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"ABSTRAKLatar belakang:Migren adalah serangan nyeri kepala primer, bersifat spesifik,paroksismal, dengan atau tanpa aura, dengan manifestasi subjektif baik sebelummaupun sesudah serangan, merupakan nyeri kepala tipe kronik dengan gejala rekurensi,menyerang usia produktif dan dapat menyebabkan penurunan produktivitas kerja hingga80%, sehingga akan mempengaruhi kualitas hidup dan kehidupan perekonomian danpendidikan secara global yang mengarah kepada kerugian bagi penderita migren daninstitusi tempat penderita migren bersekolah ,bekerja serta dalam kehidupan keluargapenderita. Dengan tingginya angka prevalensi dan disabilitas pada penderita migren,dilain pihak sampai saat ini pengobatan yang tepat terhadap migren belum didapatkansecara maksimal maka diperlukan pendalaman dalam pengobatan maupun pencegahanmigren sangat dibutuhkan., dan sampai saat ini belum didapatkan obat yang pasti, baikterhadap pencegahan dan pengobatan, sehingga perlu dikembangkan terapi yang dapatmemberikan pertolongan yang lebih akurat pada penderita migrenTujuan penelitian ini adalah menilai keberhasilan dalam penatalaksanaan migren dalammengurangi frekuensi serangan, mengurangi intensitas serangan dan mengurangi durasiserangan dari minggu ke-0,ke-4 hingga ke-8. Metode: Uji klinis acak tersamar tunggaldengan kontrol dilakukan terhadap 34 subjek dengan migren yang dialokasikan secaraacak kedalam kelompok manual akupunktur (n=17), serta kelompok medikamentosa(n=17). Penilaian menilai frekuensi, durasi dan intensitas serangan migren yang dinilaipada saat sebelum perlakuan, minggu ke-4 dan minggu ke-8 dari baseline. Hasil: Hasilpenelitian menunjukkan terdapat perbedaan bermakna antara kedua kelompok padarerata jumlah frekuensi (p=0,040), durasi (p=0,012) dan intensitas (p=0,003) seranganmigren pada minggu ke-4 dibandingkan dengan medikamentosa. Serata terdapatperbedaan yang bermakna antara kedua kelompok pada rerata jumlah jumlah frekuensi(p=0,029), durasi (p=0,001) dan intensitas (p<0,001) serangan migren pada minggu ke-8. Kesimpulan: Intervensi akupunktur manual dapat menurunkan frekuensi, durasi danintensitas serangan migren lebih baik dibandingkan dengan preventif farmakologi asamvalproat pada minggu ke-4 dan minggu ke-8.

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ABSTARCTMigraine is a primary headache attack, specific, paroxysmal, with or without aura, with subjective manifestations both before and after the attack, a chronictype of headache with symptoms of recurrence, attacks at productive age and can cause a decrease in work productivity up to 80%, so that it will affect the quality of life, economic life and education globally which leads to losses for migraine sufferers andinstitutions where migraine sufferers attend school, work and in the lives of sufferersfamilies. With the high prevalence and disability rates for migraine sufferers, on theother hand, the right treatment for migraine has not yet been obtained to the maximum,it is necessary to deepen the treatment and prevention of migraine is needed, and untilnow there has been no definitive cure, both for prevention and treatment, so it isnecessary to develop therapies that can provide more accurate relief for migrainesufferers. The purpose of this study is to assess the success in managing migraine inreducing the frequency of attacks, reducing the intensity of attacks and reducing theduration of attacks from weeks 0, 4 to 8. Methods: A randomized controlled trial withcontrol was conducted on 34 subjects with migraine who were randomly allocated intothe manual group of acupuncture (n = 17), as well as the medicine group (n = 17). Theassessment of frequency, duration and intensity of migraine attacks assessed at the timebefore treatment, at the fourth and eight week from baseline. Results: The resultsshowed there were significant differences between the two groups in the mean numberof frequencies (p = 0.040), duration (p = 0.012) and intensity (p = 0.003) of migraineattacks at the fourth week. There were significant differences between the two groups inthe average number of frequencies (p= 0.029), duration (p=0.001) and intensity(p<0.001) of migraine attacks at the eight week. Conclusion: Manual acupunctureinterventions can reduce the frequency, duration and intensity of migraine attacksbetter than the use of valproic acid in the fourth and eight week."

