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Irawaty Hawari
"Bagi orang dengan penyakit kronis seperti epilepsi, kesembuhan kadang sulit dicapai dan pengobatan memakan waktu lama, sehingga kualitas hidup menjadi salah satu tujuan utama. Tujuan tulisan ini adalah untuk mendapatkan skor kualitas hidup penderita epilepsi serta faktor-faktor demografik dan medik yang mempengaruhi. Penelitian potong lintang menggunakan instrumen Quality of Life in Epilepsy (QOLIE)-31 untuk menilai kualitas hidup penderita epilepsi yang berobat jalan di Poliklinik Epilepsi RSCM. Sampel diambil secara konsekutif sejak Agustus 2005-Desember 2005. Dilakukan deskripsi demografi dan medik. QOLIE-31 terdiri dari komponen kekhawatiran akan serangan, kualitas secara umum, kesejahteraan emosional, energi/fatigue, fungsi kognitif, efek pengobatan, dan fungsi sosial. Dari 145 subjek, didapatkan skor total QOLIE-31 antara 28 ? 95 (rerata = 67.6 ; standar deviasi = 14.55). Rendahnya skor total QOLIE berhubungan dengan pendidikan yang rendah, frekuensi serangan yang sering, penggunaan obat antiepilepsi (OAE) politerapi dan jenis serangan epilepsi umum. Penggunaan obat antiepilepsi politerapi merupakan faktor yang paling dominan terhadap rendahnya skor total QOLIE-31. Penelitian ini sesuai dengan penelitian sebelumnya di India, Georgia dan Korea Selatan. Di samping itu peneliti juga menemukan pendidikan sebagai faktor risiko terhadap total skor QOLIE-31. (Med J Indones 2007; 16:101-3).

Persons with chronic disease such as epilepsy, where a cure is not attainable and therapy may be prolonged, quality of life (QoL) has come to be seen as an important goal. The objective of this study was to identify scores of quality of life (QoL related to clinical factors. A cross-sectional study using QOLIE-31 instrument to identify quality of life among ambulatory epileptic patients at Epileptic Clinic of Department of Neurology-Cipto Mangunkusumo Hospital. Samples were taken consecutively from August 2005 to December 2005. Several demographic data as well as clinical were collected. QOLIE-31 components consisted of seizure worry, overall quality of life, emotional well-being, energy/fatigue, cognitive function, medication effect and social function. We found among 145 subjects the total score of QOLIE-31 ranged from 28-95 (mean = 67.6; standard of deviation = 14.55). The total score of QOLIE-31was corelated with low education, more frequent of seizures, antiepileptic drug politherapy and type of generalized seizure. antiepileptic drug politherapy was the most dominant risk factor for lowering total score of QOLIE-31. Our finding was in accordance with previous studies in India, Georgia, South Korea. In additioin we found that education was also a risk factor for total score of QOLIE-31. (Med J Indones 2007; 16:101-3)."
Medical Journal of Indonesia, 2007
MJIN-16-2-AprJun2007-101
Artikel Jurnal  Universitas Indonesia Library
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Arif Hidayatullah
"Epilepsi merupakan serangan sesaat yang disebabkan oleh aktivitas neuronal yang berlebihan dan menghasilkan infuls listrik yang tidak normal. Epilepsi memberikan dampak terhadap beberapa aspek, yaitu aspek kesehatan fisik, aspek psikologis, aspek sosial, dan aspek lingkungan.
Tujuan penelitian ini adalah untuk mengetahui pengaruh edukasi manajemen epilepsi terhadap perubahan kualitas hidup pasien. Metode penelitian ini adalah quasy eksperiment. Sebanyak 86 pasien epilepsi yang melakukan kunjungan ke poliklinik saraf RS. Haji Jakarta yang dipilih menggunakan teknik purposive sampling.
Hasil penelitian menunjukkan bahwa ada pengaruh yang signifikan antara edukasi manajemen epilepsi dibandingkan edukasi epilepsi standar rumah sakit dalam meningkatkan kualitas hidup epilepsi (p=0,035). Faktor-faktor yang berhubungan dengan kualitas hidup pasien epilepsi adalah tingkat pendidikan (p=0,001), pekerjaan (p=0,003), dan frekuensi bangkitan (p=0,022).
Hasil analisis multivariat menunjukkan faktor yang paling dominan berhubungan dengan kualitas hidup pasien epilepsi adalah tingkat pendidikan (p=0,000; R=0,520; R2 =0,270). Penelitian ini diharapkan dapat menjadikan video edukasi manajemen epilepsi sebagai standar intervensi asuhan keperawatan pada pasien dengan epilepsi.

Epilepsy is a transient occurrence of signs or symptoms caused by abnormal neuronal activity or abnormal synchronization in the brain. The existence of epilepsy will have an impact on several aspects of life, namely the medical aspects, psychological aspects, social aspects, and environmental aspects. This impact will affect changes in the quality of life.
The aim of this study was to determine the effect of epilepsy management education on changes in the quality of life of epilepsy patients. This study was a quasy experiment method. A total of 86 epilepsy patients who visited the nerve polyclinic Jakarta Haji Hospital were selected by purposive sampling technique.
The results showed that there was a significant effect between epilepsy management education compared to hospital standard epilepsy education in improving the quality of life of epilepsy (p = 0.035). Factors related to the quality of life of epilepsy patients were the level of education (p = 0.001), employment (p = 0.003), and frequency of seizures (p = 0.022).
