Hasil Pencarian  ::  Simpan CSV :: Kembali

"In this volume, international experts in the field discuss the pathogenetic, diagnostic, preventive and possible therapeutic relevance of inflammation in atherogenesis. This book is intended for researchers and physicians in the fields of vascular biology, immunology and atherosclerosis."

"Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases."

"Ultrasound and carotid bifurcation atherosclerosis provides a comprehensive overview of the most recent advancements in instrumentation, imaging techniques including the use of contrast enhancement agents, plaque image analysis and its automation, elastography and plaque motion analysis; also, the use of ultrasonic and other biomarkers in the detection of the high risk cardiovascular individual. Finally, it deals with the application of IVUS, TCD and carotid plaque characterization in clinical practice and in stroke risk stratification. "

"Atherosclerosis is a degenerative disease of large and medium arteries which loss their elasticity and the arterial walls are thickened which may cause coronary heart disease. Atherosclerosis is related to hyperlipidemia and concentration of serum lipoprotein cholesterol which are influenced by the intake of certain dietary lipids. The polyunsaturated fatty acid (PUFA), particularly linoleic acid is believed to have a lowering effect, saturated fatty acid (SAFA) increase, and mono-unsaturated fatty acid (MUFA) is neutral or has no effect on serum triglyceride that PUFA especially when given ia a large amount besides HDL-c. MUFA seems to have a similar effect as PUFA but without lowering effect on HDL-c. Low LDL-c and high HDL-c levels have positive effect on preventing and curing atherosclerosis and contrary of high LDL-c and low HDL-c.In this study, 60 albino, 2 month old male rats were put in separate cages and divides randomly into 6 groups. Each group received proportionally the first phase diet rich in margarine (40% of total energy) and cholesterol (10% w/w) for 3 months with additional oralforced feeding of proplythiouracil treated with the second phase diet with additional different types of fat source. The control group receieved normal diet. Determination of serum TG, total cholesterol, LDL-c, HDL-c and microscopic pathological examination of the aorta were carried out after treatment with the first and second phase diets.Analysis of variance showed that there were significant differences in serum TG, total cholesterol and LDL-c levels, the amount of diet consumed and the body weight changes between the treatment serum TG, total cholesterol and LDL-c as peanut oil. Serum HDL-c appeared not to be influenced by the different types of dietary fat. Pathological examination did not reveal any identifiable atherosclerosis signs in the aorta of the rats."

"Analisis histomorfometrik pembentukan lesi aterosklerosis koroner pada model tikus (Rattus novergicus) periodontitis. Penyakit kardiovaskuler perupakan penyakit paling mematikan di dunia dan penyebab utamanya adalah aterosklerosis. Paradigma baru menjelaskan bahwa inflamasi kronis seperti periodontitis dipertimbangkan sebagai faktor risiko terjadinya aterosklerosis. Periodontitis menyebabkan bakteremia yang berpengaruh terhadap inflamasi vaskuler. Keadaan ini mempengaruhi sel endotel dan oksidasi lipid sehingga meningkatkan resiko aterosklerosis. Tujuan: Penelitian ini bertujuan untuk membuktikan pengaruh periodontitis terhadap pembentukan lesi aterosklerosis koroner. Metode: Penelitian ini merupakan eksperimen menggunakan the post test only control group design. 12 sampel tikus dibagi atas kelompok kontrol (K) tanpa perlakuan dan kelompok periodontitis (P) dibuat dengan pemasangan wire ligature dan injeksi Porphyromonas gingivalis pada M1 rahang bawah kiri selama 28 hari. Pada hari ke-29 tikus didekaputasi, arteri koroner diambil dan dibuat preparat histologi. Analisis histomorfomerik dilakukan pada morfologi dungkul (deskriptif) dan ketebalan dinding arteri (statistik dengan uji T test). Hasil: Hasil penelitian menunjukkan bahwa terbentuknya dungkul arteri lebih banyak pada kelompok Periodontitis (83,33%) daripada kelompok Kontrol (16,67%). Dinding arteri kelompok periodontitis juga lebih tebal (2,22±0,35µm) secara signifikan dibandingkan kelompok kontrol (1,28±0,20µm) (p<0,05). Simpulan: Periodontitis secara independen dapat mempengaruhi gambaran histomorfometrik pembentukan lesi aterosklerosis koroner.

---

Cardiovascular disease is the most deadly disease in the world and the main cause is atherosclerosis. New paradigm explains that chronic inflammation such as periodontitis is considered to be a risk factor for atherosclerosis. Periodontitis causes bacteremia affecting vascular inflammation. This situation affects the endothelial cells and lipid oxidation thereby increasing the risk of atherosclerosis. This study aimed to prove the effect of periodontitis on coronary atherosclerotic lesion formation. Methods: This was an experimental study using the post-test only control group design. Samples were 12 rats divided into control group (K) without treatment and periodontitis (P) was made with the installation of wire ligature and injection of Porphyromonas gingivalis on the left mandibular M1 for 28 days. On day 29, mice were decaputated, coronary artery was taken and histological slides were made. Histomorphometrical analysis was calculated on dungkul (descriptive) and the thickness of the arterial wall (with test statistic T test). Results: The results showed higher formation of arterial dungkul on Periodontitis group (83.33%) than the control group (16.67%). Arterial wall was also thicker periodontitis group (2.22±0.35µm) (p<0.05) than the control group (1.28±0.20µm). Conclusion: Periodontitis can independently affect the coronary atherosclerotic lesion formation."

