Latar belakang Obesitas sentral merupakan obesitas dengan penimbunan lemak terutama di area perut. Pada obesitas sentral didapatkan asupan karbohidrat, lemak, atau protein yang tinggi. Peningkatan massa sel lemak menimbulkan aktivasi dan infiltrasi makrofag dan menghasilkan berbagai sitokin proinflamasi. Sel netrofil dan limfosit berperan dalam respon terhadap inflamasi. Rasio neutrofil terhadap limfosit (RNL) merupakan parameter inflamasi yang relatif murah dan mudah. Penelitian ini bertujuan mengetahui hubungan antara asupan karbohidrat, protein, lemak, dan RNL pada individu dengan obesitas sentral dan non obesitas sentral. Metode Penelitian merupakan studi potong-lintang menggunakan data sekunder pada Mei 2022−November 2023, berupa data asupan makronutrien, karbohidrat, protein, lemak, dan jumlah neutrofil, limfosit. Kriteria subjek penelitian berusia 16-25 tahun dan tidak ada penyakit infeksi atau inflamasi. Hasil Didapatkan 405 subjek terdiri dari 343 (85%) non obesitas sentral dan 62 (15%) obesitas sentral. Subjek penelitian berusia 18,5 (16,6−21,6) tahun dan perempuan 248 (61%) orang. Didapatkan kadar dan nilai p kelompok non obesitas sentral dan obesitas sentral untuk total makronutrien, karbohidrat, protein, lemak, dan RNL adalah 1496,1(±387,06) dan 1595,22(±419,98) kalori/hari, p=0,068; 196,58(±55,09) dan 204.04(±58,57) gram/hari, p=0,332; 49,77(±15,19) dan 55,31(±17,09) gram/hari, p=0,010; 56(±19,63) dan 60,94(±19) gram/hari, p=0,068; 1,69 (1,35−2,23) dan 2,25(1,79−2,81), p<0,001. Nilai korelasi (r)antara asupan total makronutrien, karbohidrat, protein, dan lemak dengan RNL adalah 0,027, 0,019, 0,093, dan 0,06. Kesimpulan Didapatkan nilai lebih tinggi dan bermakna untuk asupan protein (gram/hari) dan RNL pada subjek obesitas sentral terhadap non obesitas sentral. Tidak didapatkan hubungan antara asupan total makronutrien, karbohidrat, protein, dan lemak dengan RNL.

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Background Central obesity is obesity with fat accumulation, especially in the abdominal area. In central obesity, there is a high intake of carbohydrates, fats, or proteins. Increased fat cell mass causes activation and infiltration of macrophages and produces various proinflammatory cytokines. Neutrophils and lymphocytes play a role in the response to inflammation. The neutrophil-to-lymphocyte ratio (NLR) is a relatively cheap and easy inflammatory parameter. This study aims to determine the relationship between carbohydrate, protein, fat, and NLR intake in individuals with central obesity and non-central obesity. Methods The study is a cross-sectional study using secondary data in May 2022-November 2023, in the form of data on macronutrient intake, carbohydrates, proteins, fats, and the number of neutrophils, and lymphocytes. The criteria for research subjects are 16-25 years old and have no infectious or inflammatory diseases. Results A total of 405 subjects comprised 343 (85%) non-central obesity and 62 (15%) central obesity. The subjects were 18,5 (16,6−21,6) years and 248 (61%) women. The levels and p values of the non-central obesity and central obesity groups for total macronutrients, carbohydrates, proteins, fats, and NRL were 1496,1 (±387,06) and 1595,22 (±419,98) calories/day, p=0,068; 196,58 (±55,09) and 204,04 (±58,57) grams/day, p=0,332; 49,77 (±15,19) and 55,31 (±17,09) grams/day, p=0,010; 56 (±19,63) and 60,94 (±19) grams/day, p=0,068; 1,69 (1,35−2,23) and 2,25(1,79−2,81), p<0,001. The correlation values (r) between total macronutrient, carbohydrate, protein, and fat intakes with RNL were 0,027, 0,019, 0,093, and 0,06. Conclusion A higher and more significant value was obtained for protein intake (grams/day) and RNL in central obesity subjects compared to non-central obesity. No relationship existed between total macronutrient, carbohydrate, protein, and fat intakes with RNL.