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Didik Librianto
"Background data: The treatment of bicondylar tibia plateau fractures remains controversial. Lateral buttress plate and medial antiglide is favored by AOIASIF. Recently treatment of this fracture by less invasive stabilization system in the lateral side by using locked screw plate was gained acceptances by many surgeons. In Cipto Mangunkusumo Hospital local Iocked clover plate was designed, which is given better economics solutions.
Objective: To compare the fixation stability between single lateral local locking plate and double plating system that using lateral buttress and medial antiglide in the treatment of bicondylar tibial plateau fracture.
Design: One model (Synbone 1110, normal bone quality) tibia was used. Bicondylar tibia fracture model that design by Horwitz was used. Invite biomechanical axial loading, tested to the both group was tested.
Intervention: Five pairs of fracture model was used. Stabilization using lateral buttresslmedial antiglide one third tubular in one group and unilateral local locking Clover plate (LCP) in other group. Five vertical loads levels were used (150 N, 300 N, 450 N, 600N and 750N). Irreversible (plastic) deformation was the main parameter of interest.
Main out come measures: Irreversible (plastic) deformation was the main parameter of interest. Failure was defined as more than 5 mm displacement in the particular surface in medial condyle.
Result: Vertical subsidence depended on the applied load but not on the method of fixation. The displacement of medial plateau was recorded. With confidence interval 95%, and P less than 0,05 was statistically significance. All the displacement was statistically no significantly difference P > 0,05 in five different level even the mean displacement was higher in the same loading in the local locked clover plate.
Conclusion: Single lateral local locked clover plate could give good stability in the treatment of bicondylar tibial plateau fracture that statistically no difference to double plating which using lateral buttress and medial antiglide, even though still need further investigation."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2005
T21122
UI - Tesis Membership  Universitas Indonesia Library
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Eva Rizky Prasetyaning
"Osteoporosis adalah penyakit tulang yang ditandai dengan rendahnya massa tulang yang menyebabkan peningkatan risiko patah tulang. Pada penelitian sebelumnya menunjukkan bahwa aspirin dapat mengurangi kadar S1P (Sphingosine-1-Phosphate) sehingga resorpsi tulang akibat osteoklas dapat menurun. Kombinasi aspirin dan kalsium digunakan dalam penelitian ini untuk melihat pengaruhnya terhadap jumlah sel osteoklas. Penelitian ini dilakukan pada tikus putih betina Sprague-Dawley yang dibagi menjadi 8 kelompok yaitu kelompok sham dan kontrol negatif yang diberikan CMC Na 0,5%, kelompok kontrol positif yang diberikan tamoksifen 3,6 mg/200 gBB/hari, kelompok aspirin yang diberikan aspirin 5,4 mg/200gBB/hari, kelompok kalsium yang diberikan kalsium 15 mg/200 g BB/hari, serta kelompok kombinasi aspirin dan kalsium dengan masing-masing dosisnya yaitu D1 aspirin 1,8 mg/200 g BB/hari dan kalsium 15 mg/200gBB/hari; D2 aspirin 5,4 mg/200gBB/hari dan kalsium 15 mg/200gBB/hari; dan D3 aspirin 16,2 mg/200gBB/hari dan kalsium 15 mg/200gBB/hari secara peroral. Sebelum pemberian obat, semua tikus dibedah ovariektomi kecuali kelompok sham dan kontrol negatif yang dibedah sham. Setelah pembedahan, tikus dipelihara selama 28 hari kemudian diberikan obat. Parameter yang diukur adalah berat tulang tibia dan jumlah sel osteoklas yang dilihat secara histopatologi dengan pewarnaan HE (Hematoksilin-Eosin). Berat tulang tibia kelompok sham 321,90±10,39mg, kontrol negatif 272,30±54,18mg, kontrol positif 312,50±40,86mg, aspirin 336,67±29,57mg, kalsium 335,90±60,66mg, D1 346,27±83,91mg, D2 377,00±4,51mg, D3 366,67±48,52mg. Jumlah sel osteoklas kelompok sham 7,8±0,4sel/lapang pandang, kontrol negatif 9,13±1,10sel/lapang pandang, kontrol positif 8,13±1,67sel/lapang pandang, aspirin 7,53±1,52sel/lapang pandang, kalsium 7,67±0,64sel/lapang pandang, D1 7,47±0,31sel/lapang pandang, D2 5,33±0,99sel/lapang pandang, D3 7,67±0,31sel/lapang pandang. Hasil ini menunjukkan bahwa aspirin dan kalsium dapat meningkatkan berat tulang dan menurunkan jumlah sel osteoklas.