"Latar Belakang: Aterosklerosis dan penyakit kardiovaskular merupakan penyebab utama meningkatnya morbiditas dan mortalitas penderita artritis reumatoid (AR) Pemeriksaan ketebalan intima media (KIM) arteri karotis dengan ultrasonografi B-mode merupakan surrogate marker aterosklerosis dan penyakit kardiovaskular. Metode: Dilakukan penelitian potong lintang pada 86 subyek penderita AR yang memenuhi kriteria EULAR/ACR 2010 yang berobat di Poliklinik Reumatologi Penyakit Dalam FKUI/RSCM. Aterosklerosis didefinisikan jika ditemukan pada pemeriksaan ultrasonografi KIM ≥ 1,0 mm pada salah satu : a. karotis komunis, a. karotis interna atau bulbus karotis sisi kanan atau kiri. Plak aterosklerosis didefinisikan jika didapatkan abnormalitas pada tebal KIM, bentuk dan atau tekstur dinding arteri. Hasil: Aterosklerosis dan plak aterosklerosis masing-masing didapatkan pada 47 subyek (47,7%) dan 25 subyek (29,0%).Usia ≥ 40 tahun, adanya hipertensi, lama sakit ≥ 24 bulan pada analisis multivariat mempergunakan regresi logistik didapatkan berhubungan bermakna dengan aterosklerosis dengan RO (95%KI) masing-masing 10,70 (2,93-39,10), 4,99 (1,15-21,61) dan 3,66 (1,11-11,99). Adanya hipertensi, adanya anti-CCP dan usia ≥40 tahun berhubungan bermakna dengan plak aterosklerosis dengan RO (95%KI) masing-masing 3,96 (1,15-13,57), 3,20 (1,11-9,24) dan 3,61 (1,03-12,63). Kesimpulan: Proporsi aterosklerosis dan plak aterosklerosis masing-masing didapatkan 47,7 % dan 29 %. Usia ≥ 40 tahun, adanya hipertensi dan lama sakit ≥ 24 bulan berturut-urut merupakan prediktor adanya aterosklerosis sementara adanya hipertensi, antibodi anti-CCP dan usia ≥ 40 tahun merupakan prediktor adanya plak aterosklerosis.

---

Background: Atherosclerosis and cardiovascular diseases have been known as the cause of increasing mortality among rheumatoid arthritis (RA) patients. Carotid intima media thickness (CIMT) measurement by B-mode ultrasound have been used as surrogate marker of atherosclerosis and cardiovascular disease.

Method: A cross sectional study involving 86 RA patients fulfill EULAR/ACR 2010 critera was conducted at Rheumatology Clinic FMUI/Cipto Mangunkusumo Hospital. CIMT examinations were perform at right and left side of carotid artery. Atherosclerosis was define if we found CIMT ≥ 1,0 mm at one of CCA, or ICA or carotid sinus. Plaque atherosclerosis presence if 1 of the following 3 criteria were met: abnormal wall thickness, abnormal shape, and abnormal wall texture.

Result: Atherosclerosis and plaque was found in 47,7% and 29 % of patients. Age ≥ 40 years old, hypertension and duration of illness ≥ 24 months were associated with atherosclerosis in multivariate logistic regression analysis with OR (95%CI) 10.70 (2.93-39.10), 4.99 (1.15-21.61) and 3.66 (1.11-11.99) respectively. Whereas hypertension, presence of anti-CCP antibody and age ≥ 40 years old, were associated with plaque formation with OR (95%CI) 3.96 (1.15-13.57), 3.20 (1.11-9.24) and 3.61 (1.03-12.63) respectively.

Conclusion: Proportion of atherosclerosis and plaque atherosclerosis were 47.7% and 29%. Age ≥ 40 years old, hypertension and duration of illness ≥ 24 months was the predictors of atherosclerosis, while hypertension, presence of anti-CCP antibody and age ≥ 40 years old was the predictors of plaque atherosclerosis."

"ABSTRACTAtherosclerosis is a chronic inflammatory disorder involving innate and adaptive immunity process. Effector T cell (Teff) responses promote atherosclerotic disease, whereas regulatory T cells (Tregs) have been shown to play a protective role against atherosclerosis by down-regulating inflammatory responses which include multiple mechanisms. Compelling experimental data suggest that shifting the Treg/Teff balance toward Tregs may be a possible therapeutic approach for atherosclerotic disease, although the role of Tregs in human atherosclerotic disease has not been fully elucidated. In this review, we discuss recent advances in our understanding of the roles of Tregs and Teffs in experimental atherosclerosis, as well as human coronary artery disease."

"ABSTRACTCardiovascular disease (CVD) remain a leading cause of death globally. The concept of acute myocardial infarction in young adults was uncommon. Atherosclerosis is the leading cause of CVD, including myocardial infarction, stroke, heart failure and peripheral artery disease. This condition is initiated early in childhood and progressive in nature. CVD risk factors includes hypertension, dyslipidemia and obesity play a role in the development of atherosclerosis and components in insulin resistance syndrome.One of many risk factors for insulin resistance in healthy individuals is a first-degree relative (FDR) of Type 2 Diabetes Mellitus (T2DM) patients. This group shows a higher risk of insulin resistance and pancreatic beta cells disruption even in adolescence, although they often remains asymptomatic. Clinical manifestations of metabolic disorders and atherosclerosis will appear earlier in the FDR T2DM group who have sedentary lifestyles and obesity, when compared to the non-FDR group. Several studies have attempted to detect metabolic disorders and subclinical atherosclerosis that might occur; therefore an early prevention can be carried out in these high-risk groups. Unfortunately, factors that affect the onset and the severity of the prospective clinical manifestations from the previous studies remained inconclusive."