The results of multivariate analysis showed that the most dominant factor related to the quality of life of epilepsy patients was the level of education (p = 0,000; R = 0,520; R2 = 0,270). This study is expected to make epilepsy management education videos the standard of nursing care interventions in patients with epilepsy.
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Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2019
T53283
UI - Tesis Membership  Universitas Indonesia Library
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Arifianto
"Latar belakang: Epilepsi Rolandik adalah salah satu sindrom epilepsi terbanyak pada anak dan umumnya dianggap benign dan self-limited. Tetapi komorbiditas kognitif dan perilaku dapat ditemukan pada anak-anak dengan epilepsi yang bernama lainnya benign Rolandic epilepsy with centrotemporal spikes (BECTS) ini. Pasien epilepsi Rolandik harus dievaluasi adanya komorbiditas kognitif dan perilaku.
Tujuan: Mengetahui hubungan antara usia awitan kejang dan jumlah hemisfer yang menjadi fokus kejang dengan kemampuan kognitif dan gangguan perilaku pada anak-anak dengan epilepsi Rolandik.
Metode: Penelitian potong-lintang di sembilan RS/klinik dengan konsultan neurologi anak di Jakarta dan Banten, terhadap anak-anak berusia 6 – 12 tahun dengan epilepsi Rolandik. Penelitian meliputi anamnesis semiologi kejang, interpretasi hasil elektroensefalografi (EEG) oleh dua orang konsultan neurologi anak, dan pemeriksaan intelligence quotient (IQ) oleh psikolog.
Hasil: Nilai verbal IQ sebagai parameter kognitif berbicara/berbahasa lebih banyak bernilai  average pada subjek dengan usia awitan kejang yang lebih muda (< 6 tahun). Nilai verbal IQ < average lebih banyak didapatkan pada subjek dengan fokus gelombang kejang pada salah satu sisi hemisfer. Jumlah subjek yang mengalami gangguan perilaku berupa gangguan pemusatan perhatian dan hiperaktivitas (GPPH) dan gangguan spektrum autism (GSA) lebih banyak pada kelompok usia awitan kejang < 6 tahun dan fokus kejang hemisfer bilateral. Tidak ada hubungan yang bermakna secara statistik antara usia awitan kejang dan jumlah hemisfer yang menjadi fokus kejang dengan komorbiditas kognitif dan perilaku.
Simpulan: Anak-anak dengan epilepsi Rolandik dapat memiliki komorbiditas kognitif berupa gangguan berbicara/berbahasa dan komorbiditas perilaku berupa GPPH/GSA, dan dapat dipengaruhi oleh usia awitan kejang dan jumlah hemisfer yang menjadi fokus kejang, meskipun hubungannya tidak bermakna secara statistik.

Background: Rolandic epilepsy is one of the most common epilepsy syndromes in children and is generally considered benign and self-limited. But cognitive and behavioral comorbidities can be found in children with this epilepsy, which has another name: benign Rolandic epilepsy with centrotemporal spikes (BECTS). Rolandic epileptic patients should be evaluated for cognitive and behavioral comorbidities.
Objective: To determine the relationship between age at onset of seizures and the number of hemispheres that are the focus of seizures with cognitive abilities and behavioral disorders in children with Rolandic epilepsy.
Methods: Cross-sectional study in nine hospitals/clinics with pediatric neurology consultants in Jakarta and Banten, on children aged 6-12 years with Rolandic epilepsy. The research includes interviews on seizure semiology history, interpretation of electroencephalographic (EEG) results by two child neurology consultants, and intelligence quotient (IQ) tests performed by psychologists.
Results: The verbal IQ score as a cognitive speaking/language parameter  average was found more in subjects with younger seizure onset (<6 years). Verbal IQ < average scores were greater in subjects with seizure focus on one side of the hemisphere. The number of subjects who experienced behavioral disorders in the form of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) was more in the age group of seizure onset < 6 years and bilateral hemispheric seizure focus. There was no statistically significant relationship between age at onset of seizures and the number of hemispheres that were the focus of seizures with cognitive and behavioral comorbidities.