Osteoporosis is a bone disease characterized by low bone mass which causes an increased risk of fracture. Previous study have shown that aspirin can reduce S1P (Sphingosine-1-Phosphate) levels so that bone resorption due to osteoclasts can decrease. The combination of aspirin and calcium was used in this study to see its effect on the number of osteoclasts. This study was conducted on female white Sprague-Dawley rats which were divided into 8 groups, sham, negative control groups were given 0.5% CMC Na, positive control group was given tamoxifen 3.6 mg/200gBW/day, aspirin group was given 5.4 mg/200gBW/day, calcium group was given calcium 15 mg/200gBW/day, and the aspirin and calcium combination group with each dose of D1 aspirin 1.8 mg/200gBW/day and calcium 15 mg/200gBW/day, D2 aspirin 5.4 mg/200gBW/day and calcium 15 mg/200gBW/day, and D3 aspirin 16.2 mg/200gBW/day and calcium 15 mg/200gBW/day orally. All rats were ovariectomized except for the normal group and the negative control group which underwent sham surgery. The rats were kept for 28 days and then given the drug. The parameters measured were the weight of the tibia bone and the number of osteoclasts seen histopathologically with HE (Hematoxylin-Eosin) staining. Weight of tibia bone are 321.90±10.39mg for sham, 272.30±54.18mg for negative control, 312.50±40.86mg for positive control, 336.67±29.57mg for aspirin, 335.90±60.66mg for calcium, 346.27±83.91mg for D1, 377.00±4.51mg for D2, 366.67±48.52mg for D3. The number of osteoclasts in cells/field of view are 7.8±0.4 for sham, 9.13±1.10 for negative control, 8.13±1.67 for positive control, 7.53±1.52 for aspirin, 7.67±0.64 for calcium, 7.47±0.31 for D1, 5.33±0.99 for D2, 7.67±0.31 for D3. The result is the combination of aspirin and calcium can increase bone weight and decrease the number of osteoclasts.
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Depok: Fakultas Farmasi Universitas Indonesia, 2022
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UI - Skripsi Membership  Universitas Indonesia Library
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Rifanny Adelia Dewinasjah
"Osteoporosis adalah penyakit yang ditandai dengan adanya penurunan massa tulang yang parah sehingga meningkatkan risiko terjadinya retak atau patah tulang. Penelitian sebelumnya menunjukkan bahwa pemberian aspirin dosis tinggi (300 mg) terbukti dapat menurunkan kadar Sphingosine-1-Phosphate (S1P) dalam plasma. Kadar rendah S1P dalam darah dapat mengaktifkan S1PR1 yang dapat mengarahkan prekursor osteoklas kembali ke darah sehingga proses osteoklastogenesis dapat terhambat. Penelitian ini dilakukan untuk mengevaluasi pengaruh pemberian aspirin dengan kombinasi kalsium secara in vivo. Penelitian ini menggunakan tikus putih betina Sprague-Dawley yang dibagi menjadi 8 kelompok, yaitu sham dan kontrol negatif yang diberikan 1ml CMC Na 0,5%, kontrol positif diberikan tamoksifen sitrat 3,6 mg/200 g BB/hari, kelompok aspirin diberikan aspirin 5,4 mg/200 g BB/hari, kelompok kalsium diberikan kalsium sitrat 15 mg/200 g BB/hari, serta 3 kelompok variasi dosis aspirin dalam kombinasi dengan kalsium sitrat yaitu D1 aspirin 1,8 mg/200 g BB/hari, D2 aspirin 5,4 mg/200 g BB/hari, D3 aspirin 16,2 mg/200 g BB/hari dimana ketiga variasi dosis tersebut dikombinasikan dengan