1) and zero order (F2 and F3) drug release kinetics. This study suggested that the tablets can be applied as sustained release tablets and retard drug release up to 16 hours.

---

Sustained release tablet is solid oral dosage form which is designed to release drugs slowly in the body. This research was conducted to make and characterize the cross-linked excipient of coprocessed polyvinyl alcohol-amylose as matrix for sustained release tablet with diclofenac sodium as the model drug. Cross-linked excipient of coprocessed polyvinyl alcohol-amylose (CL6 Co-PVA-A) was resulted from coprocessed excipient of polyvinyl alcohol-amylose (Co-PVA-A) that have been crosslinked with sodium trimetaphosphate. Meanwhile, Co-PVA-A was originated from two excipients, which are polyvinyl alcohol and amylose that have been coprocessed with ratio 1:2, 1:1, and 2:1. Co-PVA-A and CL6 Co-PVA-A properties were characterized physically, chemically, and functionally. Co-PVA-A and CL6 Co-PVA-A were formulated with dry granulation method in sustained release tablet as matrix. Furthermore, the sustained release tablets were evaluated and the drug release profiles were studied. As results, substitution degree of CL6 Co-PVA-A 1:2, 1:1, and 2:1 are respectively 0.080; 0.069; and 0.086. Those excipients have good swelling capability and gel strength that are 5.02; 5.22; and 5.12 gf. All sustained release tablet passed the requirement of weight variation, hardness, friability, and assay. CL6 Co-PVA-A as matrices (F1, F2, and F3) showed first order (F1) and zero order (F2 and F3) drug release kinetics. This study suggested that the tablets can be applied as sustained release tablets and retard drug release up to 16 hours."

"Tablet lepas lambat merupakan tablet yang mampu memperlama pelepasan obat dalam saluran cerna untuk memperpanjang durasi kerja obat dengan menggunakan matriks sebagai salah satu komponen utamanya Penelitian ini bertujuan untuk memperoleh eksipien koproses polivinil alkohol amilosa tersambung silang ko PVA CLA6 sebagai matriks pada tablet lepas lambat Ko PVA CLA6 dihasilkan dengan cara koproses PVA dengan CLA6 dengan perbandingan 1 1 1 2 dan 2 1 Ko PVA CLA6 yang telah diperoleh dikarakterisasi sifat fisik kimia dan fungsionalnya Ko PVA CLA6 memiliki derajat subtitusi fosfat 0 0681 kemampuan mengembang yang cukup baik memiliki viskositas yang cukup besar tetapi dengan kekuatan gel yang lemah Tablet dengan matriks ko PVA CLA6 diformulasikan dengan metode granulasi kering dan seluruhnya memenuhi persyaratan evaluasi tablet Profil pelepasan natrium diklofenak dari tablet yang mengandung matriks ko PVA CLA6 dengan perbandingan 1 1 F1 1 2 F2 dan 2 1 F3 dalam medium basa dapar fosfat selama 8 jam menunjukkan profil pelepasan obat yang diperlambat Q 20 45 dengan kinetika pelepasan orde nol Oleh karena itu formula F1 F2 dan F3 dapat diaplikasikan sebagai formula sediaan tablet lepas lambat untuk pemakaian selama 32 jam.

---

Sustained release tablet is the tablet which can retard drug release in gastro intestinal track to increase duration of drug effect This present research was intended to produce coprocessed excipient polivinyl alcohol cross linked amylose co PVA CLA6 as matrix for sustained release tablet Co PVA CLA6 was produced by coprocessing between PVA and CLA6 with a ratio of 1 1 1 2 and 2 1 The obtained coprocessed PVA CLA6 was characterized physically chemically and funtionally Coprocessed PVA CLA6 has subtitution degree of phosphate 0 0681 had good enough swelling index also high enough viscosity but low gel strenght Tablets with coprocessed PVA CLA6 as matrix was formulated by dry granulation method and passed tablet evaluations test The release profile of sodium diclofenac from tablet which contained matrix from coprocessed PVA CLA6 with a ratio 1 1 F1 1 2 F2 and 2 1 F3 in base medium of phosphate buffer for 8 hours showed the sustained release profile Q 20 45 which follow the zero order kinetic Thus F1 F2 and F3 tablets formulation could be applied as sustained release tablet formula and could retard drug release up to 32 hours."