Conclusion: Children with Rolandic epilepsy may have cognitive comorbidities in the form of speech/language disorders and behavioral comorbidities in the form of ADHD/ASD, and may be affected by the age of seizure onset and the number of hemispheres that are the focus of seizures, although the relationship is not statistically significant.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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"Diasumsikan bahwa pendidikan dan penerangan kesehatan telah dilakukan dan diberikan melalui wahana pelayanan kesehatan serta media massa, namun nampaknya di kalangan penderita dan masyarakat awam tingkat pengetahuan mereka tentang epilepsi kurang memadai. Dalam penelitian ini telah dilakukan wawancara terhadap 127 penderita epilepsi di klinik rawat jalan Rumah Sakit Dr. Kariadi Semarang, 95 orang keluarga pasien, dan 95 orang awam untuk mengungkap pengetahuan mereka tentang organ utama tubuh yang terganggu, etiologi, gejala-gejala dan tanda-tanda, dan faktor pemicu bangkitnya kejang berulang pada epilepsi. Jawaban-jawaban para responden dicatat secara verbatim, kemudian dianalisis dengan mencocokkan jawabannya dengan jawaban yang benar menurut literatur. Hasil analisis didapatkan pengetahuan yang jelek dan kurang tentang organ tubuh yang terganggu, etiologi, gejala-gejala dan tanda-tanda, dan faktor pemicu bangkitnya kejang berulang pada epilepsi pada kelompok pasien, keluarga pasien, dan orang awam. Pada ketiga kelompok tersebut tidak terdapat perbedaan bermakna tingkat pengetahuan mengenai epilepsi. Tingkat pengetahuan pasien terendah dibanding dua kelompok yang lain. Tingkat pendidikan tidak mempengaruhi tingkat pengetahuan responden. Temuan tersebut menggambarkan kurang memadainya komunikasi antar dokter dan pasien pada wahana pelayanan kesehatan serta pendidikan kesehatan masyarakat tentang epilepsi yang diterima oleh keluarga pasien dan orang awam. (Med J Indones 2003; 12: 29-39)

It is assumed that health education has been done and health information has been given through health service institutions and mass media, but it seems that the patients as well as common people have insufficient knowledge about epilepsy. Interviews had been carried out upon 127 epilepsy patients in out patient clinic Dr. Kariadi Hospital Semarang, 95 patients’ family, and 95 common people to explore their knowledge on the main disturbed organ, etiology, symptoms and signs, and trigger factors of repeating seizure in epilepsy. The respondents’ answers were recorded verbatim, and analyzed by matching to the right answers according to references. Bad and insufficient knowledge on the main organ disturbed in epilepsy, etiology, symptoms and signs, and trigger factors for repeated seizure was founded among the epilepsy patients, their family, and common people. There were no significant differences of the level of knowledge among the three groups of respondents. The patients’ knowledge was the worst, compared to the others. The level of education of the respondents did not influence their level of knowledge. In conclusion, this study reflects an insufficient communication between doctors and the patients in the health service institution, and an insufficient public health education about epilepsy received by the patients’ family and common people. (Med J Indones 2003; 12: 29-39)"
Medical Journal of Indonesia, 12 (1) January March 2003: 29-39, 2003
MJIN-12-1-JanMar2003-29
Artikel Jurnal  Universitas Indonesia Library
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Irawaty Hawari
"Latar Belakang: Bagi orang dengan penyakit kronis seperti epilepsi, dimana kesembuhan sulit dicapai dan pengobatan memakan waktu lama, kualitas hidup menjadi salah satu tujuan utama.
Tujuan: Untuk mendapatkan rerata skor kualitas hidup serta faktor-faktor demografik dan medik yang dapat mempengaruhi kualitas hidup penderita epilepsi.
Metodologi: Penelitian potong lintang deskriptif menggunakan instrumen Quality of Life in Epilepsy (QOLIE)-31 untuk menilai kualitas hidup 145 penderita epilepsi yang berobat jalan di Poliklinik Epilepsi RSCM. Sampel diambil secara konsekutif sejak Agustus 2005-Desember 2005. Dilakukan deskripsi demografi dan medik, serta analisis bivariate, multivariate untuk menentukan faktor-faktor apa saja yang berhubungan dengan skor total QOLIE maupun skor masing-masing komponen QOLIE (kekhawatiran akan serangan, kualitas secara umum, kesejahteraan emosional, energilfatigue, fungsi kognitif, efek obat, fungsi sosial).
Hasil: Pada penelitian ini didapatkan rerata skor total QOLIE 67.62 ± 14.55. Faktor-faktor yang mempengaruhi (p< 0.05) rendahnya skor total QOLIE-31 adalah tingkat pendidikan, frekuensi serangan dan jenis pengobatan. Tingkat pendidikan berhubungan kuat dengan kekhawatiran akan serangan; frekuensi serangan dengan kekhawatiran akan serangan dan fungsi sosial; jenis pengobatan dengan fungsi kognitif dan efek obat.
Simpulan: Tingkat pendidikan rendah, frekuensi serangan yang sering dan jenis pengobatan politerapi berhubungan kuat dengan rendahnya kualitas hidup.

Background: For persons with a chronic disease such as epilepsy, where a cure is not attainable and therapy may be prolonged, quality of life (QoL) has come to be seen is an important goal.
Objective: is determine mean scores of QoL, demographic and clinical factors that influence the epileptic patient?s QoL.
Method: Cross-sectional study using QOLIE-31 instrument to determine the quality of life of 145 ambulatory epileptic patients at Epileptic Clinic of Department of Neurology-Ciptomangunkusumo Hospital. Samples were taken consecutively from August 2005 to December 2005. Clinical and demographic data were collected Bivariate and multivariate analysis were used to determine which factors influenced QOLIE-3 either the total scores or the scores from each component of the QOLIE-31 (seizure worry, overall quality of life, emotional well-being, energy/fatigue, cognitive function, medication effect and social function).
