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"Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching."

"This book offers an easy-to-read introduction to the theoretical underpinnings of analysis of missing data, provides clear, step-by-step instructions for performing state-of-the-art multiple imputation analyses, and offers practical advice, based on over 20 years' experience, for avoiding and troubleshooting problems. For more advanced readers, unique discussions of attrition, non-Monte-Carlo techniques for simulations involving missing data, evaluation of the benefits of auxiliary variables, and highly cost-effective planned missing data designs are provided. Most analysis described in the book are conducted using the well-known statistical software packages SAS and SPSS, supplemented by Norm 2.03 and associated Java-based automation utilities. "

"Understanding bioavailability is critical to determining the amount of a drug to administer. Integrating physiochemistry with physiology and molecular biology, Oral bioavailability offers a coherent and focused perspective to allow the reader to appreciate all the facets of the complex problem of oral bioavailability, a major hurdle in drug development and delivery. The text helps chemists, biologists, research fellows, pharmaceutical scientists, pharmacologists, and students understand basic barriers to oral bioavailability, be acquainted with the methods used to determine relevant parameters, and comprehend challenges of drug delivery."

"This book provides students and research workers in the biological, medical and social sciences with the statistical background needed to collect and analyse data in an intelligent and critical manner. Key examples and case studies are used to illustrate commonly encountered research problems and to explain how they may be solved or even avoided altogether. Professor Manly also presents a clear understanding of the opportunities and limitations of different research designs, as well as an introduction to some new methods of analysis that are proving increasingly popular. Topics covered include the differences between observational and experimental studies; the design of sample surveys; multiple regression and its generalizations to log-linear and logistic models; experimental and quasi-experimental designs; interrupted time series; computer intensive methods of statistical inference; and the ethical considerations of research. In the final chapter, there is a useful discussion of how the various components of a research study (including deciding on the objectives, planning, designing, and the collection and analysis of data) come together. This practical and well-structured book will be essential reading for graduate students and researchers in a wide range of disciplines, including biology, anthropology, medicine and the social sciences."

"In this book the authors describe the bioavailability and basic biological mechanisms of action of dietary flavonoids and polyphenols, and explore their beneficial effects on human health and cognition"