dosis kalsium sitrat 15 mg/200 g BB/hari secara peroral. Semua tikus dilakukan ovariektomi, kecuali kelompok sham dilakukan pembedahan tanpa pengambilan ovarium. Tikus dipelihara 4 minggu pasca operasi, lalu diberi perlakuan selama 28 hari. Parameter pertama yang diukur adalah berat tulang tibia dengan rata-rata kelompok sham 321,90 ± 10,39 mg, kontrol negatif 272,300 ± 54,18 mg, kontrol positif 312,50 ± 40,86 mg, aspirin 336,67 mg, kalsium 335, 90 ± 60,66 mg, D1 346,27 ± 83,90 mg, D2 377,00 ± 36,10 mg, dan D3 336,67 ± 4,5 mg. Parameter kedua yang diukur adalah kadar kalsium dengan rata-rata kelompok kelompok sham 111,08 ± 4,74 mg, kontrol negatif 89,30 ± 23,94 mg, kontrol positif 109,69 ± 20,25 mg, aspirin 123,01 ± 17,98 mg, kalsium 124,53 ± 32,11 mg, D1 120,19 ± 3,63 mg, D2 149,22 ± 17,13 mg, dan D3 121,60 ± 5,21 mg. Berdasarkan penelitian, pengaruh pemberian dosis kombinasi aspirin 5,4 mg/200 g BB/hari dan dosis kalsium 15 mg/200 g BB/hari pada tikus dapat meningkatkan berat dan kadar kalsium tulang tibia secara efektif.

Osteoporosis is a disease characterized by a severe decrease in bone mass that increases the risk of fractures. Previous studies have shown that high-dose aspirin (300 mg) has been shown to reduce plasma levels of Sphingosine-1-Phosphate (S1P). Low levels of S1P in the blood can activate S1PR1 which can direct osteoclast precursors back to the blood so that the process of osteoclastogenesis can be inhibited. This study was conducted to evaluate the effect of aspirin and calcium combination in vivo. This study used female Sprague-Dawley rats which were divided into 8 groups, namely sham and negative control which were given 1ml CMC Na 0.5%, positive control was given tamoxifen citrate 3.6 mg/200 g BW/day, aspirin group was given aspirin. 5.4 mg/200 g BW/day, the calcium group was given calcium citrate 15 mg/200 g BW/day, as well as 3 groups with variations in the dose of aspirin in combination with calcium citrate, namely D1 aspirin 1.8 mg/200 g BW/day, D2 aspirin 5.4 mg/200 g BW/day, D3 aspirin 16.2 mg/200 g BW/day where the three variations of the dose were combined with a dose of calcium citrate 15 mg/200 g BW/day. All rats were ovariectomized, except for the sham group which underwent surgery without removing the ovaries. After 4 weeks of ovariectomy, rats were treated for 28 days orally. The first parameter that was measured was the mass of the tibia bone with the average for bone mass in each group are 321.90 ± 10.39 mg for sham group, 272.300 ± 54.18 mg for negative control, 312.50 ± 40.86 mg for positive control, 336.67 mg for aspirin group, 335, 90 ± 60.66 mg for calcium group, 346.27 ± 83.90 mg for D1, 377.00 ± 36.10 mg for D2, and 336.67 ± 4.5 mg for D3. The second parameter measured was calcium levels with the average for calcium levels in each group are 111.08 ± 4.74 mg for sham group, 89.30 ± 23.94 mg for negative control, 109.69 ± 20.25 mg for positive control, 123.01 ± 17.98 mg for aspirin group, 124.53 ± 32.11 mg for calcium group, 120.19 ± 3.63 mg for D1, 149.22 ± 17.13 mg for D2, and 121.60 ± 5.21 mg for D3. Based on the research, the effect of a combination dose of aspirin 5.4 mg/200 g BW/day and calcium dose 15 mg/200 g BW/day in rats can increase the weight and calcium levels of the tibia bone effectively."
