Horizons in Medicine is a series of books based on the highly respected annual Advanced Medicine Conference organized by the Royal College of Physicians. Each volume contains carefully edited papers and texts of lectures by eminent speakers from a range of specialties. The series makes an important contribution to the continuing medical education of all physicians, both consultants and those in training grades, by acquainting them with recent developments in the understanding and practice of modern clinical medicine. This new volume in the Horizons in Medicine series will continue the high standard of earlier volumes and has added the feature of multiple-choice questions to help doctors evaluate their understanding of the most important aspects of the papers.