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"Insidens kanker paru terus meningkat baik di negara maju maupun negara berkembang. Saat ini berkembang berbagai modaliti gabungan yang dianggap berperan dalam menurunkan morbiditi dan memperpanjang usia. Terapi pilihan kanker paru jenis karsinoma bukan sel kecil (KPKBSK) bila masih memungkinkan adalah pembedahan. Dua puluh lima persen sampai 45% dari seluruh kasus KPKBSK yang dilaporkan, dapat menjalani pembedahan. Pembedahan pada stage yang tepat akan memberikan masa tahan hidup yang lebih panjang terutama bagi penderita KPKBK. Di Rumah Sakit Persahabatan, pembedahan dilakukan terhadap 10% kasus kanker paru. Kasus dengan stage yang rendah mempunyai angka tahan hidup 5 tahun atau 5 year survival rate yang baik. Pembedahan pada stage yang tepat mempunyai angka tahan hidup 5 tahun yang meningkat pada KPKBSK. Kemoterapi dan radioterapi dianjurkan pada kasus yang tidak mungkin dibedah. Angka tahan hidup penderita pascabedah dipengaruhi oleh berbagai faktor di antaranya stage, jenis histologis, usia, jenis pembedahan dan jenis kelamin serta penggunaan, terapi neoadjuvan I adjuvan. Angka tahan hidup secara sederhana dapat dihitung memakai metoda life table.Radiasi atau kemoterapi saja dapat memperbaiki kualiti hidup penderita tetapi tidak meningkatkan angka tahan hidup 5 tahun. Jenis histologis juga merupakan faktor yang berpengaruh terhadap angka tahan hidup penderita. Faktor lain yang berperan dalam prognosis KPKBSK adalah usia dan jenis kelamin dan jenis reseksi. Terapi neoadjuvan ditujukan bagi kasus stage IIIA yang akan dibedah. Multimodaliti ini meningkatkan angka tahan hidup secara bermakna."

"Pasien KPKBSK mengalami progresifitas penyakit 8-12 minggu setelah pemberian kemoterapi lini kedua sehingga pemberian kemoterapi lini kedua dapat digunakan untuk meningkatkan ketahanan hidup pasien. Dosetaksel dapat digunakan sebagai kemoterapi lini kedua pada pasien yang mengalami perburukan setelah kemoterapi lini pertama. Namun penelitian pemberian dosetaksel sebagai kemoterapi lini kedua belum ada di Indonesia. Sampai saat ini, kami belum mendapatkan data mengenai efikasi dosetaksel seperti ketahanan hidup toksistitas pada orang Indonesia. Objektif : Tujuan penelitian ini adalah untuk menilai ketahanan hidup pasien KPKBSK yang diberikan dosetaksel sebagai kemoterapi lini kedua di RS Persahabatan. Metode : Desain penelitian ini adalah kohort retrospektif. Kami mengumpulkan catatan rekam medis pasien yang mendapatkan dosetaksel sebagai kemoterapi lini kedua di RS Persahabatan sejak bulan Januari 2011 hingga Februari 2014. Kami melakukan kunjungan rumah atau komunikasi via telepon apabila informasi dalam rekam medis tidak lengkap. Kami melakukan analisis Kaplan-Meier dan uji Log Rank untuk menilai faktor yang mempunyai korelasi terhadap ketahanan hidup pasien. Hasil : Subjek terbanyak yang dijumpai adalah laki-laki (72,7%) dengan kelompok usia >50 tahun sebanyak (79,5%) serta rerata usia 57,00±SD 10,00 dengan rentang 30?74 tahun. Angka tahan hidup 1 tahun yang kami temukan adalah 70,5% dengan masa tengah tahan hidup16,18 bulan. Toksisitas hematologi anemia grade 1 sebanyak (40,9%), anemia grade 2 sebanyak (2,3%), anemia grade 3 sebanyak (2,3%). Toksisitas hematologi leukopenia grade 1 sebanyak (4,5%) dan leukosit grade 1 sebanyak (2,3%) serta toksisitas hematologi neutropenia grade 1 sebanyak (2,3%). Toksisitas nonhematologi yang ditemukan adalah mual-muntah (84,1%), mialgia (90,9%) serta neuropati (97,7%). Tampilan status dan modalitas selain kemoterapi merupakan faktor prognostik yang baik. Berdasarkan uji Cox Regression, tampilan status berperan dalam ketahanan hidup Exp(B) 0,109(95%CI 0,015-0,816; p= 0,031). Kesimpulan : Dosetaksel dapat digunakan sebagai kemoterapi lini kedua karena ketahanan hidup yang didapatkan cukup baik dengan toksisitas ringan. Tampilan status dan pemberian modalitas terapi lain merupakan faktor prognostik yang baik.

