Latar Belakang: Diantara berbagai risiko penyakit kardiovaskular, hipertensi dan hiperkolesterolemia merupakan risiko yang terbesar. Medikasi renin-angiotensinaldosterone system inhibitor, yang terdiri atas angiotensin converting enzyme inhibitor dan angiotensin receptor blockers, serta statin digunakan untuk terapi hipertensi dan hiperkolesterolemia secara berurutan. Efek medikasi ini terhadap reaksi inflamasi telah ditunjukkan oleh berbagai studi dan juga efeknya terhadap jaringan periodontal. Tujuan: Mengetahui pengaruh antara medikasi renin-angiotensin-aldosterone system inhibitor dan statin terhadap status periodontal pasien dengan risiko penyakit kardiovaskular. Metode: Pencarian studi melalui electronic database menggunakan panduan Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA). Studi yang sesuai kriteria inklusi dinilai risiko bias kemudian dilakukan meta-analisis. Hasil: Sintesis kualitatif menunjukkan adanya hasil yang inkonsisten terhadap pengaruh RAAS Inhibitor terhadap status periodontal. Meta-analisis antara kelompok statin dibandingkan dengan intervensi lain seperti diet ditemukan rerata bleeding on probing index ditemukan perbedaan signifikan secara statistik dengan perbedaan rerata -13,4% (95% CI:[-23,08;- 3,72], p=0,007), rerata kehilangan perlekatan klinis tidak menunjukkan adanya perbedaan yang signifikan dengan perbedaan rerata -0,16 mm (95% CI:[-0,40;-0,07], p=0,17), dan] rerata kedalaman probing terdapat perbedaan yang signifikan secara statistik antar kelompok dengan perbedaan rerata -0,38 mm (95% CI:[-0,53;-0,23], p<0,00001). Kesimpulan: Pengaruh medikasi renin-angiotensin-aldosterone system inhibitor berupa angiotensin converting enzyme inhibitor dan angiotensin receptor blockers pada pasien hipertensi terhadap status periodontal menunjukkan hasil yang inkonsisten dan medikasi statin secara sistemik dapat memperbaiki status periodontal bleeding on probing index dan kedalaman probing pada pasien dengan hiperkolesterolemia.

---

Background: Among the various risks of cardiovascular disease, hypertension and hypercholesterolemia are the greatest risks. Renin-angiotensin-aldosterone system inhibitor medication, consisting of angiotensin converting enzyme inhibitors and angiotensin receptor blockers, as well as statins are used to treat hypertension and hypercholesterolemia respectively. The effect of this medication on inflammatory reactions has been demonstrated by various studies as well as its effect on periodontal tissue. Objectives: To determine the effect of renin-angiotensin-aldosterone system inhibitor medication and statins on the periodontal status of patients at risk of cardiovascular disease. Materials and Methods: Search for studies through electronic databases using the Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines. Studies that met the inclusion criteria were assessed for risk of bias and then meta-analyzed. Results: Qualitative synthesis showed inconsistent results regarding the effect of RAAS inhibitors on periodontal status. Meta-analysis between the statin group compared with other interventions such as diet found that the mean bleeding on probing index found a statistically significant difference with a mean difference of - 13.4% (95% CI:[-23.08;-3.72], p= 0.007), the mean clinical attachment loss did not show any significant difference with a mean difference of -0.16 mm (95% CI: [-0.40;-0.07], p=0.17), and] mean probing depth there was a statistically significant difference between groups with a mean difference of -0.38 mm (95% CI:[-0.53;-0.23], p<0.00001). Conclusion: The effect of renin-angiotensin-aldosterone system inhibitor medication in the form of angiotensin converting enzyme inhibitors and angiotensin receptor blockers in hypertensive patients on periodontal status showed inconsistent results and statin medication systemically could improve periodontal status, bleeding on probing index and probing depth in patients with hypercholesterolemia.