Depok: Fakultas Farmasi Universitas Indonesia, 2022
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UI - Skripsi Membership  Universitas Indonesia Library
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Rifqa Inasa Syahrila
"Osteoporosis merupakan masalah kesehatan yang dicirikan dengan menurunnya massa dan struktur tulang yang menyebabkan kerapuhan dan patah tulang. Pada penelitian sebelumnya analog L-serin H-Ser(tBu)-OMe.HCl, terbukti dapat mengatasi gejala osteoporosis dengan meningkatkan massa tulang melalui penghambatan Serine Palmitoyltransferase (SPT). Pada penelitian ini, dilakukan eksperimen secara in vivo pada analog serin yang terbukti menghambat SPT yaitu L-sikloserin. Penelitian ini menggunakan tikus putih betina Sprague-Dawley yang dibagi menjadi 6 kelompok, yaitu sham dan kontrol negatif yang diberikan 1ml NaCl 0,9%, kontrol positif diberikan natrium alendronat 1mg/kg BB/hari, serta 3 kelompok variasi dosis L-sikloserin dengan D1 0,9mg/kg BB/hari, D2 1,8mg/kg BB/hari, dan D3 3,6mg/kg BB/hari dengan injeksi intraperitoneal. Semua tikus dilakukan ovariektomi, kecuali kelompok sham dilakukan pembedahan tanpa pengambilan ovarium. Tikus dipelihara 4 minggu pasca operasi, lalu diberi perlakuan selama 28 hari. Parameter yang diukur adalah berat tulang dengan rata-rata kelompok sham 255,9±3,12mg, kontrol negatif 212,1±7,90mg, kontrol positif 268,93±11,12mg, D1 284,50±28,59mg, D2 294,73±15,96mg, dan D3 277,43±24,38mg; kadar kalsium tulang dengan sham54,93±7,72mg, kontrol negatif 44,37±4,86mg, kontrol positif 53,26±3,16mg, D1 53,73±1,22mg, D2 58,45±6,29mg, serta D3 53,35±1,62mg; serta jumlah osteoklas dihitung secara histopatologi menggunakan pewarnaan TRAP dengan hasil sham 26,6±2,88sel/lapang pandang, kontrol negatif 61,27±14,64sel/lapang pandang, kontrol positif 21,6±3,5sel/lapang pandang, D1 29,2±1,31sel/lapang pandang, D2 22,53±1,45sel/lapang pandang, dan D3 28,4±11,93sel/lapang pandang. Berdasarkan penelitian, L-sikloserin meningkatkan berat dan kadar kalsium tulang, serta dapat menurunkan jumlah sel osteoklas.

Osteoporosis is characterized by decreasing bone mass and bone structure, causing bone fragility and fracture. L-serine analog H-Ser(tBu)-OMe.HCl, has been known to increase BMD and inhibit Serine Palmitoyltransferase (SPT) thus inhibits osteoclastogenesis. In this study, we evaluated another L-serine analog which is SPT inhibitor, L-cycloserine. This experiment is done by using Sprague-Dawley rats, divided into 6 different groups: sham and negative control were given 1ml of NaCl 0.9%, positive control was given 1mg/kg/day of sodium alendronate and the last 3 groups D1, D2, and D3 were given 0.9mg/kg/day, 1.8mg/kg/day, and 3.6mg/kg/day of L-cycloserine respectively. Ovariectomy was performed on all groups except for sham which underwent surgery without ovarium removal. After 4 weeks of ovariectomy, rats were treated for 28 days by intraperitoneal injection. Bone mass, calcium content, and osteoclast number histopathologically counted using TRAP staining were determined after 28 days of treatment. Mean bone mass in each group are 255.9±3.12mg for sham, 212,1±7.90mg for negative control, 268.93±11.12mg for positive control, 284.50±28.59mg for D1, 294.73±15.96mg for D2, and 277.43±24.38mg for D3. Mean calcium content in each group are 54.93±7.72 mg for sham, 44.37±4.86 mg for negative control, 53.26±3.16 mg for positive control, 53.73±1.22 mg for D1, 58.45±6.29 mg for D2, and 53.35±1.62 mg for D3. Mean of osteoclast numbers in cell/microscopic field of view are 26.6±2.88, 61.27±14.64, 21.6±3.5, 29.2±1.31, 22.53±1.45, 28.4±11.93 for sham, negative control, positive control, D1, D2, and D3 groups respectively. The results showed that L-cycloserine increases bone mass and calcium content, and reduces the number of osteoclasts.
