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"The four parts of this book largely follow the curriculum for biochemistry training of undergraduate medical and science students. The parts on protein structure and enzymology can be covered at the beginning of the course, the special proteins and membrane transport at the end, once molecular biology has been studied."

"This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. Such methods help extract maximum value from new experimental structures, but can often be applied to protein models. The book also, therefore, provides comprehensive coverage of methods for predicting or inferring protein structure, covering all structural classes from globular proteins and their membrane-resident counterparts to amyloid structures and intrinsically disordered proteins. The book is split into two broad sections, the first covering methods to generate or infer protein structure, the second dealing with structure-based function annotation. Each chapter is written by world experts in the field. The first section covers methods ranging from traditional homology modelling and fold recognition to fragment-based ab initio methods, and includes a chapter, new for the second edition, on structure prediction using evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each assigned chapters, while two new chapters deal with amyloid structures and means to predict modes of protein-protein interaction. The second section includes chapters covering functional diversity within protein folds and means to assign function based on surface properties and recurring motifs. Further chapters cover the key roles of protein dynamics in protein function and use of automated servers for function inference. The book concludes with two chapters covering case studies of structure prediction, based respectively on crystal structures and protein models, providing numerous examples of real-world usage of the methods mentioned previously. This book is targeted at postgraduate students and academic researchers. It is most obviously of interest to protein bioinformaticians and structural biologists, but should also serve as a guide to biologists more broadly by highlighting the insights that structural bioinformatics can provide into proteins of their interest."

"High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective."

"This is a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body. The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, "Drug transporters : molecular characterization and role in drug disposition": provides a comprehensive overview of drug transporters; and, includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy.It describes transporter-mediated drug disposition, a newly emerging field in drug therapy. It gives a comprehensive summary of drug transport across biological membranes in the liver, brain, kidney, and intestine."

"This book is an introduction to syntactic theory and analysis which can be used for both introductory and advanced courses in theoretical syntax. Offering an alternative to the standard generative view of the subject, it deals with the major issues in syntax with which all theories are concerned. It presents syntactic phenomena from a wide range of languages and introduces students to the major typological issues that syntactic theories must address. A generous number of exercises is included, which provide practice with the concepts introduced in the text and in addition expose the student to in-depth analysis of data from many languages. Each chapter contains suggestions for further reading which encompass work from many theoretical perspectives."