"Tablet lepas lambat merupakan tablet yang didesain untuk dapat melepaskan zat aktif secara perlahan di dalam tubuh. Penelitian ini bertujuan untuk membuat dan mengkarakterisasi eksipien protein kedelai tersuksinilasi yang digunakan sebagai matriks dalam formulasi tablet lepas lambat dengan propranolol hidroklorida sebagai model obat. Konsentrat protein kedelai suksinat (PKS 1) diperoleh melaui cara esterifikasi konsentrat protein kedelai (PK) dengan anhidrida suksinat 100% b/b pada kondisi basa. PK dan PKS 1 dikarakterisasi secara fisik, kimia dan fungsional, kemudian diformulasikan menjadi matriks tablet lepas lambat dengan metode granulasi basah. Tablet lepas lambat yang dihasilkan dievaluasi dan dipelajari profil pelepasan obatnya. Hasil penelitian menunjukkan pita serapan pada bilangan gelombang 1653,05 cm-1; 1697,41 cm-1; 2359,02 cm-1 dan derajat substitusi PKS 1 sebesar 35,74 ± 0,38%. Eksipien tersebut menunjukkan kemampuan mengembang yang baik sebesar 35,38 ± 2,08% dalam HCl pH 1,2 dan 66,36 ± 2,12% dalam dapar fosfat pH 7,5. Profil pelepasan propranolol hidroklorida dari tablet lepas lambat yang mengandung PKS 1 sebagai pembentuk matriks (F1, F2, dan F3) menunjukkan profil pelepasan obat yang mengikuti persamaan Higuchi. Dari penelitian ini, dapat disimpulkan bahwa PKS 1 dapat digunakan sebagai eksipien pembentuk matriks pada tablet lepas lambat dan dapat digunakan untuk pemakaian 24 jam.

---

Sustained release tablet is solid oral dosage form which is designed to release drugs slowly in the body. This research was conducted to produce and characterize the succinylated excipient of soybean protein as matrix for sustained release tablet formulation with propranolol hydrochloride as model drug. Soybean protein succinate (SPS 1) was obtained by esterification of soybean protein (SP) with anhydride succinic 100% b/b in alkaline solution. SP and SPS 1 were characterized physically, chemically, and functionally, then were formulated as matrix in sustained release tablet by wet granulation method. Furthermore, the sustained release tablets were evaluated and the drug release profiles were studied.

Characterization of excipient results showed a peak at the wave number 1653,05 cm-1; 1697,41 cm-1; 2359,02 cm-1 and substitution degree of PKS 1 is 35,74 ± 0,38%. That modified excipient show good swelling capability that are 35,38 ± 2,08% in medium HCl pH 1,2 and 66,36 ± 2,12% in medium buffer phosphate pH 7,5. Drug released profil of Propranolol hydrochloride from sustained release tablet which contain PKS 1 as matrices (F1, F2, and F3) showed Higuchi drug release kinetics. This study suggested that the PKS 1 can be applied as matrix for sustained release tablets and extend drug release up to 24 hours."

"Kompleks polielektrolit (KPE) adalah kompleks yang terbentuk antara muatan partikel yang berlawanan. Dalam penelitian ini, kompleks polielektrolit yang digunakan adalah alginat (bersifat anionik) dan gelatin (bersifat kationik). Gugus karboksilat dari alginat dapat memberikan muatan negatif yang dapat berikatan secara ionik dengan gugus amin dari gelatin yang bermuatan positif. Larutan alginat dan gelatin 2% b/v dicampur dengan perbandingan 3:7 dan 4:7. Kondisi terbaik untuk menghasilkan KPE adalah perbandingan larutan alginat-gelatin 4:7. Perbedaan karakteristik KPE alginat-gelatin dengan polimer asalnya ditunjukkan dengan analisis gugus fungsi, analisis termal, daya mengembang dan kekuatan gel. Selanjutnya KPE digunakan sebagai matriks dalam sediaan tablet lepas lambat dengan verapamil HCl sebagai model obat. Formula I dan II masing-masing mengandung KPE 420 dan 478 mg, formula III dan IV masing-masing mengandung alginat dan gelatin 478 mg. Hasil uji disolusi terbaik yaitu formula II menunjukkan pelepasan kumulatif sebesar 65,38% selama 8 jam. Berdasarkan Banakar, nilai ini masuk dalam kisaran Q0,5 (45-75% terlarut) sehingga tablet dapat digunakan selama 16 jam untuk sekali pemakaian.

---

Polyelectrolyte complexes (PECs) are the complexes formed between oppositely charged particles. In this study, polyelectrolyte complexes used is alginate (anionic) and gelatin (cationic). Carboxylate groups of alginate may provide a negative charged which may be an ionic bond with the amine group of gelatin is positively charged. The solution of alginate and gelatin 2% w/v mixed in the ratio 3:7 and 4:7. The best conditions to produce the PEC is a solution of alginate-gelatin ratio of 4:7. The differences in the characteristics of PEC alginate-gelatin with origin polymer is indicated by functional group analysis, thermal analysis, swelling index and gel strength. The PEC subsequently used as a matrix in sustained release tablet dosage with verapamil hydrochloride as model drug. Formula I and II each containing PEC 420 and 478 mg, formula III and IV each containing alginate and gelatin 478 mg. The results of the best dissolution testing is formula II shows the cumulative release of 65,38% for 8 hours. Based Banakar, this value is entered in the range Q0, 5 (45-75% dissolved) so that the tablet can be used for 16 hours for a single use."