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"30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as- the chemistry and biochemistry of cisplatin,- the clinical status of Pt anticancer drugs,- the impact of cisplatin on inorganic and coordination chemistry,- new developments in drug design, testing and delivery.It also includes a chapter describing the historical development of the discovery of cisplatin. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter."

"Drugs in Sport is the most comprehensive and accurate text available on this complex and controversial subject. Now in a fully revised and updated fifth edition, taking into account the latest regulations, methods and landmark cases, the book explores the hard science behind drug use in sport, as well as the ethical, social, political and administrative contexts. It is supported throughout by data, illustrative case studies, and references for further reading.ContentsSect 1 The basis for and regulation of drug use in sport 1. An introduction to drugs and their use in sport2. A historical perspective of doping and anti-doping in sport3. Medicines for Olympic and Commonwealth GamesSect 2 Substances and methods prohibited in sport 4. Anabolic agents5. Peptide hormones and related substances6. Beta-2 agonists7. Hormone antagonists and modulators8. Diuretics and other masking agents9. Enhanced oxygen transfer10. Prohibited methods: chemical and physical manipulation11. Gene doping12. Stimulants13. Narcotic analgesic drugs14. Cannabinoids15. Glucocorticosteroids16. Alcohol17. Beta blockersSect 3 Substances and methods permitted in sport 18. Supplements for high intensity exercise: creatine and other ergogenic aids19. Supplement use in sport20. Caffeine21. Over-the-counter stimulants and herbal preparations22. Non-steroidal anti-inflammatory drugs23. Melatonin and related substances24. Hypoxic chambers and other artificial environmentsSect 4 The extent of doping in sport 25. Prevalence of drug misuse in sport."

"1. Chemical structure and bonding; 2. Intermolecular interactions; 3. Acids and bases; 4. Stereochemistry; 5. Chemical reaction mechanisms; 6. Chemistry of electrophiles and nucleophiles; 7. Chemistry of aromatic compounds; 8. Chemistry of carbonyl compounds; 9. Chemistry of aromatic heterocyclic compounds; 10. Amino acids, peptides and proteins; 11. Carbohydrates and nucleic acids; 12. Lipids and steroids; 13. Chemical stability of drugs; 14. Drug metabolism; 15. Molecular spectroscopy and pharmaceutical analysis; 16. Drug licensing and pharmacopoeia; Answers to self-assessment"

"Presents information on every drug class used to treat cardiovascular disease. This title features dosages, interactions, indications and contraindications, side effects, and more at your fingertips, equipping you to make effective clinical decisions on behalf of your patients"