Result: The mean total score of QOLIE-31 was 67.62 t 14.55. The variables that were most strongly predicted (p
Conclusion: low education level, high frequency of seizures, and antiepileptic polytherapy are correlated with lower QOLIE-31 scores."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2006
T21315
UI - Tesis Membership  Universitas Indonesia Library
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Roezwir Azhary
"untuk mengetahui berapa banyak penderita epilepsi parsial kompleks yang menampilkan aktivitas epileptik pada rekaman EEG jika ditidurkan dengan kloralhidrat
Kebanyakan dari rekaman EEG diwaktu bangun normal pada penderita yang didiagnosis dengan epilepsi Subdivisi EEG bagian Neurologi FKUI/RSUPNCM mendapatkan kelainan spileptik 23% dari 483 rekaman BEG selama tahun 1996 dari seluruh pasien yang dikirim dengan diagnosis epilepsi Untuk meningkatkan nilai diagnostik EEG telah mengembangkan berbagai macam tehnik Pada penelitian ini kami mencoba melakukan induksi tidur sebagai suatu prosedur prosedur der gan kloralhidrat 50 mg/kg berat badan pasien. studi pra dapat melakukan tes, semua pasien yang secara klinis didiagnosis sebagai epilepsi parsial kompleks yang berkembang menjadi serangan umura Upa 13-60 tahun, masih mendapat serangan dalam 1 tahun terakhir, tidak menderita penyakit darah tinggi dan jantung. Sebelum direkam, semus parlen harus makan pagi dan melanjutkan makan obat anti epilepsi sesuai dosis yang telah ditetapkan sebelumnya. Kami memakai alat EEG merek Neurofax 12 saluran dengan EOG dan ECG, filter 70 Hz dan elektroda sistim 10-20 ditambah sepasang elektrode zygomatikus. Semua subyek direkam selama 14 menit waktu bangun, kemudian diberikan 50 mg/kg berat badan klorelhidrat, setelah menunggu 15-30 menit rekaman dilanjutkan selama periode waktu yang sama. Studi dilakukan mulai dari bulan Mei sampai Oktober 1996. Dari 36 pasien yang memenuhi kriteria, 2 dikeluarkan karena tidak bisa tidur dalam waktu yang telah ditentukan. Ada 13 penderita laki-laki (38,2%) dan 21 penderita wanita (61,8%) dari 34 penderita. Usia rata-rata 27,2 ± 1,37. Aktivitas epileptik terlihat pada 11 dari 34 (32,4%) penderita pada rekaman EEG banggun dan 20 dari 34 (58,8%) pada rekaman tidur dimana perbedaan tersebut cukup bermakna secara statistik P<0,05. Empat dari 20 penderita (20%) aktivitas epileptik terlihat pada lobus frontal dan 16 dari 20 penderita (80%), terlihat pada lobus temporal. Kebanyakan aktivitas epileptik (80%) terlihat pada stadium II tidur non REM dan 55% pada stadium III tidur non REM. Pada stadium 1 aktivitas epileptik 25%, namun ada beberapa rekaman dimana stadium I tidur non REM tak terlihat. Stadium IV tidur non REM tidak tercapai dalam penelitian ini. Aktivitas cepat bervoltage rendah terlihat tidak terlalu menyolok pada setiap rekaman. Kloralhidrat dapat digunakan sebagai obat penginduksi tidur dengan hasil yang cukup baik, dimana aktivitas cepat voltage rendah terlihat tidak begitu menyolok. Penderita dengan aktivitas epileptik terlihat lebih banyak pada rekaman tidur dibandingkan dengan rekaman diwaktu bangun dan perbedaan tersebut bermakna secara statistik.

to find out how many people with complex partial epilepsy display epileptic activity on EEG recordings if put to sleep with chloralhydrate
Most of the EEG recordings when awake were normal in patients diagnosed with epilepsy. The EEG Subdivision of the Neurology Department, FKUI/RSUPNCM, found spileptic abnormalities, 23% of the 483 BEG recordings during 1996 from all patients sent with a diagnosis of epilepsy. To increase the diagnostic value of EEG, we have developed various techniques. In this study, we tried to induce sleep as a procedure using 50 mg chloralhydrate/kg of the patient's body weight. Preliminary studies were able to carry out tests, all patients who were clinically diagnosed as complex partial epilepsy that developed into attacks aged up to 13-60 years, still had attacks in the last 1 year, did not suffer from high blood pressure or heart disease. Before being recorded, Semus Parlen must eat breakfast and continue taking anti-epileptic drugs according to the previously determined dose. We use a 12 channel Neurofax brand EEG device with EOG and ECG, 70 Hz filter and 10-20 electrode system plus a pair of zygomatic electrodes. All subjects were recorded for 14 minutes while awake, then given 50 mg/kg body weight of chlorelhydrate, after waiting 15-30 minutes the recording was continued for the same time period. The study was conducted from May to October 1996. Of the 36 patients who met the criteria, 2 were excluded because they were unable to sleep within the specified time. There were 13 male sufferers (38.2%) and 21 female sufferers (61.8%) out of 34 sufferers. Mean age 27.2 ± 1.37. Epileptic activity was seen in 11 of 34 (32.4%) patients on waking EEG recordings and 20 of 34 (58.8%) on sleeping recordings where the difference was statistically significant at P<0.05. In four of 20 patients (20%), epileptic activity was seen in the frontal lobe and in 16 of 20 patients (80%), it was seen in the temporal lobe. Most epileptic activity (80%) was seen in stage II non-REM sleep and 55% in stage III non-REM sleep. In stage 1, epileptic activity is 25%, but there are several recordings where stage I non-REM sleep is not visible. Stage IV non-REM sleep was not achieved in this study. Fast, low-voltage activity appears less prominent in each recording. Chloralhydrate can be used as a sleep-inducing drug with quite good results, where low voltage fast activity does not appear to be so striking. Patients with epileptic activity were seen more frequently in sleep recordings compared to waking recordings and this difference was statistically significant.
