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"Summary: The most concise, current, and comprehensive overview of general ophthalmology . extensively revised and updated. For five decades, General Ophthalmology has offered authoritative, state-of-the-art coverage of the diagnosis and treatment of all major ophthalmic diseases, as well as neurological and systemic diseases causing visual disturbances. The eighteenth edition builds on this tradition of excellence by offering an increased number of color illustrations, new chapters, and major revisions of existing chapters. To deliver all-inclusive coverage that encompasses pathophysiology, basic science, and the latest clinical perspectives. A must-read for medical students, ophthalmology residents, practicing ophthalmologists, nurses, optometrists, clinicians in other fields of medicine and surgery, and health-related professionals."

"This concise text is an ideal complement to the medical student curriculum and is an important text for primary care residents and physicians. It features practical information on the diagnosis, management and referral of common ocular disorders and summarizes important ophthalmic concepts, techniques and facts with annotated resources for additional information. This new edition includes updates on neuro-ophthalmology, ocular manifestations of systemic diseases, and drugs and the eye. Additional topics include eye examination, acute and chronic visual loss, the red eye, ocular and orbital injuries, and amblyopia and strabismus."

"Part of the Pediatric Practice series, Pediatric Practice: Ophthalmology is filled with practical, clinically relevant guidance on the successful diagnosis and management of children with ophthalmic symptoms and diseases. The care of the patient forms the core of this book, which also provides perspectives on epidemiology, pathophysiology, and diagnosis that every pediatrician, pediatric resident, and nurse should be familiar with. Over 600 full-color clinical images and illustrations highlight the techniques, diseases, and disorders discussed throughout the book. The book is logically divided into three parts: the first section describes the examination techniques, instruments, and ancillary tests used for evaluation of pediatric eye disorders. The second section on symptoms provides a straightforward how-to approach based on specific clinical presentations allowing pediatricians to quickly evaluate and accurately diagnose a patient in the office. The third section on diseases follows the style of traditional medical textbooks, offering greater detail on treatment of disease while maintaining the book?s easy-to-absorb presentation."

"ABSTRAK TujuanUntuk mengetahui reliabilitas pemeriksaan hematoksilin eosin (HE) dan panelimunohistokimia (IHK) dalam membedakan pseudotumor dan limfoma malignadi mata dengan menilai intraobserver agreementMetodeDeskriptif analitik. Peneliti yang tersamar meninjau ulang sediaan HE dankombinasi HE dengan panel IHK yang terdiri dari CD20, CD3, CD43, Ki67, Bcl-2 . Evaluasi HE dilakukan 3 kali, sedangkan evaluasi IHK dilakukan 2 kalidengan interval 2 minggu. Intraobserver agreement dihitung dengan nilai kappa.Ekspresi masing masing penanda akan dideskripsikan secara kuantitatif.Predominansi limfosit dihitung dengan rasio CD20 terhadap CD3 dan CD43.HasilNilai kappa evaluasi HE adalah moderate (! = 0.59-0.80), sedangkan kombinasiHE dan panel imunohistokimia adalah excellent (! = 0.93). Median (kisaran)CD20 lebih tinggi pada limfoma [97.41 (80-100)] dibandingkan pseudotumor[80.79 (1-94.49)]. Median (kisaran) CD3 lebih tinggi pada pseudotumor [48.84(2.32-64.27)] dibandingkan limfoma [36.19 (0.01-82.13)]. Median (kisaran) CD43 relatif sama pada limfoma [73.81 (9.28-100)] dan pseudotumor [72.36 (46.55-100)]. Median (kisaran) Bcl2 relatif sama pada limfoma [85.22(0.37-99.54)] danpseudotumor [78.95 (64.24-91.73)]. Median (kisaran) Ki67 relatif sama rendahpada limfoma [11.13 (1.89-93.54)] dan pseudotumor [6.59 (0.05-49.60)]. Medianrasio CD20:CD3 limfoma [2.75 (1.12-8766)] lebih tinggi dibandingkanpseudotumor [1.60 (0.43-2.74)].