"Fisik yang tidak aktif menempati peringkat keempat dalam daftar faktor risiko kematian. Bukti ilmiah semakin banyak mendukung bahwa dengan menjadikan latihan fisik sebagai bagian dari gaya hidup, dapat menurunkan risiko terjadinya berbagai penyakit. Namun, kelelahan otot dan nyeri otot juga banyak dirasakan oleh orang tidak terlatih yang baru memulai latihan. Penumpukan asam laktat di dalam otot sering dihubungkan dengan terjadinya kelelahan otot dan nyeri otot ini, yang akan memengaruhi kenyamanan melakukan latihan fisik. Saat ini, belum ada obat – obatan ataupun intervensi yang direkomendasikan secara resmi untuk menunda munculnya kelelahan otot atau nyeri otot. Penelitian ini menilai pengaruh akupunktur manual terhadap kenyamanan melakukan latihan fisik yang dievaluasi dengan menilai rerata kadar asam laktat, denyut nadi, tekanan darah sistolik dan diastolik, skala Borg untuk menilai tingkat kelelahan, serta Visual Analogue Scale (VAS) untuk menilai nyeri otot. Dua puluh enam pasien dibagi secara acak menjadi dua, kelompok akupunktur manual (n=13) dan akupunktur sham (n=13). Kedua kelompok menerima seri akupunktur yang sama, sebanyak 12 sesi dengan jarak 1 – 3 hari. Kedua kelompok juga melakukan latihan fisik yang sama, yaitu treadmill dengan intensitas sedang selama sepuluh menit, sebelum dan setelah seri terapi akupunktur. Penilaian rerata kadar asam laktat, denyut nadi, tekanan darah, skala Borg, dan VAS dilakukan dua kali, yaitu setelah latihan fisik sebelum memulai terapi pertama dan setelah latihan fisik setelah terapi terakhir. Hasil menunjukkan terdapat perbedaan bermakna pada rerata kadar asam laktat, denyut nadi, tekanan darah sistolik, tekanan darah diastolik, skala Borg, dan VAS pada kelompok akupunktur manual dibandingkan akupunktur sham. Rerata kadar asam laktat setelah terapi akupunktur 12 kali (p = 0,041). Rerata denyut nadi setelah terapi akupunktur 12 kali (p = 0,042). Rerata tekanan darah sistolik setelah terapi akupunktur 12 kali  (p = 0,024). Rerata tekanan darah diastolik setelah terapi akupunktur 12 kali (p = 0,035). Skala Borg setelah terapi akupunktur 12 kali (p = 0,043). VAS setelah terapi akupunktur 12 kali (p = 0,049). Penemuan ini menunjukkan bahwa terapi akupunktur manual memberikan pengaruh yang lebih baik terhadap kenyamanan melakukan latihan fisik.

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Physical inactivity ranks fourth in the list of risk factors for death. Scientific evidence increasingly supports that by making physical exercise a part of lifestyle, it can reduce the risk of various diseases. However, muscle fatigue and muscle aches are also felt by many untrained people who are just starting training. The buildup of lactic acid in the muscles is often associated with the occurrence of muscle fatigue and muscle pain, which will affect the comfort of doing physical exercise. At present, there are no drugs or officially recommended interventions to delay the appearance of muscle fatigue or muscle aches. This study assessed the effect of manual acupuncture on the comfort of physical exercise which was evaluated by assessing the mean levels of lactic acid, pulse, systolic and diastolic blood pressure, the Borg scale to assess the level of fatigue, and the Visual Analogue Scale (VAS) to assess muscle pain. Twenty-six patients were randomly divided into two groups, manual acupuncture (n = 13) and sham acupuncture (n = 13). Both groups received the same series of acupuncture, with 12 sessions spaced 1-3 days. Both groups also did the same physical exercise, which was a treadmill with moderate intensity for ten minutes, before and after the acupuncture therapy series. The average assessment of lactic acid levels, pulse rate, blood pressure, the Borg scale, and VAS was carried out twice, namely after physical exercise before starting the first therapy and after physical exercise after the last therapy. The results showed that there were significant differences in the average levels of lactic acid, pulse, systolic blood pressure, diastolic blood pressure, Borg scale, and VAS in the manual acupuncture group compared to sham acupuncture. Average lactic acid levels after acupuncture therapy 12 times (p = 0.041). Mean pulse rate after acupuncture therapy 12 times (p = 0.042). The mean systolic blood pressure after acupuncture therapy was 12 times (p = 0.024). Average diastolic blood pressure after acupuncture therapy 12 times (p = 0.035). Borg scale after acupuncture therapy 12 times (p = 0.043). VAS after acupuncture therapy 12 times (p = 0.049). These findings indicate that manual acupuncture therapy has a better effect on the comfort of physical exercise."