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Jakarta : Fakultas Kedokteran Universitas Indonesia, 1997
T-pdf
UI - Tesis Open  Universitas Indonesia Library
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Nadia Devianca
"Latar belakang: Prevalensi ketidakpatuhan pasien pada pengobatan epilepsi cukup besar. Penyebab ketidakpatuhan terdiri dari banyak faktor, yang dapat diklasifikasikan menjadi intensional ataupun non intensional. Perilaku kepatuhan pasien dibentuk oleh bagaimana pasien melakukan representasi terhadap penyakit yang dideritanya, sehingga pengetahuan, sikap, dan perilaku (PSP) pasien epilepsi dinilai dapat berhubungan dengan kepatuhan pasien. Penelitian ini dilakukan untuk menilai hubungan tersebut.
Metode penelitian: Penelitian ini dilakukan dengan desain potong lintang. Populasinya adalah pasien epilepsi yang berobat ke poli neurologi RSUPNCM bulan Agustus – September 2022. Sampel diambil dengan cara consecutive sampling. Analisis statistik menggunakan regresi logistik.
Hasil: Rerata nilai pengetahuan sebesar 15,41+/-3,827 dengan rentang 7-35 (nilai 7 mengindikasikan ukuran pengetahuan paling baik). Median nilai sikap adalah 18 (10-27)dengan rentang 8-40 (nilai 8 mengindikasikan sikap paling baik). Median nilai perilaku adalah 10 (5-20), dengan rentang 5-25 (nilai 5 menunjukkan perilaku paling baik). Nilai kepatuhan pasien pada penelitian ini adalah 55,7%. Analisis multivariat menunjukkan bahwa semakin buruk nilai pengetahuan maka akan meningkatkan probabilitas terjadinya ketidakpatuhan sebesar 1,271 kali.
Kesimpulan: Pengetahuan mengenai epilepsi memiliki hubungan dengan kepatuhan pengobatan, sedangkan sikap dan perilaku pasien epilepsi tidak memiliki hubungan dengan kepatuhan pengobatan

Background: There was a high prevalence of patient’s non-adherence to anti-seizure medication (ASM). It caused by many factors and classified as intentional or non intentional. Patient’s adherence was formed when they represent their ilness, so knowledge, attitudes, and behavior of patient with epilepsy (PWE) are considered to be related to their adherence. This study was aimed to assess this relationship.
Methods: We conducted a cross sectional study on PWE who came to RSUPNCM Neurology outpatient clinic from August to September 2022. All consecutive patients were asked to complete the given questionnaire. We used a logistic regression for statistical analysis.
Results: The mean score of knowledge was 15,41+/-3,827 (range, 7-35), with score of 7 indicated the best knowledge. The median score of attitudes was 18, interquartile range (IQR) 10-27 (range, 8-40), with score of 8 indicated the best attitudes. The median score of behavior was 10, IQR 5-20 (range, 5-25), with score of 5 indicated the best behavior. Fifty-five-point seven percent were estimated to be adherent. The multivariate analysis showed that with the worse score of knowledge, the probability of non-adherence will increase by 1,271 times.
Conclusion: Knowledge about epilepsy has a relationship with ASM adherence, while attitude and behavior of PWE has no relationship with ASM adherence
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Depok: Fakultas Kedokteran Universitas Indonesia, 2022
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Andira Larasari
"ABSTRAK
Latar Belakang. Gangguan cemas menyeluruh (GCM) merupakan salah satu bentuk gangguan ansietas tersering pada populasi epilepsi yang dapat menurunkan kualitas hidup, sehingga deteksi dini sangatlah penting. Generalized Anxiety Disorder-7 (GAD-7) merupakan instrumen penapis GCM satu-satunya yang pernah divalidasi pada pasien epilepsi, yaitu di Korea dengan titik potong ≥7. Instrumen GAD-7 dapat dikerjakan pasien sendiri kurang dari 3 menit, sehingga cocok digunakan di poliklinik neurologi. Penelitian ini bertujuan untuk mendapatkan kuesioner GAD-7 versi bahasa Indonesia yang valid, reliabel dan akurat untuk menapis GCM pada pasien epilepsi dewasa.
Metode Penelitian. Penelitian dibagi menjadi 2 tahap. Tahap pertama meliputi adaptasi lintas budaya berdasarkan ketentuan World Health Organization (WHO), uji validitas isi berdasarkan penilaian pakar mengenai relevansi butir pertanyaan GAD-7 hasil adaptasi, dilanjutkan uji validitas interna, reliabilitas interna dan reliabilitas test-retest pada 30 pasien epilepsi yang memenuhi kriteria inklusi. Tahap kedua adalah uji diagnostik. Hasil GAD-7 dengan titik potong ≥7 dibandingkan dengan wawancara Mini International Neuropsychiatric Interview International Classification of Diseases-10 (MINI ICD-10) sebagai baku emas.
Hasil. Koefisien validitas isi berdasarkan metode Martuzua dari GAD-7 hasil adaptasi bahasa Indonesia adalah 0,847. Hasil uji validitas interna dengan korelasi Spearman didapatkan koefisien korelasi 0,648 hingga 0,800 (p<0,01). Uji reliabilitas konsistensi interna dengan Cronbach?s Alpha 0,867. Perbedaan nilai koefisien korelasi dan Cronbach?s Alpha antara pemeriksaan pertama dan retest menunjukkan reliabilitas test-retest yang baik. Dari 146 subyek uji diagnostik, prevalensi GCM hasil pemeriksaan MINI ICD-10 sebesar 16,4%. Dengan titik potong ≥7, GAD-7 memiliki sensitivitas 100% dan spesifisitas 84,4%.