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Since NSCLC patients had disease progression after 8-12 weeks after first line chemotherapy so that second line chemotherapy could be applied to prolong survival. Docetaxel could be applied for NSCLC patient who had disease progression. However, research on Docetaxel application as second line chemotherapy had not yet conducted in Indonesia. So far, we had not data on docetaxel efficacy such as its survival rate and its toxicity on Indonesian subjects.

Purpose : The objective of the study to evaluate the survival rate of docetaxel as second line chemotherapy for NSCLC patients in Persahabatan Hospital.

Methode : This study used the cohort retrospective method. We collected the data from medical records of NSCLC patients who had docetaxel as second line chemotherapy in Persabatan Hospital, within Januari 2011 until February 2014. If the medical record didn?t give the information that was needed, we did the phone callor home visit. The Kaplan-Meier analysis was done and continued with Log Rank test to evaluate factors that correlate with patients survival rate.

Result : Subjects in this study were mostly male (72,7%) with predominant age group of over 50 years old (79,5%) and mean age were 57,00±SD 10,00 within range 30?74 years old. Predominant histopathologic type of NSCLC was adenocarcinoma(91%). This study found that 1-year survival rate of patients after docetaxel chemotherapy was 70,5% amd median survival time of 16,18 month. hematological toxicity found were anemia grade 1 (40,9%), grade (2,3%), grade 3 (2,3%), also leucopenia grade 1 (4,5%) grade 2 (2,3%) and neutropenia grade 1 (2,3%). Nonhematological toxicity found were nausea (84,1%), myalgia (90,9%) and neuropathy (97,7%). We found that performance status and additional treatment modality were good prognostic factors on bivariate analysis. Furthermore, only performance status was found as prognostic factors on Cox Regression Exp(B) 0,109 (95%CI 0,015-0,816; p= 0,031).

Conclusion : Docetaxel could be applied as second line chemotherapy since its survival rate was good while its toxicity found was mild. Performance status and additional treatment modality were good prognostic factor."

"Kehidupan bermasyarakat senantiasa diatur oleh sebuah sistem etika yang dianut secara kolektif oleh anggotanya. Pada masyarakat Islam fundamental Indonesia, perempuan muslim, terutama yang berhijab, memiliki tanggung jawab yang lebih besar dalam menjalankan sistem etika yang ada. Ini berkaitan dengan kepercayaan kolektif masyarakat bahwa ritual penggunaan hijab adalah hal yang sakral. Oleh karena itu, kesucian hijab harus dijaga dengan baik. Adanya kepercayaan ini menyebabkan kecanggungan saat mencampurkan hijab dengan kesenian dalam konteks selain ibadah. Kecanggungan sangat berat dirasakan oleh Hijab Cosplayer yang mencampurkan hijab dengan hobi mereka. Hijab Cosplayer kerap kali mengalami penolakan dari masyarakat karena dianggap telah menistakan hijab dengan melakukan cosplay. Pemahaman ini lah yang ingin didobrak oleh komunitas Hijab Cosplay Gallery melalui kode etik yang dianut oleh anggotanya. Kode etik ini kemudian menjadi sebuah norma yang diemban oleh Hijab Cosplayer sebagai bentuk komitmen terhadap Tuhan juga pembuktian akan kesalehan mereka. Tulisan ini akan berfokus pada kode etik Hijab Cosplayer dan bagaimana ia dijaga dan dijalankan dalam komunitas imajiner melalui kesadaran kolektif kelompok. Melalui tulisan ini, saya berharap dapat memberikan perhatian yang lebih terhadap komunitas Hijab Cosplayer dan religiusitas dalam dunia modern.