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Fakultas Farmasi Universitas Indonesia, 2021
S70509
UI - Dokumentasi  Universitas Indonesia Library
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"The first bone cement developed by Charnley in the 1960s using polymethyl methacrylate (PMMA) remains the most widely used material for fixation of orthopaedic joint replacement. In the field of dentistry, polycarbocylate and glass ionomer cements first came to prominence as dental cements in the late 1960s and early 1970s. Although biocompatible, the zinc component results in the formation of a fibrous collagen capsule around the zinc polycarboxylate cement in vivo, which compromises the strength of the intermediate region between the bone and cement. Glass ionomer cements were anticipated to have potential in orthopaedic applications. The discovery of a well integrated intermediate layer between bone and many bioactive ceramic phases from the calcium-phosphate systems, such as hydroxyapatite (HA), resulted in the development of new cements incorporating such phases. Investigations into bioglass and apatite/wollastonite glass-ceramics prompted the development of off-the-shelf bone graft substitute materials. Synthetic hydroxyapatite is commercially available and serves primarily as a scaffold in order to facilitate the bone regeneration process. Many investigations have ranged from the development of castable bioactive materials to modified bioactive composites. This article attempts to give a broad overview of the different types of cements."
Journal of Dentistry Indonesia, 2004
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Artikel Jurnal  Universitas Indonesia Library
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Liem, Isabella Kurnia
"Perkiraan panjang utuh tulang dari panjang fragmen-fragmennya perlu dilakukan sebagai langkah pertama dalam memperkirakan tinggi badan pada kasus identifikasi atas mayat tak dikenal yang ditemukan dalam keadaan tidak lengkap (kasus mutilasi, berupa bagian-bagian kerangka atau fragmen-fragmen tulang). Penelitian perkiraan panjang utuh tulang dari panjang fragmen-fragmennya pada populasi Indonesia belum pernah dilaporkan, sehingga di lapangan digunakan rumusan yang dibuat berdasarkan penelitian-penelitian pada populasi lain dengan hasil yang kemungkinan kurang tepat. Oleh karena itu, maka dilakukan penelitian analitik-non eksperimental yang bertujuan memperkirakan panjang utuh tulang femur, tibia dan humerus dari panjang fragmen-fragmennya pada populasi Melayu (Deuteromalayid) Indonesia.
Pada penelitian ini dilakukan pemeriksaan terhadap 454 tulang yang berasal dari 158 tulang femur (114 pria dan 44 wanita), 125 tulang tibia (90 pria dan 35 wanita), dan 169 tulang humerus (128 pria dan 41 wanita). Pada setiap tulang dilakukan pengukuran terhadap panjang utuh tulang dan panjang fragmen-fragmennya berdasarkan definisi Steel. Kemudian dilakukan analisis mengenai perbedaan panjang utuh tulang dan panjang fragmen-fragmennya serta rasio panjang fragmen-fragmen tulang terhadap panjang utuh tulangnya antara pria dan wanita, dan antara posisi lateral kanan dan kiri dengan uji ANOVA dua jalur, yang dilanjutkan dengan analisis regresi dan faktor multiplikasi untuk mencari hubungan di antara kedua parameter tersebut.