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ABSTRACT ObjectiveTo investigate the reliability of haematoxylin eosin (HE) staining andimmunohistochemistry (IHC) panel in differentiating ocular adnexal lymphomaand pseudotumor by measuring intra observer agreement.MethodsA descriptive analytical study. Haematoxylin eosin staining and IHC panels(CD20, CD3, CD43, Ki67, Bcl-2) of 32 cases (15 lymphoma and 17pseudotumor) were reviewed by a pathologist whose blinded to its previousdiagnosis. The review was performed twice in two weeks apart. The intra observeragreement was analyzed using ! statistics. IHC markers were analyzedquantitatively. Lymphocytes predominance was indicated by CD20 ratio to CD3or CD43.ResultsThe ! statistics of HE stainings evaluation was moderate (! = 0.59-0.80), whilethat of HE and IHC panel was excellent (! = 0.93). Median (range) of CD20 washigher in lymphoma [97.41 (80-100)] compared to that of pseudotumor [80.79 (1-94.49)]. Median (range) of CD3 was higher in pseudotumor [48.84 (2.32-64.27)]compared to that of lymphoma [36.19 (0.01-82.13)]. Median (range) of CD 43was comparable in lymphoma [73.81 (9.28-100)] and that of pseudotumor [72.36(46.55-100)]. Median (range) of Bcl2 was comparable in lymphoma [85.22(0.37-99.54)] and that of pseudotumor [78.95 (64.24-91.73)]. Median (range) of Ki67was comparably low both in lymphoma [11.13 (1.89-93.54)] and pseudotumor[6.59 (0.05-49.60)]. Median (range) of CD20:CD3 ratio of lymphoma [2.75 (1.12-8766)] was higher than that of pseudotumor [1.60 (0.43-2.74)]."

"Tujuan: Mendeteksi perubahan kerusakan saraf optik pada penderita TB paru yang diterapi dengan Etambutol setelah diberikan suplementasi ion Zinc peroral.Desain: Uji klinik eksperimental secara acak dan tersamar ganda.Metode: duapuluh dua penderita tuberkulosis paru dengan anti tuberkulosis mendapatkan suplementasi 20 mg ion Zinc (kelompok perlakuan) begitupula duapuluh dua penderita tuberkulosis pare mendapatkan anti tuberkulosis dan plasebo (kelompok kontrol) satu kali sehari selama 4 minggu. Pemeriksaan P 100 [atensi VEP dilakukan pra dan paska suplementasi.Hasil: Pada kelompok perlakuan dan kelompok kontrol tidak terdapat perbedaan bermakna pada variabel usia, jenis kelamin dan VEP awal. Sehingga kedua kelompok setara untuk dibandingkan. Sebesar 18 penderita (81,8%) pads kelompok kontrol dan hanya sebesar 5 penderita (22,7%) pada kelompok perlakuan mengalami perubahan nilai P 100 latensi abnormal (p< 0.05). Rerata perubahan nilai P 100 latensi abnormal pada kelompok perlakuan sebesar 4A5 + 1.18 msec dan pada kelompok kontrol sebesar 5.21 + 1.49 msec (p< 0.05).Kesimpulan: VEP dapat mendeteksi neuropati optik subklinis sehingga dapat dipakai sebagai alat ukur memonitor efek toksik dari anti tuberkulosis. Suplementasi Ion Zinc mampu berperan sebagai neuroproteksi terhadap efek toksik Etambutol.

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Treated with Etambutol and ion Zinc supplementation orally.

Design: Randomized, double blind experimental clinical trial.

Methods: Twenty two tuberculosis pulmonary patients treated with anti tuberculosis and 20 mg ion Zinc (subject group) while other twenty two patients were treated with anti tuberculosis and placebo (control group) once daily for 4 weeks. P 100 latency examination was done before and after the treatment.

Result: There were no significant difference on both groups in age,gender, and early VEP examination. Both groups can be compare statistically. Eighteen patients (81.8%) of the control group and only 5 patients (22.7%) of the subject group resulted abnormal changes on P 100 latency ( p< 0.05). In the subject group, the abnormal mean of P 100 latency was 4.15 + 118 msec and in the control group was 5.21 + 1.49 msec ( p<0.05).

Conclusion: VEP could be use to detect subclinic optic neuropathy in monitoring anti tuberculosis toxic effect. Ion Zinc supplementation could be use as neuroprotector to the Ethambutol toxic effect."