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The life of a society is bounded by the existence of an ethical system that is collectively believed and internalized by the members. In Indonesian Fundamentalist Muslim society, Muslim women, especially those who wear the hijab, carry a greater responsibility in doing said system. It is connected to how society’s collective belief, that the ritual of wearing a hijab is sacred. Therefore, the hijab’s pureness needs to be protected at all costs. This belief then caused awkwardness when mixing the hijab with art in a non-sacred context. This awkwardness is felt more by the Hijab Cosplayers who mix the hijab with their hobby. They are often subjected to rejection from Muslim society because it is believed that they have committed blasphemy towards the hijab by doing cosplay. Hijab Cosplay Gallery then tries to breach said beliefs using the code of ethics that is held collectively by its members. This code of ethics was later internalized by Hijab Cosplayer as some kind of a norm among them as a form of commitment to God and proof of their faith. This writing focuses on Hijab Cosplayer’s code of ethics and how it is preserved by an imagined community through the community members' collective consciousness. Through this writing, I am hoping to shed more light on the Hijab Cosplayer community and religiosity in modern world."

"[ABSTRAKPendahuluan. Kanker paru jenis karsinoma bukan sel kecil (KPKBSK) terdiri dari nonskuamosa dan skuamosa. Kanker paru jenis karsinoma bukan sel kecil nonskuamosa adalah adenokarsinoma dan karsinoma sel besar. Saat ini terapi kanker paru sangat berkembang dari agen kemoterapi sampai terapi target terutama EGFR-TKI. Penelitian ini bertujuan untuk menilai angka tahan hidup pasien KPKSBK nonskuamosa yang mendapat kemoterapi lini pertama dibandingkan terapi EGFR-TKI di RSUP Persahabatan.Metode. Penelitian ini adalah penelitian retrospektif antara tahun 2010 sampai 2013 dari rekam medis pasien KPKBSK non skumosa yang mendapatkan kemoterapi lini pertama dan EGFR-TKI. Pasien dikemoterapi dengan platinum baseddan EGFR-TKI diterapi gefitinib 1x250 mg/hari atau erlotinib 1x150 mg/hari. Angka tahan hidup dinilai dari mulai tegak diagnosis sampai pasien meninggal atau saat penelitian dihentikan.Hasil. Dari 96 sampel KPKBSK non skuamosa terdiri dari 48 pasien yang mendapat kemoterapi lini pertama dan 48 pasien yang diterapi EGFR-TKI. Berdasarkan karakteristik pasien, usia terbanyak adalah 40-60 tahun (kemoterapi 32 (66,7%) dan EGFR-TKI 31 (64,6%) dengan jenis kelamin laki-laki yang mendominasi (kemoterapi 25(52,1%), EGFR-TKI 27 (56,2%). Pasien merokok yang mendapat kemoterapi lini pertama 41,7% dan EGFR-TKI 56,3% dengan IB terbanyak untuk kemoterapi (IB ringan 27,1%) dan untuk EGFR-TKI (IB sedang 22,9%). Jenis histologi adenokarsinoma 95,8% dengan dominasi stage IV 89,6% (kemoterapi 91,7% dan EGFR-TKI 87,5%) disertai tampilan status 2 59,4%. Angka tahan hidup pasien (ATH) 6 bulan 74%, ATH 1 tahun 22,90% dan ATH 2 tahun 6,20%. Masa tengah tahan hidup (MTTH) pasien yang mendapat EGFR-TKI lebih lama sedikit dibandingkan yang mendapat kemoterapi lini pertama (263 hari versus 260 hari.Kesimpulan. Masa tahan hidup 1 tahun pasien KPKBSK non skuamosa yang diterapi EGFR-TKI sedikit lebih lama dibandingkan kemoterapi lini pertama (263 hari vs 260 hari). Sedangkan ATH 1 tahun pasien kemoterapi lini pertama lebih besar dibandingkan EGFR-TKI (25% vs 20,8%). Faktor yang paling mempengaruhi angka tahan hidup adalah stage dengan nilai p<0,05.