"[ABSTRAKUremik pruritus masih menjadi masalah dan mengurangi kualitas hidup pada pasien hemodialisis, meskipun telah banyak kemajuan dalam teknik dialisis, serta terapi yang ada belum memberikan hasil yang maksimal. Terapi akupunktur dapat dikembangkan sebagai terapi pendamping pada terapi hemodialisis untuk mengurangi gejala uremik pruritus. Penelitiasn ini merupakan penelitian akupunktur pertama di Indonesia dengan subyek pasien hemodialisis. Tiga puluh tujuh pasien hemodialisis dengan uremik pruritus dibagi dalam dua kelompok secara acak, kelompok akupunktur (n=18) mendapat terapi akupunktur pada titik tunggal LI11 Quchi, sementara kelompok kontrol (n=19) mengunakan jarum plasebo The Park Sham Device. Terapi akupunktur dilakukan saat hemodialisis, seminggu dua kali sebanyak 12 kali. Skor pruritus dinilai menggunakan kuesioner pruritus 5D sebelum terapi, setelah terapi ke-4, ke-8 dan setelah terapi ke-12, serta penilaian lanjutan 4 dan 8 minggu setelah terapi selesai. Perbedaan bermakna skor pruritus 5D antara kelompok akupunktur dan kelompok kontrol terjadi setelah akhir terapi akupunktur (7,89±0,832 vs 10,63±3,166; p=0,003) dan penilaian lanjutan 4 minggu setelah terapi selesai(8,06±1,830 vs 10,95±3,341; p=0,001). Terapi akupunktur efektif menurunkan skor uremik pruritus pada pasien hemodialisis yang menjalani dialisis seminggu dua kali.

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ABSTRACTUremic pruritus still gives problems for hemodialysis patients especially to reducing their quality of life, although it has been many advancements in dialysis techniques, recent therapies not yet provide optimum results. Acupuncture has a role as a complement in hemodialysis therapy to alleviate the symptoms of uremic pruritus in hemodialysis patients. This study is the first acupuncture research in Indonesia with the subject of hemodialysis patients. Thirty-seven hemodialysis patients with uremic pruritus were divided randomly into two groups, the acupuncture group (n = 18) received acupuncture treatment at a single point LI11 Quchi, while the control group (n = 19) using a placebo needle The Park Sham Device. Acupuncture treatment was done simultaneously with hemodialysis therapy, twice a week for 12 times. The pruritus scores was assessed using a 5D pruritus questionnaire before treatment, after 4th, 8th, 12th acupuncture treatment and at 4 and 8 weeks follow up. Significant differences 5D pruritus scores between the acupuncture group and the control group occurred after the end of acupuncture treatment (7.89±0.832 vs 10.63±3.166; p = 0.003) and at 4 weeks follow up (8.06±1.830 vs. 10.95±3.341; p = 0.001). Acupuncture treatment is effective in lowering the score of uremic pruritus in hemodialysis patients who undergo dialysis twice a week.;Uremic pruritus still gives problems for hemodialysis patients especially to reducing their quality of life, although it has been many advancements in dialysis techniques, recent therapies not yet provide optimum results. Acupuncture has a role as a complement in hemodialysis therapy to alleviate the symptoms of uremic pruritus in hemodialysis patients. This study is the first acupuncture research in Indonesia with the subject of hemodialysis patients. Thirty-seven hemodialysis patients with uremic pruritus were divided randomly into two groups, the acupuncture group (n = 18) received acupuncture treatment at a single point LI11 Quchi, while the control group (n = 19) using a placebo needle The Park Sham Device. Acupuncture treatment was done simultaneously with hemodialysis therapy, twice a week for 12 times. The pruritus scores was assessed using a 5D pruritus questionnaire before treatment, after 4th, 8th, 12th acupuncture treatment and at 4 and 8 weeks follow up. Significant differences 5D pruritus scores between the acupuncture group and the control group occurred after the end of acupuncture treatment (7.89±0.832 vs 10.63±3.166; p = 0.003) and at 4 weeks follow up (8.06±1.830 vs. 10.95±3.341; p = 0.001). Acupuncture treatment is effective in lowering the score of uremic pruritus in hemodialysis patients who undergo dialysis twice a week., Uremic pruritus still gives problems for hemodialysis patients especially to reducing their quality of life, although it has been many advancements in dialysis techniques, recent therapies not yet provide optimum results. Acupuncture has a role as a complement in hemodialysis therapy to alleviate the symptoms of uremic pruritus in hemodialysis patients. This study is the first acupuncture research in Indonesia with the subject of hemodialysis patients. Thirty-seven hemodialysis patients with uremic pruritus were divided randomly into two groups, the acupuncture group (n = 18) received acupuncture treatment at a single point LI11 Quchi, while the control group (n = 19) using a placebo needle The Park Sham Device. Acupuncture treatment was done simultaneously with hemodialysis therapy, twice a week for 12 times. The pruritus scores was assessed using a 5D pruritus questionnaire before treatment, after 4th, 8th, 12th acupuncture treatment and at 4 and 8 weeks follow up. Significant differences 5D pruritus scores between the acupuncture group and the control group occurred after the end of acupuncture treatment (7.89±0.832 vs 10.63±3.166; p = 0.003) and at 4 weeks follow up (8.06±1.830 vs. 10.95±3.341; p = 0.001). Acupuncture treatment is effective in lowering the score of uremic pruritus in hemodialysis patients who undergo dialysis twice a week.]"

