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"This research is for one of the pharmaceutical companies in Indonesia. The company's production area is composed of two parts, namely a Black Area and a Grey Area for processing and packaging. There are four types of packaging in the Secondary Packaging Area. Each type of packaging uses different processes, but there are also some processes that are used by all types of packaging. Based on these observations, the layout of the production area for secondary packaging in the pharmaceutical company is not optimal because the material handling distances are still quite long and there are some similar processes for same packaging type that are not adjacent, so that the production process is inefficient. This study aims to redesign the layout in the area with the Computerized Relationship Layout Planning (CORELAP) method. Data such as the name of the process, the order of the process, and the relationship between processes into the Activity Relationship Chart (ARC), are subsequently processed to obtain the Total Closeness Rating (TCR) values for each process iterated with the CORELAP method. From the calculations, the proposed layout has material handling distances that are shortened by 9.017% compared with the current layout. The same type of packaging processes are located in adjacent positions."

"Tujuan Menunjukkan adanya A. anitratus pada isolat klinik (darah) yang berasal dari pasien rawat di rumah sakit di Jakarta selama periode 2002-2008 dan pola sensitivitas mikroorganisme ini terhadap antibiotika. Metode Penelitian ini merupakan penelitian retrospektif dari semua spesimen darah yang masuk ke laboratorium Mikrobiologi Klinik Fakultas Kedokteran Universitas Indonesia (LMK-FKUI) dari tahun 2002-2008. Kultur dan pemeriksaan kepekaan terhadap antibiotik dilakukan berdasarkan praktek standar di LMK-FKUI dan Clinical Laboratory Standard Institute pada tahun yang bersangkutan. Data dikumpulkan dengan menggunakan program WHO-NET 5.4. Semua mikroorganisme Gram negative yang diisolasi dari spesimen darah ditabulasi juga termasuk dengan uji kepekaan A. anitratus terhadap antibiotik. Selain itu juga dilakukan analisis terhadap asal spesimen atau dari institusi mana spesimen tersebut berasal. Hasil A. anitratus merupakan bakteri Gram negatif yang paling banyak diisolasi selama tujuh tahun sejak 2002 sampai 2008 dari spesimen darah, dan selalu ditemukan setiap tahunnya. Hampir 50% bakteri yang diisolasi terdiri dari bakteri tersebut dan Pseudomonas aeruginosa, dan keduanya adalah bakteri lingkungan. Pemeriksaan kepekaan bakteri A. anitratus terhadap antibiotik menunjukkan adanya resistensi terhadap beberapa antibiotik yang diuji. Evaluasi asal spesimen darah menunjukan sebagai berikut: 88 spesimen (74%) berasal dari Rumah Sakit pemerintah, 18 spesimen (15%) dari Rumah Sakit swasta, 3 spesimen (3%) dari pasien praktek dokter dan 10 spesimen (8%) tidak diketahui asalnya. Kesimpulan Ditemukan A.anitratus setiap tahun sejak 2002 sampai 2008 dari spesimen darah dari pasien rawat inap di beberapa Rumah Sakit di Jakarta. Diperlukan penelitian lebih lanjut untuk mencari faktor resiko bakteremia A. anitratus agar dapat mengurangi kemungkinan terjadinya infeksi rumah sakit. Selain itu sangat dianjurkan untuk melanjutkan sampai tahap genotyping untuk menentukan hubungan antara strain yang ada di Rumah Sakit dengan strain yang diisolasi dari pasien.

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AbstractAim To report the presence of environmental microorganisms, A. anitratus, in blood of hospitalized patients in Jakarta from 2002 to 2008 and their susceptibility to antibiotics. Methods A Retrospective study w as performed on all blood specimens that were received in Clinical Microbiology Laboratory (CML) Faculty of Medicine University of Indonesia during 2002-2008. Culture and antimicrobialsusceptibility examination were carried out according to up to date standard practice in CML and Clinical Laboratory Standard Institute, recpectively. Data was collected by WHONET 5.4 program. All Gram-negative microorganisms that were isolated from blood specimens were tabulated, and so the antibiotics susceptibility of A. anitratus. The origin of the specimens in term of institutions where the specimens came from was also analyzed. Results In a 7 year period up to 2008, A. anitratus was found in blood specimens, and these invironmental bacteria were in fact the most predominant isolated Gram negative microorganisms. Together with another environmental microorganism, Pseudomonas aeruginosa, it composed nearly 50%. Antimicrobial susceptibility test of this microorganism showed some degree of resistance to all tested antibiotics. The origin of those blood specimens which yielded A. anitratus were mainly from government-owned hospitals, that was 88 specimens (74%), followed by private hospitals (18 specimens, 15%), individuals (3 specimens, 3%), and unknown source (10 specimens, 8%). Conclusion Persistent occurrence of A. anitratus in blood specimens of hospitalized patients in hospitals in Jakarta was observed. In the near future, a study to fi nd risk factors for the acquisition of A. anitratus bacteremia is needed to reduce potential hospital associated infection. Moreover, genotyping is advised in order to determine the relationship of hospital and patient derived strains."