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"Orthodontic medical treatment is performed to move a tooth to the optimal position to obtain optimal occlusion. Orthodontic treatment is accompanied by mechanical stress due to orthodontic force and by psychological stress that is experienced as pain or displeasure. The purpose of this study was to identify stress marker proteins during orthodontic treatment. Levels of receptor activator of NFκB (RANKL) and heat shock protein 70 (HSP70) in the gingival crevicular fluid (GCF) were analyzed as markers of mechanical stress, and levels of chromogranin A (CgA) and amylase in whole saliva were analyzed as markers of psychological stress. GCF was collected from control and experimental teeth at initiation of treatment and 24 h after treatment. Whole saliva was collected before treatment, at initiation of treatment and 24 h after treatment. RANKL was expressed at 24 h after treatment in the experimental GCF, but not in the control GCF. HSP70 appeared to be constitutively expressed in GCF, and its levels showed no major change between the control and experimental groups from initiation of treatment to 24 h after treatment. Amylase activity in whole saliva was enhanced at 24 h after treatment compared to control, but CgA levels showed little change between the groups. These results indicated that RANKL and amylase may be the candidate markers for mechanical and psychological stress, respectively, during orthodontic treatment, even though the total protein concentration and amylase activity displayed a large standard deviation among subjects. Further studies are therefore required to establish these markers for clinical use."

"Demand for dental health care is increasing, especially in the Orthodontic field. The main objective of orthodontic treatment is to restore malocclusion conditions. Malocclusion causes aesthetics issues for the patient’s face and several discomforts like a difficulty in breathing or swallowing or speaking. If not repaired, a malocclusion could lead to other diseases, such as a greater risk of perforated teeth, gum irritation and temporomandibular disorder or pain in the lower jaw. Malocclusion can be remedied by Orthodontic Brackets. This research aim is to fabricate an orthodontic bracket that is suitable for the teeth structure of the Indonesian people. The fabrication method uses an Investment Casting process. The results show that orthodontic brackets have been successfully produced within an acceptable geometric tolerance, with the exception that surface finish quality has to be improved."

"Inflamasi gingiva adalah kondisi patologis yang paling sering disebabkan oleh plak bakteri.Secretory immunoglobulin A (sIgA) adalah immunoglobulin yang menonjol pada saliva dan merupakan mekanisme pertahanan spesifik utama rongga mulut.Secretory immunoglobulin A meningkat jika terdapat stimulus imunologi lokal, salah satunya adalah alat ortodonti cekat.Pada penggunaan alat ortodonti cekat juga terjadi peningkatan akumulasi plak dan inflamasi gingiva. Penelitian mengenai hubungan sIgA dengan inflamasi gingiva menunjukkan hasil yang bervariasi Penelitian ini bertujuan untuk menganalisis hubungan antara kadar sIgA saliva dan inflamasi gingiva pada anak yang menggunakan alat ortodonti cekat. Sampel saliva didapatkan dari 16 anak yang menggunakan alat ortodonti cekat dengan inflamasi gingiva dan 16 yang menggunakan alat ortodonti cekat tanpa inflamasi gingiva. Seluruh subjek dilakukan pemeriksaan Gingival Index untuk menilai inflamasi gingiva,dan sample saliva diukur kadar sIgAnya dengan ELISA. Hasil penelitian menunjukkan terdapat hubungan positif lemah tidak bermakna antara kadar sIgA saliva dan inflamasi gingiva pada anak yang menggunakan alat ortodonti cekat (r =0,282 p=0.290). Semakin tinggi kadar sIgA saliva pada anak yang menggunakan alat ortodonti cekat, maka semakin tinggi inflamasi gingivanya.

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Gingival Inflammation is a pathologic condition that often caused by bacterial plaque. Secretory immunoglobulin A (sIgA) is the main immunoglobulin in saliva and specific defense mechanism in oral cavity.Secretory immunoglobulin A is stimulated by local immune factor. Orthodontic fixed appliance is one of the local factor. Fixed appliance may increase the value of plaque and gingival inflammation. Research about correlation between sIgA level and gingival inflammation shows vary results. This study aimed to analyze correlation between salivary sIgA and gingival inflammation in children with fixed ortodontic appliance.Saliva samples were collected from 32 children with ortodontic appliance. Sixteen of them have gingival inflammation, and 16 of them have no gingival inflammation. Gingival Index were examined and use ELISA to asses salivary sIgA level. The study showed there is weak and not significant positive correlation between salivary sIgA level and gingival inflammation in children with orthodontic appliance (r =0,282 p=0.290)."