Dan hasil analisis tersebut ditemukan bahwa: 1) panjang utuh dan panjang fragmen tulang femur, tibia dan humerus pria lebih panjang daripada wanita, kecuali fragmen T5 dan H3, 2) rasio panjang fragmen-fragmen tulang tibia (T2, T4 dan T5) dan humerus (HI dan H3) pria berbeda dengan wanita, tetapi pada tulang femur rasio tersebut antara pria dan wanita sama; 3) panjang utuh dan panjang fragmen-fragmen tulang femur, tibia dan humerus serta rasio panjang fragmen-fragmen tulang femur, tibia dan humerus kanan sama dengan kiri; 4) persamaan regresi dengan menggunakan prediktor panjang fragmen-fragmen tulang femur, tibia dan humerus layak digunakan untuk memperkirakan panjang utuh tulangnya, kecuali fragmen T1 dan T5 pria dan wanita, dan H3 wanita; 5) faktor multiplikasi fragmen-fragmen tulang femur, tibia dan humerus layak digunakan memperkirakan panjang utuh tulangnya; 6) persamaan regresi lebih tepat dalam memperkirakan panjang utuh tulang femur, tibia dan humerus dan fragmen-fragmennya dibanding faktor multiplikasi, namun secara statistik tidak ditemukan adanya perbedaan yang bermakna.

Estimating Bone Length Of Femur, Tibia And Humerus From The Fragment Length In Indonesian Malay (Deuteromalayid) PopulationEstimating length from its fragment length is required as the first step in estimating stature for identification of incomplete unknown bodies (for example, in mutilation cases and in cases in which only parts of human skeletons or fragmented bone are found). The method for estimating bone length from its fragment length in Indonesian population has not been reported yet. Therefore, in the real case, the estimation of bone length is calculated based on the other population data that usually result on relatively inaccurate result. Based on that reason, an analitic-non-experimental research was executed to get better method for estimating bone length of femur, tibia and humerus from the fragment length in Indonesian Malay (Deuteromalayid) population.
The examination was performed on 454 bones that consisted of 158 femur (114 males and 44 females), 125 tibia (90 males and 35 females), and 169 humerus (128 males and 41 females). The measurements of the complete bone lengths and their fragment lengths were based on Steel definition. The analysis of the differences between bone lengths, the fragment lengths and the ratio of the fragmented bone versus the bone length were done between males and females, and between right and left side with two way ANOVA analysis. The analysis was continued with the regression and multiplication factor analysis to find the relationship between these two parameters.
The results showed: 1) the male's bone length of femur, tibia and humerus and the fragment length were longer than the female's, except T5 and 1-13 fragments, 2) the male's ratio of the fragmented bones of tibia (T2, T4, and T5) and humerus (HI and H3) to their total length were different from the female's, but for femur, the male's ratio was the same as the female's; 3) the bone length, fragments length and the ratio of the fragmented bone of femur, tibia and humerus on the right side were equal with the left side; 4) regression equations fragment of femur, tibia and humerus can be used for estimating the, bone length, except the male's dan female's T1 and T5 fragments, and the female's H3 fragmen; 5) multiplication factor of fragmented bone of femur, tibia and humerus can be used for estimating the bone length; 6) regression equation is more precise than multiplication factor in estimating the bone length from the fragment length, although, statisticaly, there are no significant differences."
Depok: Fakultas Kedokteran Universitas Indonesia, 2003
T 11302
UI - Tesis Membership  Universitas Indonesia Library
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Husnul Fuad Albar
"Masih terdapat kontroversi dalam penanganan burst fracture pada tulang belakang bagian thoracolumbar. Tujuan utama dari penanganan pasien dengan burst fracture adalah reduction, stabilization dan fusion. Pada pasien dengan defisit neurologis akibat burst fracture, dekompresi dari canal spinalis rnerupakan tujuan utama dari pembedahan. Dekompresi anterior, strut graft dan instrumentasi anterior diindikasikan untuk penatalaksanaan unstable burst fracture. Sebaliknya instrumentasi posterior sering digunakan untuk penanganan burst fracture pada thoracolumbar spine. Penggunaan instrumentasi transpedicular semakin popular saat ini karena dapat menghasilkan fiksasi yang rigid yang menggunakan implant lebih pendek dengan segmental fixation dan fusi.
