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"This best-selling undergraduate textbook provides an introduction to key experimental techniques from across the biosciences. It uniquely integrates the theories and practices that drive the fields of biology and medicine, comprehensively covering both the methods students will encounter in lab classes and those that underpin recent advances and discoveries. Its problem-solving approach continues with worked examples that set a challenge and then show students how the challenge is met. New to this edition are case studies, for example, that illustrate the relevance of the principles and techniques to the diagnosis and treatment of individual patients. Coverage is expanded to include a section on stem cells, chapters on immunochemical techniques and spectroscopy techniques, and additional chapters on drug discovery and development, and clinical biochemistry. Experimental design and the statistical analysis of data are emphasised throughout to ensure students are equipped to successfully plan their own experiments and examine the results obtained"--Provided by publisher. "This textbook integrates the theoretical principles and experimental techniques common to all undergraduate courses in the bio- and medical sciences."

"Several series of trawl surveys were carried out in the waters of Perhentian Islands using commercial trawlers.16S mithochondrial rRNA gene sequences were used to infer the phylogenetic relationship among nine morphospecies of leiognathids...."

"A unique, adaptable textbook for upper-level undergraduate and graduate courses emphasizing particular aspects of modern biotechnology.Features straightforward, jargon-free writing and extensive figures to help students make sense of complex biological systems and processes.Includes expanded coverage of the latest innovations in DNA sequencing techniques, therapeutics, vaccines, transgenic plants, and transgenic animals.Allows instructors to easily tailor the content to courses focusing on the fundamentals of biotechnology as well as courses dedicated to medical, agricultural, environmental, or industrial applications."

"The metabolites from microorganisms for rapidly grawing field,due to the suspicion that a number of metabolites obtained from reef's invertebrates are produced by associated microorganisms....."

"ABSTRAKLatar Belakang Papiloma inverted (PI) merupakan papiloma yang berasal daritraktus sinonasal yang dilapisi oleh epitel Schneiderian, yang secara ektodermalberasal dari mukosa respiratorius. Tumor jinak ini memiliki karakter yang bersifatagresif secara lokal, memiliki angka rekurensi tinggi dan kemampuan untukbertransformasi ke arah keganasan. Karakteristik biomolekuler dari tumor PIbelum banyak diteliti. Perkembangan PI diduga berasal dari ketidakseimbanganantara peningkatan proliferasi sel epitel yang berlebihan dan peningkatanapoptosis yang tidak bermakna. Tujuan Mengetahui gambaran karakteristikbiomolekuler tumor PI berdasarkan ekspresi HSP 70, HSF-1, NF-kappa-B danBcl-2. Metode Penelitian ini menggunakan desain penelitian studi potong lintanguntuk mencari gambaran ekspresi HSP 70, HSF-1, NF-kappa-B dan Bcl-2 padaepitel dan stroma jaringan tumor PI melalui pemeriksaan imunohistokimia. HasilTerdapat korelasi yang bermakna antara HSF-1 epitel dan Bcl-2 epitel dengan p =0,022 (p<0,05) dan r = 0,709. Hasil korelasi yang bermakna juga didapatkanantara HSF-1 stroma dan HSP 70 stroma dengan p = 0,024 (p<0,05) dan r =0,699. Terdapat hubungan yang bermakna antara nilai ekspresi NF-kappa-B padaepitel dan stroma dengan adanya transformasi keganasan (p<0,05). KesimpulanTerdapat peran dari HSP 70, HSF-1 dan Bcl-2 dalam perkembangan tumor PIsecara umum. Proses transformasi keganasan berkaitan erat dengan ekspresi NFkappa-B. Penelitian lebih lanjut diperlukan untuk menentukan titik potong nilaiekspresi NF-kappa-B sebagai prediktor transformasi keganasan pada tumor PI.

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ABSTRACTBackground Inverted papilloma (IP) is a papiloma that is lined by theSchneiderian epithelials, derived ectodermally from the respiratory mucosa. Thisbenign neoplasm has a characteristic of local aggresiveness, high recurrence rateand possibility of malignant transformation. Biomolecular characteristics havenot been studied extensively. Development of IP is thought to arise due to theimbalance between excessive cell proliferation and insignificant apoptosis.Objective To describe the expressions of HSP 70, HSF-1, NF-kappa-B and Bcl-2in IP. Methods This research is a cross-sectional study to describe theexpressions of HSP 70, HSF-1, NF-kappa-B and Bcl-2 in epithelial and stromalIP using immunohistochemistry. Results There is a strong positive correlationbetween epithelial HSF-1 with epithelial Bcl-2 with p=0,022 (p<0,05) andr=0,709. There is also a strong positive correlation between stromal HSF-1 andstromal HSP 70 with p=0,024 (p<0,05) and r=0,699. There is a relationshipbetween epithelial and stromal NF-kappa-B expression with signs of malignancytransformation (p<0,05). Conclusion There is a role of HSP 70, HSF-1 and Bcl-2 in the development of IP. There is a close relationship between malignanttransformation and the expression of NF-kappa-B. Further research is needed todetermine the cut-off point for NF-kappa-B expression to predict malignanttransformation in IP.;;"

"The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed."