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Tumor di dalam toraks
Jakarta: Balai Penerbit Fakultas Kedokteran Universitas Indonesia, 2001
616.994 TUM
Buku Teks SO  Universitas Indonesia Library
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Fadli Syamsuddin
Analisis praktik residensi keperawatan medikal bedah pada gangguan sistem neurologi : tumor otak dengan menggunakan pendekatan model adaptasi ROY di Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo = Analysis of medical surgical nursing residency practice on neurological system disorders with tumor brain cases using ROY adaptation model approach at Cipto Mangunkusumo Hospital in Jakarta
"ABSTRAK
Perawat spesialis neurosains berperan dalam praktik keperawatan berupa pemberi asuhan keperawatan lanjut, melakukan pembuktian ilmiah dan agen pembaharu. Asuhan keperawatan dilakukan pada kasus pasien dengan Tumor Otak dan 30 pasien gangguan neurologis dengan pendekatan Model adaptasi Roy. Perilaku maladaptif paling banyak terganggu pada mode fisologis dengan diagnosa resiko ketidakefektifan perfusi jaringan serebral. Evidence Based Nursing dilakukan dengan menerapkan thermal tactile stimulation pada 3 pasien stroke yang mengalami disfagia dengan hasil yang signifikan p value 0,038 . Program inovasi menerapkan enam screening tools yaitu Insomnia Severity Index ISI , National Institute Health Stroke Scale NIHSS , 3 Incontinence Question 3 IQ , Berg Balance Scale BBS , Frenchay Aphasia Screening Test FAST dan Adult Non Verbal Pain Scale ANVPS pada pasien dengan gangguan neurologi yang terbukti memudahkan perawat dalam menegakkan diagnosa keperawatan yang tepat. Model Adaptasi Roy telah berpengaruh besar terhadap profesi keperawatan. Model ini adalah salah satu model yang paling banyak digunakan dalam memandu penelitian, pendidikan dan praktik keperawatan ABSTRACT Neuroscience nurse specialist play role in nursing practice as advanced nursing care providers, conduct scientific evidence and innovator. Roy adaptation model approach was used in the nursing care of the tumor brain patients and 30 patients of neurological disorders cases. Risk of cerebral tissue perfusion ineffectiveness was the most often of nursing diagnosis enforced which was caused maladaptive behavior in physiological mode. Evidence based nursing was implemented by thermal tactile stimulationin 3 stroke patients with disfagia with significant results p value 0.038 . The Innovation program application six screening tools are Insomnia Severity Index ISI , National Institute of Health Stroke Scale NIHSS , 3 Incontinence Questions 3 IQs , Berg Balance Scale BBS , Frenchay Aphasia Screening Test FAST and Adult Non Verbal Pain Scale ANVPS in neurological disorders patients proven to facilitate nurses in establishing nursing diagnoses. Roy Adaptation Model has greatly influenced the profession of nursing. It is one of the most frequently used models to guide nursing research, education and practice"
Fakultas Ilmu Keperawatan Universitas Indonesia, 2017
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Yusi Amalia
Kesesuaian aktivitas epileptiform pada EEG dan lokasi tumor primer intrakranial pada MRI dengan klinis kejang = Epileptiform activity on EEG suitability and location of primary intracranial tumors in MRI with clinical seizure
"ABSTRAK
Latar Belakang. Kejang merupakan gejala yang sering ditemukan pada tumor primer intrakranial dan penyebab utama morbiditas terhadap pasien.Pemeriksaan EEG diperlukan untuk menentukan kesesuaian antara fokus kejang dengan lokasi tumor pada MRI yang akan menentukan prognosis kejang serta banyak faktor-faktor yang mempengaruhi kesesuaian antara fokus kejang dengan lokasi tumor. Belum adanya data mengenai kejang pada tumor primer intrakranial serta kesesuaian berdasarkan gambaran EEG dan MRI menjadi dasar dilakukannya penelitian ini. Tujuan.Mengetahui kesesuaian antara aktivitas epileptiform pada EEG dan lesi tumor dengan MRI pada pasien tumor primer intrakranial dengan klinis kejang. Metode.Desain penelitian berupa studi potong lintang (cross sectional).Subyek penelitian adalah semua pasien dengan tumor primer intrakranial yang ada di ruang rawat inap dan rawat jalan neurologi, bedah saraf, radiologi RS Cipto Mangunkusumo yang sudah dilakukan EEG dan MRI.Ditentukan aktivitas epileptiform dan dianalisa kesesuaiannya dengan lokasi tumor berdasarkan MRI. Hasil.Dari 33 subyek dengan tumor primer intrakranial dengan klinis kejang , didapatkan hanya 17 subyek yang menunjukkan aktivitas epileptiform (51,5%), perempuan lebih banyak dari lelaki, dengan rerata usia adalah 34 tahun. Sebagian besar mengalami kejang parsial dan secondary generalized seizure(SGS) merupakan tipe kejang parsial terbanyak (16 dari 17 subyek). Kejang sering ditemukan pada tumor di frontal (11 dari 17 subyek) dan pada jenis tumor primer Low grade(8 dari 17 subyek). Kesesuaian aktivitas epileptiform dengan lokasi tumor didapatkan pada 8 dari 17 subyek dengan lebih banyak yang sesuai pada lobus temporal. Kesimpulan.Dari seluruh pasien tersangka tumor primer intrakranial dengan klinis kejang hanya didapatkan 8 dari 17 subyek yang sesuai antara aktivitas epileptiform pada EEG dengan lesi tumor pada MRI.Gambaran aktivitas epileptiform pada EEG tidak dipengaruhi oleh usia, bentuk bangkitan kejang, jenis tumor, lokasi berdasarkan lobus, lokasi berdasarkan parenkim otak, durasi sakit, dan ukuran tumor.
ABSTRAT
Background.Seizures are a common symptom in primary intracranial tumors and a major cause of morbidity to the patient. EEG examination is necessary to determine the suitability of the seizure focus to the location of the tumor on MRI that will determine the prognosis of seizures as well as a lot of factors that affect compatibility between focal seizures with tumor location. The absence of data on seizures in primary intracranial tumors and suitability based on EEG and MRI picture is the basis of this study. Purpose.Knowing the correspondence between epileptiform activity on EEG and MRI tumor lesions in patients with primary intracranial tumors with clinical seizures. Method.Design research is a cross-sectional study (cross-sectional). Subjects were all patients with primary intracranial tumors that exist in the inpatient and outpatient neurology, neurosurgery, radiology Cipto Mangunkusumo already done EEG and MRI. Epileptiform activity determined and analyzed for compliance with the location of the tumor by MRI. Result. From 33 subjects with primary brain tumors with clinical seizures, obtained only 17 subjects demonstrated epileptiform activity (51.5%), more women than men, with a mean age was 34 years. Most had partial seizures and secondary generalized seizures (SGS) is a type of partial seizure majority (16 of 17 subjects). Seizures are often found in tumors in the frontal (11 of 17 subjects) and the type of primary tumor Low grade (8 of 17 subjects). Suitability of epileptiform activity by tumor location obtained in 8 of 17 subjects with more appropriate in the temporal lobe. Conclusion.From all patients suspected of primary brain tumors with clinical seizures obtained only 8 of the 17 subjects that fit between epileptiform activity on EEG with tumor lesions on MRI. Picture of epileptiform activity on EEG was not influenced by age, shape seizures, tumor type, location based lobes, based on the location of the brain parenchyma, duration of illness, and tumor size."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Rahmat Wahjudiana
Tumor ganas maksila
"Pendahuluan
Tumor ganas maksila tidak sering dijumpai. Gejala permulaan samar-samar, dapat menyerupai radang sinus paranasal. Umumnya penderita datang telah ada benjolan sehingga penyakit telah meluas, dan telah mengenai struktur yang berdekatan. Diagnosa biasanya dibuat setelah stadium lanjut. Pengobatannya kompleks dan pronogsanya kurang baik.
Penanganan tumor ganas maksila di RSCM, disamping oleh bagian bedah, juga dilakukan oleh bagian THT. Akan dilaporkan kasus tumor ganas maksila yang dirawat di bagian bedah RSCM 1985-1986.
"
1989
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
cover
Hutahaean, Peter Parulian Patriaganesha
Hubungan kejadian invasi limfovaskular dengan lokasi tumor, ukuran tumor, dan kejadian rekurensi lokal pada pasien Giant Cell Tumor of Bone di RSUPN dr. Cipto Mangunkusumo pada tahun 2016-2020 = Association of lymphovascular invasion with tumor location, tumor size, and tumor local recurrence in Giant Cell Tumor of Bone patients at RSUPN dr. Cipto Mangunkusumo in 2016-2020
"Latar belakang: Giant cell tumor of bone (GCT tulang) adalah tumor tulang lokal agresif dengan gambaran histopatologik terdiri atas kumpulan sel besar multinuklear dan proliferasi sel mononuklear di stroma. Berdasarkan data Departemen Patologi Anatomik RSUPN Dr. Cipto Mangunkusumo, terdapat 86 kasus GCT tulang pada tahun 2016-2020. Adanya invasi limfovaskular adalah petunjuk prognosis buruk beberapa tumor. Riset ini bertujuan untuk mengetahui hubungan kejadian invasi limfovaskular dengan lokasi tumor, ukuran tumor, dan kejadian rekurensi lokal pada pasien GCT tulang di RSUPN Dr. Cipto Mangunkusumo.
Metode: Data dari 86 kasus GCT tulang di RSUPN Dr. Cipto Mangkunkusumo pada tahun 2016-2020 diambil melalui formulir pemeriksaan patologi anatomi. Variabel bebas berupa lokasi tumor, ukuran tumor, dan kejadian rekurensi lokal diuji statistik menggunakan uji kai-kuadrat dengan variabel terikat berupa invasi limfovaskular. Hasil: Invasi limfovaskular ditemukan pada 18 (20,9%) pasien GCT tulang. Uji statistik kai-kuadrat menunjukkan hubungan tidak bermakna lokasi tumor pada ekstremitas atas (p=0,227) dan ekstremitas bawah (p=0,521) dengan invasi limfovaskular. Hubungan ukuran tumor <8 cm dengan invasi limfovaskular ditemukan tidak bermakna (p=0,956). Hubungan kejadian rekurensi lokal dengan invasi limfovaskular juga tidak bermakna (p=0,692 dengan uji Fisher).
Kesimpulan: Tidak terdapat hubungan invasi limfovaskular dengan lokasi tumor, ukuran tumor, dan kejadian rekurensi lokal pada pasien GCT tulang di RSUPN Dr. Cipto Mangunkusumo.
Introduction:Giant cell tumor of bone is a local aggressive bone tumor with histopathologic features of multinuclear large cell aggregates and mononuclear cell proliferation in the stroma. According to data from Department of Anatomical Pathology RSUPN Dr. Cipto Mangunkusumo, there are 86 giant cell tumor of bone cases in 2016- 2020. Lymphovascular invasion is believed to have a bad prognostic sign for some tumors. Hence, this research aims to describe the association between tumor location, tumor size, and tumor local recurrence with lymphovascular invasion in giant cell tumor of bone patients at RSUPN Dr. Cipto Mangunkusumo.
Method: 86 giant cell tumor of bone cases at RSUPN Dr. Cipto Mangkunkusumo in 2016-2020 were collected from anatomical pathology examination form. Independent variables being tumor location, tumor size, and tumor local recurrence are statistically tested with the dependent variable, being lymphovascular invasion. A Chi-square test was used to describe the association.
Result: Lymphovascular invasion was found in 18 (20,9%) giant cell tumor of bone patients. Chi-square test showed no association between tumor location at upper extremity (p=0,227) and lower extremity (p=0,521) with lymphovascular invasion. Association of tumor size <8 cm with lymphovascular invasion was also not found (p=0,956). Similarly, association of tumor local recurrence with lymphovascular invasion was not found (p=0,692, using Fisher’s test).
Conclusion: No association was found between tumor location, tumor size, and tumor local recurrence with lymphovascular invasion of giant cell tumor of bone patients at RSUPN Dr. Cipto Mangunkusumo in 2016-2020."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
cover
Siregar, Marsintauli Hasudungan
Gambaran klinis radiologis histopatologis dan faktor prognostik tumor otak pada anak = Clinical radiology histopathology features and prognostic factor of child brain tumor
"[ABSTRAK
Tumor otak (TO) merupakan penyebab kematian kedua dari
semua kanker yang terjadi pada anak. TO memiliki gambaran klinis, radiologis
dan histopatologis yang sangat bervariasi karena proses pengembangan sel-sel
jaringan otak masih berlanjut sampai usia 3 tahun. Data penelitian mengenai TO
pada anak masih sedikit.
Tujuan: Untuk mengetahui gambaran klinis, radiologis, histopatologis dan faktor
prognostik TO di Departemen Ilmu Kesehatan Anak FKUI/ RS. Dr.
Ciptomangunkusumo Jakarta periode tahun 2010 - 2015.
Metode Penelitian: Kohort retrospektif dilakukan pada semua anak dengan TO
primer yang berobat/dirawat di Departemen Ilmu Kesehahatan Anak FKUI/RS
Dr. Ciptomangunkusumo Jakarta.
Hasil: Didapatkan 88 pasien TO primer, terdiri dari 16 pasien berusia kurang dari
3 tahun dan 72 pasien berusia lebih dari 3 tahun, laki-laki 53% dan perempuan
47%. Anak usia kurang dari 3 tahun mengalami gejala sakit kepala (63%) dan
kejang (56%), berdasarkan radiologis letak TO yang terbanyak adalah di cerebral
ventrikel (25%) dan cerebellum (24%), berdasarkan histopatologis jenis TO yang
terbanyak adalah Astrositoma (31%) dan Medulloblastoma (25%). Anak usia
lebih dari 3 tahun mengalami gejala sakit kepala (81%) dan gangguan penglihatan
(65%), berdasarkan radiologis letak TO yang terbanyak adalah di cerebellum
(24%) dan suprasellar (10 %), berdasarkan histopatologis jenis TO yang
terbanyak adalah Medulloblastoma (21%), Astrositoma (18%) dan Glioma (17%).
Angka kehidupan TO adalah 37 %. Tidak didapatkan faktor prognostik TO yang
bermakna.
Kesimpulan: Gejala TO tersering adalah sakit kepala, berdasarkan radiologis
letak tumor terbanyak adalah di cerebellum serta berdasarkan histopatologis jenis
tumor terbanyak adalah Medulloblastoma dan Astrositoma. Tidak didapatkan
faktor prognostik TO pada anak.
ABSTRACT
Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.;Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor., Background: Primary brain tumors rank second as the most frequent neoplasm in
children. The lesions occurring in neonates or infants have been reported to differ
from those in older children in terms of their clinical presentation, radiology and
histopathology features.
Objective To clarify the clinical presentation, radiology, histopathology features.
and prognostic factor of primary brain tumors in Child Department
Ciptomangunkusumo Hospital Jakarta in 2010 - 2015.
Method: Retrospective cohort using medical records and neuroradiological dan
histopathological studies, we analyzed each patient?s clinical presentation, tumor
location, histopathological diagnosis and treatment then we compared between
under 3 years of age and more 3 years of age . The patients were followed until
their death or until the end of October 2015.
Result: 88 patient of primer brain tumor that consist of 16 patients with under 3
years of age and 72 patients with more 3 years of age. Boys are 53% and girls
are 47% . The most symptoms of children under 3 years of age is headache (63%)
and seizure (56%), based on radiology the most location tumor is cerebral
ventrikel (25%) and cerebellum (24%), based on histopathology the predominant
tumor is Astrositoma (31%) and Medulloblastoma (25%). The most symptoms
of children more 3 years of age is headache (81%) and visual difficulties (65%),
based on radiology the most tumor location is cerebellum (24%) and suprasellar
(10 %), based on histopathology the predominat tumor is Medulloblastoma
(21%), Astrositoma (18%) and Glioma (17%). The life expectancy rate is 37 %.
There is no prognostic factor of brain tumor.
Conclusion: The most symptom of brain tumor is headache, based on radiology
the most tumor location is cerebellum, and based on histopathology the
predominant tumor is Medulloblastoma and Astrositoma. There is no prognostic
factor of brain tumor.]"
2016
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Wachyu Hadisaputra
Serum biomarker profiles of interleukin-6, tumor necrosis factoralpha, matrix-metalloproteinase-2, and vascular endothelial growth factor in endometriosis staging
"Latar belakang: Penelitian ini bertujuan untuk membandingkan kadar serum penanda biologis: interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), matrik-metaloproteinase-2 (MMP-2), dan vascular endothelial growth factor (VEGF) pada endometriosis stadium I-II dan stadium III-IV.
Metode: Penelitian ini adalah penelitian potong lintang pada empat puluh pasien endometriosis yang didiagnosis berdasarkan laparoskopi. Sampel serum diambil sebelum operasi, pemeriksaan penanda biologis dilakukan pada akhir penelitian dengan metode ELISA. Rerata kadar serum dibandingkan dengan menggunakan uji t tidak berpasangan.
Variabel yang memiliki perbedaan rerata bermakna diuji dengan pemeriksaan ROC dan ditentukan titik potong optimal.
Hasil: Kadar serum IL-6, TNF-a, dan MMP-2 tidak berbeda bermakna pada pasien endometriosis stadium I-II dan stadium III-IV dengan hasil rerata 1,58 ± 0,78 vs 1,55 ± 0,98 pg/mL; 1,5 ± 0,47 vs 1,49 ± 0,29 pg/mL; 152,04 ± 27,32 vs 140,98 ± 28,08 ng/mL. Hanya kadar VEGF yang memiliki perbedaan yang bermakna (289,76 ± 188,13 vs 581,29 ±
512,85 pg/mL (p < 0,05)). Perbedaan rerata VEGF memiliki nilai AUC 74,5%. Titik potong optimal VEGF = 314,75 pg/mL dengan sensitivitas 78,6% dan spesifisitas 69,2%.
Kesimpulan: Penelitian ini menunjukkan penanda biologis serum VEGF (tetapi tidak IL-6, TNF-a, dan MMP-2)dapat digunakan untuk mengukur derajat keparahan endometriosis. Kadar VEGF dari 314,75 pg/mL merupakan titik potong antara stadium yang lebih rendah dan lebih tinggi dari derajat keparahan.
Background: The focus of this study was to compare serum biomarkers: interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), matrix-metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in endometriosis stage I-II and stage III-IV.
Methods: This is a cross-sectional study. Forty endometriosis patients were diagnosed using laparoscopy procedure. Serum
sample was taken before the surgery. The serum biomarkers (IL-6, TNF-α, MMP-2, and VEGF) were analyzed with ELISA method at the end of research. Mean of serum biomarkers in endometrosis stage I-II and stage III-IV were compared using unpaired t-test. Variables that show significant mean difference were tested using ROC measurement and the optimal cut-off point was determined.
Results: There was no significant difference in mean serum biomarkers level of IL-6, TNF-α, and MMP-2 between endometriosis stage I-II and stage III-IV (1.58 ± 0.78 vs 1.55 ± 0.98 pg/mL, 1.5 ± 0.47 vs 1.49 ± 0.29 pg/mL, and 152.04 ± 27.32 vs 140.98 ± 28.08 ng/mL, respectively). On the other hand, the comparison of VEGF level in endometriosis stage I-II and stage III-IV demonstrated significant difference (289.76 ± 188.13 vs 581.29 ± 512.85 pg/mL (p < 0.05)). Mean
difference of VEGF had AUC of 74.5%. Optimal cut-off point for VEGF was ≥ 314.75 pg/mL with sensitivity 78.6% and specificity 69.2%.
Conclusion: This study showed that serum biomarkers of VEGF level (but not IL-6, TNF-α, and MMP-2) can be used to measure the degree of severity in endometriosis. VEGF level of 314.75 pg/mL represents the cut-off point between lower and higher stage of severity."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 20113
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Virnanto Buntarja
Hubungan antara usia dan lokasi pada giant cell tumor tulang di RSUPN dr. Cipto Mangunkusumo pada tahun 2016 sampai 2020 = Correlation between age and tumor site in patients with giant cell tumor of bone at RSUPN dr. Cipto Mangunkusumo from 2016 to 2020
"Latar belakang: Giant Cell Tumor of Bone (GCT tulang) adalah tumor tulang primer yang bersifat jinak-agresif dan dapat bermetastasis. Rentang usia pasien GCT tulang adalah antara 13 sampai 69 tahun. Tumor ini sering ditemukan di bagian distal femur, distal radius, dan proximal tibia. Berdasarkan tipe tulang, GCT tulang sering ditemukan pada ujung tulang panjang. Namun, GCT tulang juga dapat ditemukan pada tipe tulang lainya. Pada beberapa keganasan tulang, seperti osteosarcoma, terdapat korelasi antara usia dengan lokasi tumor. Namun, untuk GCT tulang korelasi ini masih belum diketahui. Penelitian ini bertujuan untuk melihat adanya korelasi usia dengan lokasi pada GCT tulang
Metode: Peneliti mengambil data rekam medis pasien GCT tulang di RSUPN dr.Cipto Mangunkusumo dari tahun 2016 sampai 2020. Kemudian, data usia dengan lokasi (topografi dan tipe tulang) dianalisis menggunakan tabel baris kolom.
Hasil: Pada kelompok usia 10-39 tahun ditemukan 52 kasus pada tulang apendikular dan 1 kasus pada tulang axial. Pada kelompok usia 40-69 tahun ditemukan 29 kasus pada tuang apendikular dan 4 kasus pada tulang axial. Korelasi antara usia dan lokasi topografis tidak bermakna (p>0.05). Pada kelompok usia 10-39 tahun ditemukan 49 kasus pada tipe tulang panjang dan 4 kasus pada tipe tulang lainnya. Pada kelompok usia 40-69 tahun, ditemukan 27 kasus pada tulang panjang dan 6 kasus pada tipe tulang lainnya. Korelasi antara usia dengan lokasi tipe tulang tidak bermakna (p>0.05).
Kesimpulan: Tidak ada hubungan bermakna antara usia dengan lokasi tumor (topografi dan tipe tulang) pada kasus GCT tulang
Introduction: Giant cell tumor of bone (GCTB) is a primary bone tumor with benign- aggressive behavior and capacity to metastasize. The age range for GCTB is 13 to 69 years old. GCTB is commonly in distal femur, distal radius, and proximal tibia. Based on bone type, GCTB is frequently found on meta epiphyseal site of long bone. Although, some GCTB can be found on other bone type such as flat bone, short bone, and irregular bone. In some bone neoplasms, like osteosarcoma, there is a correlation between age and tumor site. Unfortunately for GCTB, this correlation is still unknown. This study aims to determine the correlation between age and tumor site of GCTB
Method: Medical record of patients with the diagnosis of GCTB in RSUPN dr.Cipto Mangukusumo from 2016 to 2020 is included in this study. Age at diagnosis and tumor site (topographically and bone type) of patient are analyzed using cross tabulation. Result: For age group 10-39 years old, there are 52 cases of GCTB in appendicular skeleton and one case in axial skeleton. For age group 40-69 years old there are 29 cases of GCTB in appendicular skeleton and 4 cases in axial skeleton. The correlation between age and tumor topographic site is statistically not significant (p > 0.05). For the bone type, there are 49 cases of GCTB in long bone and 4 cases in other bone type for age group 10- 39 years old. For age group 40-69 years old, there are 27 cases of GCTB in long bone and 6 cases in other bone type. The correlation between age and bone type is statistically not significant (p> 0.05)
Conclusion: There are no significant correlation between age and tumor site (topographically and bone type) in GCTB"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
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Gambaran penggunaan tembakau/roko pada tumor/kanker paru di Indonesia (Tobacco use and smoking pattern on lung tumor/cancer in Indonesia basic health research 2007/2008)
BULHSR 15:3(2012)
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Efficacy of NETDC (New England Trophoblastic Disease Center) prognostic index score to predict gestational trophoblastic tumor from hydatidiform mole
"Penelitian longitudinal prospektif analitik untuk menilai ketepatan prediksi timbulnya penyakit trofoblas ganas melalui sistem penilaian prognosis mola hidatidosa yang dikembangkan oleh NETDC (New England Trophoblast Disease Center) telah dilakukan. Di antara parameter faktor risiko yang dinilai; usia penderita, jenis mola hidatidosa, pembesaran uterus, kadar hCG serum, kista lutein, serta ada-tidaknya komplikasi merupakan factor risiko yang bermakna untuk timbulnya keganasan setelah mola hidatidosa dievakuasi (p=0,032). Penelitian dilakukan pada 50 penderita mola hidatidosa dengan pengamatan lanjutan selama 1 tahun (Januari 2001-Desember 2002) di Bagian Obstetri dan Ginekologi RS Mohammad Hoesin, Palembang. Hasilnya menunjukan prediksi keganasan skor NETDC 50% pada risiko tinggi dan 10% risiko rendah untuk berkembang menjadi ganas (p<0,05). Hasil ini lebih besar dibandingkan dengan nilai yang diajukan WHO yaitu 19-30%. Risiko untuk terjadinya keganasan pasca mola hidatidosa pada kelompok risiko tinggi ialah 9,0 kali lebih tinggi disbanding pada kelompok risiko rendah (CI: 1,769-45,786). (Med J Indones 2004; 13: 40-6)
A prospective longitudinal analytic study assessing the efficacy of NETDC (New England Trophoblastic Disease Center) prognostic index score in predicting malignancy after hydatidiform mole had been performed. Of the parameter evaluated; age of patients, type of hydatidiform mole, uterine enlargement, serum hCG level, lutein cyst, and presence of complicating factors were significant risk factors for malignancy after hydatidiform mole were evacuated (p<0.032). The study were done on 50 women diagnosed with hydatidiform mole with 1 year observation (January 2001-December 2002) at the Department of Obstetrics and Gynecology, Mohammad Hoesin Hospital, Palembang. The results showed that the NETDC prognostic index score predicted malignancy in 50% of high risk group and 10% in low risk group (p<0.05). This showed a higher number than that found by the WHO (19%-30%). The risk for incidence of malignancy after hydatidiform mole in the high risk group is 9.0 times higher compared to that of the low risk group (CI: 1.769-45.786). (Med J Indones 2004; 13: 40-6)"
Medical Journal of Indonesia, 13 (1) January March 2004: 40-46, 2004
MJIN-13-1-JanMar2004-40
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