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ABSTRACT Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients of non-squamous type who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Persahabatan hospital.Methods. This study is a retrospective study between 2010 to 2013 from the medical records of NSCLC patients of non-squmous type who receive first-line chemotherapy and thise who recieve EGFR-TKI.Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the study is discontinued.Result. From 96 subject of NSCLC patients with non-squamous type consisted of 48 patients who receive first-line chemotherapy, and 48 patients are treate with EGFR-TKI. Based on the characteristics of the patients, most are 40-60 years old (chemotherapy 32 (66.7%) and EGFR-TKI 31 (64.6%) with the male gender that dominates (chemotherapy 25 (52.1%), EGFR-TKI 27 (56.2%). Smoking patients who received first-line chemotherapy are 41.7% and 56.3% of EGFR-TKIs with chemotherapy highest IB (mild IB 27.1%) and for EGFR-TKI (moderate IB are 22.9%). 95.8% of adenocarcinoma histology type with a predominance of stage IV 89.6% (91.7% for chemotherapy and EGFR-TKI 87.5%) with performance status 2 59.4% . Survival rate of patients are 74% for 6 months survival, 1 year survival rate is 22.90% and 2 years survival rate of 6.20%. Median period of survival rate in patients who receiving EGFR-TKI longer than they received first-line chemotherapy (263 days versus 260 days).Conclusion. Median survival rate of non-squamous NSCLC that treated by EGFR-TKI is longer than first-line chemotherapy (263 days vs 260 days). Although 1 year survival rate first-line chemotherapy in patients is greater than EGFR-TKI (25% vs 20.8%). The factors that most influence the survival rate is stages with p value<0.05.;Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients of non-squamous type who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Persahabatan hospital.Methods. This study is a retrospective study between 2010 to 2013 from the medical records of NSCLC patients of non-squmous type who receive first-line chemotherapy and thise who recieve EGFR-TKI.Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the study is discontinued.Result. From 96 subject of NSCLC patients with non-squamous type consisted of 48 patients who receive first-line chemotherapy, and 48 patients are treate with EGFR-TKI. Based on the characteristics of the patients, most are 40-60 years old (chemotherapy 32 (66.7%) and EGFR-TKI 31 (64.6%) with the male gender that dominates (chemotherapy 25 (52.1%), EGFR-TKI 27 (56.2%). Smoking patients who received first-line chemotherapy are 41.7% and 56.3% of EGFR-TKIs with chemotherapy highest IB (mild IB 27.1%) and for EGFR-TKI (moderate IB are 22.9%). 95.8% of adenocarcinoma histology type with a predominance of stage IV 89.6% (91.7% for chemotherapy and EGFR-TKI 87.5%) with performance status 2 59.4% . Survival rate of patients are 74% for 6 months survival, 1 year survival rate is 22.90% and 2 years survival rate of 6.20%. Median period of survival rate in patients who receiving EGFR-TKI longer than they received first-line chemotherapy (263 days versus 260 days).Conclusion. Median survival rate of non-squamous NSCLC that treated by EGFR-TKI is longer than first-line chemotherapy (263 days vs 260 days). Although 1 year survival rate first-line chemotherapy in patients is greater than EGFR-TKI (25% vs 20.8%). The factors that most influence the survival rate is stages with p value<0.05.;Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients of non-squamous type who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Persahabatan hospital.Methods. This study is a retrospective study between 2010 to 2013 from the medical records of NSCLC patients of non-squmous type who receive first-line chemotherapy and thise who recieve EGFR-TKI.Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the study is discontinued.Result. From 96 subject of NSCLC patients with non-squamous type consisted of 48 patients who receive first-line chemotherapy, and 48 patients are treate with EGFR-TKI. Based on the characteristics of the patients, most are 40-60 years old (chemotherapy 32 (66.7%) and EGFR-TKI 31 (64.6%) with the male gender that dominates (chemotherapy 25 (52.1%), EGFR-TKI 27 (56.2%). Smoking patients who received first-line chemotherapy are 41.7% and 56.3% of EGFR-TKIs with chemotherapy highest IB (mild IB 27.1%) and for EGFR-TKI (moderate IB are 22.9%). 