PSSW (Pedicle Screw Sublaminary Wiring) sistem instrumentasi posterior untuk tulang belakang yang dikembangkan di RSCM-FKUI. Instrumentasi ini menggunakan sekrup cortical 4,5 mm untuk pedicle screw dan soft wire 1,2 mm untuk sublaminary wiring.
Oleh karena itu kami melakukan penelitian yang membandingkan stabilitas antara instrumentasi anterior dan instrumentasi posterior berupa PSSW untuk membuktikan hypothesis bahwa fiksasi burst fracture dengan menggunakan PSSW akan memberikan fiksasi yang minimal setara dengan instrumentasi anterior terhadap gaya axial."
Depok: Universitas Indonesia, 2006
T18019
UI - Tesis Membership  Universitas Indonesia Library
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Vanissa
"Defisiensi estrogen pada wanita post-menopausal berakibat pada menurunnya massa tulang seperti yang terlihat pada penderita osteoporosis. Oleh karena itu, diperlukan bahan pengganti estrogen sebagai terapi osteoporosis post-menopausal. Melalui penelitian ini diteliti efektifitas pegagan sebagai bahan pengganti estrogen. Terapi dengan pegagan berbagai konsentrasi pada tikus yang telah diovariektomi menunjukkan hasil peningkatan jumlah osteosit, diikuti dengan penurunan jumlah osteoklas namun tidak ada peningkatan jumlah osteoblas yang bermakna.

Estrogen deficiency in post-menopausal women results in reduced bone quality as seen in osteoporotic patients. Thus, an alternative estrogen source is needed as post-menopausal osteoporosis therapy. In this research, the efectivity of Centella as phytoestrogens is examined. Therapy with Centella in different concentrations in ovariectomized rats shows increased number of osteocytes, followed by decreased number of osteoclasts but no significant increase of osteoblasts.
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Jakarta: Fakultas Kedokteran Gigi Universitas Indonesia, 2013
S568895
UI - Skripsi Membership  Universitas Indonesia Library
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Yanto
"[ABSTRAK
Pendahuluan: Tatalaksana osteomielitis dengan debridement, guttering, pemberian antibiotika sistemik sering tidak mencapai hasil yang memuaskan dikarenakan antibiotik tidak dapat mencapai lokasi infeksi dengan baik. Cara lain dengan pemberian antibiotik lokal untuk mencapai lokasi infeksi dalam bentuk beads dinilai tidak efektif karena memerlukan 2 kali operasi. Kombinasi antibiotik lokal dengan scaffolding berupa hidroxyapatite (HA) porous yang dapat diserap dan pembawa antibiotik belum pernah diteliti.
Metode penelitian: Dilakukan uji pre test post test kelompok kontrol pada model kelinci osteomielitis. Sepuluh ekor kelinci New Zealand digunakan dengan berat 2.500-3500 gr yang dibagi kedalam 2 kelompok yaitu kelompok kontrol dan kelompok perlakuan (n=5). Dilakukan penyuntikan bakteri
pada tulang tibia kelinci, setelah terbentuk model osteomielitis kemudian dilakukan perlakuan. Untuk kelompok kontrol dilakukan debridement dan diberikan injeksi antibiotik ceftriaxon selama 4 minggu dan kelompok perlakuan dilakukan debridement, diberikan kombinasi HA dan Gentamisin serta injeksi antibiotik ceftriaxon selama 4 minggu. Setelahnya dilakukan penilaian klinis, x- ray, kultur dan histopatologis.
