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"This book constitutes the refereed proceedings of the International Symposium on Bioinformatics Research and Applications, ISBRA 2012, held in Dallas, Texas, USA, in May 2012. The 26 revised full papers presented together with five invited talks were carefully reviewed and selected from 66 submissions. The papers address issues on various aspects of bioinformatics and computational biology and their applications."

"The challenge remains to find the proper combination of these techniques in view of their respective potential, limitations, and costs, in order to pick up the right compounds quickly while keeping the risk of eliminating ‘good’ candidates as low as possible. Potential and limitations of a number of approaches to get early information on solubility and permeability, the main factors governing absorption via passive diffusion, will be discussed with practical examples.It aims at offering longlasting knowledge and stimulating food for thought. This is why its three main parts (biological, physicochemical, and computational strategies) are accompanied by two chapters which set the scene, four others which review the molecular and biological background of pharmacokinetic lead optimization, and finally two which conclude the book. "

"The profiling of ADME properties (absorption, distribution, metabolism, and excretion) is the topic of this book. In this unique work, international authorities and practicing experts from academia and industry offer state-of-the-art presentations of concepts, methods and technologies now in use or development in drug research. The biological strategies emphasized in the book include cell cultures, drug-metabolizing enzymes, transporters and plasma protein binding. The physicochemical strategies focus on artificial membrane-permeability assays, on solubility and lipophilicity and related molecular properties as factors and predictors of pharmacokinetic behavior, and on stability and solid-state properties. Computational strategies comprize the exploration of property spaces, pharmacophore searching to predict biotransformation and enzyme inhibition, and expert systems to process biopharmaceutical profiling data."

"This book constitutes the refereed proceedings of the 16th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2012, held in Barcelona, Spain, in April 2012. The 31 revised full papers presented together with 5 keynote lectures were carefully reviewed and selected from 200 submissions. The papers feature current research in all areas of computational molecular biology, including, molecular sequence analysis, recognition of genes and regulatory elements, molecular evolution, protein structure, structural genomics, analysis of gene expression, biological networks, sequencing and genotyping technologies, drug design, probabilistic and combinatorial algorithms, systems biology, computational proteomics, structural and functional genomics, and information systems for computational biology and imaging."

"The Three-Volume-Set CCIS 323, 324, 325 (AsiaSim 2012) together with the Two-Volume-Set CCIS 326, 327 (ICSC 2012) constitutes the refereed proceedings of the Asia Simulation Conference, AsiaSim 2012, and the International Conference on System Simulation, ICSC 2012, held in Shanghai, China, in October 2012. The 267 revised full papers presented were carefully reviewed and selected from 906 submissions. The papers are organized in topical sections on modeling theory and technology, modeling and simulation technology on synthesized environment and virtual reality environment, pervasive computing and simulation technology, embedded computing and simulation technology, verification, validation and accreditation technology, networked modeling and simulation technology, modeling and simulation technology of continuous system, discrete system, hybrid system, and intelligent system, high performance computing and simulation technology, cloud simulation technology, modeling and simulation technology of complex system and open, complex, huge system, simulation based acquisition and virtual prototyping engineering technology, simulator; simulation language and intelligent simulation system, parallel and distributed software, CAD, CAE, CAM, CIMS, VP, VM, and VR, visualization; computing and simulation applications in science and engineering, computing and simulation applications in management, society and economics, computing and simulation applications in life and biomedical engineering, computing and simulation applications in energy and environment, computing and simulation applications in education, computing and simulation applications in military field, and computing and simulation applications in medical field."