"Luka bakar didefinisikan sebagai kerusakan jaringan yang terjadi akibat aksi panas baik secara langsung maupun tidak langsung. Meskipun telah banyak kemajuan yang dibuat dalam terapi luka bakar, namun penyembuhan luka yang lambat masih menjadi tantangan dalam perawatan luka bakar. Akupunktur manual dapat mempercepat penyembuhan luka bakar melalui efek anti-inflamasi, meningkatkan re-epitelisasi dan angiogenesis. Sedangkan laser akupunktur merupakan terapi yang menggunakan laser enersi rendah untuk merangsang titik akupunktur. Penelitian ini menilai pengaruh akupunktur manual dan laser akupunktur terhadap kecepatan penyembuhan luka bakar yang diamati secara makroskopik dan mikroskopik. Tiga puluh enam tikus Wistar jantan dibagi secara acak kedalam kelompok kontrol (n=12), kelompok akupunktur manual (n=12), dan kelompok laser akupunktur (n=12). Setelah dilakukan induksi luka bakar, pengukuran luka dan perlakuan diberikan setiap dua hari sekali selama 14 hari. Separuh jumlah dari setiap kelompok diterminasi pada hari ke-7 dan separuh sisanya diterminasi pada hari ke-14 untuk dilakukan pengamatan mikroskopik. Pada pengukuran penutupan luas luka hari ke-14, didapatkan perbedaan bermakna (p=0,009) antara kelompok akupunktur manual (66,96 ± 9,17) dibandingkan kelompok kontrol (49,93 ± 9,15), dan perbedaan yang bermakna (p=0,009) antara kelompok laser akupunktur (72,48 ± 14,62) dibandingkan kelompok kontrol. Namun tidak didapatkan perbedaan bermakna (p=0,451) antara kelompok akupunktur manual dan laser akupunktur. Pada penilaian skoring mikroskopik hari ke-14 didapatkan perbedaan yang bermakna (p<0,001) antara kelompok akupunktur manual (16,17 ± 1,17) dibandingkan kelompok kontrol (10,33 ± 1,21), dan perbedaan yang bermakna (p=0,004) antara kelompok laser akupunktur (17,83 ± 1,47) dibandingkan kelompok kontrol. Namun tidak didapatkan perbedaan bermakna (p=0,058) antara kelompok akupunktur manual dan laser akupunktur. Hasil penelitian menunjukkan bahwa baik terapi akupunktur manual ataupun laser akupunktur dapat digunakan sebagai terapi tambahan untuk mempercepat penyembuhan luka bakar.

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Burns are defined as tissue damage that occurs as a result of the direct or indirect action of heat. Although many advanced treatments have been made in burn therapy, slow wound healing remains a challenge in burn treatment. Acupuncture can accelerate burn healing through its anti-inflammatory effect, increasing re-epithelialization and angiogenesis. While laser acupuncture is a therapy that uses low energy lasers to stimulate acupuncture points. This study assessed the effect of manual acupuncture and laser acupuncture on the speed of wound healing which were observed macroscopically and microscopically. Thirty-six male Wistar rats were randomly divided into control group (n=12), acupuncture group (n=12), and laser acupuncture group (n=12). After burn induction, wound measurements and treatments were given every two days for 14 days. Half of the numbers from each group were terminated on the 7th day and the remaining half were terminated on the 14th day for microscopic observation. On the 14th day of measurement of wound closure, there was a significant difference (p=0.009) between the acupuncture group (66.96 ± 9.17) compared to the control group (49.93 ± 9.15), and a significant difference (p =0.009) between laser acupuncture group (72.48 ± 14.62) compared to control group. However, there was no significant difference (p=0.451) between acupuncture and laser acupuncture groups. On the 14th day of microscopic scoring, there was a significant difference (p<0.001) between the acupuncture group (16.17 ± 1.17) compared to the control group (10.33 ± 1.21), and a significant difference (p = 0.004) between the laser acupuncture group (17.83 ± 1.47) versus the control group. However, there was no significant difference (p=0.058) between acupuncture and laser acupuncture groups. The results showed that either acupuncture therapy or laser acupuncture could be used as an adjunct therapy to accelerate burn healing."