95.8% of adenocarcinoma histology type with a predominance of stage IV 89.6% (91.7% for chemotherapy and EGFR-TKI 87.5%) with performance status 2 59.4% . Survival rate of patients are 74% for 6 months survival, 1 year survival rate is 22.90% and 2 years survival rate of 6.20%. Median period of survival rate in patients who receiving EGFR-TKI longer than they received first-line chemotherapy (263 days versus 260 days).Conclusion. Median survival rate of non-squamous NSCLC that treated by EGFR-TKI is longer than first-line chemotherapy (263 days vs 260 days). Although 1 year survival rate first-line chemotherapy in patients is greater than EGFR-TKI (25% vs 20.8%). The factors that most influence the survival rate is stages with p value<0.05.;Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients of non-squamous type who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Persahabatan hospital.Methods. This study is a retrospective study between 2010 to 2013 from the medical records of NSCLC patients of non-squmous type who receive first-line chemotherapy and thise who recieve EGFR-TKI.Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the study is discontinued.Result. From 96 subject of NSCLC patients with non-squamous type consisted of 48 patients who receive first-line chemotherapy, and 48 patients are treate with EGFR-TKI. Based on the characteristics of the patients, most are 40-60 years old (chemotherapy 32 (66.7%) and EGFR-TKI 31 (64.6%) with the male gender that dominates (chemotherapy 25 (52.1%), EGFR-TKI 27 (56.2%). Smoking patients who received first-line chemotherapy are 41.7% and 56.3% of EGFR-TKIs with chemotherapy highest IB (mild IB 27.1%) and for EGFR-TKI (moderate IB are 22.9%). 95.8% of adenocarcinoma histology type with a predominance of stage IV 89.6% (91.7% for chemotherapy and EGFR-TKI 87.5%) with performance status 2 59.4% . Survival rate of patients are 74% for 6 months survival, 1 year survival rate is 22.90% and 2 years survival rate of 6.20%. Median period of survival rate in patients who receiving EGFR-TKI longer than they received first-line chemotherapy (263 days versus 260 days).Conclusion. Median survival rate of non-squamous NSCLC that treated by EGFR-TKI is longer than first-line chemotherapy (263 days vs 260 days). Although 1 year survival rate first-line chemotherapy in patients is greater than EGFR-TKI (25% vs 20.8%). The factors that most influence the survival rate is stages with p value<0.05., Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients of non-squamous type who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Persahabatan hospital.Methods. This study is a retrospective study between 2010 to 2013 from the medical records of NSCLC patients of non-squmous type who receive first-line chemotherapy and thise who recieve EGFR-TKI.Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the study is discontinued.Result. From 96 subject of NSCLC patients with non-squamous type consisted of 48 patients who receive first-line chemotherapy, and 48 patients are treate with EGFR-TKI. Based on the characteristics of the patients, most are 40-60 years old (chemotherapy 32 (66.7%) and EGFR-TKI 31 (64.6%) with the male gender that dominates (chemotherapy 25 (52.1%), EGFR-TKI 27 (56.2%). Smoking patients who received first-line chemotherapy are 41.7% and 56.3% of EGFR-TKIs with chemotherapy highest IB (mild IB 27.1%) and for EGFR-TKI (moderate IB are 22.9%). 95.8% of adenocarcinoma histology type with a predominance of stage IV 89.6% (91.7% for chemotherapy and EGFR-TKI 87.5%) with performance status 2 59.4% . Survival rate of patients are 74% for 6 months survival, 1 year survival rate is 22.90% and 2 years survival rate of 6.20%. Median period of survival rate in patients who receiving EGFR-TKI longer than they received first-line chemotherapy (263 days versus 260 days).Conclusion. Median survival rate of non-squamous NSCLC that treated by EGFR-TKI is longer than first-line chemotherapy (263 days vs 260 days). Although 1 year survival rate first-line chemotherapy in patients is greater than EGFR-TKI (25% vs 20.8%). The factors that most influence the survival rate is stages with p value<0.05.]"