Temuan dan Diskusi: Secara radiologis ditemukan perbaikan skor penebalan kortek tibia pada kelompok perlakuan dibanding kelompok kontrol (p=0.48), begitu juga pada Histopatological osteomyelitis evaluation score (p=0,009). Secara klinis terdapat perbaikan skor pembengkakan pada semua (n=5) kelompok perlakuan dibanding dengan kelompok kontrol, namun secara statistik tidak bermakna (p=0,053). Sementara pada penilaian kultur tidak ditemukan perbedaan bermakna antar kedua kelompok (p=1,00)
Kesimpulan: Kombinasi Hydroxyapaptite porous dan gentamisin sebagai antibiotik lokal pada pengobatan model osteomielitis tibia kelinci memberikan perbaikan skor radiologis, histopatologis dan perbaikan klinis dibanding dengan prosedur standar pengobatan oseomielitis kronis yang sudah ada.

ABSTRACT
Introduction. Treatment of osteomyelitis with debridement, guttering, systemic antibiotics often do not achieve satisfactory results due to the antibiotic can not reach the infection site. Another way of local antibiotic delivery to reach the site of infection in the form of beads is considered ineffective because it requires two separate surgeries. Local antibiotic combined with scaffold in the form of porous hidroxyapatite that can be absorbed and antibiotics cariere have not been studied.
Methods. We conducted pretest and posttest control group in a rabbit model of osteomyelitis. Ten rabbits divided in control group and the treatment group (n=5). We injected Staphylococcus aureus in the rabbit tibia, forming the osteomyelitis model, and then performed treatment for osteomyelitis. In the control group, we performed debridement and gave ceftriaxone injection for 4 weeks. Whereas in the treatment group, we add the combination of porous hidroxyapatite and Gentamicin. Afterwards, we did clinical assessment, x-ray, culture, and histopathology.
Results and discussion. Radiologically, tibia cortical thickening scores improved in the treatment group compared to the control group (p=0.48) as well as histopatological osteomyelitis evaluation score (p=0,009). Clinically, there were improvements in the swelling scores (n=5) of the treatment group compared to control group, but no significant statistically (p=0.053). In culture, there were no significant difference between the two groups (p=1.00).
Conclusion. Combination of porous hydroxyapaptite and gentamycin as a local treatment of osteomyelitis of the rabbit tibial osteomyelitis models improved radiological and histopathological scores and also clinically compared to existing standard treatment procedures for chronic osteomyelitis., Introduction. Treatment of osteomyelitis with debridement, guttering, systemic antibiotics often do not achieve satisfactory results due to the antibiotic can not reach the infection site. Another way of local antibiotic delivery to reach the site of infection in the form of beads is considered ineffective because it requires two separate surgeries. Local antibiotic combined with scaffold in the form of porous hidroxyapatite that can be absorbed and antibiotics cariere have not been studied.
Methods. We conducted pretest and posttest control group in a rabbit model of osteomyelitis. Ten rabbits divided in control group and the treatment group (n=5). We injected Staphylococcus aureus in the rabbit tibia, forming the osteomyelitis model, and then performed treatment for osteomyelitis. In the control group, we performed debridement and gave ceftriaxone injection for 4 weeks. Whereas in the treatment group, we add the combination of porous hidroxyapatite and Gentamicin. Afterwards, we did clinical assessment, x-ray, culture, and histopathology.
Results and discussion. Radiologically, tibia cortical thickening scores improved in the treatment group compared to the control group (p=0.48) as well as histopatological osteomyelitis evaluation score (p=0,009). Clinically, there were improvements in the swelling scores (n=5) of the treatment group compared to control group, but no significant statistically (p=0.053). In culture, there were no significant difference between the two groups (p=1.00).
Conclusion. Combination of porous hydroxyapaptite and gentamycin as a local treatment of osteomyelitis of the rabbit tibial osteomyelitis models improved radiological and histopathological scores and also clinically compared to existing standard treatment procedures for chronic osteomyelitis.]"
2015
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