Kesimpulan. Kuesioner GAD-7 versi Indonesia terbukti valid dan reliabel sehingga dapat digunakan untuk menapis GCM. Dengan titik potong ≥7, GAD-7 memiliki nilai akurasi yang tinggi untuk menapis GCM pada pasien epilepsi dewasa.ABSTRACT
Background. Generalized anxiety disorder (GAD) is one of the most common type among anxiety disorders in epilepsy population that can impaired patients quality of life. The Generalized Anxiety Disorder-7 (GAD-7) is a screening tool for detecting GAD that has been validated in epilepsy patients in Korea with cut-off point ≥7. The GAD-7 could be filled by the patients themselves in less than three minutes; hence, it is appropriate to be used in the neurology outpatient setting. The objective of this study is to obtain a valid, reliable, and accurate GAD-7 in Indonesian language as a screening tool of GAD in adult epilepsy patients.
Method. The study was conducted in two phases. The first phase included transcultural adaptation based on World Health Organization standards, content validity test based on expert consideration regarding the relevance of GAD-7 question items, followed by internal validity test, internal reliability test and test-retest in 30 epilepsy patients. The second phase was diagnostic test, in which, the GAD-7 with cut off point ≥7 will be compared with Mini International Neuropsychiatric Interview International Classification of Diseases-10 (MINI ICD-10) as the gold standard examination for diagnosing GAD.
Results. Content validity coefficient of GAD-7 adapted version based on Martuzua method was 0.847. Internal validity test with Spearman correlation obtained the correlation coefficient 0.648 to 0.800 (p< 0.01). Internal consistency reliability test with Cronbach?s Alpha was 0.867. The difference of correlation coefficient and Cronbach?s Alpha between the first and the retest showed good test-retest reliability. Out of 146 subjects of diagnostic test, the prevalence of GAD using MINI ICD-10 was 16.4%. With cut off point >7, GAD-7 had sensitivity 100% and specificity 84.4%.
Conclusion. The Indonesian version of the the GAD-7 was proven to be valid and reliable, also was found to be accurate as a screening tool for GAD in adult epilepsy patient with cut off point ≥7.;Background. Generalized anxiety disorder (GAD) is one of the most common type among anxiety disorders in epilepsy population that can impaired patients quality of life. The Generalized Anxiety Disorder-7 (GAD-7) is a screening tool for detecting GAD that has been validated in epilepsy patients in Korea with cut-off point ≥7. The GAD-7 could be filled by the patients themselves in less than three minutes; hence, it is appropriate to be used in the neurology outpatient setting. The objective of this study is to obtain a valid, reliable, and accurate GAD-7 in Indonesian language as a screening tool of GAD in adult epilepsy patients.
Method. The study was conducted in two phases. The first phase included transcultural adaptation based on World Health Organization standards, content validity test based on expert consideration regarding the relevance of GAD-7 question items, followed by internal validity test, internal reliability test and test-retest in 30 epilepsy patients. The second phase was diagnostic test, in which, the GAD-7 with cut off point ≥7 will be compared with Mini International Neuropsychiatric Interview International Classification of Diseases-10 (MINI ICD-10) as the gold standard examination for diagnosing GAD.
Results. Content validity coefficient of GAD-7 adapted version based on Martuzua method was 0.847. Internal validity test with Spearman correlation obtained the correlation coefficient 0.648 to 0.800 (p< 0.01). Internal consistency reliability test with Cronbach?s Alpha was 0.867. The difference of correlation coefficient and Cronbach?s Alpha between the first and the retest showed good test-retest reliability. Out of 146 subjects of diagnostic test, the prevalence of GAD using MINI ICD-10 was 16.4%. With cut off point >7, GAD-7 had sensitivity 100% and specificity 84.4%.
Conclusion. The Indonesian version of the the GAD-7 was proven to be valid and reliable, also was found to be accurate as a screening tool for GAD in adult epilepsy patient with cut off point ≥7.;Background. Generalized anxiety disorder (GAD) is one of the most common type among anxiety disorders in epilepsy population that can impaired patients quality of life. The Generalized Anxiety Disorder-7 (GAD-7) is a screening tool for detecting GAD that has been validated in epilepsy patients in Korea with cut-off point ≥7. The GAD-7 could be filled by the patients themselves in less than three minutes; hence, it is appropriate to be used in the neurology outpatient setting. The objective of this study is to obtain a valid, reliable, and accurate GAD-7 in Indonesian language as a screening tool of GAD in adult epilepsy patients.
Method. The study was conducted in two phases. The first phase included transcultural adaptation based on World Health Organization standards, content validity test based on expert consideration regarding the relevance of GAD-7 question items, followed by internal validity test, internal reliability test and test-retest in 30 epilepsy patients. The second phase was diagnostic test, in which, the GAD-7 with cut off point ≥7 will be compared with Mini International Neuropsychiatric Interview International Classification of Diseases-10 (MINI ICD-10) as the gold standard examination for diagnosing GAD.
Results. Content validity coefficient of GAD-7 adapted version based on Martuzua method was 0.847. Internal validity test with Spearman correlation obtained the correlation coefficient 0.648 to 0.800 (p< 0.01). Internal consistency reliability test with Cronbach?s Alpha was 0.867. The difference of correlation coefficient and Cronbach?s Alpha between the first and the retest showed good test-retest reliability. Out of 146 subjects of diagnostic test, the prevalence of GAD using MINI ICD-10 was 16.4%. With cut off point >7, GAD-7 had sensitivity 100% and specificity 84.4%.
Conclusion. The Indonesian version of the the GAD-7 was proven to be valid and reliable, also was found to be accurate as a screening tool for GAD in adult epilepsy patient with cut off point ≥7.;Background. Generalized anxiety disorder (GAD) is one of the most common type among anxiety disorders in epilepsy population that can impaired patients quality of life. The Generalized Anxiety Disorder-7 (GAD-7) is a screening tool for detecting GAD that has been validated in epilepsy patients in Korea with cut-off point ≥7. The GAD-7 could be filled by the patients themselves in less than three minutes; hence, it is appropriate to be used in the neurology outpatient setting. The objective of this study is to obtain a valid, reliable, and accurate GAD-7 in Indonesian language as a screening tool of GAD in adult epilepsy patients.
Method. The study was conducted in two phases. The first phase included transcultural adaptation based on World Health Organization standards, content validity test based on expert consideration regarding the relevance of GAD-7 question items, followed by internal validity test, internal reliability test and test-retest in 30 epilepsy patients. The second phase was diagnostic test, in which, the GAD-7 with cut off point ≥7 will be compared with Mini International Neuropsychiatric Interview International Classification of Diseases-10 (MINI ICD-10) as the gold standard examination for diagnosing GAD.
Results. Content validity coefficient of GAD-7 adapted version based on Martuzua method was 0.847. Internal validity test with Spearman correlation obtained the correlation coefficient 0.648 to 0.800 (p< 0.01). Internal consistency reliability test with Cronbach?s Alpha was 0.867. The difference of correlation coefficient and Cronbach?s Alpha between the first and the retest showed good test-retest reliability. Out of 146 subjects of diagnostic test, the prevalence of GAD using MINI ICD-10 was 16.4%. With cut off point >7, GAD-7 had sensitivity 100% and specificity 84.4%.
Conclusion. The Indonesian version of the the GAD-7 was proven to be valid and reliable, also was found to be accurate as a screening tool for GAD in adult epilepsy patient with cut off point ≥7."
Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Regina Putri Apriza
"Epilepsi merupakan penyakit kronik dengan gejala yang cukup khas yaitu adanya bangkitan kejang tanpa pemicu. Angka prevalensi epilepsi tergolong tinggi di Indonesia dan hal ini merupakan masalah yang harus segera diatasi. Selain itu, epilepsi pada anak dapat menyebabkan berbagai gangguan perkembangan. Salah satu pemeriksaan penunjang untuk mendiagnosis klasifikasi epilepsi yang tersedia saat ini adalah EEG yang memberikan gambaran pola gelombang spesifik tertentu. Oleh karena itu, dalam penelitian ini akan dianalisis hubungan antara epilepsi pada anak dengan gambaran EEG serta perkembangan anak. Desain penelitian ini adalah potong lintang dengan menggunakan data sekunder rekam medik dari Departemen Ilmu Kesehatan Anak RSUPN Cipto Mangunkusumo tahun 1995-2010. Hasil penelitian ini menunjukkan bahwa terdapat 115 anak (61,5%) dengan klasifikasi epilepsi simtomatik, 105 anak (56,1%) dengan gambaran EEG abnormal, dan 96 anak (51,3%) dengan perkembangan terlambat. Dari hasil analisis hubungan antar variabel menggunakan Chi-Square, terdapat hubungan bermakna antara perkembangan anak dengan klasifikasi epilepsi (p<0,001) disertai dengan hubungan bermakna antara aspek perkembangan yaitu motorik kasar (p<0,001), sosial personal (p=0,024), dan bahasa (p<0,001) tetapi tidak ada hubungan bermakna antara aspek motorik halus terhadap klasifikasi epilepsi.Tidak ada hubungan bermakna antara gambaran EEG secara umum dengan klasifikasi epilepsi tetapi terdapat hubungan bermakna antara adanya gambaran epileptiform multifokal (p=0,018) dan nonspesifik (p=0,015) terhadap klasifikasi epilepsi.

Epilepsy is a chronic disease with typical symptom, seizure without provocation. The prevalence of epilepsy in Indonesia can be classified as high which creates another health problem to overcome. Furthermore, epilepsy in children may cause variety of development impairment. EEG is one of the current available examination to diagnose the classification of epilepsy through specific wave pattern findings. Therefore, this study is determined to analyze the association between epilepsy in children with EEG recording and child development. This study is a cross-sectional study using secondary data from Child Health Department of RSUPN Cipto Mangunkusumo medical records from 1995-2010.The result of the study shows that 115 subjects (61,5%) has symptomatic epilepsy, 105 subjects (56,1%) with abnormal EEG finding, and 96 subjects (51,3%) with delayed development. After performing Chi-Square test, there is a significant association between child development and epilepsy classification (p<0,001)followed by significant association between gross motoric (p<0,001), social personal (p=0,024), and language (p<0,001), however there were no association between gross motoric and epilepsy classification.There were no association between EEG recording with epilepsy classification,however there were a significant association between multifocal epileptiform finding (p=0,018) and nonspecific wave finding (p=0,015) to classify epilepsy
"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Skripsi Membership  Universitas Indonesia Library
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Ismi Adhanisa Hamdani
"ABSTRAK
Tujuan: Menentukan prevalensi excessive daytime sleepiness (EDS) pada pasien
dengan epilepsi dan faktor-faktor yang berhubungan di Rumah Sakit Cipto
Mangunkusumo (RSCM).
Metode: Studi potong lintang deskriptif ini menggunakan kuesioner Epworth
Sleepiness Scale (ESS) pada pasien epilepsi yang diambil secara konsekutif di
poliklinik neurologi RSCM, pada bulan Oktober-November 2015. Faktor-faktor
yang dianalisis meliputi usia, jenis kelamin, jenis bangkitan, sindrom epilepsi,
etiologi epilepsi, frekuensi bangkitan, bangkitan nokturnal, risiko Obstructive
Sleep Apnea (OSA), depresi mayor, gangguan cemas menyeluruh, obat anti
epilepsi, dan potensial resistensi obat. EDS ditentukan jika skor ESS > 10. Risiko
OSA ditetapkan dengan kuesioner STOP-Bang; depresi mayor ditentukan dengan
kuesioner Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)
versi Indonesia; gangguan cemas menyeluruh ditentukan dengan kuesioner Mini
International Neuropsychiatric Interview for International Classification of
Diseases-10 (MINI ICD-10).
Hasil: Diantara 93 pasien epilepsi, prevalensi EDS adalah sebanyak 32.3%;
wanita lebih banyak dari pria. Faktor-faktor yang berhubungan secara signifikan
dengan EDS adalah usia kurang dari 35 tahun, frekuensi bangkitan dalam 1 tahun
lebih dari sama dengan 8 kali, depresi mayor, dan potensial resisten obat. Dari
analisis multivariat, terdapat 2 faktor independen yang berhubungan dengan EDS
yaitu depresi mayor dan potensial resisten obat.
Kesimpulan: EDS umum dijumpai pada pasien epilepsi dengan prevalensi
32.3%. Depresi mayor dan potensial resistensi obat merupakan faktor yang
berhubungan dengan EDS pada pasien epilepsi ABSTRACT
Purpose: To determine the prevalence of excessive daytime sleepiness (EDS) in
epilepsy patients and its related factors at Cipto Mangunkusumo Hospital
Jakarta, Indonesia.
Materials and Method: This cross-sectional descriptive study using Epworth
Sleepiness Scale (ESS) questionnaire to identify EDS in epilepsy patients visited
our neurology clinic during October-November 2015 consecutively. Related
factors that had been analyzed were age, sex, seizure type, epilepsy syndrome,
etiology, seizure frequency, nocturnal seizures, risk of Obstructive Sleep Apnea
(OSA), major depression, general anxiety disorder, anti epileptic drug, and
potentially drug resistant epilepsy (DRE). EDS was determined if ESS score > 10.
Risk of OSA was assessed by STOP-Bang questionnaire; major depression was
assessed by Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)
Indonesian version; general anxiety disorder was assessed by Mini International
Neuropsychiatric Interview for International Classification of Diseases-10 (MINI
ICD-10). Data analysis was done using SPSS 17.0.
Results: Among 93 subjects, prevalence of EDS was 32.3%; female was more
common than male. Related factors that significantly influenced to EDS were age
< 35 years old, seizure frequency within 1 year >8 times, major depression and
potentially DRE. From multivariate analysis, there were 2 independent factors
that related to EDS that were major depression and potentially DRE.
Conclusions: EDS is common in epilepsy patients (32.3%). Major depression and
potentially DRE were related factors of EDS in epilepsy patients.
;Purpose: To determine the prevalence of excessive daytime sleepiness (EDS) in
epilepsy patients and its related factors at Cipto Mangunkusumo Hospital
Jakarta, Indonesia.
Materials and Method: This cross-sectional descriptive study using Epworth
Sleepiness Scale (ESS) questionnaire to identify EDS in epilepsy patients visited
our neurology clinic during October-November 2015 consecutively. Related
factors that had been analyzed were age, sex, seizure type, epilepsy syndrome,
etiology, seizure frequency, nocturnal seizures, risk of Obstructive Sleep Apnea
(OSA), major depression, general anxiety disorder, anti epileptic drug, and
potentially drug resistant epilepsy (DRE). EDS was determined if ESS score > 10.
Risk of OSA was assessed by STOP-Bang questionnaire; major depression was
assessed by Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)
Indonesian version; general anxiety disorder was assessed by Mini International
Neuropsychiatric Interview for International Classification of Diseases-10 (MINI
ICD-10). Data analysis was done using SPSS 17.0.
Results: Among 93 subjects, prevalence of EDS was 32.3%; female was more
common than male. Related factors that significantly influenced to EDS were age
< 35 years old, seizure frequency within 1 year >8 times, major depression and
potentially DRE. From multivariate analysis, there were 2 independent factors
that related to EDS that were major depression and potentially DRE.
Conclusions: EDS is common in epilepsy patients (32.3%). Major depression and
potentially DRE were related factors of EDS in epilepsy patients.
"
Fakultas Kedokteran Universitas Indonesia, 2016
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UI - Tugas Akhir  Universitas Indonesia Library
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