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"Mathematical concepts and methods in modern biology offers a quantitative framework for analyzing, predicting, and modulating the behavior of complex biological systems. The book presents important mathematical concepts, methods and tools in the context of essential questions raised in modern biology.Designed around the principles of project-based learning and problem-solving, the book considers biological topics such as neuronal networks, plant population growth, metabolic pathways, and phylogenetic tree reconstruction. The mathematical modeling tools brought to bear on these topics include boolean and ordinary differential equations, projection matrices, agent-based modeling and several algebraic approaches. Heavy computation in some of the examples is eased by the use of freely available open-source software."

"Represents a small and highly selective sample of the quantitative approach to biology. The author encourages the reader to disseminate further the cause of mathematics applied to the biological sciences."

"HIV (Human Immunodeficiency Virus) merupakan virus infeksi berbahaya yang tidak dapat disembuhkan. Penularan infeksi HIV melalui jarum suntik rentan terjadi dalam komunitas pecandu narkoba suntik (Injecting Drug Users / IDU) yang saling berbagi jarum suntik dalam grup ?sahabat?. Penulisan ini membahas perilaku penyebaran infeksi HIV pada komunitas IDU melalui model matematika berdasarkan model klasik epidemik SIR (Susceptibles, Infectious, Recovered). Model menggunakan asumsi bahwa pecandu yang menyadari sudah mengidap AIDS tidak ikut berbagi jarum suntik dalam komunitas IDU. Model penyebaran infeksi HIV pada komunitas IDU memperhatikan kekuatan infeksi dengan mekanisme pertukaran jarum suntik. Untuk menganalisa perilaku penyebaran infeksi HIV pada komunitas IDU, model dianalisa dengan menentukan basic reproduction ratio ( ) dan dua titik kesetimbangan yaitu titik kesetimbangan bebas infeksi dan titik kesetimbangan epidemik. Analisa sistem dinamik dilakukan dengan menganalisa basic reproduction ratio ( ) untuk menentukan kestabilan dari titik kesetimbangan bebas infeksi dengan menggunakan teorema kestabilan global Lyapunov dan kestabilan titik kesetimbangan epidemik dengan teorema kestabilan lokal dan didukung oleh kriteria Bendixon-Dulac. Hasil penelitian menunjukkan bahwa infeksi HIV mewabah pada komunitas IDU jika R⍺ > 1, sedangkan jika R⍺ ≤ 1 maka infeksi HIV tidak mewabah pada komunitas IDU.

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Human immunodeficiency Virus (HIV) is a dangerous infection virus that cannot be recovered. The spreading of HIV infection through drug injecting equipment (DIE) is susceptible for Injecting Drug Users (IDU) Community who shared drug injecting equipment for the ?friendship? group. This paper explains the behavior of HIV transmission among community of IDU through by mathematical models based on classical epidemic models SIR (Susceptibles, Infectious, Recovered). Model uses assumption that the users who aware suffered AIDS will not share drug injecting equipment among IDU community. Models for HIV transmission among IDU community notice the mechanism of exchange of a drug injecting equipment. To analyze the behavior of HIV transmission among IDU community, models is going to be analyze by determine the basic reproduction ratio and two equilibriums which are disease-free equilibrium and epidemic equilibrium. Dynamic system analysis can be done by analyze of basic reproduction ratio to determine the stability of disease-free equilibrium by Lyapunov global stable theorem and the stability of epidemic equilibrium by local stable theorem with Bendixon-Dulac criterion. As the results of this paper, Infection of HIV become an epidemic on IDU community if R⍺ > 1, whereas HIV is not an epidemic on IDU community if R⍺ ≤ 1."

"Mathematical Models in Biology is an introductory book for readers interested in biological applications of mathematics and modeling in biology. A favorite in the mathematical biology community, it shows how relatively simple mathematics can be applied to a variety of models to draw interesting conclusions. Connections are made between diverse biological examples linked by common mathematical themes. A variety of discrete and continuous ordinary and partial differential equation models are explored. Although great advances have taken place in many of the topics covered, the simple lessons contained in Mathematical Models in Biology are still important and informative.Shortly after the publication of Mathematical Models in Biology, the genomics revolution turned Mathematical Biology into a prominent area of interdisciplinary research. With this new millennium, biologists have discovered that mathematics is not only useful, but indispensable! As a result, there has been much resurgent interest in, and a huge expansion of, the fields collectively called mathematical biology. This book serves as a basic introduction to concepts in deterministic biological modeling."